Indocyanine green fluorescence-guided imaging enhances the efficiency and accuracy of inferior mesenteric artery lymph node dissection in rectal cancer.

Background: Indocyanine green fluorescence-guided imaging (ICG-FGI) enhances surgical precision in rectal cancer procedures; however, it is technically demanding. This study evaluated the effects of ICG-FGI on the efficacy of lymphadenectomy during radical rectal cancer surgery.

Methods: This multi-center retrospective cohort study analyzed patients who underwent laparoscopic radical resection for rectal cancer between January 2021 and December 2024.

Development of a gold-nanorod-based lateral flow immunoassay for a fast and dual-modal detection of C-reactive protein in clinical plasma samples.

Fast and simple detection of C-reactive protein (CRP) is highly significant for the diagnosis and prognosis of inflammatory or infectious diseases. Lateral flow immunoassay has the advantages of rapid detection, simple operation and low cost, but it is usually limited by the quantitative ability and speed of data extraction. Herein, a gold-nanorod-based lateral flow immunoassay was developed to rapidly detect CRP by simultaneously monitoring the colorimetric and temperature signals.

Renal-clearable hyaluronic acid functionalized NaGdF nanodots with enhanced tumor accumulation.

Integration of high tumor-targeting capacity, controlling transport and low normal tissue retention into one engineered nanoparticle is a critical issue for future clinically translatable anti-cancer nanomedicines. Herein, hyaluronic acid functionalized 3.8 nm NaGdF nanodots (named NaGdF ND@HAs) have been prepared through conjugation of tryptone capped NaGdF nanodots (NaGdF ND@tryptone) with hyaluronic acid (HA, a naturally occurring glycosaminoglycan), which can recognize the overexpressed CD44 on cancer cell membranes.

Uncovering the Binding Specificities of Lectins with Cells for Precision Colorectal Cancer Diagnosis Based on Multimodal Imaging.

There is a high desire for novel targets/biomarkers to diagnose and treat colorectal cancer (CRC). Here, an approach starting from a polyacrylamide hydrogel-based lectin microarray is presented to screen the high expression of glycans on the CRC cell surface and to identify new lectin biomarkers for CRC. Three common CRC cell lines (SW480, SW620, and HCT116) and one normal colon cell line (NCM460) are profiled on the microarray with 27 lectins.