Genomic characterization and pathogenic mechanisms of WGPSB-2 isolated from the Himalayas.

The utilization of microbial agents for the management of white grub has been a long-standing practice in biocontrol. In a previous study, we isolated entomopathogenic bacteria WGPSB-2 from the Himalayan region. To gain insights into the genetic characteristics and potential mechanisms underlying the pathogenicity of WGPSB-2, we performed genomic analysis of WGPSB-2.

VR/AR in ergonomics and workspace design: a dual-perspective analysis of applications and implications.

This literature review systematically examines virtual reality (VR) and augmented reality (AR) technologies in ergonomics and workspace design using a comprehensive dataset of scholarly articles from Web of Science database. A hybrid review methodology integrating both bibliometric and content analysis used HistCite enabled citation-based analysis and performance mapping on 279 articles. Bibliographic coupling analysis using VOSviewer identified five major research themes based on two distinct perspectives: (1) application of VR/AR as tools for improving ergonomic assessments and workspace design, and (2) ergonomic implications of VR/AR system usage.

Shear-driven segregation kinetics in binary polymer blends: Insights from dissipative-particle-dynamics simulations.

This study investigates the phase separation kinetics of binary (AB) polymer blends under various shear conditions using dissipative particle dynamics simulations. The system, confined by two parallel walls, is subjected to different shear cases, including stationary and moving walls. The simulations explore critical and off-critical polymer compositions, analyzing morphological evolution, scaling behavior, domain growth, and structural anisotropy.

Effect of botanicals, organic nutrient sources, and bio-control agents on root-knot nematode () infecting tomato.

Root-knot nematode () causes up to 30% yield loss in tomato () worldwide, and reliance on synthetic nematicides poses serious environmental and health risks. This study explores sustainable alternatives by evaluating the nematicidal potential of sp and essential oils and extracts, along with and , under both and microplot conditions. Essential oils exhibited significant juvenile mortality and egg hatching inhibition at low concentrations, outperforming solvent extracts.

Isolation, morphological, and molecular characterization of a native strain from the Mid-Indian Himalayas with insights into biocontrol potential.

Entomopathogenic nematodes (EPNs) from the families Steinernematidae and Heterorhabditidae are biocontrol agents for the management of a wide range of insect pests. There is a tremendous opportunity for the discovery of new nematode strains and species adapted to local environmental conditions and insect pests. Therefore, in the present study, efforts were made to isolate EPN strains/species from the Northwestern Himalayas (NWH) region.

A clinico-epidemiological study, assessing possible predictors of mortality and health-related quality of life for people living with visceral leishmaniasis - human immune virus (VL-HIV) co-infection in a high burden kala-azar endemic state of India: a descriptive cross-sectional study.

Background: Visceral leishmaniasis-human immunodeficiency virus (VL-HIV) co-infection has emerged as a serious concern, which could adversely affect the VL elimination efforts of the country. These patients have a poor VL therapeutic success rate, more drug-related toxicity, and relapses resulting in high mortality. Despite the emerging pattern of VL-HIV co-infection, there have been limited studies analyzing the presentation of VL-HIV co-infection in Bihar, India.

Advancements in Cancer Care by Exploring Multimodality Imaging Techniques and their Applications.

Advancements in multimodality imaging have significantly improved cancer diagnosis, treatment planning, and patient management. This review explores the integration of imaging techniques, such as MRI, CT, and PET, alongside emerging technologies like radiomics and AI to provide comprehensive insights into tumor characteristics. By combining imaging data with laboratory tests, clinicians can achieve more accurate cancer staging and personalized treatment strategies.

A comprehensive comparative analysis of fatty acid profiles and GC-MS based metabolomics in Barbari and Beetal goat milk.

This study investigated breed-specific compositional and metabolic differences in milk from Barbari (BaGM) and Beetal (BeGM) goats, two prominent Indian breeds. Physicochemical analysis revealed no significant differences (p > 0.05) in pH, acidity, fat, protein, or total solids, although BaGM had higher solids-not-fat, and BeGM exhibited higher ash content (p > 0.

