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Neonatal brain tumors (NBTs) are rare, with specific characteristics distinguishing them from tumors in older children. NBTs occur in the first 28 days of life with a low incidence rate. They present unique histological features, with teratomas and gliomas being the most relevant types of NBTs. The most common clinical finding is macrocephaly and hydrocephaly, but non-specific symptoms can also occur. Researchers illustrated multiple risk factors predominantly carcinogens and genetic factors. Managing these tumors is challenging, with surgery being the gold standard for treatment whereas the use of chemotherapy and radiotherapy is risky with this age group. Thus, balancing between aggressive intervention and adverse effects is crucial. This review will be relevant to clinicians and researchers interested in understanding the epidemiology, classification, clinical features, diagnostic features, and management options of NBTs.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055082 | PMC |
http://dx.doi.org/10.1097/MS9.0000000000003229 | DOI Listing |
J Anat
September 2025
Department of Biological Sciences (Anthropology), Graduate School of Science, The University of Tokyo, Tokyo, Japan.
The uniqueness of human brain growth and development has been considered promising for its contribution to understanding the origins of the unique human cognitive abilities. Compared with that of chimpanzees, the human endocranium undergoes several characteristic shape changes immediately after birth, which has been termed "endocranial globularization." However, how the brain structures and surrounding neurocranium interact with each other during early development in the context of brain-neurocranium integration remains to be investigated.
View Article and Find Full Text PDFGene
September 2025
Institute of Physiology, Medical School, University of Pécs H-7624 Pécs, Hungary. Electronic address:
In this edition of Gene's "Editor's Corner" we summarize the complex interactions of different molecular mechanisms behind the pathogenesis of neonatal hypoxic-ischemic encephalopathy (HIE). The topic is relevant, as the therapeutic options for HIE are limited, it is important to have as much knowledge as possible about the molecular processes underlying the disease. In the recent issue of Gene (Gene 952, 2025, 149363), Wang et al.
View Article and Find Full Text PDFPol Merkur Lekarski
September 2025
AMERIDENT NON-PUBLIC HEALTH CARE INSTITUTION CIVIL LAW PARTNERSHIP MARIA AND LAZARZ LEGIEN, BIELSKO-BIALA, POLAND.
Objective: Aim: Iodine is an essential nutrient for the synthesis of thyroid hormones. It has a huge impact on the normal brain development of the foetus and the health of the pregnant woman. During pregnancy and lactation, the need for iodine increases significantly.
View Article and Find Full Text PDFJ Neurophysiol
September 2025
Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, China.
Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of developmental disorders and permanent central nervous system damage, with functional recovery closely linked to myelin sheath integrity. This study aimed to analyze the expression of pH and the voltage-gated proton channel (Hv1) in the brains of neonatal pigs with HIE at various time points, alongside changes in myelin-related proteins. MRI was employed to localize the basal ganglia and assess pH changes post-hypoxia-ischemia, while immunofluorescence staining was used to evaluate Hv1, myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and myelin-associated glycoprotein (MAG).
View Article and Find Full Text PDFPLoS One
September 2025
Department of Pathology, Boston Children's Hospital, Harvard School of Medicine, Boston, Massachusetts, United States of America.
The Sudden Infant Death Syndrome (SIDS) is a major global health problem, with increased risk among socioeconomically disadvantaged populations. We propose SIDS, or a subset, is due to a defect in the brainstem serotonin system mediating cardiorespiratory integration and arousal. This defect impinges on homeostasis during a critical developmental period in infancy, especially in populations experiencing maternal and infantile stress, resulting in sleep-related sudden death.
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