THE EFFECT OF SOFT ROBOTIC GLOVE ON THE FLEXION AND EXTENSION OF HAND FOR STROKE PATIENTS: A CLINICAL TRIAL.

Background: Stroke defined by diminished cerebral blood flow, results in brain damage and neurological impairments. It often leads to considerable difficulties, such as limited mobility and compromised hand function, usually manifesting as a weakening in the ability to open and shut the hand.

Objective: The study evaluates the differences between opening and closing hands when utilizing a soft robot.

ABO BLOOD GROUPS IN RELATION TO ANXIETY, STRESS AND DEPRESSION.

Introduction: People have been suffering from affective illnesses including anxiety, stress, and depression as a result of the lifestyle changes that have occurred in our cultures. Research indicates a connection between specific blood types and several medical or mental illnesses. Stress, anxiety, and depression are common events in life and are more noticeable among college students.

MECHANICAL PROPERTY CHANGES IN ORTHODONTIC WIRES AFTER EXPOSURE TO CHLORHEXIDINE MOUTHWASH: A REVIEW STUDY.

Orthodontic wires, especially nickel-titanium (NiTi) and stainless steel (SS), are widely used in clinical orthodontics due to their favorable mechanical properties. However, these materials are prone to degradation when exposed to chemical agents commonly used in oral hygiene, such as chlorhexidine (CHX). This review aims to assess the effects of chlorhexidine mouthwash exposure on the mechanical properties and corrosion resistance of different orthodontic wire types.

Unlocking the role of tRNA-derived fragments in shaping breast cancer signaling.

A new class of tiny non-coding RNAs (ncRNAs) known as tRNA-derived fragments (tRFs) is produced when mature tRNAs or tRNA precursors are cleaved. The discovery of more and more tRFs with essential roles in many physiological and pathological processes has been made possible by advancements in high-throughput sequencing. tRFs are considered important regulators of human disorders, particularly cancer, because they may control cell viability, differentiation, and homeostasis via various methods.

Harnessing IDO inhibitors to optimize cancer immunotherapy.

The tumor microenvironment (TME) is rich in immunosuppressive molecules that collectively hinder effective anti-tumor immune responses and promote tumor progression. Among the most prominent are transforming growth factor-beta (TGF-β), which suppresses T cell proliferation, promotes the differentiation of regulatory T cells, and remodels the extracellular matrix to exclude immune cells. Enzymes such as indoleamine 2,3-dioxygenase 1 and 2 (IDO1, IDO2) and tryptophan 2,3-dioxygenase (TDO) degrade tryptophan into kynurenine metabolites, leading to T cell anergy, apoptosis, and expansion of regulatory T cells through activation of the aryl hydrocarbon receptor.

Effect of Centrifugation of Stallion Semen Through a Low Density Colloid Prior to Freezing on Sperm Cryosurvival.

Sperm quality is adversely affected by cryopreservation due to the increased production of reactive oxygen species, which affects the integrity of sperm membranes, motility, and DNA fragmentation. Three methods for removing seminal plasma, washing (centrifuging extended semen at 800× for 10 min) and Single Layer Centrifugation with high or low density Equicoll, were used to prepare 29 ejaculates from ten stallions for freezing. Sperm quality parameters (kinematics, plasma membrane integrity, superoxide and hydrogen peroxide production, mitochondrial membrane potential, and DNA fragmentation) were evaluated before and after freezing using kinematic and flow cytometric analysis.

Finite element analysis of the transpalatal arch force systems activated in the Burstone geometries with different materials.

Aim Of The Study: This research paper was intended to quantify the stresses and the displacement distribution pattern released by Omega-loop transpalatal arch (TPA) activated in the Burstone geometries (II, III, and V) within two different materials.

Materials And Methods: Three-dimensional solid models of the maxilla and maxillary teeth were created using CBCT data for a 20-year-old man. A molar band and Omega-loop TPA were constructed.

Redefining knowledge-generation-driven blockchain for healthcare use: Insights from medical institutions.

This study explores the factors influencing healthcare professionals' willingness to adopt knowledge-generation-driven Blockchain technology (KGDBT) in government healthcare facilities, using the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) framework. It introduces transparency as an independent variable and examines the mediating role of knowledge generation in the relationship between transparency and healthcare professionals' intention to adopt KGDBT. Data were collected from 322 healthcare professionals in government hospitals and analyzed using SPSS version 26 and SmartPLS version 3.

