Restoration of antibiotic associated diarrhea induced gut microbiota disorder by using water-insoluble polysaccharides in C57BL/6J mice.

Background: A healthy gut depends on a balance of commensal and probiotic bacteria, and prolonged and inappropriate clinical use of antibiotics can cause an imbalance in the gut flora, resulting in antibiotic-associated diarrhea (AAD). Macrofungal polysaccharides are rich in bioactivities and have attracted much attention for their good performance in anti-inflammatory, antioxidant, anti-obesity and anti-tumor properties. Therefore, we explored the role of water-insoluble polysaccharides (DIPY) in modulating the gut flora to improve AAD.

Antisense oligonucleotides targeting IRF4 alleviate psoriasis.

Interferon regulatory factor 4 (IRF4) is a critical transcription factor that governs the differentiation of cluster of differentiation 4 (CD4) T cells. The pathogenesis and progression of psoriasis are primarily attributed to an immune imbalance stemming from the overproduction of interleukin-17A (IL-17A) by T lymphocytes. However, the role of IRF4 in psoriasis remains unexplored.

Genome-Wide Meta-Analysis Identifies Five Single-Nucleotide Polymorphisms Associated With Both Vitiligo and Freckles in the Chinese Han Population.

Background: Vitiligo and freckles are both pigmentary disorders of the skin. The high prevalence of these conditions also places substantial strain on social healthcare systems. While vitiligo shows genetic predisposition, freckles exhibit autosomal dominant inheritance.

The sulfated modification of polysaccharide from Poria cocos and its prebiotic effects on gut microbiota.

Background: Poria cocos is a renowned medicinal and edible macrofungus in China. Alkali-soluble polysaccharide from Poria cocos (PCY) is one of its main active components. However, the biological activity and utilization of PCY are constrained by its poor water solubility.

CircITGA7 overexpression suppresses HCC progression via miR-330/BCL11B axis regulation.

As a kind of prevalent malignancy globally, hepatocellular carcinoma (HCC) is characterized by significant morbidity and mortality due to the difficulties in early diagnosis and limited treatment options. Circular RNAs (circRNAs) are a type of circular single-stranded RNA molecule formed by the back-splicing of the 5' end and the 3' end of linear RNA, possessing multiple biological functions. In recent years, numerous reports have demonstrated that circRNAs are potential biomarkers and therapeutic targets for HCC.

Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis.

Hepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications. It was found that HCC patients exhibiting higher levels of circDCUN1D4 demonstrated a more favorable survival rate.

Study on the Axial Compressive Behavior of Steel Fiber Reinforced Concrete Confined with High-Strength Rectangular Spiral Stirrup.

Monotonic axial compression tests were carried out on 16 steel fiber-reinforced concrete (SFRC) columns confined by rectangular spiral stirrups. The impacts of stirrup spacing, stirrup strength, concrete strength, and cross-sectional aspect ratio on the peak load, ductility, and failure mode of these columns were analyzed. The test results demonstrate that steel fibers significantly mitigate the spalling of the concrete column's protective layer through their bridging effect.

The roles of HOXB9 and MMP12 in proliferation, migration, and invasion of human laryngeal cancer cells LCC and TU212.

Objective: HOXB9 and MMP12 are involved in the initiation and progression of various tumors. This study aimed to investigate the roles of HOXB9 and MMP12 in the proliferation, migration, and invasion of human laryngeal cancer cells (LCC and TU212).

Method: The experiment was divided into five groups: control, sh-HOXB9, sh-MMP12, sh-HOXB9 + MMP12-OE, and sh-MMP12 + HOXB9-OE.

Integrated bioinformatics analysis of SEMA3C in tongue squamous cell carcinoma using machine-learning strategies.

Tongue squamous cell carcinoma (TSCC) is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. We aim to identify and verify potential biomarkers for TSCC using bioinformatics analysis. To begin with, we examined clinical and RNA expression information of individuals with TSCC from the Gene Expression Omnibus (GEO) database.

Water-Insoluble Polysaccharide Extracted from Alleviates Antibiotic-Associated Diarrhea Based on Regulating the Gut Microbiota in Mice.

Antibiotics are very effective in treating a variety of bacterial infections, while clinical overuse of antibiotics can lead to diseases such as antibiotic-associated diarrhea. Numerous studies have shown that natural polysaccharides can be used as prebiotics to alleviate antibiotic-associated diarrhea (AAD). is a medicinal and edible mushroom widely used for thousands of years in China, and our former study demonstrated that water-insoluble polysaccharide (PCY) has the potential prebiotic function.

