Research on the Combined Antibacterial and Wound-Healing Effects of Oxygen-Carrying Hydrogel Photodynamic and Photothermal Therapy-Targeting Biofilms.

Biofilms present a significant obstacle in the treatment of bacterial infections, because of their ability to evade the host immune response and to resist conventional antibacterial drugs. This study introduces an innovative approach to overcoming these challenges by targeting the biofilm microenvironment using a multifunctional therapeutic platform. The platform leverages perfluorohexane (PFH) as an oxygen carrier to alleviate the multifunctional therapeutic platform.

A modified anterolateral transdiscal percutaneous vertebroplasty with curved needle technique for C2/C3 metastases.

Objective: Percutaneous vertebroplasty (PVP) for metastases in C2 or C3 vertebrae is limited due to technical challenges and severe adverse events. This study evaluates the efficacy and safety of a modified anterolateral transdiscal approach with curved needle technique for PVP of C2 or C3 metastases.

Materials And Methods: From January 2009 to December 2024, patients with metastatic tumors in C2 or C3 vertebrae, who underwent this modified PVP were included in a single-center clinical retrospective study.

Synthesis of ZIF-8 Coated MnO Functionalized Antibacterial Peptide Nanoparticles and Its Antibacterial and Wound-Healing Promotion Studies.

Antibiotics, a milestone invention in modern medicine, have significantly improved human quality of life and serve as a primary weapon against bacterial infections. However, antibiotic abuse has led to the emergence and worsening of bacterial resistance, now a major global public health challenge. Therefore, the efficient use of nanoscale antimicrobial peptides (APs) as therapeutic and diagnostic agents offers a novel strategy to replace conventional antibiotics.

A BACH1 inhibitor ameliorates myocardial infarction and limb ischemia in mice.

The transcription factor BTB and CNC homology 1 (BACH1) is linked to coronary artery disease risk and impairs angiogenesis after ischemic injury. However, there is a scarcity of specific BACH1 inhibitors. This study identifies BI033 as a selective BACH1 inhibitor, confirming its binding to the 91st alanine in BACH1's N-terminal.

Effects of replacing sucrose and blending extrusion modified flours on the eating quality of highland barley sugar-crisp cookies.

Highland barley (HB) sugar-crisp cookies were prepared by blending three types of extruded modified HB flours (EHBF) at varying ratios (5/10/15 %) after formula optimization on sucrose replacing (SR). The effects of SR and EHBF blending on the quality of whole HB products were evaluated. The results showed that isomaltulose could not only decrease glucose content during in vitro digestion, improve texture properties, but also effectively mask the eggy smell of cookies.

Cr(VI)-bioremediation mechanism of a novel strain Bacillus sp. Cr02 with simultaneous aerobic/anaerobic reduction for Cr(VI) from soil to groundwater.

Microbial remediation strategies have been developed to alleviate chromium (Cr) contamination in soil and groundwater. However, the complex redox conditions resulting from variations in oxygen content at different depths of the soil-groundwater system limit the ability of most microorganisms to achieve aerobic/anaerobic sustained bioreduction of Cr(VI) from topsoil to groundwater in contaminated industrial sites. This work screened a novel strain, Bacillus megaterium Cr02, investigated its unique Cr(VI) reduction mechanisms under aerobic and anaerobic conditions, and evaluated its performance in practical soil-groundwater remediation.

A Golgi apparatus-related signature for predicting prognosis and evaluating the tumor immune microenvironment of uveal melanoma.

Uveal melanoma (UVM), a highly invasive and metastatic primary eye cancer with poor prognosis, contributes significantly to melanoma-related deaths despite being less common. Despite advances in therapy, the mortality rate remains unchanged due to frequent liver metastases and limited effective prognostic biomarkers. This study employed gene expression data from The Cancer Genome Atlas and Gene Expression Omnibus databases to investigate Golgi apparatus-related gene sets (GGRGs) in UVM.