Ferroptosis rewired: ncRNA gatekeepers as pharmacological targets in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) can alter cellular programs, such as iron homeostasis and antioxidant defenses, creating a pathway to ferroptosis, an iron-dependent mechanism of cellular death, as a viable therapeutic approach. Non-coding RNAs (ncRNAs), including both microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have recently been shown to be potent regulatory molecules involved in gene expression and cell fates, including apoptosis and inflammation. This review summarizes the current literature regarding ncRNAs' multiple and complex roles in mediating HCC ferroptosis.

Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms.

Aging is an inevitable, multifaceted biological process characterized by the progressive decline of physiological functions, ultimately leading to increased susceptibility to chronic diseases and mortality. A combination of genetic, lifestyle, and environmental factors, including dietary habits, exposure to pollutants, and ultraviolet radiation, influence this natural phenomenon. The consequences of aging manifest as various health complications, such as cardiovascular diseases, Type 2 diabetes, neurodegenerative disorders, malignancies, and visible signs like dermal dryness and wrinkles.

Anti-Müllerian hormone as a diagnostic and prognostic marker in polycystic ovary syndrome: a clinical study.

A study was conducted on anti-Müllerian hormone (AMH) and polycystic ovary syndrome (PCOS) in women. Samples were collected from 96 women with PCOS and 91 control women, aged 20 to 45 years for both groups. Levels of AMH, estrogen, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), LH/FSH ratio, endometrial growth rate (WHR), and body mass index (BMI) were measured.

Optimizing micropropagation and microcorm induction in saffron (Crocus sativus L.) using PGRs (NAA and BAP) and elicitor salicylic acid.

The objective of this study was to optimize in vitro tissue culture conditions for Crocus sativus L. (saffron) by evaluating various concentrations of NAA (naphthaleneacetic acid), BAP (benzylaminopurine), and SA (salicylic acid) on callus induction, shoot regeneration, rooting, and microcorm production. The highest callus induction rate (46.

Chicory () Leaves Extract: Phenolic Composition, Antibacterial Activity, and Antioxidant Capacity Assessment.

, a plant with a long history of medicinal use, was extracted using three solvents: hexane, ethanol, and ethyl acetate. The resulting extracts were subjected to chromatographic analysis, yielding five distinct fractions. Fractions I and II were obtained from the ethyl acetate extract, whereas Fractions III, IV, and V were derived from the ethanol extract.

Evaluating the mechanical performance and durability of cement mortars incorporating sesame shells as partial cement and sand replacement.

This study examines the mechanical and durability behaviors of cement mortar containing sesame shells (SS) as partial substitutes of cement and sand with regard to sustainable construction using an agricultural by-product. Three types of SS-raw powder, vinegar-treated powder and vinegar-thermal-treated powder (250 °C)-were used as the fine aggregate replacements at 1%, 2%, and 3% by weight. Mechanical performances (compressive strength, dry density) and durability (UPV, water absorption, water porosity, workability) of the composites were investigated in a systematic manner.

Analysis of ovarian morphometry and age-related T Lymphocyte localization in adult () dwarf hamsters.

Background: Dwarf hamsters are extensively used as models in reproductive disorders studies, reproductive endocrinology, embryo transplantation, and and egg fertilization.

Aim: This study aimed to explore the morphological and morphometric development of the ovary with T lymphocyte distribution at different ages using immunohistochemical cluster of differentiation 40 (CD40) expression.

Methods: Fifteen dwarf hamster () females were used in this study and divided into three groups at three different ages (2, 4, and 8 weeks) after birth.

Accuracy of Image-guided Tru-cut biopsy in the diagnosis of breast tumors.

Background: Histopathological examination is the gold standard for the diagnosis of breast cancer. This study aims to ascertain the extent to which image-guided Tru-cut biopsy is sensitive and accurate in the diagnosis of breast cancer cases in our locality.

Method: This prospective study included 115 patients who presented with one or more breast lumps and suspected to be neoplastic based on the clinical and radiological assessment.

A comprehensive review of immunotherapy in gastrointestinal tumors with a focus on the role of combination therapy with PARP inhibitors.

