Noninvasive multiclass milk contaminants detection using hyperspectral imaging and hybrid ensemble learning.

Food contamination remains a serious global concern due to its health risks, with milk being one of the most commonly adulterated foods in developing countries such as Pakistan, India, and Bangladesh. Accurate detection of milk contamination is essential for ensuring consumer safety and maintaining food industry standards. This study explores both invasive and noninvasive approaches for contamination analysis.

In silico identification of peptidomimetic inhibitors targeting PXR and RXR interaction to overcome the inactivation of vitamin D in asthma.

Asthma is a chronic inflammatory disorder of the airways. Standard treatments, such as inhaled corticosteroids like fluticasone, beclomethasone, and budesonide, are effective in managing asthma symptoms by reducing inflammation through immune suppression. However, prolonged corticosteroid therapy can impair vitamin D metabolism, exacerbating vitamin D deficiency, which is essential for immune regulation and anti-inflammatory responses via the vitamin D receptor (VDR).

River transport of Hg as a potential contamination pathway for sediments, soils and vegetation: management practices.

River systems, besides shaping their landscapes through the formation of Fluvisols, can also act as pathways for transporting significant pollutants, affecting both the river and its surrounding areas. One such pollutant is mercury (Hg). To assess the impact on sediments and adjacent riverbanks, including Fluvisols and their vegetation, the alluvial plains near Poland's most important river have been studied to understand this process and propose effective management measures.

Drenched Pages: A Primer on Wet Books.

Molds readily grow on wet books, documents, and other library materials where they ruin them chemically, mechanically, and aesthetically. Poor maintenance of libraries, failures of Heating, Ventilation, and Air Conditioning (HVAC) systems, roof leaks, and storm damage leading to flooding can all result in accelerated fungal growth. Moreover, when fungal spores are present at high concentrations in the air, they can be linked to severe respiratory conditions and possibly to other adverse health effects in humans.

Is Deceleration the Key Element in Vertical Jump Performance to Return to Sport After Anterior Cruciate Ligament Reconstruction With Hamstring Graft? A Preliminary Study.

Background/purpose: Anterior cruciate ligament reconstruction (ACLR) often leads to persistent neuromuscular deficits, complicating return-to-sport decisions. Reliable functional assessments are needed to guide RTS after ACLR. The main objective was to examine countermovement jump (CMJ) measures to identify which parameters can best distinguish between ACLR and control participants.

Kinetics and seroprevalence of anti-SARS-CoV-2 antibodies in vaccinated and unvaccinated health workers in Bamako, Mali, November 2021-February 2023.

Background: This prospective study aimed to evaluate the dynamics and seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of vaccinated and unvaccinated health workers (HWs) in Bamako, Mali. The study also measured antibody responses as a function of SARS-CoV-2 infections, socio-demography, vaccination status and associated comorbidities.

Method: 685 vaccinated and 413 unvaccinated HWs (total = 1098) were monitored over a 15-month periods with follow-up visits every 3 months for the first 6 months and a final visit after 15 months.

Innovative advanced processes for treatment of multiple emerging pesticides from water: Performance, statistical design, QuEChERS-GC-MS/MS sensitive identification and degradation mechanism.

The objective of this study is the degradation of a mixture of three pesticides from three distinct families: Metalaxyl (fungicide), Metolachlor (herbicide), and Diazinon (organophosphate Insecticide). In this work, the enhanced advanced oxidation process known as "Photo-Fenton" was first optimized, and the mineralization step was determined. The experimental design and response surface "three-parameter Doehlert design" were employed as the experimental methodology to modeling and optimizing the experimental parameters.

Advancements in nasopharyngeal carcinoma radiotherapy: Dosimetric evaluation of arc therapy with hippocampal sparing.

Background: Nasopharyngeal carcinoma (NPC) is located near critical structures like the hippocampus, essential for memory and cognitive function. While Volumetric Modulated Arc Therapy (VMAT) has improved dose conformity in NPC treatment, the integration of hippocampal-sparing (HS) approaches remains underexplored. This study evaluates the dosimetric feasibility and effectiveness of hippocampal-sparing VMAT (HS-VMAT) in NPC, focusing on reducing radiation exposure to the hippocampus while maintaining target volume coverage.

The electronic structure, optical, and thermoelectric properties of novel BiPbCh (Ch = Se, Te) materials: insights from first-principles study.

