Publications by authors named "Subhankar Kumar Singh"
Article Synopsis
- A study was conducted to evaluate the treatment outcomes of single-dose liposomal amphotericin B for visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL), involving 527 cases, primarily VL.
- The cure rate for VL was found to be 95%, with significant differences in treatment success between genders and age groups; males had higher success rates than females, while younger patients (≤23 years) also fared better.
- The study highlighted that PKDL patients treated with this drug had a significantly shorter duration of disease development compared to those who received alternative treatments, emphasizing the need for ongoing monitoring of treatment strategies.
Introduction: Presence of asymptomatic individuals in endemic areas is common. The possible biomarkers in asymptomatic individuals once they get exposed to infection as well as following conversion to symptomatic disease are yet to be identified.We identified asymptomatic Visceral leishmaniasis (VL) infection amongst rK39+sorted direct agglutination test positive (DAT+) endemic healthy population and confirmed it by quantitative PCR(qPCR).
View Article and Find Full Text PDFLeishmania donovani: impairment of the cellular immune response against recombinant ornithine decarboxylase protein as a possible evasion strategy of Leishmania in visceral leishmaniasis.
Int J Parasitol
January 2015
Ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthesis pathway, is significant in the synthesis of trypanothione, T(SH)2, the major reduced thiol which is responsible for the modulation of the immune response and pathogenesis in visceral leishmaniasis. Data on the relationship between ornithine decarboxylase and the cellular immune response in VL patients are limited. Therefore, we purified a recombinant ornithine decarboxylase from Leishmania donovani (r-LdODC) of approximately 77kDa and examined its effects on the immunological responses in peripheral blood mononuclear cells of human visceral leishmaniasis cases.
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