Synergistic effects of a carbohydrate-controlled diet and herbal infusion on metabolic syndrome.

Background: Metabolic syndrome (MetS) is a growing global health concern and a major risk factor for conditions such as diabetic nephropathy and atherosclerosis. It is marked by chronic inflammation, insulin resistance, and dyslipidemia. Dietary interventions, including carbohydrate-controlled diets, have shown potential in improving metabolic outcomes.

Computational Screening and Cytotoxic Analysis of Beta vulgaris L. phytoconstituents as potent Dengue virus-NS5 Polymerase inhibitors.

Dengue infection is one of the most widely spread flavivirus infections. Despite the fatality it could cause, no antiviral treatment is currently available to treat the disease and its associated pathophysiological conditions. This study aimed to search drug-like compounds for possible inhibitors of the NS5 protein of dengue virus (serotype 2).

Phylogenetic analysis of the enigmatic Kalash population in Pakistan.

The genetic origin of the Kalash, an isolated community in northern Pakistan, have long been a subject of debate. This study aimed at investigating the genetic diversity and ancestral composition of Kalash people using an advanced set of genetic data including 22 autosomal and 23 Y chromosomal STRs. We elucidated their historical movements and potential connections to ancient populations by investigating their distinct alleles and comparing them with other regional and global populations to catalog their phylogenetic associations.

Safety of Gadoterate Meglumine: A Review of 35 Years of Clinical Use and More Than 170 Million Doses.

Aim: The aim of this review was to evaluate the safety profile of gadoterate meglumine from published literature and pharmacovigilance reports of adverse drug reactions (ADRs) encompassing 35 years of clinical use and more than 170 million administered doses.

Materials And Methods: A review of published literature up to December 31, 2024 was performed through a search in Embase and PubMed databases. The analysis focused on current safety concerns associated with gadolinium-based contrast agents, the hypersensitivity reactions (HSRs), nephrogenic systemic fibrosis (NSF), gadolinium accumulation, and symptoms associated with gadolinium exposure.

An Integrative Computational Approach for Identifying Cotton Host Plant MicroRNAs with Potential to Abate CLCuKoV-Bur Infection.

-Burewala (CLCuKoV-Bur) has a circular single-stranded ssDNA genome of 2759 nucleotides in length and belongs to the genus (family, ). CLCuKoV-Bur causes cotton leaf curl disease (CLCuD) and is transmitted by the whitefly cryptic species. Monopartite begomoviruses encode five open reading frames (ORFs).

Symptoms Associated With Gadolinium Exposure: Different Patterns and Rates Between Linear and Macrocyclic Gadolinium-Based Contrast Agents.

Objective: Some patients who received multiple administrations of gadolinium-based contrast agents (GBCAs) have been reported to develop "symptoms associated with gadolinium exposure" (SAGE). The aim of this study was to analyze pharmacovigilance data and to explore the various SAGE patterns of linear and macrocyclic GBCAs among patients exhibiting 3 or more SAGE symptoms.

Materials And Methods: SAGE were identified from a review of the scientific literature, and the corresponding preferred terms (PTs) were searched in each system organ class recorded in the FDA Adverse Event Reporting System (FAERS).

Exploring antiviral activity of Betanin and Glycine Betaine against dengue virus type-2 in transfected Hela cells.

Dengue virus (DENV) infection is a worldwide public health concern infecting approximately 400 million individuals and about 40,000 mortalities yearly. Despite this, no licensed or readily available antiviral medication is currently available specifically for DENV infection, and therapy is typically symptomatic. Therefore, the objective of the study was to investigate the antiviral activity of Beta vulgaris L.

Chemical composition of indoor and outdoor PM in the eastern Arabian Peninsula.

Water-soluble and trace metal species in fine particulate matter (PM) were determined for indoor and outdoor environments in Doha, Qatar. During the study period, PM concentrations showed significant variability across several indoor locations ranging from 7.1 to 75.

Carbon based sensors for air quality monitoring networks; middle east perspective.

IoT-based Sensors networks play a pivotal role in improving air quality monitoring in the Middle East. They provide real-time data, enabling precise tracking of pollution trends, informed decision-making, and increased public awareness. Air quality and dust pollution in the Middle East region may leads to various health issues, particularly among vulnerable populations.

Thermal and hydraulic performance of ZnO/EG based nanofluids in mini tubes of different diameters: An experimental investigation.

The present experimental study investigates the thermal and hydraulic performance of Ethylene Glycol (EG)-based ZnO nanofluids (NFs) in circular minichannel test sections, each of 330 mm in length and 1.0-2.0 mm inner diameters.

Evaluating sustainable municipal solid waste management scenarios: A multicriteria decision making approach.

Due to increasing urbanization and population growth, municipal solid waste management (MSWM) is a significant environmental concern in developing countries. Inadequate waste management systems lead to environmental pollution, health hazards, and economic losses. While considering the challenges and limitations, policymakers and authorities need to opt for such waste management scenarios that are environmentally friendly and resolve energy issues.

Synthesis and Characterization of Graphene Oxide/Polyethylene Glycol/Folic Acid/Brucine Nanocomposites and Their Anticancer Activity on HepG2 Cells.

