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Background: Supraglottic airway (SGA) devices are frequently used during cardiopulmonary respiration (CPR), but little is known about their ability to consistently seal the airway during CPR.
Objectives: The objective of this prospective crossover human cadaver study was a comparison of intrathoracic pressures (ITPs) generated during automated CPR (aCPR) with an Impedance Threshold Device (ZOLL Medical Corporation, Chelmsford, MA) with six currently available SGAs to a standard endotracheal tube (ETT). The hypothesis was that current SGAs would vary in their ability to develop ITPs compared with the ETT.
Methods: Airway pressures and negative ITP were measured in six recently deceased human cadavers of varying body habitus. After placement of an ETT and six different SGAs, we assessed airway and ITPs during aCPR and manual positive pressure ventilation using bag-valve mask. The ETT served as the control for airway seal and was placed first followed by each SGA. Primary outcome compared airway and ITP among all groups.
Results: SGAs varied in their ability to create negative airway pressure and negative ITP.
Conclusion: In this human cadaver model, the ability to generate negative ITP varied with different SGAs during aCPR with an Impedance Threshold Device.
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http://dx.doi.org/10.1016/j.jemermed.2024.08.012 | DOI Listing |
Resusc Plus
November 2025
Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University Hospital, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Background: The aim of this study was to analyse the influence of voice navigation in a new generation of transceivers on the time and success rate of transceiver search in a simulated avalanche rescue scenario.
Methods: Fifty participants performed two randomized test runs, using two different transmitters with and without voice navigation. Primary outcome was success rate, total transceiver search and total location time, secondary outcome parameters comprised predefined time intervals (coarse search time, fine search time, probing time) and deviations from the recommended standard search procedure.
J Refract Surg
September 2025
JENVIS Research, Jena, Germany.
Purpose: To analyze the difference in objective and subjective photic phenomena following virtual implantation of three different presbyopia-correcting diffractive intraocular lens (IOL) designs.
Methods: The study was conducted at JENVIS Research Germany. A prospective cross-over and double-masked trial design was used.
Equine Vet J
September 2025
Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
Background: Steaming hay reduces respirable particles and is commonly used to feed horses with asthma. However, it showed inconsistent benefits in clinical studies.
Objectives: (1) To assess the effects of steamed hay on lung function and airway inflammation in horses with severe equine asthma (SEA) in remission; (2) To compare these effects with a dry hay diet.
J Vet Intern Med
September 2025
Department of Specialty Medicine, Midwestern University College of Veterinary Medicine, Glendale, Arizona, USA.
Background: Vitamin D modulates the immune response in many species, including dogs. To date, research investigating the immunological effects of vitamin D in dogs is limited to in vitro studies.
Objectives: Provide PO calcifediol supplementation to healthy dogs to evaluate its tolerability and assess its effect on leukocyte production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10.
Knee Surg Sports Traumatol Arthrosc
September 2025
Orthopaedic Research Foundation of Western Australia, Perth, Western Australia, Australia.
Purpose: The purpose of the study was to identify the safety and effectiveness of an accelerated (AR) versus conservative (CR) rehabilitation regimen following surgical repair of proximal hamstring tendon avulsions.
Methods: This prospective randomized controlled trial (RCT) allocated patients undergoing proximal hamstring tendon repair to either a braced, partial weight-bearing rehabilitation regime (CR = 30) or an accelerated, unbraced regime, which permitted full weight-bearing as tolerated (AR = 27). Patients were evaluated pre-operatively and at 6 weeks, 3 and 6 months post-surgery, via patient-reported outcome measures (PROMs), patient satisfaction and global rating of change (GRC) scores.