Autologous Retinal Transplant in Refractory Macular Holes.

To report the structural and functional outcomes of autologous neurosensory retinal transplant for closure of refractory macular holes (MHs) and to highlight the long-term follow-up findings. Nine eyes of 9 patients with full-thickness MH refractory to previous vitrectomy with internal limiting membrane (ILM) peeling and tamponade underwent pars plana vitrectomy, autologous retinal transplant with short-term perfluoro-n-octane heavy liquid, followed by gas tamponade. Patients were followed for 12.

Visualization of mRNA Translation Within Germ Granule Biphasic Organization in Early Embryo.

Super-resolution imaging of RNA-protein (RNP) condensates has shown that most are composed of different immiscible phases reflected by a heterogenous distribution of their main components. Linking RNA-protein condensate's inner organization with their different functions in mRNA regulation remains a challenge, particularly in multicellular organisms. germ granules are a model of RNA-protein condensates known for their role in mRNA storage and localized protein production in the early embryo.

Isolation of cannabinoids and triterpenoids from D.Don (Ericaceae) Leaves.

D.Don (Ericaceae) is a medicinal plant that occurs in the Swat District, Pakistan. Column chromatography was used to isolate cannabichromeorcinic acid (), cannabigerorcinic acid (), ursolic acid (), friedelin () and 2-phenylethyl 4-methoxybenzoate () from the methylene chloride extract of leaves that were collected from the Daral region in the Swat District, Pakistan.

Exploring neonatal brain tumors: a narrative review about epidemiology, classification, and management.

Neonatal brain tumors (NBTs) are rare, with specific characteristics distinguishing them from tumors in older children. NBTs occur in the first 28 days of life with a low incidence rate. They present unique histological features, with teratomas and gliomas being the most relevant types of NBTs.

The burden of mental disorders and substance abuse in the Middle East and North Africa (MENA) region: findings from the Global Burden of Disease Study.

Background: Mental disorders pose significant morbidity and mortality risks globally. Despite this, research on mental health in the Middle East and North Africa (MENA) region is scarce, hindered by social stigmas and limited healthcare expenditure. This study, utilizing the Global Burden of Disease (GBD) database, aims to address this gap by examining the prevalence, incidence, and demographic patterns of mental disorders in MENA.

Assessing the Impact of Pre-surgical Delay on Extradural Hematoma Outcomes.

Background: Extradural hematoma (EDH) is a life-threatening neurosurgical emergency, with timely surgical intervention critical to preventing neurological deterioration and improving patient outcomes. Delays in surgical treatment are a persistent concern, yet the specific impact of pre-surgical delays on clinical outcomes in EDH patients remains underexplored.

Objective: This study aimed to evaluate the impact of pre-surgical delay duration on clinical outcomes in patients with EDH, specifically examining survival rates, neurological status, and recovery outcomes.

Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting.

Purpose: We aimed to characterize genomic alterations with potential prognostic or predictive significance in patients with metastatic triple-negative breast cancer (mTNBC) treated with chemotherapy in a real-world setting.

Patients And Methods: Next-generation sequencing with FoundationOne® CDx was conducted primarily on primary tumor tissue from 112 consecutive patients with mTNBC. Genomic alterations were subdivided into canonical oncogenic pathways and noted for their involvement in homologous recombination deficiency (HRD).

Faricimab Treatment of Polypoidal Choroidal Vasculopathy Resistant to Intravitreal Ranibizumab Injections and Ranibizumab Port Delivery (Susvimo).

To report a case of polypoidal choroidal vasculopathy (PCV) recalcitrant to treatment with ranibizumab and with a ranibizumab port delivery system (Susvimo) but responsive to faricimab-svoa. A case and its findings were analyzed. A 69-year-old Filipino man with PCV in the left eye was treated for 2 years with multiple ranibizumab intravitreal (IVT) injections followed by ranibizumab port delivery combined with rescue ranibizumab IVT injections, with no significant response clinically or on imaging.

Incidence and Risk Factors of Intraventricular Hemorrhage in Early Preterm Infants: A Cross-Sectional Study.

Background: Early preterm infants are susceptible to a serious disorder called intraventricular hemorrhage (IVH), which may cause severe neurological damage.

Objective: To determine the incidence of IVH in preterm infants at Lady Reading Hospital, Peshawar, Pakistan, and to identify associated risk factors and potential preventive measures.

Methodology: This cross-sectional research examined the prevalence of IVH among early preterm infants and was carried out at Lady Reading Hospital in Peshawar from 1 January 2021 to 31 December 2023.

Evaluating machine learning performance in predicting sodium adsorption ratio for sustainable soil-water management in the eastern Mediterranean.

Soil salinization is a critical global issue for sustainable agriculture, impacting crop yields and posing a threat to achieving the Sustainable Development Goal (SDG) of ensuring food security. It is necessary to monitor it in detail and uncover its underlying factors at a regional scale. In this context, the present study aimed to evaluate soil health in the eastern Mediterranean region by using the Sodium Adsorption Ratio (SAR) as an indicator of soil salinity in three distinct soil horizons.

Spatial organization of translation and translational repression in two phases of germ granules.

Most RNA-protein condensates are composed of heterogeneous immiscible phases. However, how this multiphase organization contributes to their biological functions remains largely unexplored. Drosophila germ granules, a class of RNA-protein condensates, are the site of mRNA storage and translational activation.

Enhanced CPU Design for SDN Controller.