Automated severity level estimation of wheat rust using an EfficientNet-CBAM hybrid model.

Wheat rust is a severe fungal disease that significantly impacts wheat crops, resulting in substantial losses in quality and quantity, often exceeding 50%. Timely and early accurate estimation of disease severity in fields is critical for effective disease management. Early identification of Rust at low severity levels can facilitate prompt implementation of control measures, potentially saving crops.

The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability.

Background: ATP-dependent nucleosome remodeling complexes of the imitation switch (ISWI) family slide and space nucleosomes. The ISWI ATPase subunit forms obligate complexes with accessory subunits whose mechanistic roles remain poorly understood. In baker's yeast, the Isw2 ATPase subunit associates with Itc1, the orthologue of human ACF1/BAZ1A.

Effect of customized 3D-printed MARPE appliance on hard tissues, soft tissues, and airway: A prospective CBCT study.

Background: The advances in technology have enabled the customization of appliances including mini-screw-assisted rapid palatal expansion (MARPE) appliances for skeletal expansion in young adult patients. The study assessed the short-term effects of customized MARPE appliances on the hard tissues, soft tissues, and airway volume over a period of 6 months.

Methods: A total of 15 patients in the age range of 15 to 25 years were treated for transverse maxillary deficiency using a three-dimensional (3D) printed customized MARPE appliance.

Impact of polysaccharide addition on the technological aspects of low lactose milk powders.

The research aimed to assess the effect of polysaccharides (maltodextrin and β-cyclodextrin) on technological properties of low-lactose milk powder obtained by spray drying of β-galactosidase hydrolysed milk. Low-lactose milk powders i.e.

Evaluation of the effectiveness of road safety measures and their impact on the pattern and distribution of extracranial and intracranial hemorrhages in fatal head injury cases in Uttar Pradesh, India.

Introduction: In Uttar Pradesh, India, there are many fatal head injuries as a result of road traffic accidents (RTAs). Studying the pattern and distribution of intracranial hemorrhages, a frequent complication of severe head trauma might provide vital information on the efficacy of traffic safety regulations. To improve road safety tactics and lower fatal head injuries in Uttar Pradesh, this study intends to assess the effect of road safety measures on the frequency and distribution of intracranial hemorrhages in fatal head injury patients.

Exploring Gonadal Functions in Patients With Alcoholic Liver Disease: A Correlative Analysis With Disease Severity.

Background and objective Alcoholic liver disease (ALD) encompasses a spectrum of liver conditions caused by excessive alcohol consumption, including fatty liver, alcoholic hepatitis, and cirrhosis. Both phenotypical and biochemical changes in gonadal hormones are observed across these stages. This study aimed to evaluate the clinical, biochemical, and hormonal abnormalities in patients with varying degrees of ALD and to assess their correlation with disease severity.

Antibacterial efficacy of nanoparticles on orthodontic materials-A systematic review and meta-analysis.

Aim: This study aims to evaluate the efficacy of coated nanoparticles within orthodontic appliances as a novel strategy to enhance their antibacterial properties.

Material And Methods: A systematic search for relevant articles published between 2013 and March 2024 was conducted across electronic databases including PubMed, Scopus, Web of Science, and EBSCOhost. Studies meeting pre-defined eligibility criteria were included and assessed for methodological quality.

Development of an Artificial Intelligence-Based Algorithm for the Assessment of Skeletal Age and Detection of Cervical Vertebral Anomalies in Patients with Cleft Lip and Palate.

To develop an artificial intelligence (AI)-based algorithm for the assessment and comparison of skeletal maturation in patients with and without cleft lip and/or palate and to detect the presence of cervical vertebral anomalies (CVAs). Retrospective cohort study. A university orthodontic clinic and comprehensive cleft care centers.

Unraveling microbial landscapes: high-throughput amplicon sequencing reveals distinct bacterial communities and potential health risks in potable springs of the Indian Himalayas.