Mathematical model-assisted HPLC-MS/MS analysis on global, pseudo-targeted ceramide profiling and quantitation in serum.

Ceramides (Cers) play a crucial role in sphingolipid metabolism with multiple biological activities and functions. Due to the high regularity and variability of their structures, there exist thousands of possible Cers. The structural diversity endows them with various biological functions but also poses significant challenges for qualitative and quantitative analysis.

Vacancy Engineering Strategy Releases the Electrocatalytic Oxygen Evolution Reaction Activity of High-Entropy Oxides.

The sluggish kinetics of oxygen evolution reaction (OER) poses a great challenge to the industrial promotion of electrocatalytic water splitting and zinc-air battery. Herein, we demonstrate that the kinetic limitation of the OER imposed by a conventional adsorbate evolution mechanism can be successfully overcome through activating lattice oxygen in the electrocatalyst. For example, incorporating aluminum (Al) into high-entropy oxides (HEO) remarkably enhances the oxygen vacancy concentration, facilitates the generation of reactive oxygen species, and promotes the deprotonation during the electrochemical OER process, thereby boosting the kinetic reaction.

Combined UPLC-Q-TOF-MS/MS and Network Pharmacology to Analyze the Potential Mechanism of Jieyu Fuwei Powder for Functional Dyspepsia Treatment.

Background: Jieyu Fuwei Powder (JFP) is a modified prescription of Chinese medicine used to treat functional dyspepsia (FD). However, its components and how it works are still unknown. Identifying the active ingredients of JFP and understanding its therapeutic mechanism for FD were the objectives of the study.

Genetic analysis reveals the shared genetic architecture between breast cancer and atrial fibrillation.

Background: Epidemiological studies have observed an association between atrial fibrillation (AF) and breast cancer (BC). However, the underlying mechanisms linking these two conditions remain unclear. This study aims to systematically explore the genetic association between AF and BC.

Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis.

We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers. Results were validated through bidirectional two-sample Mendelian Randomization (MR), heterogeneity tests, and pathway enrichment, leading to a mediation pathway model.

Cobalt-glycerolates derived Co@C-T catalysts for the catalytic transfer hydrodeoxygenation of lignin-derived vanillin.

The hydrodeoxygenation of lignin-derived bio-oil is the key to its upgrading into biofuels. Currently, the catalytic transfer hydrodeoxygenation (CTHDO) has been widely studied due to the avoidance of the use of hydrogen gas. In this work, cobalt-glycerolates nanospheres derived Co@C-T catalysts were synthesized via the solvothermal method, followed by the carbothermic method at different calcination temperatures in a nitrogen atmosphere.

Hemoglobin as a mediator between air pollution and growth outcomes in children under 60 months: the moderating role of nutritional supplementation.

Background: Prior research has yielded incongruent results about the association between air pollutants and offspring hemoglobin levels, as well as between air pollutants and child development. This may be because previous studies have not taken both air pollution and nutrition into account. This study sought to examine the correlations between postnatal exposure to air pollution (PM, PM, SO, and CO), offspring hemoglobin levels, stunting, and underweight.

A theranostic three-photon fluorescent Mn complex with mixed double and triple bond for drug-induced liver injury: ONOO activatable and CO-releasing.

Recent research indicates that it is crucial to understand the relationship between peroxynitrite (ONOO) levels and the progression of drug induced liver injury (DILI). Therefore, we present an ONOO activatable probe, Mn(tpy)(CO)Br, which exhibits enhanced three photon excitation fluorescence after specific recognizing ONOO. The fluorescence enhancement mechanism is to format Mn-O double and triple bonds with a mixed oxidation state.

Construction of a synthetic microbial community and its application in salt-reduced soy sauce fermentation.

