N4-acetylcytidine coordinates with NP1 and CPSF5 to facilitate alternative RNA processing during the replication of minute virus of canines.

RNA modifications play crucial roles in RNA metabolism, structure, and functions. N4-acetylcytidine (ac4C) modifications have been shown to enhance stability and translation efficiency of messenger RNAs and viral RNAs. However, the relationship between ac4C and alternative RNA processing remains unexplored.

End-to-End Implicit Object Pose Estimation.

To accurately estimate the 6D pose of objects, most methods employ a two-stage algorithm. While such two-stage algorithms achieve high accuracy, they are often slow. Additionally, many approaches utilize encoding-decoding to obtain the 6D pose, with many employing bilinear sampling for decoding.

NSUN2 mediates distinct pathways to regulate enterovirus 71 replication.

Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function of m5C deposition is well characterized, other potential roles of NSUN2 in regulating viral replication remain largely unknown. In this study, the m5C modified residues catalyzed by NSUN2 on enterovirus 71 (EV71) RNAs were mapped.

Constant Tension Control System of High-Voltage Coil Winding Machine Based on Smith Predictor-Optimized Active Disturbance Rejection Control Algorithm.

In the production process of high-voltage coils, a constant tension control system is designed to improve the quality of the transformer. The system is composed of a controller, execution structure, detection structure, etc. The active disturbance rejection control (ADRC), optimized by the Smith predictor (SP), is adopted to achieve constant tension control.

Synthesis of Polylactic Acid Oligomers for Broad-Spectrum Antimicrobials.

Infectious microbial diseases are a major public health hazard, calling for more innovative antimicrobials. Herein, polylactic acid (PLA) oligomers have been explored and reported as a bio-safe and eco-friendly functional antimicrobial agent against pathogens, such as viruses (H1N1, H3N2, and SARS-CoV-2), bacteria (E. coli, S.

N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71.

Chemical modifications are important for RNA function and metabolism. N4-acetylcytidine (ac4C) is critical for the translation and stability of mRNA. Although ac4C is found in RNA viruses, the detailed mechanisms through which ac4C affects viral replication are unclear.

A Novel Hybrid Algorithm for the Forward Kinematics Problem of 6 DOF Based on Neural Networks.

The closed kinematic structure of Gough-Stewart platforms causes the kinematic control problem, particularly forward kinematics. In the traditional hybrid algorithm (backpropagation neural network and Newton-Raphson), it is difficult for the neural network part to train different datasets, causing training errors. Moreover, the Newton-Raphson method is unable to operate on a singular Jacobian matrix.

Attitudes Toward Advance Directives Among Patients and Their Family Members in China.

Objectives: Chinese people are generally unfamiliar with the concept of advance care planning or advance directives (ACP/ADs), which raises dilemmas in life-support choice and can even affect clinical decision making. To understand and address the issues involved better, we investigated the awareness of ACP/ADs in China, as well as people's attitudes toward medical autonomy and end-of-life care.

Design: A multicenter cross-sectional survey, conducted from August 1 to December 31, 2016.

Impact of Alzheimer's Disease in Nine Asian Countries.

Background: Asia will soon have the majority of demented patients in the world.

Objective: To assess dementia using a uniform data system to update the current status of dementia in Asia.

Methods: A uniformed data set was administered in Taiwan, China, Hong Kong, Korea, Japan, Philippines, Thailand, Singapore, and Indonesia to gather data with regard to Alzheimer's disease (AD) and its related issues for these countries.

Optimal cutoff scores for dementia and mild cognitive impairment of the Montreal Cognitive Assessment among elderly and oldest-old Chinese population.

Background: All versions of the Montreal Cognitive Assessment (MoCA) lack population-based data of 80-plus individuals. The norms and cut-off scores for mild cognitive impairment (MCI) and dementia of the MoCA are different among five Chinese versions.

Objective: To provide the cut-off scores in detecting MCI and dementia of the Peking Medical Union College Hospital version of the MoCA (MoCA-P).

Construction of the Chinese Veteran Clinical Research (CVCR) platform for the assessment of non-communicable diseases.

Background: Based on the excellent medical care and management system for Chinese veterans, as well as the detailed medical documentation available, we aim to construct a Chinese Veteran Clinical Research (CVCR) platform on non-communicable diseases (NCDs) and carry out studies of the primary disabling NCDs.

Methods: The Geriatric Neurology Department of Chinese People's Liberation Army General Hospital and veterans' hospitals serve as the leading and participating units in the platform construction. The fundamental constituents of the platform are veteran communities.