Design, Synthesis, and Biological Evaluation of Triazolopyrimidine-Isatin Hybrids as Promising Candidates for Triple-Negative Breast Cancer.

Triple-negative breast cancer (TNBC) is a highly aggressive subtype marked by pronounced intra-tumoral heterogeneity and frequent therapeutic resistance. In this study, we report the design, synthesis, and biological evaluation of a novel series of triazolopyrimidine-isatin hybrids against the TNBC cell lines MDA-MB-231 and MDA-MB-468. Among them, 9h emerged as the most promising candidate, exhibiting potent cytotoxic activity against TNBC cell lines.

Design, Synthesis, and Antiproliferative and Apoptotic Assessment of Triazole-Tethered Bisnaphthalimide-Isatin Hybrids on Triple-Negative Breast and Prostate Cancers.

This study reports the design, synthesis, and biological evaluation of 1H-1,2,3-triazole-tethered bisnaphthalimide-isatin hybrids as potential antiproliferative agents. The compounds are efficiently synthesized via copper-promoted azide-alkyne cycloaddition and assayed against triple-negative breast (MDA-MB-231) and prostate (DU-145) cancer cell lines. Structure-activity relationship studies reveal that halogen substitution and spacer length substantially influenced anticancer activity.

Development of novel seleno-ciprofloxacin derivatives: an X in the antibiotic treasure map.

The growing emergence of pathogens resistant to the currently available antibacterial agents is an increasing and troublesome health problem worldwide. Modifying known active compounds has received wide attention and has become one of the hot spots in developing novel antibiotics. Herein we describe the synthesis of fifteen novel analogs of ciprofloxacin with a selenocyanate or selenoester functionality in the scaffold of this fluoroquinolone.

Selenium in Action: Exploring the Biological Wonders of Hydroselenite Salts.

Despite the wealth of data related to the advantages of formulating a wide range of compounds as salts to ameliorate their biological properties, there is scant information regarding the therapeutic potential of selenium (Se) salts. In this work, we have formulated six antibiotics as hydroselenite salts in order to compare their in vitro antibacterial and anticancer effects and evaluate if this approach could enhance their water solubility. In this regard, in almost all the cases, their solubility was increased by one order of magnitude.

Lithiophilic 3D-Si/SiO host for dendrite free lithium metal battery via simple magnesiothermic reduction process.

In the development of renewable energy sources, batteries are considered the best option for energy storage. High energy density and high performance are key demands for emerging technologies. Lithium-metal batteries (LMBs) are considered promising candidates for storing generated energy.

An ionic ultramicroporous polymer with engineered nanopores enables enhanced acetylene/carbon dioxide separation.

A nanopore engineering approach enhances acetylene (CH) over carbon dioxide (CO) selectivity in ionic ultramicroporous polymers (IUPs), an understudied class of sorbents. Extending the cationic arm of a prototypical IUP nearly doubles its CH/CO selectivity from 4.9 to 8.

Masking of iron and other interferences during the spectrophotometric analysis of aluminum from soil samples using Alizarin Red S.

In whole-rock geochemical analysis, the quantification of aluminum in geological samples is performed using different analytical techniques including UV-Vis spectrophotometry. During the spectrophotometric analysis of aluminum utilizing Alizarin Red S, iron causes significant interference, leading to inaccurate measurements of the amount of aluminum in the sample. In cases where leached or processed samples contain titanium, interference is also observed.

Lightweight-CancerNet: a deep learning approach for brain tumor detection.

Detecting brain tumors in medical imaging is challenging, requiring precise and rapid diagnosis. Deep learning techniques have shown encouraging results in this field. However, current models require significant computer resources and are computationally demanding.

Enhancing built-in electric field via ZnInS nanosheet decorated with ZnS quantum dots photocatalyst for highly efficient hydrogen evolution.

Two dimensional (2D) photocatalytic materials are desirable to achieve synergistic charge transfer and segregation. Here, we have developed 2D ZnInS nanosheet (3-4 nm) that generates more active sites for excellent photocatalytic activity. Further, we have fabricated ZnS quantum dots (QDs) and ZnS nanoparticles (NPs) embedded with ZnInS nanosheet in the form of ZnS QDs/ZnInS and ZnS NPs/ZnInS heterostructures prepared via one step hydrothermal method.

Optimizing potato leaf disease recognition: Insights DENSE-NET-121 and Gaussian elimination filter fusion.

Ensuring a sustainable global food security status which necessitated by achieving an equilibrium state between the anticipated and significant rise in the global population and the projected agricultural output which is essential for their food adequacy. The absence of such a harmonious balance may be a contributing factor to the emergence of food crises worldwide. Hence, it is imperative to proactively address and mitigate both direct and indirect factors that could potentially lead to this agricultural yield imbalance.

Metastatic Clear Renal Cell Carcinoma in Urinary Bladder at Presentation-A Rare Incidental Case Report and Literature Review.

This case highlights the rare occurrence of concurrent clear cell renal carcinoma with metastatic urinary bladder involvement, presenting as hematuria and flank pain. Initial screening revealed both renal and bladder tumors, confirmed as metastases. Histopathology emphasized thorough investigations for unexplained urinary symptoms and the need for multimodal treatment and follow-up.

