Personalizing elective oocyte cryopreservation: a novel predictive model for oocyte yield across multiple stimulation cycles.

Study Question: Can patient age and ovarian reserve tests predict the number of cryopreserved oocytes in patients undergoing one or more ovarian stimulation cycles for elective oocyte cryopreservation (EOC)?

Summary Answer: A predictive model incorporating patient age, antral follicle count (AFC), anti-Müllerian hormone (AMH), and FSH levels achieved the greatest predictive accuracy.

What Is Known Already: As a consequence of societal evolution, women are increasingly delaying starting a family. However, the natural decline in ovarian reserve and oocyte quality as age advances can increase the risk of age-related fertility decline (ARFD) and involuntary childlessness.

Taking advantage of open data in coastal science and conservation.

Human society relies on, and interacts with, a diverse assortment of organisms and ecological systems, from the local to the global level. Research and management of these coupled social-ecological systems requires data that speaks to the variety of processes, statuses, and situations defined by them. Effective stewardship is enhanced by interdisciplinary thinking and, critically, access to interoperable data describing human society and governance and ecological and environmental conditions.

Braiding archaeology, geomorphology and indigenous knowledge to improve the understanding of local-scale coastal change.

Coastal landforms and associated archaeological records are at risk of erosion from a combination of rising sea levels and increasingly frequent high-intensity storms. Improved understanding of this risk can be gained by braiding archaeological and geomorphological methodologies with Indigenous knowledge. In this article, archaeological, geomorphological and (a form of Indigenous knowledge) are used to analyse a prograded Holocene foredune barrier in northern Aotearoa/New Zealand.

Bibliometric Analysis: Insights Into the Podiatric Medicine Landscape of Diabetic Sensory Peripheral Neuropathy and Genomics.

Background And Aims: Research into diabetic foot complications is extensive; it remains challenging to identify critical literature. Evolving interprofessional boundaries, alongside advances in molecular medicine and pathophysiological understanding, necessitates mapping of the scientific literature (corpus). Impact of these advances on podiatric medicine remains unclear.

Tenure and research trajectories.

Tenure is a cornerstone of the US academic system, yet its relationship to faculty research trajectories remains poorly understood. Conceptually, tenure systems may act as a selection mechanism, screening in high-output researchers; a dynamic incentive mechanism, encouraging high output prior to tenure but low output after tenure; and a creative search mechanism, encouraging tenured individuals to undertake high-risk work. Here, we integrate data from seven different sources to trace US tenure-line faculty and their research outputs at a remarkable scale and scope, covering over 12,000 researchers across 15 disciplines.

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons.

Cortical neurons are specified during embryonic development but often acquire their mature properties at relatively late stages of postnatal development. This delay in terminal differentiation is particularly prominent for fast-spiking parvalbumin-expressing (PV) interneurons, which play critical roles in regulating the function of the cerebral cortex. We found that the maturation of PV interneurons is triggered by neuronal activity and mediated by the transcriptional cofactor peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α).

Considerations of Fertility in Elite Sportswomen: A Narrative Review.

Background: Increasingly more women are participating in professional and recreational sports. Whilst vigorous intensity physical activity is considered beneficial, evidence demonstrates higher rates of menstrual disturbance in elite athletes. There is less clear evidence on the impact of elite-level exercise on fertility outcomes.

Drug Resistance Predictions Based on a Directed Flag Transformer.

The evolving SARS-CoV-2 virus threatens global public health, particularly with potential resistance to PAXLOVID, whose active ingredient, nirmatrelvir, targets the viral main protease (Mpro). CAPTURE (direCted flAg laPlacian Transformer for drUg Resistance prEdictions) is developed to assess Mpro mutations' impact on nirmatrelvir binding and identify drug-resistant variants. CAPTURE integrates a mutation analysis with a resistance prediction module using DFFormer-seq, a novel ensemble model combining a Directed Flag Transformer and sequence embeddings.

Heterogeneity in internal medicine chief residency selection processes and role preparation: an opportunity for improvement.

Background: The chief resident (CR) role is integral to graduate medical education and the administrative, educational, and clinical functions of residency programs. There are limited data on the selection and job training of CRs in internal medicine (IM).

Methods: We used data from a previously published cross-sectional survey of IM CRs from 2018 (Garg M, et al.

Assessing the Psychosocial Impact of Expressive Writing on Adults With Spinal Cord Injury: Qualitative Study.

Background: Spinal cord injury (SCI) results in significant physical, emotional, and social consequences, often leading to profound grief and unresolved emotional burdens. While expressive writing has shown potential in facilitating emotional processing and in aiding coping after trauma, loss, and health-related adversity, its impact on individuals who have suddenly lost physical abilities due to SCI remains underexplored.

Objective: The study aimed to examine the experiences of adults with SCI who participated in a 10-week web-based coach-guided expressive writing program to understand its impact using a qualitative research design with a phenomenological approach.

Khovanov Laplacian and Khovanov Dirac for knots and links.

Khovanov homology has been the subject of much study in knot theory and low dimensional topology since 2000. This work introduces a Khovanov Laplacian and a Khovanov Dirac to study knot and link diagrams. The harmonic spectrum of the Khovanov Laplacian or the Khovanov Dirac retains the topological invariants of Khovanov homology, while their non-harmonic spectra reveal additional information that is distinct from Khovanov homology.

Annual and sub-seasonal dynamics of a rapidly eroding permafrost coastline along the Beaufort Sea in northern Alaska.

Drew Point, an unlithified ice-rich permafrost coastline along the Alaskan Beaufort Sea, is among the most rapidly eroding Arctic coastlines, with an average erosion rate of 19 m/yr from 2007 to 2019. We use 16 high-resolution remote sensing datasets (satellite, airborne, and UAV imagery) to analyze erosion mechanisms (thermal abrasion and denudation) in relation to environmental forcings along a 1.5 km stretch of coastline during the 2018 and 2019 open water seasons.

