Machine learning model for predicting in-hospital cardiac mortality among atrial fibrillation patients.

This study developed and validated a machine learning (ML) model to predict in-hospital cardiac mortality in 18,727 atrial fibrillation (AF) patients using electronic medical record data. Four ML algorithms-random forest, extreme gradient boosting (XGBoost), deep neural network, and logistic regression-were applied to 79 clinical variables, including demographics, vital signs, comorbidities, lifestyle factors, and laboratory parameters. The XGBoost model achieved the best performance, with an area under the curve of 0.

Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies.

Atrial fibrillation (AF) is a common arrhythmia associated with significant morbidity and adverse outcomes. High-throughput proteomics offers a promising approach for identifying circulating biomarkers to improve AF risk stratification. This systematic review evaluated cohort studies published from 2010 to 2024 that employed proteomic approaches to investigate associations between circulating proteins and AF incidence.

A Predictive Model and Scoring System for All-Cause Mortality in Patients With Atrial Fibrillation Combined With Obstructive Sleep Apnea Syndrome: A Retrospective Case-Control Study.

Background: The high prevalence and mortality rate of combined atrial fibrillation (AF) and obstructive sleep apnea syndrome (OSAS) impose a significant disease burden on public healthcare systems. However, there is currently a lack of risk-assessment tools for all-cause mortality in patients with both AF and OSAS. Therefore, this study utilized clinical data from patients at the First Affiliated Hospital of Xinjiang Medical University to establish a predictive model and address this gap.

The association between frailty status and cognitive function in patients with cardiovascular diseases: a nationwide cohort study.

In individuals with cardiovascular disease, the commonly observed comorbid conditions are frailty and cognitive impairment. However, currently, the impact of cognitive function on frailty and the dynamic interplay between both in patients with cardiovascular disease are ambiguous. This cohort study explored the association between frailty and cognitive function in Chinese adults with cardiovascular conditions, specifically focusing on those who were middle-aged or older.

Construction and Validation of a Hospital Mortality Risk Model for Advanced Elderly Patients with Heart Failure Based on Machine Learning.

Purpose: This study aimed to develop and validate a model based on machine learning algorithms to predict the risk of in-hospital death among advanced elderly patients with Heart Failure (HF).

Methods: A total of 4580 advanced elderly patients who were admitted to the hospital and diagnosed with HF from May 2012 to September 2023 were included in this study, among whom 552 cases (12.5%) died.

Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke-Induced Myocardial Injury.

Background: The annual rise of global temperature and the continuous occurrence of extremely high temperatures in summer have significantly increased the incidence of heat stroke (HS), which has caused serious burden on the cardiovascular system. The purpose of this study was to investigate the potential mechanisms of heat stroke-induced myocardial injury via transcriptome sequencing.

Methods: HS models of rat and H9C2 cells were constructed and transcriptomic sequencing was performed.

Sex differences and risk factors for postoperative complications following catheter ablation for pulmonary vein isolation in non-valvular atrial fibrillation: A retrospective cohort study.

Atrial fibrillation (AF) is the most common arrhythmia, significantly increasing the risk of adverse events such as stroke, heart failure, and cognitive impairment. catheter ablation is a first-line treatment for AF, with pulmonary vein isolation (PVI) as a common procedure. Although studies have reported sex-based differences in complication rates following PVI, these findings remain controversial.

Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies.

Anti-Ro/SSA antibodies, prevalent autoantibodies in connective tissue diseases, have well-established roles in fetal arrhythmias but their significance in adult arrhythmias remains underrecognized. Recent evidence highlights that anti-Ro/SSA antibodies may induce adult arrhythmias by disrupting cardiac ion channel function, particularly through interactions with calcium and potassium channels, leading to electrophysiological disturbances including QT prolongation, atrioventricular block, and increased susceptibility to sudden cardiac death. Additionally, these antibodies can initiate inflammatory cascades, further contributing to myocardial fibrosis and conduction abnormalities.

Prediction model and scoring system for the risk of atrial fibrillation recurrence in patients with atrial fibrillation and obstructive sleep apnoea syndrome: a retrospective case-control study.

Background: The high prevalence of atrial fibrillation (AF) and obstructive sleep apnea syndrome (OSAS) imposes a substantial disease burden on public healthcare, making it a significant health concern in the current era. However, there is currently a lack of risk assessment tools for AF recurrence in patients with AF and OSAS. Therefore, this study aims to explore the factors influencing AF recurrence in patients with AF and OSAS, and to establish a predictive model and scoring system for AF recurrence rates.

Construction of risk prediction model and risk score table for infant heart failure hospital death based on white blood cell count to total protein ratio.

The study analyzed 544 infants (1-36 months) with heart failure, aiming to correlate WBC/TP ratio with mortality and create a predictive model. Lasso regression identified significant mortality-associated clinical indices; logistic regression then built a death prediction model with an AUC of 0.755.

DNA methylation-based telomere length is more strongly associated with long-term all-cause mortality than quantitative polymerase chain reaction-based telomere length among middle-aged and older hypertensive adults.

Background: Telomere length (TL) has been linked to mortality risk across various populations. However, its predictive value for mortality risk specifically in hypertensive adults remains unclear.

Methods: This cohort study utilized data from the 1999-2000 and 2001-2002 cycles of the National Health and Nutrition Examination Survey (NHANES).

Prediction model and scoring system for in-hospital mortality risk in infants with heart failure aged 1-36 months: A retrospective case-control study.

