Dual-Mode Hybrid Discharge Plasma-Activated Injectable Hydrosol for Enhanced Immunotherapeutic Cancer Therapy.

Although cold atmospheric plasma is a promising therapeutic technique for tumor immunotherapy via reactive oxygen and nitrogen species (RONS), the challenges associated with the generation and delivery of these RONS hamper clinical adoption. Herein, a dual-mode hybrid discharge plasma-activated sodium alginate hydrosols (PAH) is proposed to enhance the antitumor immune response. Gaseous highly reactive RONS are generated by dual-mode hybrid plasma produced by mixed O and NO modes, which are converted into aqueous RONS in PAH via gas-liquid reactions between plasma and hydrosols.

Multifunctional Plasma-Activated Alginate Dressing Potentiates the Moist Healing of Chronic Infected Wounds.

Although they are beneficial for promoting the moist healing of wounds, alginate dressings often face inherent limitations, such as a lack of antibacterial and anti-inflammatory activity, in the management of chronic infected wounds. As a green chemical technology for generating reactive oxygen and nitrogen species (RONS), cold atmospheric plasma has shown promise in the bioactivation of medical dressings. Herein, a moist air discharge plasma-activated alginate dressing (mPA-AD) is proposed for enhanced moist healing of chronic infected wounds.

Mechanistic insights into air discharge mode transition: Revealing the indispensible roles of N_{2}(v) and N_{2}O_{5}.

The phenomenon of discharge mode transition in air plasmas, which refers to the selective production of reactive species under different external conditions, has been a longstanding issue and has regained major attention recently due to emerging plasma applications. In this letter, we present a novel kinetic model that incorporates both vibrational N_{2} kinetics and N_{2}O_{5} dissociation reactions in plasma chemistry. This model describes the experimental results of discharge mode transition self-consistently, which has not been achieved before.

G-CN Facilitates MOF-Derived with an Ultra-High Fe-N Proportion for a Record-Low ΔE of 0.615 V in Single-Atom Catalyst for Rechargeable Zinc-Air Batteries.

In this study, an ultra-high Fe-N proportion single-atom catalyst (g-Fe SAC) was synthesized on nitrogen-doped porous carbon using ZIF-7-NH as the precursor material. Comprehensive characterization via spherical aberration corrected transmission electron microscope (AC-TEM) and extended X-ray absorption fine structure (EXAFS) confirmed atomic dispersion of Fe species and dominant Fe-N coordination configurations. Density functional theory (DFT) analyses demonstrated that thermally metastable FeN/FeN intermediates undergo structural evolution into stabilized FeN motifs through interfacial interactions with g-CN-derived molecular frameworks.

Selection of irrigation regime for seed production of native plant in desert steppe.

It is of great significance to establish a suitable irrigation regime for the artificial propagation of native plant in arid areas. Taking the wild excellent herbage from desert steppe of Ningxia as test material, we set up an experiment with nine irrigation regimes (three irrigation times of 2, 3, and 4 times, crossed with three irrigation quotas of 150, 250, and 350 m·hm) to select the best regime by investigating the effects of different irrigation regimes on the agronomic characteristics related to seed production, seed yield and quality, as well as water use efficiency. We found that the irrigation time and quota had significant effect on plant height, branch number, reproductive branch number, inflorescence number, pod number, pod seed number, and the thousand-seed weight.

Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.

In this study, an electret-inspired, charge-injected hydrogel called QOSP hydrogel (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar-free healing of bacteria-infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed of quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), and polyaniline nanowires (PANI), forms a conductive network capable of storing and releasing electric charges, emulating an electret-like mechanism. This structure delivers bioelectrical signals continuously, enhancing wound healing by regulating immune responses and minimizing fibrosis.

Plasma-activated saline hyperthermic perfusion-induced pyroptosis boosts peritoneal carcinomatosis immunotherapy.

Peritoneal carcinomatosis (PC) is a common metastatic cancer with limited treatment options. Herein, we present a novel strategy for the combined treatment of PC involving plasma-activated saline (PAS) and hyperthermic intraperitoneal perfusion. PAS revealed a strong cytotoxic effect because of reactive oxygen species (ROS) in two-dimensional cultures and three-dimensional tumor spheroids of PC-related cell lines.

Nickel Thiocarbonate Cocatalyst Promoting ZnInS Photocatalytic Hydrogen Evolution via Built-In Electric Field.

Cocatalysts play an important role in the field of photocatalysis by providing active sites and reducing reaction barriers to increase the reaction rates. However, efficient cocatalysts usually contain expensive noble metals, such as platinum. It is thus of great significance for practical applications in developing low-cost cocatalysts in photocatalysis.

Saccharomyces cerevisiae inactivation during water disinfection by underwater plasma bubbles: Preferential reactive species production and subcellular mechanisms.

