Selective C-P bond cleavage in glyphosate degradation via singlet oxygen-dominated alkali-activated peroxymonosulfate.

Achieving selective degradation of glyphosate (PMG) to avoid the formation of toxic intermediate aminomethylphosphonic acid (AMPA) is still a considerable challenge. This study developed a singlet oxygen (O)-driven alkali-activated peroxymonosulfate (PMS) system to achieve selective degradation of PMG by targeting carbon sites with varying electronegativity. The alkali-activated PMS system, utilizing NaBO, NaBO, NaBO, NaOH, and NaCO, effectively degraded PMG following pseudo-first-order kinetics, with k of 0.

Selective glyphosate degradation via oxygen activation using Fe-N-C: Critical role of size exclusion.

Selective elimination of glyphosate (PMG) from complex water matrices remains a significant challenge. Metal-nitrogen-carbon (M-N-C) materials derived from metal-organic frameworks (MOFs) offer a promising platform due to their tunable porosity and abundant active sites. In this study, three Fe-N-C-x (x = 5, 10, 20) catalysts with varying pore sizes (2-4 nm) and no surface-active sites were synthesized for PMG degradation under interference with contaminants of different sizes.

The Impact of Peripheral Vascular Motion on Acute Drug Retention of Intravascular Devices.

Purpose: This goal of this study was to determine the impact of vascular motion on acute drug transfer and retention of drug-coated balloons (DCB) or drug-eluting stents (DES).

Methods: Commercially available paclitaxel DCBs (Lutonix & IN.PACT) and a paclitaxel DES (Zilver) were subjected to physiological flow and vascular motion conditions using a peripheral-simulating benchtop bioreactor system.

FePO/WB as an efficient heterogeneous Fenton-like catalyst for rapid removal of neonicotinoid insecticides: ROS quantification, mechanistic insights and degradation pathways.

Iron-based catalysts for peroxymonosulfate (PMS) activation hold considerable potential in water treatment. However, the slow conversion of Fe(III) to Fe(II) restricts its large-scale application. Herein, an iron phosphate tungsten boride composite (FePO/WB) was synthesized by a simple hydrothermal method to facilitate the Fe(III)/Fe(II) redox cycle and realize the efficient degradation of neonicotinoid insecticides (NEOs).

Design and use of an ex vivo peripheral simulating bioreactor system for pharmacokinetic analysis of a drug coated stent.

Currently, there are no ex vivo systems that can model the motion of peripheral arteries and allow for the evaluation of pharmacokinetics (PK) of endovascular devices. The objective of this study was to develop a novel peripheral simulating bioreactor system to evaluate drug pharmacokinetics of stents. We utilized 3D-printed and off-the-shelf components to construct a peripheral-simulating bioreactor system capable of mimicking the motion of peripheral arteries.

Predicting anticancer synergistic drug combinations based on multi-task learning.

Background: The discovery of anticancer drug combinations is a crucial work of anticancer treatment. In recent years, pre-screening drug combinations with synergistic effects in a large-scale search space adopting computational methods, especially deep learning methods, is increasingly popular with researchers. Although achievements have been made to predict anticancer synergistic drug combinations based on deep learning, the application of multi-task learning in this field is relatively rare.

A complete graph-based approach with multi-task learning for predicting synergistic drug combinations.

Motivation: Drug combination therapy shows significant advantages over monotherapy in cancer treatment. Since the combinational space is difficult to be traversed experimentally, identifying novel synergistic drug combinations based on computational methods has become a powerful tool for pre-screening. Among them, methods based on deep learning have far outperformed other methods.

Metabolomic analysis reveals the molecular responses to copper toxicity in rice (Oryza sativa).

Copper (Cu) is one of the essential microelements and widely participates in various pathways in plants, but excess Cu in plant cells could induce oxidative stress and harm plant growth. Rice (Oryza sativa) is a main crop food worldwide. The molecular mechanisms of rice in response to copper toxicity are still not well understood.

Stomatal morphological variation contributes to global ecological adaptation and diversification of Brassica napus.

Stomatal density and guard cell length of 274 global core germplasms of rapeseed reveal that the stomatal morphological variation contributes to global ecological adaptation and diversification of Brassica napus. Stomata are microscopic structures of plants for the regulation of CO assimilation and transpiration. Stomatal morphology has changed substantially in the adaptation to the external environment during land plant evolution.

Genome-Wide Identification, Expression Pattern and Sequence Variation Analysis of Family Genes in Barley.

Sucrose non-fermenting 1 (SNF1)-related protein kinase (SnRK) is a large family of protein kinases that play a significant role in plant stress responses. Although intensive studies have been conducted on members in some crops, little is known about the in barley. Using phylogenetic and conserved motif analyses, we discovered 46 SnRK members scattered across barley's 7 chromosomes and classified them into 3 sub-families.

Transcriptome-wide m6A methylation profile reveals regulatory networks in roots of barley under cadmium stress.

Cadmium (Cd) pollutants restrict crop yield and food security in long-term agricultural activities. Crops have evolved adaptive strategies under Cd condition, however, the transcriptional regulatory mechanism of Cd-tolerant genes remains to be largely illustrated. In this study, barley roots were exposed to 5 µM CdCl for physiological response and transcriptome-wide m6A methylation profile.

Study on the Effect of Capsaicin on the Intestinal Flora through High-Throughput Sequencing.

As a common kind of food, pepper is well known for its special effects on the physiological state of human individuals. Capsaicin, the main component of pepper, is speculated to be linked with intestinal microorganisms on account of their direct contact. Herein, we first utilized mouse models and 16S rRNA high-throughput sequencing to compare the differences in intestinal flora between mouse groups with and without capsaicin treatment by gavage.

Construction of High-Density Genetic Map and Identification of QTLs Associated with Seed Vigor after Exposure to Artificial Aging Conditions in Sweet Corn Using SLAF-seq.

Seed vigor is a key factor that determines the quality of seeds, which is of great significance for agricultural production, with the potential to promote growth and productivity. However, the underlying molecular mechanisms and genetic basis for seed vigor remain unknown. High-density genetic linkage mapping is an effective method for genomic study and quantitative trait loci (QTL) mapping.