Background: Existing studies report very few factors influencing the mortality of infant and toddler heart failure patients during hospitalization. Due to its high mortality rate, it is an important health issue. Therefore, this study aims to explore the factors influencing infant and toddler heart failure patients during hospitalization, establish predictive models, and a mortality scoring table.

Global trends and epidemiological impact of metabolic risk factors on atrial fibrillation and atrial flutter from 1990 to 2021.

Atrial fibrillation (AF) and atrial flutter (AFL) are cardiac arrhythmias associated with high morbidity and mortality. This cross-sectional observational study assesses the epidemiological burden of AF/AFL concerning metabolic risk factors using the Global Burden of Disease (GBD) 2021 database. Age-standardized disability-adjusted life years rate (ASDR), mortality, and estimated annual percentage change were calculated.

Hemolysis after pulsed-field ablation of atrial fibrillation.

Pulsed-field ablation (PFA) offers notable advantages in atrial fibrillation (AF) ablation by selectively targeting cardiomyocytes via an irreversible electroporation mechanism, thereby minimizing damage to surrounding tissues. Although clinical studies demonstrate that PFA is both safe and effective, PFA-mediated hemolysis and potential acute kidney injury (AKI) have been recently reported. This study comprehensively reviews the literature on PFA-associated hemolysis, analyzing the underlying mechanisms, risk factors, and preventive management strategies.

New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Study.

Background: The common occurrence of atrial fibrillation (AF) as a cardiac arrhythmia, along with its link to sleep deprivation (SD), is gaining more acknowledgment. Even with progress in comprehending the development of AF, the molecular connections between SD and AF are still not well-defined. The objective of this research was to pinpoint the shared molecular routes responsible for SD-induced AF and investigate possible treatment targets.

Melatonin lessens the susceptibility to atrial fibrillation in sleep deprivation by ameliorating Ca mishandling in response to mitochondrial oxidative stress.

Background: The antiarrhythmic effect of melatonin(MLT) has been demonstrated in several studies; however, this hypothesis has recently been contested. Our research seeks to determine if exogenous MLT supplementation can reduce atrial fibrillation (AF) susceptibility due to sleep deprivation (SD) by addressing Ca mishandling and atrial mitochondrial oxidative stress.

Methods: Adult rats received daily MLT or vehicle injections and were exposed to a modified water tank.

MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.

Objectives: To investigate the role and mechanism of MAPK14/AIFM2 pathway in Ang II-induced atrial fibrillation in rats.

Methods: A rat model of AF was established for in vivo experiments and HL-1 cells were treated with Ang II to develop an in vitro model. In addition, HL1 cells overexpressing AIFM2 (oeAIFM2) were constructed.

Oroxin B Resembles Bisoprolol in Attenuating Beta1-Adrenergic Receptor Autoantibody-Induced Atrial Remodelling via the PTEN/AKT/mTOR Signalling Pathway.

Beta1-adrenergic receptor autoantibodies (β1-AAbs) promote atrial remodelling and ultimately lead to the development of atrial fibrillation (AF). Oroxin B is a natural flavonoid glycoside with a variety of biological activities, including anti-inflammatory and autophagy-promoting effects, and has therapeutic benefits for a variety of diseases. The aim of this study was to investigate the potential therapeutic role of Oroxin B in the development of β1-AAb-induced atrial fibrillation and to elucidate the underlying mechanisms involved.

MCPIP1 promotes atrial remodeling by exacerbating miR-26a-5p/FRAT/Wnt axis-mediated atrial fibrosis in a rat model susceptible to atrial fibrillation.

Atrial fibrosis plays a critical role in the pathogenesis of atrial fibrillation (AF). Monocyte chemotactic protein-induced protein-1 (MCPIP1), recognized as a functional ribonuclease (RNase), exacerbates cardiac remodeling and contributes to a range of cardiovascular diseases. However, the involvement of MCPIP1 in atrial fibrosis and development of AF, along with its underlying biological mechanisms, remains poorly understood.

Assessing the impact and safety of implantable cardioverter defibrillators in treating catecholaminergic polymorphic ventricular tachycardia: a systematic review and meta-analysis protoc.

Background: While the guidelines acknowledge the anticipated benefits of using an implantable cardioverter defibrillator (ICD) in individuals with catecholaminergic polymorphic ventricular tachycardia (CPVT). However, the potential adverse effects have received less attention.

Methods And Analysis: To address this issue comprehensively, we will explore various databases such as the Cochrane Library, Web of Science, EMBASE and PubMed.

Ablation of myocardial autonomic ganglion plexus in the treatment of bradyarrhythmia A one-arm interventional study.

Objectives: To study the complications and effectiveness of the treatment of chronic arrhythmias with cardiac Ganglion Plexus (GP) ablation, and to explore the value of the treatment of chronic arrhythmias with GP ablation.

Methods: This study was a one-arm interventional study of patients from the first hospital of Xinjiang Medical University and the People's Hospital of Xuancheng City admitted (09/2018-08/2021) because of bradyarrhythmia. The left atrium was modeled using the Carto3 mapping system.

CALCOCO2 prevents AngII-induced atrial remodeling by regulating the interaction between mitophagy and mitochondrial stress.

Background: The biological functions of mitochondrial complexes are closely related to the development of atrial fibrillation (AF). Calcium binding and coiled-coil domain 2 (CALCOCO2) is a novel and specific receptor for mitophagy; however, its function in AF remains unknown. Therefore, this study aimed to investigate the role and molecular mechanisms of CALCOCO2 in AF, especially its regulatory mechanism in mitophagy and mitochondrial stress.