Gold Nanoparticle-mRNA Conjugates Encapsulated in Lipid Nanoparticles for Coordinated Codelivery of Multiple mRNAs.

Gold nanoparticles (AuNPs) can be engineered to be utilized as carriers via anchoring multiple nucleic acids, including mRNAs, in specific ratios. However, the negative charge of mRNA-AuNP conjugates presents significant challenges for efficient cellular uptake and subsequent expression. To overcome this limitation, we developed a delivery system that combines mRNA-AuNP conjugation with lipid nanoparticles (LNPs) to enhance intracellular delivery.

Asbestos exposure assessment for ceiling tile removal using glove bags in small indoor facilities.

This study aimed to evaluate the safety of small-scale asbestos dismantling and removal work, especially ceiling tile removal using glove bags (GBs), and to investigate the potential for asbestos dispersion in GBs during ceiling material removal to propose safe work practices and related regulations. Asbestos exposure assessment was conducted at five asbestos-containing ceiling tile dismantling sites nationwide. Air sampling was performed during ceiling tile removal at four points per site: near workers' respiratory tract, at the GB fixed boundary, inside the GB, and within the general work area.

Optimizing physical education strategies through circular intuitionistic Fuzzy Bonferroni based school policy formulation.

Strategic school policy formulation is critical in guaranteeing the balanced growth of education systems that facilitate both academic and extracurricular objectives. Physical education makes a considerable contribution towards this vision through the promotion of lifelong healthy living, physical well-being, and general student development. This research proposes a new decision-making model using Circular Intuitionistic Fuzzy Bonferroni Mean (CIFBM) operators, which combine Aczel-Alsina triangular norms and Bonferroni aggregation rules to handle uncertainty in policy assessment.

The Socio-Ecological Factors of Physical Activity Participation in Preschool-Aged Children with Disabilities.

Background: To effectively promote physical activity (PA) participation in preschool-aged children with disabilities (PACD), a comprehensive understanding of the associated factors is necessary. Consequently, this study aims to examine the factors influencing PA participation in PACD using the socio-ecological model.

Methods: The Disability Status Survey 2020 in South Korea has been used for the current study.

AMPK Knockout Impairs the Formation of Three-Dimensional Spheroids.

AMP-activated protein kinase (AMPK) is an important regulator of cellular energy homeostasis, and AMPK contributes to cell growth, apoptosis, and autophagy. Although most cell studies have been performed using two-dimensional (2D) cell culture, recent studies have demonstrated that the three-dimensional (3D) spheroid technique is helpful in various cell research fields, such as tumor biology, due to its resemblance to the 3D tissue structure. However, the role of AMPK in 3D spheroid formation has not been characterized clearly.

Assessing parental stress and self-efficacy: A multisite feasibility study of parent-mediated physical activity interventions for children with developmental disabilities.

Background: Children with developmental disabilities often face barriers to engaging in physical activity (PA), impacting their health and quality of life. Parent-mediated interventions (PMIs) have shown promise to reduce these barriers, but little research explores online PMIs for parents of children with developmental disabilities. Thus, the purpose of this study was to assess the feasibility and impact of a multi-site collaborative online parent-mediated PA intervention on stress levels and self-efficacy among parents of children with developmental disabilities over a 12-week period.

Translationally Controlled Tumor Protein Enhances Angiogenesis in Ovarian Tumors by Activating Vascular Endothelial Growth Factor Receptor 2 Signaling.

Translationally controlled tumor protein (TCTP) is a regulatory protein that plays pivotal roles in cellular processes including the cell cycle, apoptosis, microtubule stabilization, embryo development, stress responses, and cancer. However, the molecular mechanism by which it promotes tumor angiogenesis is still unclear. In this study, we explored the mechanisms underlying stimulation of angiogenesis by a novel TCTP.

Psychological factors of parental physical activity support among parents of children with disabilities: a meta-analysis.

Purpose: Parents of children with disabilities often encounter challenges when supporting their child's physical activity (PA). Research on the psychological factors influencing parental support for PA has produced mixed results. The purpose of this meta-analysis was to a) synthesize psychological factors associated with parental support for PA, and b) evaluate the moderators of the association between parental support for PA and these psychological factors.

Physiology of Cellular Prion Proteins in Reproduction.

Cellular prion protein (PrP) encoded at gene is well-known to form a misfolded isoform, termed scrapie PrP (PrP) that cause transmissible degenerative diseases in central nervous system. The physiological role of PrP has been proposed by many studies, showing that PrP interacts with various intracellular, membrane, and extracellular molecules including mitochondrial inner membrane as a scaffold. PrP is expressed in most cell types including reproductive organs.

Arctigenin from Fruit Inhibits the Replication of Human Coronavirus.

Coronavirus can cause various diseases, from mild symptoms to the recent severe COVID-19. The coronavirus RNA genome is frequently mutated due to its RNA nature, resulting in many pathogenic and drug-resistant variants. Therefore, many medicines should be prepared to respond to the various coronavirus variants.

Effects of robot-assisted walking training on balance, motor function, and ADL depending on severity levels in stroke patients.

Background: Despite the explosive increase in interest regarding Robot-Assisted Walking Training (RAWT) for stroke patients, very few studies have divided groups according to the severity levels of patients and conducted studies on the effects of RAWT.

Objective: The purpose of this study was to present a definite basis for physical therapy using the robot-assisted walking device through a more detailed comparison and analysis and to select the optimal target of RAWT.

Methods: This study was designed as a prospective and randomized controlled trial to investigate the effect of RAWT on balance, motor function, and Activities of Daily Living (ADL) depending on severity levels in stroke patients.

