Circulating Neutrophil Extracellular Traps as Diagnostic and Prognostic Markers for Inflammatory Bowel Disease: A Case-Control Study.

Objective: Current challenges in inflammatory bowel disease (IBD) treatment include the invasive nature of endoscopic evaluation, the gold standard for diagnosis, and the limited prognostic value of traditional inflammatory markers such as CRP and IL-6. This study aimed to explore the potential role of neutrophil extracellular traps (NETs) as biomarkers for the diagnosis, disease monitoring, and prognosis of IBD.

Methods: A total of 100 patients with Crohn's disease or ulcerative colitis and 100 healthy controls were recruited between June 2020 and September 2022.

Long noncoding RNA promotes 5-fluorouracil resistance in colorectal cancer by regulating miR-26b/p-glycoprotein axis.

Background: Colorectal cancer (CRC) is the second most prevalent cause of cancer-related mortality and is increasing in younger individuals. Chemotherapy, a crucial adjuvant systemic therapy for CRC management, often leads to resistance through poorly characterized underlying molecular mechanisms. The long noncoding RNA is highly expressed in CRC and promotes tumor proliferation and invasion, prompting us to hypothesize that may play a crucial role in the chemotherapeutic agent 5-fluorouracil (5-Fu) resistance in CRC.

Analysis of white-light imaging-based features predictive for determination of lesion depths of superficial flat esophageal squamous cell carcinoma: a retrospective multicenter study from China.

Objectives: Endoscopic diagnosis of invasion depth of superficial esophageal squamous cell carcinoma (SESCC) by white-light imaging (WLI) modality remains difficult. This study aims to clarify WLI-based features which are predictive for invasion depth of SESCC.

Methods: A two-phase study was performed by enrolling 1288 patients with 1396 SESCC lesions.

Artificial intelligence assisted detection of superficial esophageal squamous cell carcinoma in white-light endoscopic images by using a generalized system.

Background: The use of artificial intelligence (AI) assisted white light imaging (WLI) detection systems for superficial esophageal squamous cell carcinoma (SESCC) is limited by training with images from one specific endoscopy platform.

Methods: In this study, we developed an AI system with a convolutional neural network (CNN) model using WLI images from Olympus and Fujifilm endoscopy platforms. The training dataset consisted of 5892 WLI images from 1283 patients, and the validation dataset included 4529 images from 1224 patients.

Study protocol for artificial intelligence-assisted sponge cytology as pre-endoscopy screening for early esophegeal squmaous epithelial lesions in China.

Background: Endoscopic screening is the widely accepted screening strategy for esophageal squmaous cell carcinoma (ESCC). However, massive endoscopic screening is expensive and not cost-efficient, and novel pre-endoscopy detection used as a preliminary screening method arouses new concerns. We are planning to launch an artificial intelligence (AI) assisted sponge cytology for detecting esophageal squmaous high-grade intraepithelial neoplasia (HGIN) and above lesions.

Efficacy and safety of a novel submucosal injection solution for endoscopic resection in porcine models.

Objective: A submucosal injection is usually required to improve the efficacy and safety of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR). This study aimed to evaluate the performance of 3.3% sodium carboxymethyl starch (Na-CMS) solution, a novel submucosal injection solution, for ESD and EMR.

MiR-26b regulates 5-FU-resistance in human colorectal cancer via down-regulation of Pgp.

Chemotherapy resistance frequently drives tumor progression. However, the underlying molecular mechanisms remain unclear. In this study, we found that the expression level of miR-26b was down-regulated in the human colorectal cancer tissues and the resistant cells strains: HT-29/5-FU and LOVO/5-FU cells.

[Value of non-invasive continuous hemodynamic monitoring system in the differential diagnosis of the patients with dyspnea].

Objective: To evaluate non-invasive continuous hemodynamic (IQ System) monitoring in the differential diagnosis of dyspnea.

Methods: According to the diagnosis on discharge, 48 patients diagnosed as pulmonary dyspnea were enrolled in control group and 38 patients with cardiac dyspnea were in heart failure group. Each patient underwent IQ monitoring on admission and after recovery.