Prospective assessment of prognostic significance of malignant peritoneal cytology in endometrial cancer: An NRG Oncology / Gynecologic Oncology Group study on GOG-210 protocol.

Objective: To examine the association between malignant peritoneal cytology and survival outcomes in endometrial cancer.

Methods: This was an ancillary analysis of prospectively collected surgical-pathological data in the NRG Oncology / Gynecologic Oncology Group study on GOG-210 protocol. The study population included 2383 patients with stage I-III endometrial cancer from 2003 to 2011.

Indocyanine green (ICG) enhances penetration of 1300 nm optical coherence tomography imaging for murine skin.

Optical scattering in biological tissues presents a major challenge for achieving deep penetration in optical coherence tomography (OCT). Recent approaches leveraging the Kramers-Kronig (KK) relations suggest that strongly absorbing dyes can reduce scattering by modulating the tissue's refractive index. In this study, we investigate the use of indocyanine green (ICG), an FDA clinically approved near-infrared dye, as an optical clearing agent (OCA) for 1300 nm OCT imaging.

Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson's disease.

Aggregates of alpha-synuclein (α-syn) propagate through template-induced misfolding in people with Parkinson's disease (PD) and Multiple System Atrophy (MSA). Prion-like seeding is crucial in disease initiation and progression, representing a major target for disease-modifying therapies. The detection of α-syn seeding with seeding amplification assays (SAAs) has remarkable diagnostic and research potential.

Osteoarthritis in Underserved Populations: A New Lens for Social Workers in Gerontological Practice and Research.

This commentary highlights a chronic and debilitating health condition which has received limited attention from social work practitioners and researchers. Similar to other chronic health problems, Osteoarthritis (OA) is more prevalent among marginalized and racialized populations along with the associated increased negative effects. OA, commonly associated with aging and older adults, contributes to social isolation, negative mental health outcomes, and substance use within this group.

Transport Measurements of Majorization Order for Wave Coherence.

We investigate the majorization order for comparing wave coherence and reveal its fundamental consequences in transport measurements, including power distribution, absorption, transmission, and reflection. We prove that all these measurements preserve the majorization order under unitary control, enabling direct experimental characterization of the majorization order. Specifically, waves with lower coherence in the majorization order exhibit more restricted ranges of achievable measurement values.

Sleep Health Barriers and Facilitators Among African American Family Caregivers.

Objective: The cultural and historical experiences of African American family caregivers increase their risk for poor sleep health. Limited research representation hinders the development of effective sleep interventions for their unique needs. The purpose of this study is to explore the barriers and facilitators to sleep health in African American family caregivers and describe participants' preferences and recommendations for sleep health interventions.

Using a digital health platform to implement a multi-component CRC screening intervention within a federally qualified health center: study protocol for a hybrid type I trial.

Background: Over the past decade, many well-resourced health plans and systems surpassed the 80% colorectal cancer screening rate goal, while lower resource environments such as federally qualified health centers (FQHCs) lag behind. FQHCs in rural areas are especially challenged with limited resources to reach diverse patients who often lack consistent engagement with clinical care. mHealth solutions, like mPATHCRC, can address these challenges by automating tasks and expanding patient outreach.

PCB-based Miniature Vibro-Tactile Display for the Visually Impaired.

Current Braille readers are costly, limited to one or two rows of text, and there are no affordable tactile displays for images. To address this, we have developed a low-cost, electronically refreshable vibrotactile display prototype inspired by capacitive micromachined ultrasound transducers (CMUT). The design utilizes a printed circuit board (PCB) as the substrate and bottom electrode array, combined with a metalized Kapton film as the vibrating membrane and punched foam tape as a spacer.

Predictors of cessation readiness among cigarette smokers presenting for low-dose computed tomography lung cancer screening in community settings (WF-20817CD).

Background: To plan cessation services and advance health equity, understanding factors related to cessation readiness and differences among patients presenting for lung cancer screening (LCS) is imperative.

Methods: We recruited smoking patients aged 55-77 years presenting for LCS in 26 community-based imaging clinics participating in an NCI Community Oncology Research Program (NCORP) site-randomized trial (WF-20817CD, UG1CA189824). We collected outcomes of smoking cessation readiness to change and quitting self-efficacy immediately prior to screening.

Association Between Brain Substructure Dose and Scholastic Performance in Pediatric Brain Tumor Survivors Who Received Radiation Therapy.

Purpose: Radiation therapy may cause cognitive deficits in pediatric brain tumor survivors (PBTS). Scholastic data provide prediagnostic measurements, is practical for patients and families, and aligns with student learning before and after treatment. We evaluated the association between radiation dose to organs at risk (OARs) and scholastic achievement in PBTS.

Identification of a Novel Indolizine RORγT Inverse Agonist Using the AI-Driven Drug Design Platform.

Automated multiparameter optimization (MPO) at the point of initial drug design is a powerful emerging approach to improve and expedite drug development. We employed the AI-driven drug design (AIDD) platform to design novel RORγT ligands optimized using QSAR activity models, machine learning ADMET properties, 3D pharmacophore similarity, and synthetic difficulty predictions. We calculated several measures of novelty postdesign and then employed multicriteria decision analysis (MCDA) to select compounds for synthesis for this important drug target.

