199 results match your criteria: "a Red Sox Foundation and Massachusetts General Hospital Program[Affiliation]"

Individuals who experience intimate partner violence (IPV) sometimes self-report balance and vestibular problems; however, objectively measured balance has rarely been investigated in this population. Given the risk for persistent physical, neurocognitive, and psychological effects of brain injury (BI) in women who experience IPV, the present study evaluated the association between mild IPV-BIs, objective balance, and self-reported vestibular symptoms in women with at least one instance of physical IPV ( = 144). IPV-BIs and accident-related BIs were assessed using the Ohio State University traumatic BI (TBI) identification method and the Brain Injury Severity Assessment Interview.

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: There are no validated clinical diagnostic criteria for chronic traumatic encephalopathy or traumatic encephalopathy syndrome (TES). To understand the historical clinical condition, its applicability to modern day athletes, and the pathogenesis of clinical problems, we examined the literature describing boxers from the 20th century, with specific attention paid to neurological findings and characteristics of clinical disease progression. : Data were extracted for 243 boxers included in 45 articles published between 1928 and 1999, including cases from articles originally published in German.

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New Diagnostic Criteria for Mild Traumatic Brain Injury: Medical-Legal Considerations.

Arch Phys Med Rehabil

July 2025

Department of Psychology, University of British Columbia, Vancouver, Canada; Rehabilitation Research Program, Centre for Aging SMART at Vancouver Coastal Health, Vancouver, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.

The new American Congress of Rehabilitation Medicine diagnostic criteria for mild traumatic brain injury (mTBI) were published in 2023. The criteria are designed to be used across clinical settings. This article discusses some medical-legal issues and implications relating to the use of the new ACRM diagnostic criteria.

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Objective: First, to describe a clinical sample with persisting post-concussion symptoms after a mild injury to the head. Second, to explore whether patients who sustained a mild traumatic brain injury differed from those with a minimal head injury (no loss of consciousness, no post-traumatic amnesia, no neuroimaging findings).

Design: Cross-sectional clinic-referred sample.

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BackgroundResearchers have reported that hyperphosphorylated tau (p-tau) accumulates in the Cornu Ammonis 2 subfield (CA2) of the hippocampus with age, preferentially in primary age-related tau astrogliopathy, in association with early Alzheimer's disease, and preferentially in chronic traumatic encephalopathy neuropathologic change.ObjectiveExamine the possible association between preferential p-tau in the CA2 region of the hippocampus and history of playing high school American-style football.MethodsPostmortem brain tissue samples were obtained from the Lieber Institute for Brain Development for 174 men (median age at death = 65 years; range = 50-96).

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Background And Objectives: Increased mortality in the acute phase after traumatic brain injury (TBI) is well established, and there is good evidence suggesting increased long-term mortality as well. Although the reasons for increased acute phase mortality are mostly intuitive, factors associated with long-term mortality are not well understood. The objective of this study was to compare survival and causes of deaths among patients with head injuries and matched population controls.

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Background Special operations forces members often face multiple blast injuries and have a higher risk of traumatic brain injury. However, the relationship between neuroimaging markers, the cumulative severity of injury, and long-term symptoms has not previously been well-established in the literature. Purpose To determine the relationship between the frequency of blast injuries, persistent clinical symptoms, and related cortical volumetric and functional connectivity (FC) changes observed at brain MRI in special operations forces members.

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Objectives: To evaluate if the tackler correctly adhering, or not, to four different instructions of legal front-on one-on-one torso tackles altered the tackler and/or ball carrier peak inertial head kinematics.

Design: Controlled laboratory study.

Methods: Fifteen rugby-code players measured with three-dimensional optoelectronic motion capture performed two tackle instructions from the Australian National Rugby League coaching manual on under (Dominant National Rugby League) and over (Smother National Rugby League) the ball tackles, and two novel variants of these (under, Dominant, Torso Stick; over, Smother, Pop, Lock).

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Pediatric Brain Injuries Are Associated With Intimate Partner Violence-Related Brain Injuries Among Women in Adulthood.

J Head Trauma Rehabil

July 2025

Author Affiliations: Harvard Medical School, Boston, MA (Ms Macaranas); Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Mss Macaranas, Tanriverdi, and Joseph, and Dr Valera); Harvard College, Cambridge, MA (Ms Tanriverdi); Department of Psychology, Suffolk University, Boston, M

Objective: Prior studies have reported associations between childhood physical abuse and intimate partner violence (IPV). However, there has been limited literature examining the relationship between pediatric brain injuries and IPV-related brain injuries later in life. We examined the association between childhood brain injuries and brain injuries sustained from IPV in adulthood.