Spring water is a vital drinking resource for residents in the Eastern Himalayas' Sikkim, India. While our initial investigations into spring water quality highlighted concerning levels of fecal coliform bacteria, the bacterial community composition (BCC) of these springs remains largely unexplored. This study sought to elucidate the BCC of Himalayan spring water, exploring its effects on water quality and delving into the unique bacterial ecology of these high-altitude springs.

A comparative evaluation of the antimicrobial efficacy of Chlorhexidine and Chlorine dioxide on self-ligating brackets contaminated with Streptococcus mutans biofilm- An In vitro study.

Objective: To evaluate and compare antimicrobial efficacy of Chlorhexidine and Chlorine dioxide mouthwashes on . biofilm created on metal and ceramic self-ligating brackets.

Materials And Methods: A total of 162 metal and ceramic self-ligating brackets (3M™ SmartClip™ & Clarity SL™) were randomly divided into 3 groups and 2 subgroups.

Aromaticity of Heterocyclic Compounds and Their Corrosion Inhibition Property: Experimental and Theoretical Analysis.

Heterocycle derived moieties, namely, -(4-methoxyphenyl)-1-(1-pyrrol-2-yl)methanimine (MPM), 1-(furan-2-yl)--(4-methoxyphenyl)methanimine (FMM), and -(4-methoxyphenyl)-1-(thiophen-2-yl)methanimine (MTM), were synthesized followed by analysis of their structural aspects using FTIR and H NMR spectroscopic techniques. The corrosion retarding abilities of the same were distinguished by gravimetric and certain electrochemical measures for mild steel in 0.5 M HSO, and MTM was obtained with maximum inhibition efficiency of 97.

Eco-friendly and sustainable approaches against aphids management () and dissipation studies of imidacloprid in important cash crop capsicum under protected and open condition.

Capsicum is generally infested with many biotic agents mainly sucking insects, among them the major is aphid (. Chemical management is one of the most common strategies for their management. However, there are no recommended insecticides for insect management in polyhouse.

Effect of Aligning Forces by Two Preadjusted Edgewise Techniques on a Buccally Positioned Maxillary Canine at Varying Vertical Displacements: A Finite Element Study.

Objective: To evaluate the effect of continuous arch and piggyback mechanics in a straight wire appliance (SWA) for the alignment of buccal and variably vertically positioned maxillary canines.

Methods: A three-dimensional finite element model with near-normal occlusion and buccal and vertically displaced maxillary canines was used. Two groups were created to simulate two commonly used SWAs techniques, continuous archwire (Group 1) and piggyback models (Group 2).

Reduction of maillard browning in spray dried low-lactose milk powders due to protein polysaccharide interactions.

Lactose hydrolysed concentrated milk was prepared using β-galactosidase enzyme (4.76U/mL) with a reaction period of 12 h at 4 °C. Addition of polysaccharides (5 % maltodextrin/β-cyclodextrin) to concentrated milk either before or after lactose hydrolysis did not result in significant differences (p > 0.

Exploring peptidomes of by-products generated during production using WS4 for identification of novel bioactive peptides.

The considerable value of whey is evident from its significant potential applications and contributions to the functional food and nutraceutical market. The by-products were individually obtained during functional and novel soy cheese production using defined lactic acid bacterial strains of Sikkim Himalaya's traditional . Hydrolysis of substrate proteins by starter proteinases resulted in a comparable peptide content in whey and soy whey which was associated with antioxidant and ACE inhibition potential.

A Metabolomics Approach to Establish the Relationship between the Techno-Functional Properties and Metabolome of Indian Goat Yoghurt.

Introduction: Goat milk has poorer fermentation characteristics due to the absence or only traces of αs1-casein, due to which goat yoghurt contains a less dense gel structure. Moreover, the fermentation characteristics of the milk vary between the breeds of the same species. Therefore, it becomes imperative to explore a few metabolites which could regulate the techno-functional properties of goat yoghurt.