Context aware machine learning techniques for brain tumor classification and detection - A review.

Background: Machine learning has tremendous potential in acute medical care, particularly in the field of precise medical diagnosis, prediction, and classification of brain tumors. Malignant gliomas, due to their aggressive growth and dismal prognosis, stand out among various brain tumor types. Recent advancements in understanding the genetic abnormalities that underlie these tumors have shed light on their histo-pathological and biological characteristics, which support in better classification and prognosis.

Design, Synthesis, Anti-Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole-Isatin Hybrids on Triple-Negative Breast Cancer.

A series of 1H-1,2,3-triazole-tethered spirocyclopropyl oxindole-isatin hybrids were synthesized using a copper-promoted click reaction and evaluated for their anti-proliferative activities against triple-negative breast cancer cell lines. The most potent compound in the series outperformed tamoxifen and 5-fluorouracil, with selectivity indices of 1.60 and 1.

Designed 2D/2D F-doped TiO@ZnInS heterojunction for efficient photo-utilization hydrogen generation.

Comprehending the catalytic reaction implementation for heterostructure photocatalysts is crucial by scrutinizing the spatial separation and transfer process of photoexcited charges at nanoscale junctions. Herein, we fabricated the F-doped TiO/ZnInS-based S-scheme heterostructure using a direct liquid-assembly method. The optimum hydrogen evolution rate (HER) of ∼ 1.

Geometric thermodynamics of collapse of gels.

Stimulus-induced volumetric phase transition in gels may be potentially exploited for various bioengineering and mechanical engineering applications. Since the discovery of the phenomenon in the 1970s, extensive experimental research has helped understand the phase transition and related critical phenomena. However, little insight is available on the evolving microstructure.

Nettle (Urtica dioica) supplementation: impact on growth, hematology, immune response, and resilience to Aeromonas hydrophila in Labeo rohita fingerlings.

The significance of plant-derived products in aquaculture lies in their potential to offer sustainable alternatives, promoting eco-friendly practices. This study investigated the impact of nettle (Urtica dioica) leaves powder on the growth efficiency, hemato-biochemical variables and non-specific immune system of rohu, Labeo rohita fingerlings. To achieve this objective, sample average weight (5.

Crystal engineering of a new platform of hybrid ultramicroporous materials and their CH/CO separation properties.

Hybrid ultramicroporous materials (HUMs) comprised of combinations of organic and inorganic linker ligands are a leading class of physisorbents for trace separations involving C1, C2 and C3 gases. First generation HUMs are modular in nature since they can be self-assembled from transition metal cations, ditopic linkers and inorganic "pillars", as exemplified by the prototypal variant, SIFSIX-3-Zn (3 = pyrazine, SIFSIX = SiF ). Conversely, HUMs that utilise chelating ligands such as ethylenediamine derivatives are yet to be explored as sorbents.

Design and characterization of phosphonic acid-functionalized grafted sepiolite nanohybrids and their adsorption studies for removal of copper ions from aqueous solution.

In this study, we synthesized novel, economically efficient phosphonic acid-functionalized grafted sepiolite nanohybrids for selective elimination of copper ions from water. These nanohybrids were prepared by graft polymerization of glycidyl methacrylate onto sepiolite. We utilized free radical graft polymerization to graft glycidyl methacrylate (GMA) onto silanized sepiolite.

Exploring Novel Coumarin-Tethered Bis-Triazoles: Apoptosis Induction in Human Pancreatic Cancer Cells, Antimicrobial Effects, and Molecular Modelling Investigations.

In the present study, we identified that two representative compounds (7 c and 9 f) of our newly synthesized coumarin-tagged bis-triazoles induced apoptosis in human pancreatic cells (PANC-1) by caspase 3/7mediated pathway. Both 7 c and 9 f (IC=7.15±1.

Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer.

A series of compounds were designed utilizing molecular modeling and fragment-based design based upon the known protein phosphatase 2A (PP2A) activators, and , and evaluated for their ability to inhibit the viability of colorectal cancer (CRC) and folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX)-resistant CRC cells. () was identified as the most cytotoxic compound with IC values in the range of 2.36-6.

Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor.

Aldehyde dehydrogenases (ALDHs) are a family of enzymes that aid in detoxification and are overexpressed in several different malignancies. There is a correlation between increased expression of ALDH and a poor prognosis, stemness, and resistance to several drugs. Several ALDH inhibitors have been generated due to the crucial role that ALDH plays in cancer stem cells.

Synthesis of Binder-Free, Low-Resistant Randomly Orientated Nanorod/Sheet ZnS-MoS as Electrode Materials for Portable Energy Storage Applications.

The scientific community needs to conduct research on novel electrodes for portable energy storage (PES) devices like supercapacitors (S-Cs) and lithium-ion batteries (Li-ion-Bs) to overcome energy crises, especially in rural areas where no electrical poles are available. Herein, the nanostructured MoS and ZnS-MoS E-Ms consisting of nanoparticles/rods/sheets (N-Ps-Rs-Ss) are deposited on hierarchical nickel foam by a homemade chemical vapor deposition (H-M CVD) route. The X-ray diffraction patterns confirm the formation of polycrystalline films growing along various orientations, whereas the field-emission scanning electron microscope analysis confirms the formation of N-Ps-Rs-Ss.