Exploring Phytochemicals from Nigella sativa as novel NS2B/NS3 protease inhibitors of dengue virus: A Pharmacoinformatic Study.

Background Objectives: Dengue virus, a mosquito-borne flavivirus, is a serious worldwide health risk that can be fatal. Its replication is dependent on the NS2B/NS3 protease. Given the critical need for effective antivirals and the documented medicinal properties of Nigella sativa bioactive compounds, this study used molecular docking and ADMET analysis to assess the potential of N.

Nitric oxide in plant stress: Rewilding and restoring signaling for enhancing plant growth and development.

Plants, represented as a complex system, are continuously exposed to environmental conditions that affect their growth and development, and sometimes their survival. Being sessile, they complete their life cycle under the influence of varied environmental constraints (biotic and abiotic), that adversely affect the produce's quality and productivity. Plants have evolved several defense strategies orchestrated through phytohormones that play a pivotal role in conferring resistance to stress.

Comprehensive Evaluation of the Bioactives of Elaeagnus umbellata for Their Antidiabetic Potential Using In Vitro and In Silico Approaches.

Elaeagnus umbellata is known for its medicinal properties, including its ability to promote wound healing and exhibit antidiabetic and anti-inflammatory properties. In the present study, methanolic leaf and bark extract (MLE and MBE) of E. umbellata was tested for total phenol and flavonoid content and evaluated for antioxidant activity.

Synergistic effects of and biochar on the biocontrol of two soil-borne phytopathogens in chickpeas.

Introduction: This study aims to identify and characterize four isolates using molecular techniques, Fourier transform infrared spectroscopy (FTIR), and volatile organic compounds (VOC) profiling.

Methods: The antagonistic activity of these isolates was assessed against f. sp.

Genome-wide identification and characterization of pathogenesis related protein 1 gene family in Brassica juncea.

Pathogenesis related protein 1 (PR1) family are key players of plant defence response against pathogens, however, their role in Brassica juncea is not fully understood. Here, we performed genome wide identification and characterization of PR1 gene family in B. juncea.

Signaling Pathways in Oxidative Stress-Induced Neurodegenerative Diseases: A Review of Phytochemical Therapeutic Interventions.

Oxidative stress, a pivotal driver of neurodegenerative diseases, results from an imbalance between the generation of reactive oxygen species (ROS) and cellular antioxidant defenses. This review provides a comprehensive analysis of key oxidative stress sources, focusing on NADPH oxidase (NOX) hyperactivity and mitochondrial Uncoupling Protein (UCP) downregulation. Critically, we examine the therapeutic potential of phytochemicals in mitigating NOX-mediated ROS generation through direct enzyme inhibition, including impacts on NOX subunit assembly and gene expression.

Mangrove pneumatophores as biocatalysts for the fabrication of silver nanoparticles and their potential applications against biofilm formation and hepatic carcinoma.

The current study demonstrates the biogenic synthesis of silver nanoparticles using the pneumatophores of (AiP-AgNPs), which is cost-effective and biocompatible. possesses remarkable features to endure the harshest conditions for its entire life cycle and generates secondary metabolites for its sustainability in hostile mangrove ecosystems. The presence of a prominent UV-visible absorption band at 420 nm supported the distinct color change inference for the synthesized AiP-AgNPs.

Salicylic Acid-Induced Expression Profiles of LRR and LRR-RLK Candidate Genes Modulate Resistance in Blackgram and Its Two Wild Non-Progenitors.

Blackgram is an important short-duration grain legume, but its yield is highly affected by various stresses. Among biotic stresses, yellow mosaic disease (YMD) is known as a devastating disease that leads to 100% yield loss under severe conditions. The cultivated lines possess resistance, but exploring more diverse sources of resistance may be useful for pyramiding to improve the durability of said resistance.

In-silico and in-vitro study of novel antimicrobial peptide AM1 from Aegle marmelos against drug-resistant Staphylococcus aureus.

Antimicrobial peptides have garnered increasing attention as potential alternatives due to their broad-spectrum antimicrobial activity and low propensity for developing resistance. This is for the first time; proteome sequences of Aegle marmelos were subjected to in-silico digestion and AMP prediction were performed using DBAASP server. After screening the peptides on the basis of different physiochemical property, peptide sequence GKEAATKAIKEWGQPKSKITH (AM1) shows the maximum binding affinity with - 10.

Recent advances in sustainable biopolymer-based nanocomposites for smart food packaging: A review.

The main goal of emerging food-packaging technologies is to address environmental issues and minimize their impact, while also guaranteeing food quality and safety for consumers. Bio-based polymers have drawn significant interest as a means to reduce the usage and environmental impact of petroleum-derived polymeric products. Therefore, this current review highlights on the biopolymer blends, various biodegradable bio-nanocomposites materials, and their synthesis and characterization techniques recently used in the smart food packaging industry.

Combating bacterial biofilms and related drug resistance: Role of phyto-derived adjuvant and nanomaterials.

