The effect of the "exposome" on developmental brain health and cognitive outcomes.

Each child's unique environment and experiences play a crucial role in shaping neurodevelopment and cognitive outcomes. Though a long history of prior research has highlighted the importance of numerous aspects of early life environments, including physical/chemical, psychosocial, socioeconomic, and cultural factors, it remains challenging to fully capture an individual's complete set of varied exposures, experiences, and external environments ("exposome") in a single study. The growing field of "exposomics" aims to overcome these challenges by leveraging interdisciplinary ideas and diverse methodologies to assess the additive and interactive effects of multimodal environmental features in relation to health outcomes.

Understanding Safety in Online Mental Health Forums: Realist Evaluation.

Background: Online forums are used widely to facilitate mental health peer support. However, concerns exist regarding potential harm associated with their use, and little is known about forum safety from the user's perspective.

Objective: This study sought to understand how users experience safety within online mental health peer support forums.

Reproducible sex differences in personalised functional network topography in youth.

Background: A key step toward understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organisation at the critical transition from childhood to adolescence. Prior work suggests that individual differences in the spatial organisation of functional brain networks across the cortex are associated with psychopathology and differ systematically by sex.

Aims: We aimed to evaluate the impact of sex on the spatial organisation of person-specific functional brain networks.

Development of a digital treatment analyzer for the management of prostate cancer patients, with the help of real world data and use of predictive modelling.

Prostate cancer is the second most diagnosed cancer in the world. Treatment guidelines involve a multitude of therapies, however adherence to them is not fully established, while lack of personalized treatment strategies fails to put the patient as an individual clinical profile at the center of their treatment. We aim to present the concept of a digital treatment analyzer (TA) for the management of prostate cancer (PC) patients, leveraging real-world data (RWD) and predictive modeling to enhance personalized disease management strategies and adherence to PC guidelines, ultimately aiming to optimize therapeutic efficacy and improve outcomes.

Mapping hippocampal glutamate in healthy aging with glutamate-weighted CEST (GluCEST) imaging.

Introduction: Hippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal Glu in healthy old (HOA) and young (HYA) adults.

Methods: Bilateral hippocampal GluCEST data was acquired from 27 HOA and 22 HYA using 7T MRI.

A Prospective Crossover Study Comparing Six Current Generation Supraglottic Airway Device's Ability to Seal During CPR in Human Cadavers.

Background: Supraglottic airway (SGA) devices are frequently used during cardiopulmonary respiration (CPR), but little is known about their ability to consistently seal the airway during CPR.

Objectives: The objective of this prospective crossover human cadaver study was a comparison of intrathoracic pressures (ITPs) generated during automated CPR (aCPR) with an Impedance Threshold Device (ZOLL Medical Corporation, Chelmsford, MA) with six currently available SGAs to a standard endotracheal tube (ETT). The hypothesis was that current SGAs would vary in their ability to develop ITPs compared with the ETT.

Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression.

Background: Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients.

Objectives: In this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients.

The association of diet quality with the mental health of students during their transition to university.

University students are at risk of experiencing mental health and diet quality problems during their transition to university. This study aimed to examine the bidirectional associations between the diet quality and mental health of students during their transition to universities in the UK, and the impact of the transition on diet quality and mental health. The study adopted a cross-sectional design and took place during the first semester of year 2021-2022.

Understanding the Impacts of Online Mental Health Peer Support Forums: Realist Synthesis.

Background: Online forums are widely used for mental health peer support. However, evidence of their safety and effectiveness is mixed. Further research focused on articulating the contexts in which positive and negative impacts emerge from forum use is required to inform innovations in implementation.

mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.

Background: Mutations in the gene MTARC1 (mitochondrial amidoxime-reducing component 1) protect carriers from metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. MTARC1 encodes the mARC1 enzyme, which is localized to the mitochondria and has no known MASH-relevant molecular function. Our studies aimed to expand on the published human genetic mARC1 data and to observe the molecular effects of mARC1 modulation in preclinical MASH models.

The Genomic Landscape of Colorectal Cancer in the Saudi Arabian Population Using a Comprehensive Genomic Panel.

Purpose: Next-generation sequencing (NGS) technology detects specific mutations that can provide treatment opportunities for colorectal cancer (CRC) patients.

Patients And Methods: We analyzed the mutation frequencies of common actionable genes and their association with clinicopathological characteristics and oncologic outcomes using targeted NGS in 107 Saudi Arabian patients without a family history of CRC.

