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DL is a 41-year-old woman with a history of IV drug use, chronic hepatitis C, opioid use disorder, methamphetamine abuse, hypertension, endocarditis, chronic pain, and prior opioid overdoses. In 2022, she suffered a massive opioid overdose leading to cardiac arrest. After 27 min of ACLS, she regained circulation but sustained severe anoxic brain injury. She has remained unresponsive, with a tracheostomy and oxygen support, and was transferred to a long-term acute care hospital (LTAC). Without a surrogate, a court-appointed conservator was assigned. DL has remained full code with a goal of aggressive treatment. In 2025, DL presented with acute respiratory failure and aspiration pneumonia, progressing to sepsis. She required mechanical ventilation and was later transferred to step-down care. Her neurologic status remains unchanged: unresponsive to voice or pain, with roving gaze and fixed pupils (GCS 8). During care discussions, the conservator insisted on maintaining full code status, citing personal beliefs and financial concerns if DL were to die. She stated, "My job is to keep her alive at all costs," despite acknowledging no medical background. The palliative care team, while recognizing the conservator's legal authority, raised concerns about a potential conflict of interest and requested an ethics committee review.
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http://dx.doi.org/10.1177/10499091251351583 | DOI Listing |
Sci Prog
September 2025
Shenzhen University Sixth Affiliated Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Colorectal cancer ranks among the most prevalent and lethal malignant tumors globally. Historically, the incidence of colorectal cancer in China has been lower than that in developed European and American countries; however, recent trends indicate a rising incidence due to changes in dietary patterns and lifestyle. Lipids serve critical roles in human physiology, such as energy provision, cell membrane formation, signaling molecule function, and hormone synthesis.
View Article and Find Full Text PDFClin Orthop Relat Res
September 2025
Department of Orthopedics, Division of Adult Reconstruction Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Clin Orthop Relat Res
September 2025
Leni & Peter W. May Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Peripheral nerve injury commonly results in pain and long-term disability for patients. Recovery after in-continuity stretch or crush injury remains inherently unpredictable. However, surgical intervention yields the most favorable outcomes when performed shortly after injury.
View Article and Find Full Text PDFClin Appl Thromb Hemost
September 2025
Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Hemophilia, an X-linked monogenic disorder, arises from mutations in the or genes, which encode clotting factor VIII (FVIII) or clotting factor IX (FIX), respectively. As a prominent hereditary coagulation disorder, hemophilia is clinically manifested by spontaneous hemorrhagic episodes. Severe cases may progress to complications such as stroke and arthropathy, significantly compromising patients' quality of life.
View Article and Find Full Text PDFA growing body of research suggests that males can have internalized sexualities such as autogynephilia (sexual attraction to the thought or image of oneself as female) which lead to the development of trans identity. Here I present evidence that females can have analogous internalized sexualities such as autoandrophilia (sexual attraction to the thought or image of oneself as male) which similarly lead to the development of trans identity. The case for female autoandrophilia presented here uses both direct and indirect lines of evidence.
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