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Article Synopsis
  • Concussions are common among young adults and can lead to persistent symptoms complicated by anxiety, which may affect recovery; a new program called TOR-C is designed to address both issues to improve outcomes after concussion.
  • The study involved five young adults participating in four weekly video sessions with a clinician, focusing on various psychological factors and measuring symptoms and feelings before, after, and three months later.
  • Results showed high feasibility and satisfaction, with strong adherence rates to the treatment and homework; most participants found the program credible and beneficial, indicating its potential for helping with concussion recovery.
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Feasibility Randomized Controlled Trial of the Toolkit for Optimal Recovery After Concussion: A Live Video Program to Prevent Persistent Concussion Symptoms in Young Adults With Anxiety.

Arch Phys Med Rehabil

April 2025

Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Department of Psychiatry, Boston, Massachusetts.

Article Synopsis
  • The study aimed to evaluate the Toolkit for Optimal Recovery after Concussion (TOR-C) and its effectiveness in preventing continuous concussion symptoms in young adults with anxiety compared to an active control group (HE-C).
  • A total of 50 participants aged 18-35, who had suffered a concussion within the last 3-10 weeks and displayed anxiety, engaged in four 45-minute Zoom sessions focused on different interventions.
  • Results showed that both intervention groups met feasibility benchmarks and experienced notable improvements in various outcomes like concussion symptoms and anxiety levels, with the TOR-C group specifically showing greater progress in certain areas like mindfulness and all-or-nothing behavior.
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Cognition and Ventral Attention Network Connectivity: Associations With Treatment Response in Posttraumatic Stress Disorder.

J Neuropsychiatry Clin Neurosci

April 2025

Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass. (all authors); Home Base Program, A Red Sox Foundation and Massachusetts General Hospital Program, Boston (Sorg, Tanev).

Objective: Posttraumatic stress disorder (PTSD) is a highly heterogeneous disorder, which makes it difficult to link clinical phenotypes with biomarkers to improve treatment outcomes. Findings from previous studies suggest that cognitive measures such as verbal memory or attention paired with within-ventral attention network (VAN) or salience network resting-state functional connectivity may predict treatment response among individuals with PTSD.

Methods: In a sample comprising 20 individuals with PTSD and 10 healthy control group individuals, the investigators subtyped individuals by using both discriminant function analysis and standardized norms for a single measure of memory and neuropsychological batteries of memory, attention, and executive functioning; attempted to replicate previous findings of lower within-VAN connectivity among individuals with cognitive impairment; and explored whether within-VAN connectivity paired with cognitive impairment predicted treatment outcomes.

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Fear avoidance behaviour is associated with slow recovery from mild traumatic brain injury (mTBI). This study is a preliminary evaluation of graded exposure therapy (GET), which directly targets fear avoidance behaviour, for reducing post-concussion symptoms (PCS) and disability following mTBI. In a historical comparison design, we compared two groups from independent randomized trials.

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The purpose of this study was to develop and validate an algorithm for identifying Veterans with a history of traumatic brain injury (TBI) in the Veterans Affairs (VA) electronic health record using VA Million Veteran Program (MVP) data. Manual chart review ( = 200) was first used to establish 'gold standard' diagnosis labels for TBI ('Yes TBI' vs. 'No TBI').

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APOE×BDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study.

J Neuropsychiatry Clin Neurosci

October 2024

Research and Psychology Services (Ton Loy, Adler, Merritt, Bondi, Delano-Wood) and Center of Excellence for Stress and Mental Health (Merritt, Delano-Wood), Veterans Affairs (VA) San Diego Healthcare System, San Diego; Department of Psychiatry, School of Medicine, University of California, San Diego

Objective: The authors examined the interaction between apolipoprotein E (APOE) ε4 and brain-derived neurotrophic factor (BDNF) Val66Met alleles on neuropsychological functioning among veterans with histories of mild traumatic brain injury (mTBI).

Methods: Participants were 78 veterans with mTBI (85% males; mean±SD age=32.95±7.

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Strategies for Cutting Down and Stopping Alcohol Use.

Prim Care Companion CNS Disord

May 2024

Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss the diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.

