Cumulative Hepatoprotective, Antihyperlipidemic and Antioxidant Effects of Methanolic Seeds Extract of , , , and With GC-MS Profile.

The complex pathophysiological mechanism of nonalcoholic fatty liver (NAFLD) disease has made the prevention and treatment of the disease problematic. The aim of the current study is to evaluate the cumulative hepatoprotective, antihyperlipidemic as well as antioxidant actions of methanolic seed extracts of (CL), (CM), (CS), and (CuM) in NAFLD induced by a high-fat diet along with 20% fructose water in a rat model. A total of 40 male Wistar rats were kept in five groups.

Moving the Needle Forward for Low-Risk and Intermediate-Risk Pediatric Rhabdomyosarcoma in LMIC: Outcomes From a Cancer Center in Pakistan.

Pediatric rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. In low- and middle-income countries (LMIC) such as Pakistan, several challenges in the diagnosis and treatment of RMS may lead to poor outcomes. A retrospective chart review was conducted from January 1, 2017 to January 1, 2022, to identify patients with low-risk and intermediate-risk RMS at a tertiary cancer center in Pakistan.

In-silico prioritization of pathogenic Interleukin-37b variants and a fusion platform for high-yield soluble production.

Human interleukin-37 isoform 1 (IL-37b) is a key anti-inflammatory cytokine with significant therapeutic potential for inflammatory and immune-mediated disorders. However, its clinical translation is limited by poor understanding of disease-associated genetic variants and lack of an expression system for soluble production. While addressing both challenges, this study presents (a) a prioritized catalog of high-confidence, pathogenic IL-37b variants, and (b) a fusion-based expression platform for its soluble production, providing essential resources for future functional validations.

Development and Application of a Novel 'Green' Antibacterial Black Garlic ()-Based Nanogel in Epidermal Wound Healing.

Research Background: Black garlic has been reported to have several health-promoting properties compared to fresh, raw garlic. The enzyme alliinase, which converts alliin to allicin, is deactivated at moderately high temperature, thus stripping away the typical pungent odour of fresh garlic during fermentation and rendering black garlic devoid of the typical garlic-like smell. To date, the antimicrobial activity of alliin-rich extract obtained from black garlic powder has not been reported.

Assessment of iron accumulation in vegetables cultivated with excessive application of organic and inorganic fertilizers along with various water sources.

Irrigation with sewage water can offer benefits such as increased crop productivity, but it also has significant drawbacks that affect crops, soil quality, and human health. Given its diverse composition of toxins, including chemicals and heavy metals, sewage water can adversely impact both soil fertility and crop health. With this in mind, the objective of this research was to evaluate the potential health risks associated with iron (Fe) in vegetables, specifically leafy and root vegetables, irrigated with wastewater, canal water, and a combination of organic and inorganic fertilizers.

Curcumin, EGCG and apigenin in cervical cancer: mechanistic insights and therapeutic potential.

Cervical cancer (CC) continues to be the major cause of death from cancer in women worldwide and highlights the necessity for novel therapeutic approaches that target key oncogenic pathways. Conventional treatments, including chemotherapy and radiotherapy, exhibit significant limitations, including drug resistance, toxicity, and limited durability of response, highlighting the need for improved strategies. In recent years, Phytochemicals like curcumin, EGCG, and apigenin have demonstrated potent anticancer effects by modulating multiple dysregulated pathways in CC.

Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced Cardiotoxicity.

Doxorubicin (DOX) is an effective chemotherapy whose clinical utility is limited by cardiotoxicity. To investigate underlying mechanisms, we employed a multi-omics approach integrating transcriptomic and proteomic profiling leveraging established mouse models of chronic DOX- induced cardiotoxicity. Five-week-old male mice received weekly DOX (4 mg/kg) or saline injections for six weeks, with heart tissues harvested 4 days post-treatment.

Knowledge Attitude and Practices Regarding Surgical Safety Checklist: A Multicenter Study.

Background: Surgical safety checklists (SSCs) are vital tools for improving patient outcomes during surgical procedures. Despite their proven effectiveness, the adoption and implementation of SSCs vary across healthcare institutions, particularly in diverse settings like Bihar, India.