Ternary chalcogenides have attracted much interest because of their potential for use in sustainable energy applications due to their tunable electronic, optical, and transport characteristics. This work examined the structural, electronic, optoelectronic, and thermoelectric properties of novel BiPbSe and BiPbTe chalcogenides through density functional theory. The predicted energy gap values measured with the TB-mBJ and PBE-GGA are 1.

Exploring protein inhibitors of through pharmacoinformatic approaches incorporating solubility-enhancing formulation insights.

the causative agent of Whipple disease, presents a diagnostic challenge due to its diverse symptomatology, including weight loss, abdominal pain, diarrhea, joint pain, fever, and occasionally neurological manifestations. Its resistance to fluoroquinolones complicates treatment further. Traditional methods for antibiotic susceptibility testing are ineffective as cannot be cultured in axenic media.

Computational study of deleterious missense SNPs in the gene implicated in Usher syndrome.

Usher syndrome is an inherited condition that causes hearing and visual impairments, along with vestibular dysfunction, due to mutations in various genes, including , which codes for the scaffold protein SANS, essential for proper sensory function. This study employed a computational approach in order to analyze the potential impact of missense SNPs in . We started by curating and filtering SNPs from the Ensembl database, followed by a variety of computational prediction methods, such as SIFT, PolyPhen-2, MetaLR, BayesDel_addAF, and MutationTaster, to identify the pathogenic impact of the nsSNPs.

Protein networks: integrating pathways for plant heat stress adaptation.

Plants' immobility renders them highly vulnerable to heat stress, which disrupts water relations, photosynthesis, respiration, and cellular homeostasis, ultimately reducing growth and yield. To survive, plants deploy a multifaceted heat stress response (HSR) that integrates calcium signaling, molecular chaperones, antioxidant enzymes, and phytohormonal networks. This review synthesizes recent advances in understanding the molecular crosstalk between phytohormones and protein synthesis during plant heat stress responses, with a particular focus on two key HSR modules: protein synthesis pathways, especially heat shock proteins (HSPs), and phytohormone signaling networks involving abscisic acid, cytokinins, ethylene, salicylic acid, and jasmonic acid.

Unsupervised machine learning solutions for electroosmotically driven Casson hybrid nanofluid flow using sigmoid and Fibonacci neural networks: a biomedical approach.

This work investigates the electroosmotic peristaltic transport of a Casson (blood)-based hybrid nanofluid via an asymmetric channel embedded inside a porous medium. The model takes into consideration electric and magnetic field effects, Ohmic heating, as well as velocity and thermal slip conditions. The governing equations are simplified and solved by employing unsupervised sigmoid-based neural networks (SNNs), Fibonacci-based neural networks (FNNs), and their hybrid model (FSNNs) under the assumptions of low Reynolds number and long wavelength.

Environmentally relevant levels of sulfamethoxazole (SMX) alter the skin and gastrointestinal microbiome of adult male and female zebrafish (Danio rerio).

This study determined the effects of sulfamethoxazole (SMX) exposure on the gastrointestinal and skin microbiome of male and female adult zebrafish (Danio rerio). Adult male and female zebrafish were exposed to measured, environmentally relevant concentrations of 0, 0.75, and 304.

Paediatric digestive endoscopy: From conventional endoscopy to endoscopic ultrasound and endoscopic retrograde cholangiopancreatography.

Digestive endoscopy is widely performed in clinical practice, including in children, and has revolutionized the diagnosis and treatment of many gastrointestinal (GI) disorders. Interventional procedures are increasingly utilized, particularly for hepatobiliary and pancreatic diseases. However, only a limited number of gastroenterologists are trained and experienced to perform endoscopic retrograde cholangiopancreatography and endoscopic ultrasound in pediatric patients.

B-vac a robust software package for bacterial vaccine design.

Reverse Vaccinology (RV) has revolutionized vaccine discovery, utilizing bioinformatics to surpass traditional methods in identifying genes and proteins. By analyzing pathogen genomic data, RV pinpoints proteins with key traits such as immunogenicity, surface localization, and conservation across strains. Despite its advantages, current RV tools face challenges like prediction accuracy, computational demands, and accessibility.

Protective Role of GABA in Aromatic Rice Under Lead and Cadmium Toxicity: Physiological and Biochemical Insights.