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There are no validated diagnostic criteria for traumatic encephalopathy syndrome (TES). During the early and middle 20th century, TES was described as a clinical condition that was experienced by some high-exposure boxers-and it was believed to reflect chronic traumatic brain injury. Consensus criteria for the diagnosis of TES were published in 2021.

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Chronic traumatic encephalopathy neuropathologic change in former Australian rugby players.

Neuropathol Appl Neurobiol

April 2024

Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.

Aims: We applied the 2021 consensus criteria for both chronic traumatic encephalopathy neuropathological change and traumatic encephalopathy syndrome in a small case series of six former elite-level Australian rugby code players.

Methods: Neuropathological assessment of these cases was carried out at the Sydney and Victorian Brain Banks. Clinical data were collected via clinical interviews and health questionnaires completed by the participants and/or their next of kin, and neuropsychological testing was conducted with participants who were capable of completing this testing.

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Objective: Researchers and practitioners can detect cognitive improvement or decline within a single examinee by applying a reliable change methodology. This study examined reliable change through test-retest data from the English-language National Institutes of Health Toolbox Cognition Battery (NIHTB-CB) normative sample.

Method: Participants included adults (n = 138; age: M ± SD = 54.

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Treatment of chronic symptoms following mild traumatic brain injury with transcranial LED: a sham run-in pilot study of photobiomodulation therapy.

Brain Inj

May 2024

Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Schoen Adams Research Institute at Spaulding Rehabilitation, Massachusetts General Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

Primary Objective: We evaluated whether photobiomodulation with red/near infrared light applied transcranially via light emitting diodes (LED) was associated with reduced symptoms and improved cognitive functioning in patients with chronic symptoms following mild traumatic brain injury.

Research Design: Participants (3 men, 6 women; 22-61 years-old) underwent a 6-week intervention involving 18 40-minute transcranial LED treatment sessions.

Methods And Procedures: Reliable change indices were calculated for 10 neuropsychological test scores and 3 self-report questionnaires of subjective cognition, post-concussion symptoms, and depression at baseline and following treatment.

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Glial fibrillary acidic protein (GFAP) has become the most promising biomarker for detecting traumatic abnormalities on head computed tomography (CT) in patients with traumatic brain injury (TBI), but most studies have not addressed the potential added value of combining the biomarker with clinical variables that confer risk for intracranial injuries. The Scandinavian Guidelines for Initial Management of Minimal, Mild, and Moderate Head Injuries in Adults were the first clinical decision rules in the field with an incorporated biomarker, the S100 astroglial calcium-binding protein B (S100B), which is used in the Mild (Low Risk) group defined by the guidelines. Our aim was to evaluate the performance of the guidelines when S100B was substituted with GFAP.

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Article Synopsis
  • The study involved 507 older adults to analyze the relationship between repetitive head impacts from contact sports and TES symptoms, finding that only about 26% of participants showed signs of TES.
  • Current mental health issues like depression or anxiety, as well as a history of psychiatric disorders, were strongly associated with TES symptoms, while prior contact sport exposure didn't significantly impact the likelihood of meeting TES criteria.
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Article Synopsis
  • - The study investigates how age and sex affect myelin content in the brain's limbic pathways in older adults without dementia, particularly focusing on white matter integrity related to Alzheimer's disease.
  • - Using MRI and neuropsychological testing, researchers found that myelin water fraction (MWF) decreased with age in women but not in men, particularly in specific brain regions like the fornix and cingulate cingulum.
  • - The findings highlight the importance of considering sex differences in age-related myelin decline, which could aid in identifying Alzheimer's disease risk, especially among women.
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Litigation, Performance Validity Testing, and Treatment Outcomes in Adults With Mild Traumatic Brain Injury.

J Head Trauma Rehabil

May 2024

Departments of Psychology (Drs Mikolic and Silverberg) and Psychiatry (Dr Panenka), The University of British Columbia, Vancouver, British Columbia, Canada; Rehabilitation Research Program, Centre for Aging SMART at Vancouver Coastal Health, Vancouver, British Columbia, Canada (Drs Mikolic and Silve

Objective: To investigate whether involvement in litigation and performance validity test (PVT) failure predict adherence to treatment and treatment outcomes in adults with persistent symptoms after mild traumatic brain injury (mTBI).

Setting: Outpatient concussion clinics in British Columbia, Canada. Participants were assessed at intake (average 12.

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