The escalating challenges posed by water resource contamination, especially exacerbated by health concerns associated with microbial fungi threats, necessitate advanced disinfection technologies. Within this context, non-thermal plasma generated within bubble column reactors emerges as a promising antifungal strategy. The effects of direct plasma bubbles within different discharge modes and thus-produced plasma activated water (PAW) on the inactivation of Saccharomyces cerevisiae are investigated.

Toward Green Liquid Nitrogen Fertilizer Synthesis: Plasma-Driven Nitrogen Oxidation and Partial Electrocatalytic Reduction.

Liquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NHNO) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air-to-NOx-to-NHNO pathway for synthesizing liquid nitrogen fertilizer.

MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway.

Background: Alzheimer's disease (AD) is a prevalent irreversible neurodegenerative condition marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)-Hippo pathway is pivotal in regulating cell apoptosis, immune response, mitochondrial function, and oxidative stress. However, the association between MST1 and mitochondrial function in AD remains unknown.

Therapeutic potential of plasma-treated solutions in atopic dermatitis.

Atopic Dermatitis (AD) is a prevalent inflammatory skin disease that is currently incurable. Plasma-treated solutions (PTS) (e.g.

Nebulized inhalation of plasma-activated water in the treatment of progressive moderate COVID-19 patients with antiviral treatment failure: a randomized controlled pilot trial.

Background: Antiviral drugs show significant efficacy in non-severe COVID-19 cases, yet there remains a subset of moderate COVID-19 patients whose pneumonia continues to progress post a complete course of treatment. Plasma-activated water (PAW) possesses anti-SARS-CoV-2 properties. To explore the potential of PAW in improving pneumonia in COVID-19 patients following antiviral treatment failure, we conducted this study.

Plasma-generated RONS in liquid transferred into cryo-microneedles patch for skin treatment of melanoma.

Malignant melanoma is the most lethal form of skin cancer. As a promising anti-cancer agent, plasma-activated water (PAW) rich in reactive oxygen and nitrogen species (RONS) has shown significant potential for melanoma treatment. However, rapid decay of RONS and inefficient delivery of PAW in conventional injection methods limit its practical applications.

In vitro Antibacterial Effect Study of Plasma-Activated Saline on .

Purpose: This study aimed to investigate the antibacterial effects of plasma-activated saline (PAS) on My-cobacterium tuberculosis (Mtb).

Methods: We conducted a growth assay on 3 strains of Mtb and an antibiotic sensitivity test on 4 strains of Mtb. Both tests included groups treated with normal saline (NS), PAS, and hydrochloric acid (HCl).

A new Ni-based cocatalyst nickel thiocarbonate enhancing graphitic carbon nitride photocatalytic hydrogen production by constructing a built-in electric field.

Despite the excellent photocatalytic activity under visible light, graphitic carbon nitride (g-CN) exhibits a high overpotential for hydrogen evolution. To address this issue, cocatalysts have been utilized to modify g-CN. However, the use of high-performance cocatalysts typically involves noble metals such as platinum and palladium, which are cost-prohibitive for practical applications.

Long-Chain Hydrocarbons from Nonthermal Plasma-Driven Biogas Upcycling.

The burgeoning necessity to discover new methodologies for the synthesis of long-chain hydrocarbons and oxygenates, independent of traditional reliance on high-temperature, high-pressure, and fossil fuel-based carbon, is increasingly urgent. In this context, we introduce a nonthermal plasma-based strategy for the initiation and propagation of long-chain carbon growth from biogas constituents (CO and CH). Utilizing a plasma reactor operating at atmospheric room temperature, our approach facilitates hydrocarbon chain growth up to C40 in the solid state (including oxygenated products), predominantly when CH exceeds CO in the feedstock.

Inactivation of microorganisms on fabrics using plasma-activated nebulized mist driven by different plasma gases.

The disinfection of fabrics is crucial in preventing the spread of infectious diseases caused by pathogenic microorganisms to maintain public health. A previous study proved that plasma-activated nebulized mist (PANM) could effectively inactivate microorganisms both in aerosol and attached to the surface. In this study, the PANM driven by different plasma gases were employed to inactivate microorganisms on diverse fabrics.

Cold atmospheric plasma for chronic kidney disease-related skin disorders.

Background: An estimated 80% of individuals with chronic kidney disease (CKD) experience concomitant skin disorders, yet experimental research that elucidates the pathological changes in CKD-affected skin is limited. Cold atmospheric plasma (CAP) has shown promise in regulating keratinocyte proliferation, skin barrier function and anti-inflammatory activity. We hypothesize that CAP will emerge as a promising therapeutic avenue for CKD-related skin diseases.

NiCS: A cocatalyst surpassing Pt for photocatalytic hydrogen production.

Cocatalysts play a key role in improving photocatalytic performance by enhancing conductivity and providing an enormous number of active sites simultaneously. However, cocatalysts are usually made of noble metals such as Pt, which are expensive and rare. Therefore, cocatalysts derived from cheap and abundant elements are highly desirable.