Results: Approximately 98% of patients had genetic alterations.

Improving Peer Online Forums (iPOF): protocol for a realist evaluation of peer online mental health forums to inform practice and policy.

Introduction: Peer online mental health forums are commonly used and offer accessible support. Positive and negative impacts have been reported by forum members and moderators, but it is unclear why these impacts occur, for whom and in which forums. This multiple method realist study explores underlying mechanisms to understand how forums work for different people.

Investigating the prevalence of pathogenic variants in Saudi Arabian patients with familial cancer using a multigene next generation sequencing panel.

Family history is an important factor in determining hereditary cancer risk for many cancer types. The emergence of next-generation sequencing (NGS) has expedited the discovery of many hereditary cancer susceptibility genes and the development of rapid, affordable testing kits. Here, a 30-gene targeted NGS panel for hereditary cancer risk assessment was tested and validated in a Saudi Arabian population.

Clinicopathologic and genomic characterizations of brain metastases using a comprehensive genomic panel.

Central nervous system (CNS) metastasis is the most common brain tumor type in adults. Compared to their primary tumors, these metastases undergo a variety of genetic changes to be able to survive and thrive in the complex tissue microenvironment of the brain. In clinical settings, the majority of traditional chemotherapies have shown limited efficacy against CNS metastases.

Use of an Online Forum for Relatives of People With Psychosis and Bipolar Disorder: Mixed Methods Study.

Background: Relatives of people with psychosis or bipolar disorder experience high levels of distress but are typically not offered the support they need. Online peer forums may offer a solution, but knowledge about who uses them, how, and why is limited. This study reported on online forum use during the Relatives Education and Coping Toolkit (REACT) trial.

Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.

Diabetic nephropathy is a leading cause of end-stage renal disease, characterized by endothelial dysfunction and a compromised glomerular permeability barrier. Dysregulation of the angiopoietin 1 (ANGPT1)/angiopoietin 2 (ANGPT2) signaling axis is implicated in disease progression. We recently described the discovery of an IgG antibody, O010, with therapeutic potential to elevate circulating endogenous ANGPT1, a tyrosine kinase with Ig and epidermal growth factor (EGF) homology domains-2 (TIE2) agonist.

Find the silver lining or ignore the cloud? Cognitive reappraisal versus visual attention training.

This study contrasted the efficacy of two strategies for emotion regulation, cognitive reappraisal (CR) and attentional control (AC), while using eye-tracking to examine gaze fixation patterns associated with each strategy. Participants (n = 98 undergraduates) viewed emotionally negative and neutral slides before and after one of three training conditions: CR training (verbal instructions to reframe interpretations of negative images), AC training (gaze-contingent feedback emphasizing fixation away from negative portions of images), or a no-training control condition. CR training led to the most beneficial consequences for self-reported emotion ratings; AC training improved emotion ratings more than the no-training control but not as much as CR.

Contraception Use and Attitudes Among Women Seeking Pregnancy Termination: Descriptive Cross-Sectional Survey.

Objective: Unintended pregnancy has been linked to poor health and social outcomes for both mother and child. Efforts to reduce unintended pregnancies have been challenged by many financial, social, religious, and cultural factors. This study aimed to investigate how contraception use and misuse in a cohort of females seeking termination of pregnancy contribute to unintended pregnancies.

Serum D-dimer should not be used in the diagnosis of venous thromboembolism within 28 days of total knee replacement surgery.

Background: Serum D-dimer is frequently used to rule out a diagnosis of venous thromboembolism (VTE), a recognised complication following total knee replacement (TKR). TKR is known to cause a rise in D-dimer levels, reducing its specificity. Previous studies have demonstrated that D-dimer remains elevated within 10 days of TKR and therefore should be avoided.

A web-based, peer-supported self-management intervention to reduce distress in relatives of people with psychosis or bipolar disorder: the REACT RCT.

Background: Relatives caring for people with severe mental health problems find information and emotional support hard to access. Online support for self-management offers a potential solution.

Objective: The objective was to determine the clinical effectiveness and cost-effectiveness of an online supported self-management tool for relatives: the Relatives' Education And Coping Toolkit (REACT).

Methodological Challenges in Web-Based Trials: Update and Insights From the Relatives Education and Coping Toolkit Trial.

RR2-10.1136/bmjopen-2017-016965.