High salt conditions negatively affect the fermentation efficiency of soy sauce and human health. This study aimed to construct a synthetic microbial community based on dominant functional microorganisms for salt-reduced soy sauce fermentation by investigating the succession and function of the microbial community during factory soy sauce fermentation. The findings revealed that the interplay between salinity and microorganisms influenced the dynamic changes of microbial communities.

RGANet: A Human Activity Recognition Model for Extracting Temporal and Spatial Features from WiFi Channel State Information.

With the rapid advancement of communication technologies, wireless networks have not only transformed people's lifestyles but also spurred the development of numerous emerging applications and services. Against this backdrop, research on Wi-Fi-based human activity recognition (HAR) has become a hot topic in both academia and industry. Channel State Information (CSI) contains rich spatiotemporal information.

Deciphering the Population Characteristics of Leiqiong Cattle Using Whole-Genome Sequencing Data.

Long-term geographic isolation and breeding programs both influence population characteristics. Leiqiong cattle, a native breed from the southernmost region of China, are renowned for disease and heat resistance, with two subgroups on Hainan Island and the Leizhou Peninsula. However, the genomic differences between them remain unexplored.

Xin-Ji-Er-Kang balances mitochondrial fusion and fission to protect cardiomyocytes in mice with heart failure by regulating the ERα/SIRT3 pathway.

Background: Mitochondrial dynamics imbalance is an essential pathological mechanism in heart failure (HF). The Chinese herbal formula Xin-Ji-Er-Kang (XJEK) has demonstrated good therapeutic effects in various cardiovascular disease models. However, whether XJEK treats HF by regulating mitochondrial dynamics homeostasis and its specific molecular mechanisms remain elusive.

hsa_circ_0001508 as a new gene that may promote breast cancer progression via the miR‑505‑3p/HMGB1, VGLL3 axis.

Breast cancer (BC) is a malignant tumor, that damages the physical health of female patients. It is crucial to develop new treatment strategies for BC, as this disease significantly affects the quality of life of women in both developing and developed countries, despite the existence of effective treatment options to reduce mortality. Recently, several researchers have been studying circular RNAs (circRNAs) in BC due to their stability and sponge function.

Fabrication of lignin-MOF derived spherical carbon supported NiCo-bimetallic catalysts for selective hydrogenolysis lignin derived ether.

The conversion of abundant lignin was of great significance for the utilization of biomass resources. In this study, lignin sulfonate (LS) was selected as a carbon-based support, which was successfully introduced into the NiCo-MOF structure. A series of lignin and MOF hybrid catalysts (NiCo-MOF-LS) with varying metal ratios of Ni and Co were synthesized via the hydrothermal method.

VBCNet: A Hybird Network for Human Activity Recognition.

In recent years, the research on human activity recognition based on channel state information (CSI) of Wi-Fi has gradually attracted much attention in order to avoid the deployment of additional devices and reduce the risk of personal privacy leakage. In this paper, we propose a hybrid network architecture, named VBCNet, that can effectively identify human activity postures. Firstly, we extract CSI sequences from each antenna of Wi-Fi signals, and the data are preprocessed and tokenised.

Effects of Na1.5 and Rac1 on the Epithelial-Mesenchymal Transition in Breast Cancer.

Breast cancer is a disease that seriously endangers the health of women. However, it is difficult to treat due to the emergence of metastasis and drug resistance. Exploring the metastasis mechanism of breast cancer is helpful to aim for the appropriate target.

Bimetallic nickel‑cobalt sulfide derived from lignin-MOFs hybrid as a high-efficiency heterogeneous catalyst for hydrogenolysis of lignin dimers.

Lignin represents a significant source of aromatic hydrocarbons in the natural world. The production of high-value chemicals from lignin has the great potential to effectively address the issue of fossil energy scarcity. In this study, complex sulfides of nickel‑cobalt bimetallic catalysts were prepared via hydrothermal synthesis and subsequently employed in the catalytic hydrogenolysis of CO bonds present in lignin.