Advancing intercalation strategies in layered hybrid perovskites by bringing together synthesis and simulations.

Finding ways to modify the electronic structure of halide perovskites is desireable as they have applications in a variety of devices, from photovoltaics to LEDs. Additionally, designing functional materials can be facilitated through the use of computation. Here, we have used a combination of synthesis and computation to screen for intercalated, layered hybrid perovskites.

Clinical Outcomes Following Carotid Intervention in Patients with Radiation-Induced Carotid Artery Stenosis: A Propensity Score-matched Cohort Study.

Background: Radiation therapy, often combined with surgical excision is widely used in treating head and neck neoplasms. A long-term consequence of this therapy is radiation-induced carotid artery stenosis (RICS), with incidence rates reaching 27%. This study aimed to compare clinical outcomes in patients who underwent transfemoral carotid artery stenting (TFCAS) with and without RICS.

Chagas Disease in Northern California: Observed Prevalence, Clinical Characteristics, and Outcomes Within an Integrated Health Care Delivery System.

Introduction: Chagas disease (CD) is caused by the protozoan parasite and can remain clinically silent for decades. The objectives of this study were to quantify the prevalence of CD within the membership of Kaiser Permanente Northern California, to describe the demographic and clinical characteristics of patients with CD, and to report their adverse cardiovascular outcomes.

Methods: In this cohort study from 2006 to 2022, the authors identified patients with CD by screening the electronic medical record for International Classification of Diseases, 9th Revision and 10th Revision codes.

Exploring Community Co-Creation in Tree Planting and Heat-Related Health Interventions: A Qualitative Study.

Climate-amplified extreme heat events are particularly dangerous for city dwellers. Nature-based solutions such as urban greening may serve as an effective preventative strategy against extreme heat. Driven by historical injustices such as redlining, disadvantaged communities often face limited green space and a heightened risk of vulnerability to extreme heat in urban environments.

Associations Between Eating Disorders and Sociodemographic Factors in Adolescent Patients Since the Start of the COVID-19 Pandemic.

Background/objectives: The COVID-19 pandemic has been associated with significant increases in mental-health-related concerns in adolescents, including eating disorders. Disparities in screening, diagnosis, and treatment impact adolescents with eating disorders. This study aimed to describe the patterns in the prevalence and the associations between eating disorder diagnoses and demographic factors in adolescent patients since the start of the COVID-19 pandemic.

GOBeacon: An ensemble model for protein function prediction enhanced by contrastive learning.

Accurate prediction of protein function is fundamental to understanding biological processes, with computational methods becoming increasingly essential as experimental methods struggle to keep pace with the rate of newly discovered proteins. Despite significant advances in machine learning approaches, existing methods often fail to capture the complex relationships between protein structure, evolution, and function, leading to limited prediction accuracy. The challenge lies in effectively integrating diverse biological data types while maintaining computational efficiency.

Long-read sequencing is required for precision diagnosis of incontinentia pigmenti.

Incontinentia pigmenti (IP) is caused by loss-of-function variants in IKBKG, with molecular genetic diagnosis complicated by a pseudogene. We describe seven individuals from three families with IP but negative clinical genetic testing in whom long-read sequencing identified causal variants, including one family with the common exon 4-10 deletion not identified by conventional clinical genetic testing. Concurrent methylation analysis explained disease severity in one individual who died from neurologic complications, identified a mosaic variant in an individual with an atypical presentation, and confirmed skewed X chromosome inactivation in an XXY individual.

Ethics Roundtable: When the Guardian has a Conflict of Interest.

DL is a 41-year-old woman with a history of IV drug use, chronic hepatitis C, opioid use disorder, methamphetamine abuse, hypertension, endocarditis, chronic pain, and prior opioid overdoses. In 2022, she suffered a massive opioid overdose leading to cardiac arrest. After 27 min of ACLS, she regained circulation but sustained severe anoxic brain injury.

The effectiveness of fluoroscopically guided lumbar facet steroid joint injections: A systematic review.

Summary Of Background Data: Facet joint degeneration is a known source of chronic axial low back pain, and intra-articular steroid injections (IASI) have been used as a treatment.

Objectives: To systematically review the evidence of the effectiveness of fluoroscopically guided lumbar IASI for the treatment of lumbar facet joint pain.

Methods: The primary outcome was ≥50 % pain reduction at ≥ 1 month, measured by Visual Analog Scale and/or Numeric Rating Scale.

Assay for rapid quantification of capped and tailed intact mRNA.

The rapid development of mRNA vaccines since the COVID-19 pandemic has highlighted the potential of mRNA technology for vaccine and therapeutic applications. However, evaluating mRNA quality, including its integrity, 5' capping efficiency, and 3' poly(A) tailing, remains complex and challenging. Current analytical methods provide detailed insights, but are often limited by long analysis times, complex sample preparation, and the need for specialized expertise.

Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice.

Volumetric muscle loss (VML) is characterized by contractile weakness, dysfunctional mitochondrial bioenergetics, and poor rehabilitation plasticity. A hyperpolarized mitochondrial membrane potential is one attribute of the dysfunction bioenergetics and can lead to excessive reactive oxygen species (ROS) emissions. The primary objective of this study was to define the role of acute ROS emissions after VML injury.