Background: Liver cancer is the sixth most prevalent form of cancer and the second major cause of cancer-associated mortalities worldwide. Cancer nanotechnology has the ability to fundamentally alter cancer treatment, diagnosis, and detection.

Objective: In this study, we explained the development of graphene oxide/polyethylene glycol/folic acid/brucine nanocomposites (GO/PEG/Bru-FA NCs) and evaluated their antimicrobial and anticancer effect on the liver cancer HepG2 cells.

Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review.

High blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have diabetes by 2045 as the global prevalence of the disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences.

Assessing the potential of GHG emissions for the textile sector: A baseline study.

The carbon footprint (CFP) is a measure of greenhouse gases (GHGs) emitted throughout the lifecycle of a product or activity, while the energy footprint (EFP) and water footprint (WFP) measure energy and water consumption, respectively. These footprints are essential for managing emissions and consumption and promoting low-carbon consumption. A carbon labeling scheme could help consumers make informed choices.

Topical Delivery of Terbinafine HCL Using Nanogels: A New Approach to Superficial Fungal Infection Treatment.

This study investigated pH-responsive Terbinafine HCL (TBH)-loaded nanogels as a new approach to treating superficial fungal infections. Acrylic acid (AA) is a synthetic monomer that was crosslinked with a natural polymer (gelatin) using a free radical polymerization technique to fabricate gelatin-g-poly-(acrylic acid) nanogels. Ammonium persulphate (APS) and N, N'-methylene bisacrylamide (MBA) were used as the initiator and crosslinker, respectively.

A comprehensive study on the performance and emission analysis in diesel engine via optimization of novel ternary fuel blends: Diesel, manganese, and diethyl ether.

Ecosystem degradation and fossil fuel depletion are the two foremost concerns to look for alternative fuels. Rapid population growth is primarily accountable for higher consumption of fossil fuel sources, although engine technology is achieving milestones in terms of fuel efficiency and lower exhaust emissions in order to contribute towards a sustainable environment. The main root cause of global warming is carbon dioxide emissions; therefore, it is imperative to assess the impact of alternative fuels in diesel engines with an aim to minimize carbon emissions.

The Fabrication of Halogen-Doped FeWO Heterostructure Anchored over Graphene Oxide Nanosheets for the Sunlight-Driven Photocatalytic Degradation of Methylene Blue Dye.

Rapid industrialization and urbanization are the two significant issues causing environmental pollution. The polluted water from various industries contains refractory organic materials such as dyes. Heterogeneous photocatalysis using semiconductor metal oxides is an effective remediation technique for wastewater treatment.

Chitosan biopolymer functionalized with graphene oxide and titanium dioxide with Escin metallic nanocomposites for anticancer potential against colon cancer.

Our study produced GO-TiO-chitosan-escin nanocomposites (GTCEnc), characterized them using physical and biological methods, and evaluated their potential as cancer treatment candidates. Standard protocols were used to produce GTCEnc. Nanocomposites are created using XRD, FTIR, UV-Vis, and PL spectroscopy analysis.

Computer-aided identification of dengue virus NS2B/NS3 protease inhibitors: an integrated molecular modelling approach for screening of phytochemicals.

Globally, dengue (DENV) fever has appeared as the most widespread vector-borne disease, affecting more than 100 million individuals annually. No approved anti-DENV therapy or preventive vaccine is available yet. DENV NS3 protein is associated with protease activity and is essential for viral replication process within the host cell.

An application of carbohydrate polymers-based surface-modified gold nanoparticles for improved target delivery to liver cancer therapy - A systemic review.

Gold nanoparticles have been broadly investigated as cancer diagnostic and therapeutic agents. Gold nanoparticles are a favorable drug delivery vehicle with their unique subcellular size and good biocompatibility. Chitosan, agarose, fucoidan, porphyran, carrageenan, ulvan and alginate are all examples of biologically active macromolecules.

Carbohydrate polymers-based surface modified nano delivery systems for enhanced target delivery to colon cancer - A review.

Carbohydrate polymers-based surface-modified nano-delivery systems have gained significant attention in recent years for enhancing targeted delivery to colon cancer. These systems leverage carbohydrate polymers' unique properties, such as biocompatibility, biodegradability, and controlled release. These properties make them suitable candidates for drug delivery applications.

Acute thrombotic occlusion involving three coronary arteries. A unique association with COVID-19 pneumonia.

Key Clinical Message: Respiratory viruses, particularly COVID-19, can be associated with severe cases of myocardial infarction (MI). Physicians should have a low threshold for MI in COVID-19 patients who present with persistent chest pain as MI in rapidly deteriorating cases can be missed. Prompt response includes both timely diagnosis and swift treatment.

COVID-19 and severity of liver diseases: Possible crosstalk and clinical implications.

COVID-19-infected individuals and those who recovered from the infection have been demonstrated to have elevated liver enzymes or abnormal liver biochemistries, particularly with preexisting liver diseases, liver metabolic disorders, viral hepatitis, and other hepatic comorbidities. However, possible crosstalk and intricate interplay between COVID-19 and liver disease severity are still elusive, and the available data are murky and confined. Similarly, the syndemic of other blood-borne infectious diseases, chemical-induced liver injuries, and chronic hepatic diseases continued to take lives while showing signs of worsening due to the COVID-19 crisis.