Home-Based Balance Training on Balance and Mobility in Persons With Multiple Sclerosis: A Systematic Review and Meta-analysis.

Objectives: To (1) examine the effects of home-based balance training on balance and mobility outcomes; (2) evaluate comparable effects between home- and center-based balance training; (3) determine the effects of different levels of supervision on treatment effects; and (4) investigate dose-response relationships of home-based balance training on balance and mobility performance in persons with multiple sclerosis (MS).

Data Sources: Literature searches were conducted in MEDLINE, EMBASE, PsycINFO, SPORTSDiscus, and CINAHL in April 2023. Other literature sources included website and citation searches.

The Effect of a Table Tennis Exercise Program With a Task-Oriented Approach on Visual Perception and Motor Performance of Adolescents With Developmental Coordination Disorder.

In this study we investigated the effects of an 8-week table tennis exercise program with a task-oriented approach on visual perception and motor performance of 31 adolescents with developmental coordination disorder (DCD). The participants were identified by their teachers as having greater difficulty than their peers (450 students from three Korean middle schools) in physical education (PE) classes. On the Bruininks-Oseretsky Test of Motor Proficiency-2, these adolescents scored below the 15th percentile and showed difficulties in performing daily life activities due to motor performance problems; they did not have physical defects, intellectual or neurological impairments, or Attention Deficit Hyperactivity Disorder.

Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells.

Previously, we reported that epidermal growth factor-like module-containing mucin-like hormone receptor-like 1 (EMR1/ADGRE1) is abnormally expressed in colon cancer (CC) and is a risk factor for lymph node metastasis (LNM) and poor recurrence-free survival in patients with abundant tumor-associated macrophages (TAMs). However, the signaling pathways associated with EMR1 expression in CC progression remain unclear. In this study, we aimed to explore the role of EMR1 and its signaling interactions with macrophages in CC progression.

Effects of Neuromuscular Electrical Stimulation with Gastrocnemius Strengthening on Foot Morphology in Stroke Patients: A Randomized Controlled Trial.

This study aimed to investigate the effects of neuromuscular electrical stimulation (NMES) with gastrocnemius (GCM) strength exercise on foot morphology in patients with stroke. Herein, 31 patients with chronic stroke meeting the study criteria were enrolled and divided into two groups; 16 patients were randomized to the gastrocnemius neuromuscular electrical stimulation (GCMNMES) group, and 15 patients to the conventional neuromuscular electrical stimulation (CNMES) group. The GCMNMES group conducted GCM-strengthening exercise with NMES.

Compound C inhibits the replication of feline coronavirus.

Feline Coronavirus (FCoV) is a viral pathogen of cats and a highly contagious virus. Cats in a cattery can be infected by up to 100%, and even household cats are infected by 20-60%. Some strains of FCoV are known to induce a fatal disease in cats named Feline Infectious Peritonitis (FIP).

Effects of Basic Psychological Needs on Physical Self-Efficacy and Attitudes toward PE in Korean Middle-School Physical Education.

This study explored the effect of basic psychological needs in secondary physical education (PE) classes in South Korea on physical self-efficacy and attitudes toward PE. Data from 296 middle-school students were collected from May to June 2022 in Seoul or Gyeonggi-do. Participants were surveyed via simple random sampling.

AMPK inhibitor, compound C, inhibits coronavirus replication in vitro.

The coronavirus disease (COVID-19) pandemic has resulted in more than six million deaths by October 2022. Vaccines and antivirals for severe acute respiratory syndrome coronavirus 2 are now available; however, more effective antiviral drugs are required for effective treatment. Here, we report that a potent AMP-activated protein kinase (AMPK) inhibitor, compound C/dorsomorphin, inhibits the replication of the human coronavirus OC43 strain (HCoV-OC43).

A randomized parent-mediated physical activity intervention for autistic children.

The purpose of this study was to examine the immediate and post effects of a parent-mediated physical activity intervention on the fundamental motor skills of autistic children. We randomly assigned parent-child dyads (n = 31) of autistic children aged 4-11 years into three groups (workshop, an online, or control group). Each dyad participated in a 12-week intervention and was given adapted physical activity equipment and over 200 activities via a mobile application.

Understanding parental physical activity behaviours in parents of children with disabilities: An expanded theory of planned behaviour approach.

Background: The purpose of the current study was to examine association between physical activity (PA) of parents of children with developmental disabilities and theory of planned behaviour-related variables.

Methods: A total of 95 participants completed questionnaires that measured the following variables: PA behaviours, action planning, intention, affective attitude, instrumental attitude. A path analysis was used to examine the associations between the variables.

Effects of Physical Education Playfulness on Academic Grit and Attitude toward Physical Education in Middle School Students in The Republic of Korea.

The purpose of this study was to explore the effect of playability in secondary physical education classes in Korea on academic grit and attitudes toward physical education. A total of 296 middle school students located in Seoul and Gyeonggi-do, Korea were surveyed via simple random sampling. Data were analyzed via descriptive statistical analysis, confirmatory factor analysis, reliability analysis, correlation analysis, and standard multiple regression analysis.

Association of walking pace and fall-related injury among Chinese older adults: Data from the SAGE survey.

Objective: Falls are an important public health issue that poses a threat to the health of senior people and reduces their ability to maintain independence, which in turn reduces poor quality of life. Several studies have demonstrated a positive relationship between physical function and fall, it remains unclear whether there is an association between gait speed and fall-related injuries among the aging population, which represent the largest proportion of older adults in China. Therefore, the aim of this study was to examine the association between gait speed and fall-related injuries among older Chinese adults.

HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer.

The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates tumour development by inactivating pRb. However, this alone cannot explain the various characteristics acquired by HPV infection.