The emergence of antimicrobial resistance (AMR) in clinical microbes has led to a search for novel antibiotics for combating bacterial infections. The treatment of bacterial infections becomes more challenging with the onset of biofilm formation. AMR is further accelerated by biofilm physiology and differential gene expression in bacteria with an inherent resistance to conventional antibiotics.

Optimization and Characterization of an Ultra-Thermostable, Acidophilic, Cellulase-Free Xylanase from a New Obligate Thermophilic Geobacillus thermoleovorans AKNT10 and its Application in Saccharification of Wheat Bran.

Microbial xylanases are enzymes of great importance due to their wide industrial applications, especially in the degradation of lignocellulosic biomass into fermentable sugars. This study aimed to describe the production optimization and partial characterization of an ultra-thermostable, acidophilic, cellulase-free xylanase from an obligate thermophilic eubacterium Geobacillus thermoleovorans strain-AKNT10 (Ac.No.

Soil and Mineral Nutrients in Plant Health: A Prospective Study of Iron and Phosphorus in the Growth and Development of Plants.

Plants being sessile are exposed to different environmental challenges and consequent stresses associated with them. With the prerequisite of minerals for growth and development, they coordinate their mobilization from the soil through their roots. Phosphorus (P) and iron (Fe) are macro- and micronutrient; P serves as an important component of biological macromolecules, besides driving major cellular processes, including photosynthesis and respiration, and Fe performs the function as a cofactor for enzymes of vital metabolic pathways.

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact.

Pharmaceutical companies are investigating more source matrices for natural bioactive chemicals. Friedelin (friedelan-3-one) is a pentacyclic triterpene isolated from various plant species from different families as well as mosses and lichen. The fundamental compounds of these friedelane triterpenoids are abundantly found in cork tissues and leaf materials of diverse plant genera such as Celastraceae, Asteraceae, Fabaceae, and Myrtaceae.

Analysis of Auxin-Encoding Gene Family in and It's Cross-Species Expression Modulating Waterlogging Tolerance in Wild .

Mungbean is known to be susceptible to waterlogging (WL) stress. Some of the wild species have the potential to tolerate this through various physiological and molecular mechanisms. (ARF) and (AUX/IAA), an early responsive gene family, has multiple functions in growth, development, and stress tolerance.

Promising applications of phyto-fabricated silver nanoparticles: Recent trends in biomedicine.

The prospective contribution of phyto-nanotechnology to the synthesis of silver nanomaterials for biomedical purposes is attracting increasing interest across the world. Green synthesis of silver nanoparticles (Ag-NPs) through plants has been extensively examined recently, and it is now seen to be a green and efficient path for future exploitation and development of practical nano-factories. Fabrication of Ag-NPs is the process involves use of plant extracts/phyto-compounds (e.

Pollutants in aquatic system: a frontier perspective of emerging threat and strategies to solve the crisis for safe drinking water.

Water is an indispensable natural resource and is the most vital substance for the existence of life on earth. However, due to anthropogenic activities, it is being polluted at an alarming rate which has led to serious concern about water shortage across the world. Moreover, toxic contaminants released into water bodies from various industrial and domestic activities negatively affect aquatic and terrestrial organisms and cause serious diseases such as cancer, renal problems, gastroenteritis, diarrhea, and nausea in humans.

Potential use of the Asteraceae family as a cure for diabetes: A review of ethnopharmacology to modern day drug and nutraceuticals developments.

The diabetesassociated mortality rate is increasing annually, along with the severity of its accompanying disorders that impair human health. Worldwide, several medicinal plants are frequently urged for the management of diabetes. Reports are available on the use of medicinal plants by traditional healers for their blood-sugar-lowering effects, along with scientific evidence to support such claims.

Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells.

Diabetes, characterized by high blood glucose level, is a progressive metabolic disease that leads to serious health complications. One of the major pathological consequences associated with diabetes is the accumulation of highly reactive carbonyl compounds called advanced glycation end products (AGEs). Most of the AGEs are dicarbonyls and have the potential to covalently modify proteins especially at the lysine residues in a non-enzymatic fashion (a process termed as glycation) resulting in the functional impairment and/or toxic gain in function.

: A miraculous shrub with potent health-promoting benefits from Northwest Himalaya.

Medicinal plants encompassing a series of bioactive compounds have gained significant importance for use in the treatment of different diseases. Of them, Thunb. (Deciduous shrub found in dappled shade, and sunny hedge) exhibits high medicinal value, with a widespread distribution across the Pir Panjal region of the Himalayas.

Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.

Diabetes mellitus is a complex illness in which the body does not create enough insulin to control blood glucose levels. Worldwide, this disease is life-threatening and requires low-cost, side-effect-free medicine. Due to adverse effects, many synthetic hypoglycemic medications for diabetes fail.

Biosynthesis of Phytocannabinoids and Structural Insights: A Review.

Cannabis belongs to the family Cannabaceae, and phytocannabinoids are produced by the L. plant. A long-standing debate regarding the plant is whether it contains one or more species.