The establishment of lipid profiles reference ranges during pregnancy: a systematic review and meta-analysis.

Background: Maternal lipid levels, which are crucial for both foetal development and maternal health, exhibit significant physiological changes during pregnancy. Current reference ranges for lipids that are based on common adults may inadequately assess the appropriate lipid levels during pregnancy and fail to predict potential risks. Therefore, it is necessary to establish trimester-specific reference intervals (TSRIs) for pregnant women during pregnancy.

The development of thyroid autoimmunity is potentially associated with the deficiency of vitamin D3 rather than vitamin D2 in euthyroid men.

Objective: Vitamin D(VitD) deficiency has been found prevalent among patients with thyroid autoimmunity (TAI). This study aimed to investigate whether low VitD2 or VitD3 potentially contributed to the development of TAI in euthyroid male patients, which had not been reported before.

Methods: A total of 2882 euthyroid male petroleum workers were recruited from those participants in the healthcare program at the second affiliated hospital of Dalian Medical University in 2021, whose serum VitD levels, thyroid functions, and autoantibody titers were all examined at the same time.

Short-term effects of ambient air pollution on influenza incidence in Chongqing, China: a time-series analysis.

This study investigated the relationship between air pollution and influenza incidence in Chongqing from 2013 to 2022 using a generalized additive model (GAM), analyzing 199,712 cases. Subgroup analyses were conducted to investigate the impact of age, gender, season, and the COVID-19. Influenza incidence was positively associated with PM, PM, SO, NO and CO, but negatively with O.

Unveiling the link: anti-protein disulfide isomerase A3 autoantibody expression and polycystic ovary syndrome risk in euthyroid autoimmune thyroiditis women.

Background: Polycystic ovary syndrome (PCOS) is a common complication of autoimmune thyroiditis (AIT) in women, but the underlying mechanism remains unclear. Protein disulfide isomerase A3 (PDIA3) is a ubiquitous protein. We have reported that PDIA3 autoantibody (PDIA3Ab) production results from autoimmune responses against thyrocytes, resulting in its high expression in euthyroid AIT patients.

Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study.

Background: Recent studies have revealed the correlation between serum vitamin D (VD) level and polycystic ovary syndrome (PCOS), but the causality and specific mechanisms remain uncertain.

Objective: We aimed to investigate the cause-effect relationship between serum VD and PCOS, and the role of testosterone in the related pathological mechanisms.

Methods: We assessed the causality between serum VD and PCOS by using genome-wide association studies (GWAS) data in a bidirectional two-sample Mendelian randomization (TS-MR) analysis.