Homogeneous "Hard-Soft" Biphasic Bone Adhesives Promote Comminuted Fracture Healing through Interfacial Adaptation and Mechanical Property Maintenance.

Bone adhesives provide remarkable clinical solutions in treating highly comminuted fractures that are difficult to perform surgery with metal fixation. However, no commercial bone adhesives exhibit high adhesion, strength, and osteogenic activity for instant and sustainable fixation in dynamic, wet humoral environments at weight-bearing sites. Here, phase engineering is employed to construct a homogeneous hard-soft biphasic bone adhesive (HB-PTN) with a sea urchin-inspired structure of phosphorylated polyglutamic acid (P-PGA) encapsulating tetracalcium phosphate (TTCP) (hard phase) and a viscoelastic hydrogel composed of amino-functionalized PEGylated poly (glycerol sebacate) (PEGS-NH) and P-PGA (soft phases) for immediate, stable fixation.

Design and Improvement of Bone Adhesive in response to Clinical Needs.

Fracture represents one of the most common diagnoses in contemporary medical practice, with the majority of cases traditionally addressed through metallic device fixation. However, this approach is marred by several drawbacks, including prolonged operative durations, considerable expenses, suboptimal applicability to comminuted fractures, increased infection risks, and the inevitable requirement for secondary surgery. The inherent advantages of bone adhesives in these fields have garnered the attention of orthopedic surgeons, who have commenced utilizing biocompatible and biodegradable bone adhesives to bond and stabilize bone fragments.

Solvent-Triggered, Ultra-Adhesive, Conductive, and Biocompatible Transition Gels for Wearable Devices.

The development of robust adhesive, conductive, and flexible materials has garnered significant attention in the realm of human-machine interface and electronic devices. Conventional preparation methods to achieve these exceptional properties rely on incorporating highly polar raw materials, multiple components, or solvents. However, the overexposure of functional groups and the inherent toxicity of organic solvents often render gels non-stick or potentially biocompatible making them unsuitable for human-contact devices.

Environmentally Adaptable Organo-Ionic Gel-Based Electrodes for Real-Time On-Skin Electrocardiography Monitoring.

On-skin personal electrocardiography (ECG) devices, which can monitor real-time cardiac autonomic changes, have been widely applied to predict cardiac diseases and save lives. However, current interface electrodes fail to be unconditionally and universally applicable, often losing their efficiency and functionality under harsh atmospheric conditions (e.g.

A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration.

Osteoporosis is one of the most disabling consequences of aging, osteoporotic fractures and higher risk of the subsequent fractures leading to substantial disability and deaths, indicating both local fractures healing and the early anti-osteoporosis therapy are of great significance. Teriparatide is strong bone formation promoter effective in treating osteoporosis, while side effects limit clinical applications. Traditional drug delivery is lack of sensitive and short-term release, finding a new non-invasive and easily controllable drug delivery to not only repair the local fractures but also improve total bone mass has remained a great challenge.

Ionic interaction-driven switchable bactericidal surfaces.

Bacteria in the external environment inevitably invade the wound and subsequently colonize the wound surface during surgery and biomedical operations, which slows down the process of wound healing and tissue repair; this poses a significant threat to human health. Therefore, the development of an intelligent antibacterial surface has become the focus of research in the field of antimicrobial strategies, which has important social and economic significance. Here, we present a simple approach of producing an ionic interaction-driven anionic activation substratum which is then functionalized with cationic molecules through coulombic interactional immobilization.

Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing.

Development of biological dressings has received widespread attentions due to their good breathability, biocompatibility, wettability, and the ability to absorb wound exudate without sticking to the wound. However, current proposed antibacterial hydrogels are limited antibacterial ability, short service life and insufficient biocompatibility, which are still challenging to address intricate practical applications. Here we develop a cationic peptide-based, salt-responsive hydrogel dressing with triple functions of antifouling, bactericidal, and bacterial release by combining ε-poly-l-lysine, poly(ethylene glycol) diglycidyl ether, and poly(DVBAPS-co-GMA) via a one-pot method.

Retraction Notice to: Application of Inorganic Nanocomposite Hydrogels in Bone Tissue Engineering.

[This retracts the article DOI: 10.1016/j.isci.

Host-Guest Interaction-Mediated Photo/Temperature Dual-Controlled Antibacterial Surfaces.

Development of smart switchable surfaces to solve the inevitable bacteria attachment and colonization has attracted much attention; however, it proves very challenging to achieve on-demand regeneration for noncontaminated surfaces. We herein report a smart, host-guest interaction-mediated photo/temperature dual-controlled antibacterial surface, topologically combining stimuli-responsive polymers with nanobactericide. From the point of view of long-chain polymer design, the peculiar hydration layer generated by hydrophilic poly(2-hydroxyethyl methacrylate) (polyHEMA) segments severs the route of initial bacterial attachment and subsequent proliferation, while the synergistic effect on chain conformation transformation poly(-isopropylacrylamide) (polyNIPAM) and guest complex dissociation azobenzene/cyclodextrin (Azo/CD) complex greatly promotes the on-demand bacterial release in response to the switch of temperature and UV light.

Application of Inorganic Nanocomposite Hydrogels in Bone Tissue Engineering.

Bone defects caused by trauma and surgery are common clinical problems encountered by orthopedic surgeons. Thus, a hard-textured, natural-like biomaterial that enables encapsulated cells to obtain the much-needed biophysical stimulation and produce functional bone tissue is needed. Incorporating nanomaterials into cell-laden hydrogels is a straightforward tactic for producing tissue engineering structures that integrate perfectly with the body and for tailoring the material characteristics of hydrogels without hindering nutrient exchange with the surroundings.

Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics.

Success in disease therapy depends on precision medicines, where development of formulations with diagnostic and therapeutic functions is quite important. In this study, multifunctional theranostics based on a magnetic graphene oxide (GO) nanohybrid (GIPD) has been developed for magnetic resonance (MR) imaging-guided chemo-photothermal therapy of cancer. The GIPD is endowed with T/T MR imaging capacity via precipitation of small-sized IONP nanoparticles (8.

A novel strategy for tumor therapy: targeted, PAA-functionalized nano-hydroxyapatite nanomedicine.

The rapid development of nanotechnology has provided new strategies for the treatment of tumors. Nano-scale hydroxyapatite (HAP), as the main component of hard tissues in humans and vertebrates, have been found to specifically inhibit tumor cells. However, achieving controllable synthesis of HAP and endowing it with cancer cell-targeting properties remain enormous challenges.

Bimetallic Metal-Organic Framework-Derived Carbon Nanotube-Based Frameworks for Enhanced Capacitive Deionization and Zn-Air Battery.

Carbon-based materials have attracted intensive attentions for a wide range of energy and environment-related applications. Energy storage/conversion devices with improved performance have been achieved by utilization of metal-organic-framework (MOF)-derived carbon structures as active materials in recent years. However, the effects of MOF precursors on the performance of derived carbon materials are rarely investigated.