Materials And Methods: A cross-sectional study was conducted at Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar, involving 250 healthcare professionals, including surgeons, anesthesiologists, and nursing staff.

: An Adjunct in the Non-Surgical Management of Chronic Periodontitis.

Background: Periodontitis is a persistent inflammatory condition resulting in tooth loss. Mechanical treatment alone may inadequately eradicate microorganisms from pockets, necessitating the additional local injection of pharmaceuticals. Pomegranate has strong antibacterial, antiviral, antioxidant, anti-inflammatory, wound healing, and probiotic effects.

Anthropogenic dust pollution influences leaf and root morpho-anatomical traits by altering the metabolism and biochemical properties of indigenous vegetation.

The current investigation analyzed the impact of dust pollution from the stone crushing industry in the Kirana Hills of Sargodha on plant communities, with a focus on seasonal variations in plant metabolism, structure, and heavy metal accumulation at different study sites. The results revealed that heavy metal concentrations were notably higher at extreme dust sites, particularly during the winter season, indicating a significant impact of dust pollution on the environment. Soil analysis revealed distinct compositions across different sites and seasons, highlighting the variability in environmental conditions.

Solvent-mediated crystallization and defect passivation mechanisms in ambient-air MAPbI films: a combined experimental and simulation study.

Understanding solvent-induced crystallization and defect dynamics in hybrid perovskites is crucial for stable and high-efficiency solar cells. Here, we investigate the influence of DMF : DMSO solvent ratios on the nucleation, grain boundary passivation, and optoelectronic behaviors of MAPbI thin films prepared under ambient conditions. X-ray diffraction and photoluminescence analyses reveal that increasing DMSO content promotes PbI segregation, which passivates grain boundaries and modulates trap-assisted recombination.

Determination of heavy metals and morphoanatomical characteristics of the monocots Aristida mutabilis and Cenchrus ciliaris in the dust-contaminated stone crushing industry of Sargodha, Pakistan.

The current investigation analyzed the population dynamics of vegetation in the severely dust-polluted environment of the stone crushing industry in the Kirana Hills of Sargodha. Data pertaining to dust levels, soil composition, and vegetation characteristics were systematically collected from all the study sites throughout the year to explore the seasonal fluctuations in the plant community structure and the underlying determinants of these variations. Heavy metal analysis revealed increased concentrations of all heavy metals at the most heavily dust-polluted sites, particularly during the winter season.

Solitary waves, bifurcation, chaos, sensitivity, and multistability of electrical transmission line model.

This research explores the (2+1)-D nonlinear electrical transmission line equation (NLETLE), highlighting its unique localized wave solutions and the interactions that arise from them. Through the application of a novel multivariate generalized exponential differential function technique and generalized logistic equation approach, we have successfully generated a diverse array of new structures, particularly characterized by bright soliton, bright-singular soliton, kink soliton, and periodic waveforms. These solutions play a crucial role in demonstrating the complex structure and varied dynamics that are characteristic of nonlinear systems in higher dimensions.

High-performance p-type bilayer WSe field effect transistors by nitric oxide doping.

Two-dimensional (2D) materials are promising candidates for next-generation electronics, but the realization of high-performance p-type 2D field-effect transistors (FETs) has remained challenging, hindering the development of fully integrated 2D complementary metal-oxide-semiconductor (CMOS) technology. Here, we present p-type 2D FETs based on bilayer WSe synthesized via an industry-compatible metal-organic chemical vapor deposition (MOCVD) process. These devices achieve on-state current as high as 421 μA/μm at a drain voltage of 1 V and a gate overdrive voltage of 2.

Chemotherapy Response as a Predictor of Survival in Post-neoadjuvant Esophagectomy Specimens.

Background Esophageal carcinoma is one of the most common cancers worldwide, which is conventionally treated with neoadjuvant chemoradiation and surgery. Presurgical treatment impacts outcomes by various factors. Objective This study aims to evaluate the prognostic significance of chemotherapy response in esophagectomy specimens and its association with survival outcomes in a post-neoadjuvant setting.