The (Re)-emerging And ePidemic Infectious Diseases (RAPID) Stigma Scales: a cross-outbreak scale development and pyschometric validation study.

Reducing stigma during infectious disease outbreaks is crucial for delivering an effective response. However, no validated stigma scales exist for use across outbreaks, and outbreak-specific scales are developed too slowly to guide timely interventions. To enable more real-time monitoring and mitigation of stigma across outbreak contexts, we developed and validated the (Re)-emerging and ePidemic Infectious Diseases (RAPID) Stigma Scales.

The pivot penalty in research.

Scientists and inventors set the direction of their work amid evolving questions, opportunities and challenges, yet the understanding of pivots between research areas and their outcomes remains limited. Theories of creative search highlight the potential benefits of exploration but also emphasize difficulties in moving beyond one's expertise. Here we introduce a measurement framework to quantify how far researchers move from their existing work, and apply it to millions of papers and patents.

Parental Barriers and Sociodemographic Disparities in Childhood Vaccination Post-COVID-19 in Tennessee.

Introduction: The COVID-19 pandemic disrupted routine childhood vaccinations schedules, posing significant challenges among underserved communities. Understanding how different sociodemographic groups in Tennessee perceive and navigate childhood vaccination barriers is critical for developing strategies to improve vaccination rates and reduce vulnerability to vaccine-preventable diseases.

Methods: A cross-sectional survey was conducted to explore barriers to vaccination across diverse sociodemographic groups in Tennessee.

Exploring the Therapeutic Role of Coach-Guided Videoconferencing Expressive Writing in Multiple Sclerosis: A Qualitative Study.

: Emotional changes significantly affect people with multiple sclerosis (PwMS), often leading to negative psychological symptoms including grief. Effective management of these symptoms can foster personal growth, increase confidence, and renew hope. While expressive writing has demonstrated psychological benefits in processing trauma and chronic conditions, its effects on PwMS remain underexplored.

What influences the implementation of health checks in the prevention and early detection of chronic diseases among Aboriginal and Torres Strait Islander people in Australian primary health care? Findings from an evidence mapping review.

Background: Chronic disease is the leading cause of morbidity and mortality among Aboriginal and Torres Strait Islander peoples in Australia. A comprehensive health assessment is available as an annual health check (HC) to Aboriginal and Torres Strait Islander peoples through the Medicare Benefits Schedule in primary health care settings. This review aims to systematically identify contextual and mechanistic factors that contribute to the success or failure of implementing effective HCs in the prevention and early detection of chronic diseases among Aboriginal and Torres Strait Islander people in Australian primary health care (PHC).

Understanding particulate matter emissions from cooking meals, health impacts and policy path in Ecuador.

Cooking is a major source of indoor air pollution, but little is known about its emissions or health impacts in Ecuadorian households. This study quantified PM₂.₅ and PM₁₀ emissions from six common menus (three fried, three stewed) cooked in a real-life kitchen in Guayaquil lacking natural or mechanical ventilation.

Matching planting methods to species and site conditions is key in seed-based intertidal seagrass restoration.

Seagrass meadows continue to be lost and degraded globally. Restoration is one promising and emerging conservation strategy to combat such losses and place seagrass on a pathway to net gain. However, successful restoration methods remain limited to a few species, and geographically constrained, with few experimental trials comparing planting methods across species and seagrass bioregions.

An hourglass model for conceptualising stigma in infectious disease outbreaks.

Stigma is widely observed during (re)emerging infectious disease outbreaks, contributing to psychological distress, social isolation, and care-seeking hesitancy. Despite this, it is often inadequately addressed in public health responses, partly due to the lack of a fit-for-purpose approach. The objective of this study was to develop a conceptual model to facilitate structured consideration of stigma during (re)emerging disease outbreaks.

Statistical signature of subtle behavioral changes in large-scale assays.

The central nervous system can generate various behaviors, including motor responses, which we can observe through video recordings. Recent advances in gene manipulation, automated behavioral acquisition at scale, and machine learning enable us to causally link behaviors to their underlying neural mechanisms. Moreover, in some animals, such as the Drosophila melanogaster larva, this mapping is possible at the unprecedented scale of single neurons, allowing us to identify the neural microcircuits generating particular behaviors.

Persistent Directed Flag Laplacian (PDFL)-Based Machine Learning for Protein-Ligand Binding Affinity Prediction.

Directionality in molecular and biomolecular networks plays an important role in the accurate representation of the complex, dynamic, and asymmetrical nature of interactions present in protein-ligand binding, signal transduction, and biological pathways. Most traditional techniques of topological data analysis (TDA), such as persistent homology (PH) and persistent Laplacian (PL), overlook this aspect in their standard form. To address this, we present the persistent directed flag Laplacian (PDFL), which incorporates directed flag complexes to account for edges with directionality originated from polarization, gene regulation, heterogeneous interactions, etc.

Societal value of seagrass from historical to contemporary perspectives.

Seagrasses have been entwined with human culture for millennia, constituting a natural resource that has supported humanity throughout this history. Understanding the societal value of seagrass fosters appreciation of these ecosystems, encouraging conservation and restoration actions to counteract historic and predicted losses. This study overviews the plethora of seagrass use in human history, ranging from spiritual and ceremonial roles, direct and indirect food resources, medicines and raw materials, dating back more than 180 000 years.

Rheumatic heart disease 2025 - current status and future challenges.

Rheumatic heart disease remains a major health problem for Aboriginal and Torres Strait Islander peoples. In this Reflection, potential solutions to this lamentable situation are reviewed.