Software-Defined Networking (SDN) revolutionizes network management by decoupling control plane functionality from data plane devices, enabling the centralized control and programmability of network behavior. This paper uses the ternary system to improve the Central Processing Unit (CPU) inside the SDN controller to enhance network management. The Multiple-Valued Logic (MVL) circuit shows remarkable improvement compared to the binary circuit regarding the chip area, propagation delay, and energy consumption.

Small-Angle Scattering Indicates Equilibrium Instead of Metastable Capillary Condensation in SBA-15 Mesoporous Silica.

Questions about the origin of the adsorption/desorption hysteresis in mesoporous materials are as old as sorption experiments themselves. The historical conception that underlines most existing methods to extract pore size distributions from sorption data assumes that adsorption is a metastable process and that desorption takes place at thermodynamic equilibrium. In this work, we measure nitrogen and argon sorption on a series of 14 SBA-15 ordered mesoporous silicas and use small-angle X-ray scattering to independently determine their pore sizes.

Imaging of an exceptional urinoma complicating a cervical cancer and leading to death: A case report.

Spontaneous urinoma is a rare urological complication that can occur following acute urinary obstruction. It involves a collection of urine that typically forms around the kidney as a result of rupture of the fornix. There are several causes of acute urinary stasis, including lithiasis, tumors, prostatic hypertrophy, and others.

Ternary Full Adder Designs Employing Unary Operators and Ternary Multiplexers.

The design of the Ternary Full Adders (TFA) employing Carbon Nanotube Field-Effect Transistors (CNFET) has been widely presented in the literature. To obtain the optimal design of these ternary adders, we propose two new different designs, TFA1 with 59 CNFETs and TFA2 with 55 CNFETs, that use unary operator gates with two voltage supplies (Vdd and Vdd/2) to reduce the transistor count and energy consumption. In addition, this paper proposes two 4-trit Ripple Carry Adders (RCA) based on the two proposed TFA1 and TFA2; we use the HSPICE simulator and 32 nm CNFET to simulate the proposed circuits under different voltages, temperatures, and output loads.

Outcome prediction models incorporating clinical variables for Head and Neck Squamous cell Carcinoma: A systematic review of methodological conduct and risk of bias.

Multiple outcome prediction models have been developed for Head and Neck Squamous Cell Carcinoma (HNSCC). This systematic review aimed to identify HNSCC outcome prediction model studies, assess their methodological quality and identify those with potential utility for clinical practice. Inclusion criteria were mucosal HNSCC prognostic prediction model studies (development or validation) incorporating clinically available variables accessible at time of treatment decision making and predicting tumour-related outcomes.

Open-source, fully-automated hybrid cardiac substructure segmentation: development and optimisation.

Radiotherapy for thoracic and breast tumours is associated with a range of cardiotoxicities. Emerging evidence suggests cardiac substructure doses may be more predictive of specific outcomes, however, quantitative data necessary to develop clinical planning constraints is lacking. Retrospective analysis of patient data is required, which relies on accurate segmentation of cardiac substructures.

Standardising Breast Radiotherapy Structure Naming Conventions: A Machine Learning Approach.

In progressing the use of big data in health systems, standardised nomenclature is required to enable data pooling and analyses. In many radiotherapy planning systems and their data archives, target volumes (TV) and organ-at-risk (OAR) structure nomenclature has not been standardised. Machine learning (ML) has been utilised to standardise volumes nomenclature in retrospective datasets.

Comparative Study of Planar Octahedron Molecular Structure via Eccentric Invariants.

A branch of graph theory that makes use of a molecular graph is called chemical graph theory. Chemical graph theory is used to depict a chemical molecule. A graph is connected if there is an edge between every pair of vertices.

On Topological Properties for Benzenoid Planar Octahedron Networks.

Chemical descriptors are numeric numbers that capture the whole graph structure and comprise a basic chemical structure. As a topological descriptor, it correlates with certain physical aspects in addition to its chemical representation of underlying chemical substances. In the modelling and design of any chemical network, the graph is important.

Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers.

The proteome represents all the proteins expressed by a genome, a cell, a tissue, or an organism at any given time under defined physiological or pathological circumstances. Proteomic analysis has provided unparalleled opportunities for the discovery of expression patterns of proteins in a biological system, yielding precise and inclusive data about the system. Advances in the proteomics field opened the door to wider knowledge of the mechanisms underlying various post-translational modifications (PTMs) of proteins, including glycosylation.

Molecular and Biochemical Characterization, Antimicrobial Activity, Stress Tolerance, and Plant Growth-Promoting Effect of Endophytic Bacteria Isolated from Wheat Varieties.

Endophytic bacteria have been utilized as an alternative source to chemical fertilizers and pesticides to enhance plant productivity and defense mechanisms against biotic and abiotic stress. Five endophytic bacterial strains were isolated from the seeds of three different Pakistani wheat varieties (Ghaneemat-e-IBGE, Atta-Habib, and Siren). The isolated strains AH-1, S-5, S-7, GI-1, and GI-6 showed phylogenetic similarity with , , , , and , respectively.

Soils of the Southern Syria - A big database for the future land management planning.

As non-renewable natural resources, restoring Syrian soil quality is a vital issue for sustainable future planning after conflict ends. The data provided in this research exhibit features and physiochemical properties for soils from the southern part of Syria until the Jordanian border, which can provide decision-makers with sufficient information for rehabilitation stage after conflict in a regional scale. The data were collected from 107 representative soil profiles covering diverse agroecosystems throughout the area (i.