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Background: The advances in technology have enabled the customization of appliances including mini-screw-assisted rapid palatal expansion (MARPE) appliances for skeletal expansion in young adult patients. The study assessed the short-term effects of customized MARPE appliances on the hard tissues, soft tissues, and airway volume over a period of 6 months.
Methods: A total of 15 patients in the age range of 15 to 25 years were treated for transverse maxillary deficiency using a three-dimensional (3D) printed customized MARPE appliance. The changes in hard tissues, soft tissues, and airway volume were evaluated using cone beam computed tomography before expansion (T0) and at 6 months post-expansion (T1). The Digital Imaging and Communications in Medicine files were analyzed for post-expansion changes using the NemoCeph 3D and 3D Slicer 5.6.1 software.
Results: An effective skeletal expansion was observed with significant changes in intercanine, interpremolar, and intermolar width; and decreased mid-palatal suture density in the anterior region (P < .05). The changes in tooth inclination and alveolar bone thickness were mostly non-significant apart from a significant decrease in buccal bone thickness in the coronal third region (P < .05). There was no significant root resorption or change in airway volumes (P > .05). The philtrum height increased significantly by 1.17 mm (P = .019) with no significant change on right and left sides.
Conclusions: Rapid palatal expansion with 3D-printed customized MARPE enables effective and symmetrical expansion with a significant increase in philtrum height and no significant adverse effects in terms of alveolar bone thickness, dental inclination, root resorption, and airway volumes.
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http://dx.doi.org/10.1016/j.ejwf.2024.12.002 | DOI Listing |
Drug Dev Ind Pharm
September 2025
Jiangsu Medical College, Yancheng, 224005, China.
Objective: To prepare astragaloside IV dripping pills (ASDP) and assess their therapeutic effects on mice with doxorubicin hydrochloride-induced dilated cardiomyopathy (DCM).: Astragaloside IV (AS) exhibits pharmacological effects in treating cardiovascular diseases, however, its clinical application is hindered by poor solubility and low bioavailability. The study sheds light on new therapeutic strategy of DCM and development of AS formulations.
View Article and Find Full Text PDFSmall
September 2025
College of Science, Nanjing Forestry University, Nanjing, 210037, China.
Inspired by the rigid exoskeleton and elastic inner tissues of crustaceans, a bilayer gel integrating high-strength rigidity and soft cushioning with high interfacial adhesion (1060 ± 40 J m ) is developed via a stepwise solid-liquid phase crosslinking strategy. Herein, a prefrozen high-concentration polyvinyl alcohol (PVA) solution forms a solid-state structural framework, while a subsequently cast low-concentration PVA solution generates a flexible layer. Partial thawing of the frozen gel during casting triggers molecular chain interpenetration at the interface, synergistically enhanced by controlled molecular penetration, freeze-thaw cycles, and salt-induced crystallization.
View Article and Find Full Text PDFInt J Gen Med
September 2025
Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Purpose: The fourth most common cause of cancer-related deaths in women is cervical cancer. Though treatment of early-stage cervical cancer is often effective, middle and advanced stage cervical cancer is hard to treat and prone to recurrence. We sought to explore the mechanism underlying cervical cancer progression to identify new therapeutic approaches.
View Article and Find Full Text PDFMed Phys
September 2025
Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Background: Radiotherapy workflows conventionally deliver one treatment plan multiple times throughout the treatment course. Non-coplanar techniques with beam angle optimization or dosimetrically optimized pathfinding (DOP) exploit additional degrees of freedom to improve spatial conformality of the dose distribution compared to widely used techniques like volumetric-modulated arc therapy (VMAT). The temporal dimension of dose delivery can be exploited using multiple plans (sub-plans) within one treatment course.
View Article and Find Full Text PDFIEEE Trans Med Imaging
September 2025
Computed Tomography (CT) to Cone-Beam Computed Tomography (CBCT) image registration is crucial for image-guided radiotherapy and surgical procedures. However, achieving accurate CT-CBCT registration remains challenging due to various factors such as inconsistent intensities, low contrast resolution and imaging artifacts. In this study, we propose a Context-Aware Semantics-driven Hierarchical Network (referred to as CASHNet), which hierarchically integrates context-aware semantics-encoded features into a coarse-to-fine registration scheme, to explicitly enhance semantic structural perception during progressive alignment.
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