Lead (Pb) and cadmium (Cd) severely impair rice growth, yield, and grain quality. This study assessed the role of exogenous gamma-aminobutyric acid (GABA) in mitigating Pb and Cd toxicity in aromatic rice 'Guixiangzhan'. Treatments included the control (no Pb, Cd, or GABA), GABA (1 mM), Pb (800 mg/kg of soil)+GABA, Cd (75 mg/kg of soil)+GABA, Pb+Cd+GABA, Pb, Cd, and Pb+Cd without GABA.

Effectiveness of Feed-Based Monovalent Vaccine in Farmed Carp.

() is responsible for causing abdominal dropsy, swimming abnormalities, skin ulcerations, and pale gills in fish. Vaccination is an essential strategy for disease prevention in aquaculture. This study evaluated the efficacy of an oral vaccine against in ().

Cervico-Vaginal Microbiome Dynamics Across HPV-Driven Lesion Stages in Moroccan Women.

Cervical cancer (CC), often caused by persistent high-risk HPV infection, is a major health issue for Moroccan women. This study is the first in Morocco to examine how the cervico-vaginal microbiome differs across HPV-related clinical stages. Using 16S rRNA sequencing, the researchers analyzed samples from 247 women-100 healthy controls, 43 hr-HPV pre-cancer cases, and 104 post-treatment CC cases.

Advanced Cellulose Triacetate-Based Mixed Matrix Membranes Enhanced by Bimetallic Ni-Cu-BTC MOFs for CO/CH Separation.

Cu-BTC (HKUST-1) metal-organic framework (MOF) is widely recognized for its carbon capture capability due to its unsaturated copper sites, high surface area, and well-defined porous structure. This study developed mixed matrix membranes (MMMs) using cellulose triacetate (CTA), incorporating bimetallic Ni-Cu-BTC MOFs for CO/CH separation, and benchmarked them against membranes fabricated with monometallic Cu-BTC. CTA was selected for its biodegradability, membrane-forming properties, and cost-effectiveness.

Genotype Frequency of and Its Association with Paraclinical Characteristics and rs9263726 in Gout Patients.

: The allele is strongly linked to severe cutaneous adverse reactions (SCARs) during allopurinol treatment, and it has been associated with the A allele of rs9263726 (G>A). Paraclinical characteristics of gout are indicative of associated comorbid conditions. This study investigated the genotype frequency of and its association with paraclinical characteristics and rs9263726 in gout patients from Northeast Vietnam.

A Systematic Review of Preclinical Studies Investigating the Effects of Pharmacological Agents on Learning and Memory in Prolonged Aluminum-Exposure-Induced Neurotoxicity.

Aluminum accumulation in the brain causes cognitive deficits. No comprehensive synthesis of pharmacological treatments against aluminum neurotoxicity has been conducted, which led us to systematically review the effects of various pharmacological agents against aluminum-induced neurotoxicity, primarily addressing learning and memory after chronic aluminum exposure (≥2 months) in rodent models. A literature search was performed in PubMed, Google Scholar, Science Direct, and Scopus for studies published between 2000 and 2023.

A Narrative Review of Heavy Metals and Sperm Quality: The Interplay with Antioxidant Imbalance and Reactive Oxygen Species.

Reproductive infertility is characterized by the inability to achieve pregnancy after a year or more of unprotected sexual intercourse. This review highlights the significant impact of exposure to both types of heavy metals (essential and non-essential) on the reproductive performance of various species, particularly humans. Heavy metals present a high atomic density and weight, including lead, mercury, cadmium, nickel, chromium, and arsenic, and are delivered into the environment through natural and human activities, posing a threat to ecological systems and human reproductive health.

Unlocking iron: nutritional origins, metabolic pathways, and systemic significance.

Iron is a vital micronutrient, involved in numerous cellular functions including DNA synthesis, oxygen transport, energy generation, and immunity enhancement. It has unique redox properties that make it necessary for multiple metabolic reactions. However, the same property warrants its tight regulation as well.

Exercise parameters to consider for Achilles tendinopathy: a modified Delphi study with international experts.

To assess the level of agreement among experts on the heel raise exercise parameters that influence midportion and insertional Achilles tendinopathy (AT) rehabilitation outcomes.An international expert panel in AT rehabilitation was invited to complete a three-round Delphi survey. In the first two rounds, experts were asked to review a pregenerated list of exercise parameters (based on the heel raise exercise) and rate their perceived influence on rehabilitation outcome, using a 5-point Likert scale.