Defects in the DNA damage response (DDR) can cause genomic instability, leading to genetic mutations or abnormalities that promote cancer growth and progression. Gastrointestinal (GI) cancers are lagging behind other types of tumors in terms of customized therapy with targeted drugs. PARP inhibitors (PARPi) were the first approved cancer treatments to target the DNA damage response in BRCA1/2-mutated breast and ovarian malignancies.

Update on Application of Oncolytic Virus-Based Combination Therapy in the Treatment of Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the fourth leading cause of cancer-related mortality. Despite the development of several therapeutic strategies to treat HCC, the highly refractory nature of this disease limits therapeutic outcomes and patient survival. Oncolytic viruses (OVs) are a type of natural virus that can specifically infect and kill human tumor cells in HCC and have been extensively investigated as attractive live therapeutic agents for the treatment of HCC.

AWARENESS, USE AND EFFECTIVENESS OF EMERGENCY CONTRACEPTION.

Background: Emergency contraception (EC) is a method that is used to prevent pregnancy after unprotected sexual intercourse (UPSI), it can decrease the risk of unplanned pregnancy by up to 95% when given within 72 hours of UPSI; therefore may reduce the rates of unsafe abortion.

Objectives: The aim of this study is to assess awareness, use of emergency contraception among a sample of reproductive age in Iraqi women and effectiveness of this method in preventing unplanned pregnancy.

Methods: This study used an observational cross sectional design conducted in Iraq between January and August 2023, consist of (131) reproductive age Iraqi women, data is collected using an online structured self-administered questionnaire, Descriptive data were presented using tables and statistical analysis performed using Minitab version 23 statistic program.

CARNOSINE VARIATIONS IN MALES: THE ROLE OF BMI AND VITAMIN D STATUS.

Background: Carnosine is a crucial metabolite for maintaining normal health and function, particularly in the skeletal system, including muscles and bones. While its roles in pH buffering, antioxidant activity, and anti-inflammatory effects are well-documented, the relationship between carnosine levels, body mass index (BMI), and vitamin D status remains poorly understood, especially in healthy males. This study investigates variations in carnosine levels in healthy males, focusing on the potential influence of BMI and vitamin D status (25-hydroxyvitamin D [25(OH)D]), aiming to fill this gap and provide insights into the interplay between these metabolic factors.

Impact of genetically modified organisms on meat quality.

A unique class of gene biotechnology known as genetic modification modifies the genetic makeup of living things such as microbes, plants, and animals. Several possible advantages and hazards are associated with gene biotechnology. Due to increased food demands and improved food quality, interest in using gene technology to produce food has grown.

Isolation and molecular detection of from water samples in Mosul city.

Background: can be transferred via water- and food-borne routes, and it causes diseases; therefore, it is considered a major public health concern worldwide.

Aim: The objectives of this study were to detect in water using microscopic examination and molecular biology and to determine the relationship between in the current research and registered in GenBank based on the phylogenetic tree.

Methods: Sixty-five water samples (35 house tanks and 30 tap water) were collected from Mosul city's left and right sides between September 2023 and March 2024.

Beyond TRAIL resistance: Novel strategies for potentiating TRAIL-induced apoptosis in cancer.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic candidate because it induces apoptosis preferentially in malignant cells. However, intrinsic and acquired resistance mechanisms severely limit its clinical efficacy. This review highlights strategies to overcome TRAIL resistance, mainly using natural compounds, engineered mesenchymal stem cells (MSCs), and nanoparticle-based delivery systems.

Antimicrobial, Anti-Biofilm Activity and Antioxidants of Phenolic Compounds Isolated From on Periodontal Pathogenic Oral Bacteria.

Wild plants are a rich source of phenolic compounds with antimicrobial and antioxidant properties. This study extracted and analyzed leaf fractions for their phenolic profile, antioxidant capacity, and activity against antibiotic-resistant oral bacteria. Phenolic compounds were identified using column chromatography, TLC, and HPLC.

Anti-metastatic potential of flavonoids for the treatment of cancers: focus on epithelial-mesenchymal transition (EMT) process.

The leading factor contributing to patient mortality is the local invasion and metastasis of tumors, which are influenced by the malignant progression of tumor cells. The epithelial-mesenchymal transition (EMT) is key to understanding malignancy development. EMT is a critical regulatory mechanism for differentiating cell populations initially observed during the neural crest and embryonic gastrulation formation.