Effect of metastasectomy on the outcome of patients with ovarian metastasis of colorectal cancer: A systematic review and meta-analysis.

Purpose: Patients with ovarian metastasis of colorectal cancer (CROM) usually have poor prognosis. Metastasectomy is controversial in patients with CROM. This study aims to evaluate the prognostic value of ovarian metastasectomy and other factors in CROM patients.

Gut microbiota regulation and prebiotic properties of polysaccharides from Oudemansiella raphanipes mushroom.

Oudemansiella raphanipes is a type of fungus used as both medicine and food. Fungal polysaccharides have demonstrated various bioactivities, involving the adjust and control of gut microbiota, but no such studies on O. raphanipes polysaccharides (OrPs) have been reported.

Metagenomic and targeted metabolomic analyses reveal distinct phenotypes of the gut microbiota in patients with colorectal cancer and type 2 diabetes mellitus.

Background: Type 2 diabetes mellitus (T2DM) is an independent risk factor for colorectal cancer (CRC), and the patients with CRC and T2DM have worse survival. The human gut microbiota (GM) is linked to the development of CRC and T2DM, respectively. However, the GM characteristics in patients with CRC and T2DM remain unclear.

A novel alternative strategy for monitoring and insight into liver fibrosis progression: The combination of surface-enhanced Raman spectroscopy (SERS) and gut microbiota.

Nowadays, the studies on the interaction and relationship between the intestinal microorganisms and liver diseases are increasing. However, it is still a huge challenge for the in-depth investigation and dynamic monitoring of such a complex network. Herein, a significant discovery was made.

Discovery of enzymes to biotransform ginsenoside Rd into ginsenosides F2 and CK using metagenomics and genomic mining.

Ginsenosides are the main active components of ginseng, including many types and different contents. Among them, minor ginsenosides have better biological functions and pharmacological activities than those of the major ginsenosides. However, minor ginsenosides cannot be obtained in large quantities, but by means of enzymatic transformation technology, some major ginsenosides can be de-glycosylated at a specific position to generate minor ginsenosides.

Annealing-Insensitive, Alcohol-Processed MoO Hole Transport Layer for Universally Enabling High-Performance Conventional and Inverted Organic Solar Cells.

At present, most solution-processed molybdenum oxide (s-MoO) hole transport layers (HTLs) are still mainly used in conventional organic solar cells (OSCs) but unsuitable for inverted OSCs. Herein, we demonstrate for the first time an annealing-insensitive, alcohol-processed MoO HTL that can universally enable high-performance conventional and inverted OSCs. The s-MoO HTL is spin-coated from the MoO nanoparticle dispersion in alcohol, where the MoO nanoparticles are synthesized by simple nonaqueous pyrolysis conversion of MoO(acac).

Three main metabolites from (F. A. Wolf) Ryvarden & Gilb regulate the gut microbiota in mice: A comparative study using microbiome-metabolomics.

(F. A. Wolf) Ryvarden & Gilb, also known as is an ancient edible and medicinal mushroom that has been valued for thousands of years for its tranquilizing, diuretic, and spleen-enhancing properties.

Predictive value of proteomic markers for advanced rectal cancer with neoadjuvant chemoradiotherapy.

Background: Preoperative neoadjuvant chemoradiation (nCRT) has been the standard treatment for locally advanced rectal cancer. Serum biomarkers to stratify patients with respect to prognosis and response to nCRT are needed due to the diverse response to the therapy.

Methods: Thirteen paired pre- and post-nCRT sera from rectal cancer patients were analyzed by isobaric tags for relative and absolute quantitation (iTRAQ) method.

Polysaccharides from the leaves of Polygonatum sibiricum Red. regulate the gut microbiota and affect the production of short-chain fatty acids in mice.

Polysaccharides from the rhizome of Polygonatum sibiricum display a variety of biological activities, including the regulation of intestinal microbiota, but the polysaccharides from the leaves of P. sibiricum have not been studied extensively. Here, we extracted crude polysaccharides from the leaves of P.

Characterization and prebiotic properties of pectin polysaccharide from Clausena lansium (Lour.) Skeels fruit.

Pectins have proven to be advantageous for human health as they regulate beneficial microbial communities and enhance immunity. The fruit of Clausena lansium (Lour.) Skeels (Wampee), also referred to as "treasure in fruit", is rich in pectin polysaccharides.