Publications by authors named "Chunsheng Fu"

Article Synopsis
  • * A novel photo-thermal-controlled drug delivery system was created to inhibit tumor glycolysis and enhance T cell activation, using a drug encapsulated in modified nanoparticles that respond to specific light wavelengths.
  • * This approach effectively reduces tumor growth and immune evasion by decreasing lactate and PD-L1 levels, ultimately improving the efficiency of immunotherapy treatments.
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This study was conducted to survey the effects of garlic powder on growth performance, nonspecific immunity, antioxidant capacity, and intestinal flora structure of Chinese mitten crabs. Altogether, 216 crabs which originally weigh 20.71 ± 0.

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  • Sengers syndrome is a rare genetic disorder characterized by hypertrophic cardiomyopathy, and this study reports the first known case associated with left ventricular non-compaction (LVNC).
  • Genetic testing revealed a novel compound heterozygous splicing mutation in the AGK gene, affecting the protein's structure and function, which was confirmed through both computational and laboratory methods.
  • The findings suggest that patients with AGK splicing mutations might exhibit milder forms of Sengers syndrome and could lead to improved understanding and potential treatment options for this condition.
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  • - The research investigated how glycerol monolaurate (GML) affects laying hens' production, egg quality, health of reproductive organs, and gut microbiota by comparing a control group to a group receiving a GML-enhanced diet.
  • - Findings revealed that GML supplementation led to improved laying rates, better egg quality indicators (like yolk color and albumen height), and enhanced intestinal health by increasing villi height and the gut’s protective functions.
  • - GML also positively influenced immune responses in reproductive tissues, boosted beneficial gut bacteria, and raised levels of certain volatile fatty acids, indicating overall better health and production performance in the hens.
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This study aims to investigate the effects of glycerol monolaurate (GML) on growth performance, non-specific immunity, antioxidant capacity and intestinal microflora in Chinese mitten crabs. The crabs were randomly arranged to three experimental diets groups containing 0 (control group), 1000 mg/kg GML (GML1000 group), and 2000 mg/kg GML (GML2000 group), respectively. After 8 weeks of breeding, results showed a better growth performance in GML2000 group, with a higher PWG, SGR and lower FCR (P < 0.

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Constipation in gestating and lactating sows is common and the inclusion of dietary fiber may help to alleviate this problem. We investigated the effects of inulin (INU) and isomalto-oligosaccharide (IMO), two sources of soluble dietary fiber, on gastrointestinal motility-related hormones, short-chain fatty acids (SCFA), fecal microflora, and reproductive performance in pregnant sows. On day 64 of gestation, 30 sows were randomly divided into three groups and fed as follows: a basal diet, a basal diet with 0.

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Hypertensive nephropathy is a common complication of hypertension. Traditional Chinese medicine has been used in the clinical treatment of hypertensive nephropathy for a long time, but the commonly used prescriptions have not been summarized, and the basic therapeutic approaches have not been discussed. Based on data from 3 years of electronic medical records of traditional Chinese medicine used at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, a complex network and machine learning algorithm was used to explore the prescribed herbs of traditional Chinese medicine in the treatment of hypertensive nephropathy (HN).

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Accumulating evidence suggests that coronavirus disease 2019 (COVID-19) is associated with hypercoagulative status, particularly for critically ill patients in the intensive care unit. However, the prevalence of venous thromboembolism (VTE) in these patients under routine prophylactic anticoagulation remains unknown. A meta-analysis was performed to evaluate the prevalence of VTE in these patients by pooling the results of these observational studies.

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel pathogen, has caused an outbreak of coronavirus disease 2019 (COVID-19) that has spread rapidly around the world. Determining the risk factors for death and the differences in clinical features between severely ill and critically ill patients with SARS-CoV-2 pneumonia has become increasingly important.

Aim: This study was intended to provide insight into the difference between severely ill and critically ill patients with SARS-CoV-2 pneumonia.

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Ethnopharmacology Relevance: Cinnamomum camphora (L.) J. Presl has been used for the traditional medicine as a therapeutic agent of inflammation-related diseases, including sprains, rheumatic arthritis, abdominal pain, cough and bronchitis, for a long history.

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Cinnamaldehyde analogues are a class of chemical substances originated from derivatization of cinnamaldehyde, and are structurally characterized by the presence of cinnamoyl moiety. Due to the presence of highly reactive α,α-unsaturated carbonyl pharmacophore (Michael acceptor) in their structures, these molecules are apt to react with some enzymes and/or receptors as electrophiles, and consequently produce diverse therapeutically relevant pharmacological functions. Naturally occurring molecules, trans-cinnamaldehyde (CA), 2-benzoyloxycinnam-aldehyde (2-BCA), and 2- hydroxycinnamaldehyde (2-HCA) are representatives of this group, and have attracted lots of interest for their bioactivities, especially the anti-cancer and anti-inflammatory properties.

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