The effect of the "exposome" on developmental brain health and cognitive outcomes.

Each child's unique environment and experiences play a crucial role in shaping neurodevelopment and cognitive outcomes. Though a long history of prior research has highlighted the importance of numerous aspects of early life environments, including physical/chemical, psychosocial, socioeconomic, and cultural factors, it remains challenging to fully capture an individual's complete set of varied exposures, experiences, and external environments ("exposome") in a single study. The growing field of "exposomics" aims to overcome these challenges by leveraging interdisciplinary ideas and diverse methodologies to assess the additive and interactive effects of multimodal environmental features in relation to health outcomes.

An Interdisciplinary Challenge: Responsibilities in German Cancer-related Fatigue Management from the Professional and Patient Perspective.

Objectives: Due to its complexity, the management of cancer-related fatigue (CRF) is best based on an inter-disciplinary care approach. Thus, we examined the preferred and the actual distribution of responsibilities from the perspectives of healthcare professionals and patients.

Materials And Methods: An online survey was conducted among physicians (N =148), nurses (N =184), and psycho-oncologists (N =144) in Germany.

[Recent advances in immunotherapy for gastrointestinal tumors].

Immunotherapy has revolutionized the management of digestive cancers, particularly in esophagogastric and colorectal tumors. Immune checkpoint inhibitors (ICI) significantly improve survival, especially in patients whose tumors exhibit DNA repair system alterations or strong immune infiltration. Patient selection based on biomarker evaluation is essential to optimize treatment response.

Nurses' Knowledge of Cancer-Related Fatigue and the Coverage of This Subject in Nursing Training: A Cross-Sectional Study.

Background: Although cancer-related fatigue has a major impact on daily functioning and quality of life of patients, it remains underestimated in cancer care. Nurses play a significant role in multidisciplinary approaches to fatigue care.

Purpose: This study was designed to investigate knowledge and attitudes among nurses regarding cancer-related fatigue and its management in daily clinical practice and training to suggest future actions for improvement.

[Cancer-related fatigue: How (good) is the quality of care at cancer care facilities in Germany?].

Background: One of the most common sequelae of cancer and/or its treatment is cancer-related fatigue (CRF). For those affected, CRF is often accompanied by considerable, even long-term impairment. This makes it all the more important to examine how care is provided in Germany and to what extent guideline recommendations are implemented in clinical practice.

How do I treat dMMR/MSI gastro-oesophageal adenocarcinoma in 2025? A position paper from the EORTC-GITCG gastro-esophageal task force.

In less than a decade, immune checkpoint inhibitors (ICIs) have transformed the management of mismatch repair-deficient (dMMR) and microsatellite instability-high (MSI) cancers. However, beyond colorectal cancer (CRC), much of the evidence is mostly derived from non-randomized phase II studies or post-hoc analyses of broader clinical trials. dMMR/MSI tumours represent a specific subgroup of gastro-esophageal adenocarcinomas (GEA), accounting for approximately 9 % of cases, with a higher prevalence in early-stage compared to advanced-stage disease and older female patients.

Sex differences in toxicities and survival outcomes among Japanese patients with Stage III colorectal cancer receiving adjuvant fluoropyrimidine monotherapy: A pooled analysis of 4 randomized controlled trials (JCOG2310A).

Background: Fluoropyrimidine remains the key agent of adjuvant chemotherapy for stage III colorectal cancer (CRC). Western studies have shown that female sex is a favorable prognostic factor after surgery, but it is also a risk factor for adverse events (AEs) during adjuvant chemotherapy with fluoropyrimidine. However, little is known about whether sex differences in treatment outcomes exist in this setting in the Asian population.

Physicians' perspectives on cancer-related fatigue management and their suggestions for improvements in medical training: a cross-sectional survey study in Germany.

Purpose: Contrary to guidelines, many cancer patients are not screened for cancer-related fatigue (CRF) and do not receive information or adequate treatment. As physicians play a key role in cancer therapy, their knowledge of this common sequela and perspectives on its management are of major interest.

Methods: For an online survey, physicians working in oncology in Germany were systematically drawn from registers and invited by using institutional newsletters or colleagues.

Importance of Sex-Dependent Differences for Dosing Selection and Optimization of Chemotherapeutic Drugs.

Background: Despite major advances in cancer treatment in the past years, there is a need to optimize chemotherapeutic drug dosing strategies to reduce toxicities, suboptimal responses, and the risk of relapse. Most cancer drugs have a narrow therapeutic index with substantial pharmacokinetics variability. Yet, current dosing approaches do not fully account for the complex pathophysiological characteristics of the patients.

Dedicated developmental programing for group-supporting behaviors in eusocial honeybees.

