Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling.

Adipose tissue remodels via hypertrophy or hyperplasia in response to nutrient status, but the mechanisms governing these expansion modes remain unclear. Here, we identify a nutrient-sensitive epigenetic circuit linking glucose metabolism to chromatin remodeling during adipogenesis. Upon glucose stimulation, α-ketoglutarate (α-KG) accumulates in the nucleus and activates the histone demethylase JMJD1A to remove repressive histone H3 lysine 9 dimethylation (H3K9me2) marks at glycolytic and adipogenic gene loci, including Pparg.

Robust Oxygen-Vacancy-Engineered Co(OH)/Cu Heterostructures Boost Nitrate Electroreduction to Ammonia beyond 2 A cm.

Electrocatalytic nitrate reduction reaction (NORR) presents a sustainable paradigm for green NH synthesis and NO wastewater valorization. However, overcoming sluggish NORR kinetics under industrial-current operation persists as a critical challenge. Herein, robust oxygen vacancy-enriched heterostructures (O-Co(OH)/Cu) are engineered through in situ electrochemical reconstruction.

The functional connectivity between the right rostral anterior cingulate cortex and the right dorsolateral prefrontal cortex underlies the association between future self-continuity and self-control.

Future self-continuity refers to the perceived degree of similarity between one's present self and future self. Self-control refers to the ability to regulate and control inappropriate behaviors, enabling individuals to suppress immediate reactions that are inconsistent with long-term goals. Previous studies demonstrated a positive correlation between future self-continuity and self-control, yet the neural mechanisms underlying this relationship remain unclear.

Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways.

Background: Cardiac hypertrophy is a precursor to heart failure and represents a significant global cause of mortality, thereby necessitating timely and effective therapeutic interventions. Zinc finger protein 36 (Zfp36) is recognised as a critical regulator of ferroptosis; however, its role and underlying mechanisms in cardiac hypertrophy remain largely unexplored. This study aims to investigate the regulatory function of Zfp36 in ferroptosis within the context of cardiac hypertrophy.

Multi-chamber membrane capacitive deionization coupled with peroxymonosulfate to achieve simultaneous removal of tetracycline and peroxymonosulfate reaction byproducts.

Advanced oxidation technologies based on peroxymonosulfate (PMS) have been extensively applied for the degradation of antibiotics. However, the degradation process inevitably introduces SO and other sulfur-containing anions, these pollutants pose a huge threat to the water and soil environment. Addressing these concerns, this study introduced PMS oxidation into a multi-chamber membrane capacitive deionization (MC-MCDI) device to achieve simultaneous tetracycline (TC) degradation and removal of PMS reaction byproduct ions.

Natural small-molecules reverse Xeroderma Pigmentosum Complementation Group C (XPC) deficient-mediated drug-resistance in renal cell carcinoma.

Background: Renal cancer is insensitive to radiotherapy or most chemotherapies. While the loss of the XPC gene was correlated with drug resistance in colon cancer, the expression of XPC and its role in the drug resistance of renal cancer have not yet been elucidated. With the fact that natural small-molecules have been adopted in combinational therapy with classical chemotherapeutic agents to increase the drug sensitivity and reduce adverse effects, the use of herbal compounds to tackle drug-resistance in renal cancer is advocated.

Efficacy of intra-articular polynucleotides associated with hyaluronic acid vs hyaluronic acid alone in the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized clinical trial.

Background: The reduced range of motion and pain are the most characteristic clinical features of osteoarthritis (OA). Hyaluronic acid (HA), which is one of the infiltrative therapies for OA treatment, and polynucleotides (PNs), which is a DNA-derived macromolecule favored cell growth and collagen production, are an ongoing debate in clinical effectiveness.

Methods: We plan to perform a systematic review and meta-analysis of randomized clinical trial to evaluate efficacy of intra-articular polynucleotides associated with hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis.

The effects of total hip arthroplasty in treating hip bony fusion in young and middle-aged patients with ankylosing spondylitis.

Background: This study aims to investigate the curative effects of total hip arthroplasty (THA) in treating hip bony fusion for young and middle-aged patients with ankylosing spondylitis (AS).

Methods: The clinical data of 26 young and middle-aged patients with AS (31 coxae), who were treated with THA and followed-up for more than 3 years in the period between February 1998 and May 2013, were retrospectively analyzed. Among these patients, 22 patients were male (25 coxae) and 4 patients were female (6 coxae).