Insight into NaSiCl: a lead-free perovskite for the next generation revealed by DFT and SCAPS-1D.

This study theoretically explores the potential of lead-free NaSiCl, a chloride-based perovskite, highlighting its potential as an efficient photovoltaic absorber. Using density functional theory (DFT) calculations WIEN2k and CASTEP, alongside SCAPS-1D simulations, we assess the material's suitability from both atomic and device perspectives. The results confirm that NaSiCl is structurally, thermodynamically, dynamically ( phonon dispersion), and mechanically stable.

A complementary two-dimensional material-based one instruction set computer.

Silicon has enabled advancements in semiconductor technology through miniaturization, but scaling challenges necessitate the exploration of new materials. Two-dimensional (2D) materials, with their atomic thickness and high carrier mobility, offer a promising alternative. Although significant progress has been made in wafer-scale growth, high-performance field-effect transistors and circuits based on 2D materials, achieving complementary metal-oxide-semiconductor (CMOS) integration remains a challenge.

Effect of Integrating Social and Behavior Change Communication Strategies in Nutrition-Sensitive Social-Protection Programs on Specific Nutritional Outcomes: A Systematic Review.

Context: Achieving adequate nutrition for vulnerable populations is central to the second Sustainable Development Goal. Nutrition-sensitive social-protection programs combined with social and behavior change communication (SBCC) interventions can support this goal, particularly in developing countries. However, systematic evidence on the impact of integrating SBCC strategies into these programs is limited, especially concerning anthropometric outcomes, dietary diversity, food consumption, and food security.

Multiclassification of Colorectal Polyps from Colonoscopy Images Using AI for Early Diagnosis.

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, emphasizing the critical need for the accurate classification of precancerous polyps. This research presents an extensive analysis of the multiclassification framework leveraging various deep learning (DL) architectures for the automated classification of colorectal polyps from colonoscopy images. The proposed methodology integrates real-time data for training and utilizes a publicly available dataset for testing, ensuring generalizability.

Enabling static random-access memory cell scaling with monolithic 3D integration of 2D field-effect transistors.

Static Random-Access Memory (SRAM) cells are fundamental in computer architecture, serving crucial roles in cache memory, buffers, and registers due to their high-speed performance and low power consumption. However, scaling SRAM cells to advanced technology nodes poses significant challenges. Three-dimensional (3D) integration offers a promising solution for reinstating SRAM scaling by vertically stacking devices, thereby reducing the physical footprint.

Active Learning Strategies for Improving Dental Students' Skills in Preclinical Restorative Dentistry.

Practical assessment in dental education is crucial for developing clinical competencies. This study investigated the effectiveness of action research (AR) and active learning strategies in improving student achievement in a preclinical restorative dentistry course among 58 third-year dental students.The intervention focused on teaching composite cavity preparation techniques through student engagement and participation.

Clinical significance of FOXN3 expression in Indian breast cancer patients.

Globally, breast cancer is the most common cancer to affect women. There are different molecular and pathological factors that are involved in the uncontrolled proliferation of breast cancer cells. FOXN3 that is member of Forkhead box family proteins is well recognized for having a crucial role in different biological processes and is reported to be dysregulated in various malignancies.

Correction: Solution of time-fractional gas dynamics equation using Elzaki decomposition method with Caputo-Fabrizio fractional derivative.

[This corrects the article DOI: 10.1371/journal.pone.

Multiple Pendants-Bearing Triglucosides for Membrane Protein Studies: Effects of Pendant Length and Number on Micelle Interior Hydration and Protein Stability.

Membrane proteins play central roles in cell physiology and are the targets of over 50% of FDA-approved drugs. In the present study, we prepared single alkyl-chained triglucosides decorated with multiple pendants, designated multiple pendant-bearing glucosides (MPGs), to enhance membrane protein stability. The new detergents feature two and four pendants of varying size at the hydrophilic-lipophilic interfaces, designated MPG-Ds and MPG-Ts, respectively.