The evolutionary changes from solitary to eusocial living in vertebrates and invertebrates are associated with the diversification of social interactions and the development of queen and worker castes. Despite strong innate patterns, our understanding of the mechanisms manifesting these sophisticated behaviors is still rudimentary. Here, we show that () manifests group-supporting behaviors in the honeybee () worker caste.

Using One App Only - Collecting a Comprehensive Set of Health-Related Data for Prevention of Chronic Conditions.

This paper presents the design, implementation and early tests of an app that collects a comprehensive set of health-related data, as part of the EU-project WARIFA. To achieve the main aim of the project - using AI to prevent chronic conditions - a wide range of data needs to be collected and stored at a backend server for processing. The methods and elements for creating this system are presented, as well as results from the co-creation process and early user-tests.

Population Pharmacokinetics of Trametinib and Impact of Nonadherence on Drug Exposure in Oncology Patients as Part of the Optimizing Oral Targeted Anticancer Therapies Study.

Trametinib is a targeted therapy used for the treatment of solid tumours, with significant variability reported in real-life studies. This variability increases the risk of suboptimal exposure, which can lead to treatment failure or increased toxicity. Using model-based simulation, this study aims to characterize and investigate the pharmacokinetics and the adequacy of the currently recommended doses of trametinib.

Moving away from willful ignorance: A critical whiteness examination of leadership educator socialization.

In the face of calls for the standardization and professionalization of leadership education, a sub-field in higher education, it is important to understand who leadership educators are and how they come to understand themselves as belonging to this sub-field. Recent critiques have arisen about the overwhelming whiteness that permeates the knowledge accepted within leadership education. To be cognizant of that critical perspective, this article applies the critical whiteness studies framework to analyze existing literature about leadership educator identity and socialization.

European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4).

Introduction: The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).

Methods: Guidelines were developed according to AGREE II and GRADE principles. Guidelines were based on a systematic review (OMEC-1), clinical case discussions (OMEC-2), and a Delphi consensus study (OMEC-3) by 49 European expert centers for esophagogastric cancer.

Patient-physician communication about cancer-related fatigue: a survey of patient-perceived barriers.

Purpose: Cancer-related fatigue is a subjective, distressing, and common sequela of cancer which is often disregarded and underdiagnosed. Fatigue is assessed by self-report requiring communication between patient and physician. In this study, we investigated the patients' perspective on the patient-physician communication about fatigue.

[Oncology: what's new in 2023].

The oncology field continues its remarkable evolution over the years, with promising advances leading to innovative and individualized treatments. The development of new molecules, the identification of new therapeutic targets and the search for new sequences or combinations promise to revolutionize cancer treatments and contribute to improving survival rates, patients' quality of life and to open new perspective in oncology research. In this article, the newest data released in 2023 are reviewed.

Cancer-related fatigue: Quality, credibility, usability, and readability of information on websites of health care institutions in Germany.

Objectives: This study aimed to portray available information on cancer-related fatigue on German health care institution websites considering the idea of patient empowerment.

Methods: Based on website quality criteria, we developed a website-rating tool comprising 18 items. Descriptive analyses, a KruskalWallis test, and corresponding post hoc tests comparing rating sum scores between institution groups were performed.

A genetic history of the Balkans from Roman frontier to Slavic migrations.

The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for human history. The Middle Danube was a crucial frontier and a crossroads for population and cultural movement. Here, we present genome-wide data from 136 Balkan individuals dated to the 1 millennium CE.

Glycan-Driven Formation of Raft-Like Domains with Hierarchical Periodic Nanoarrays on Dendrimersome Synthetic Cells.

The accurate spatial segregation into distinct phases within cell membranes coordinates vital biochemical processes and functionalities in living organisms. One of nature's strategies to localize reactivity is the formation of dynamic raft domains. Most raft models rely on liquid-ordered phases in a liquid-disordered phase lacking correlation and remaining static, often necessitating external agents for phase separation.

Examining feasibility, acceptability, and participant experiences of an anti-racist parenting intervention for White U.S. parents.

Many White parents engage in minimal discussion of race and racism with their children, instead engaging in color-evasive practices that communicate that race is unimportant and that White people are racially neutral. Even White parents who express a commitment to anti-racist parenting frequently struggle to act on this commitment and feel underprepared to do so. The current mixed methods pilot study focused on the feasibility, acceptability, and participant experiences of an intervention ("CounterACT") that aimed to address this gap in White U.

Concurrence of seizures and peri-ictal delirium in the critically ill - its frequency, associated characteristics, and outcomes.

Background: To assess the frequency, clinical features, and outcome of peri-ictal delirium in adult patients experiencing seizures during intensive care.

Methods: This observational study was conducted at a Swiss intensive care unit from 2015 to 2020. Patients aged ≥ 18 years with seizures were categorized as peri-ictal delirious (Intensive Care Delirium Screening Checklist [i.