Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.

Biomechanical Implications of Mass Loading in a Swine Model of Acute Hypoxemic Respiratory Failure.

In obesity, excess weight of the chest and abdomen (mass loading) decreases lung volume and can worsen acute hypoxemic respiratory failure (AHRF). We investigated whether positive end-expiratory pressure (PEEP) fully reverses the effects of mass loading on lung volume and respiratory mechanics in an AHRF swine model. Eighteen Yorkshire pigs were studied: six healthy, eight pre- and post-injury, and four post-injury only.

The Clinical Significance of Atrial Fibrillation in Non-High-Risk Brugada Syndrome: The BruFib Study.

Background: Atrial fibrillation (AF) occurs in up to 20% of patients with Brugada syndrome (BrS), yet its risk factors and prognostic implications remain uncertain.

Objectives: This study sought to identify risk factors for AF in patients with non-high-risk BrS and to evaluate the impact of AF on ventricular arrhythmias (VAs), sick sinus syndrome (SSS), and stroke in non-high-risk BrS.

Methods: This was a multicenter, retrospective study conducted across 20 international centers.

Pediatricians' Recommendations on Screen Media Use Significantly Improve Parents' Management Behaviors and Self-Efficacy: Evidence from a Quasi-Experimental Study.

The widespread use of screen technologies among young children has raised concerns on their potential impact on health, development, and family dynamics. Although pediatric guidelines worldwide recommend clear limitations and supervised use of screens for toddlers and children, these guidelines are often overlooked in the daily practices of most parents. Digital Guardians [] seeks to address this gap by providing tailored guidance on screen management, from birth to adolescence, through family pediatricians during mandatory health checkups.

Comparison of operative microscope and exoscope for execution of microanastomoses on an artificial model.

Introduction: While the improved ergonomics, depth of field, and freedom of movement offered by Exoscopes compared to Operative Microscopes are well established, their value in surgical education and training is often mentioned but remains poorly documented.

Methods: In this study, we used a using a slightly modified version of the NOMAT score to compare the microvascular anastomoses on an artificial model made using traditional Operative Microscopes and the Orbeye 4K 3D Exoscope. Each participant performed the task 3 times.

Standardising Simulation-Based Obstetric Emergency Training: A Delphi Consensus Study.

Objective: To develop standardised Objective Structured Assessment of Technical Skills (OSATS) forms for major obstetric emergencies, thereby improving the quality and consistency of obstetric simulation training.

Design And Setting: A panel of national experts with extensive experience in teaching Gynaecology and Obstetrics, simulation training, and the clinical management of labour complications and peripartum emergencies.

Population And Methods: A Delphi process with four iterative rounds was conducted to create, evaluate, revise, and finalise OSATS checklists for 11 obstetric emergencies.

Liver hypertrophy techniques: a position paper from the Italian Group of Regenerative and Occlusive Worldwide-used techniques of hepatic Hypertrophy (I GROWtoH).

In candidates for hepatectomy, different techniques to induce liver hypertrophy and modulate the future liver remnant are available. However, their use in specific clinical scenarios is highly heterogeneous and there is no consensus about minimal safety standards needed to incorporate these strategies into routine clinical practice. The aim of this position paper was to summarize newly available evidence in the field and compare medical practice among different hepatobiliary surgical units to evaluate the transformative potential of liver hypertrophy techniques in surgical oncology.

Temporal Changes in Biomarkers, Functional Status, and Quality of Life Prior to Adverse Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.

Background: Mapping clinical, biomarker, and diuretic dosing trajectories before adverse clinical outcomes in patients with heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) may inform population monitoring approaches.

Objectives: We assessed temporal patterns of 2 biomarkers (N-terminal pro-B-type natriuretic peptide [NT-proBNP] and estimated glomerular filtration rate [eGFR]), physician assigned functional status (NYHA functional class), a patient-reported outcome (Kansas City Cardiomyopathy Questionnaire Total Symptom Score [KCCQ-TSS]), and diuretic dosing leading up to a clinical event.

Methods: FINEARTS-HF was a double-blind, randomized clinical trial testing finerenone vs placebo in 6,001 patients with symptomatic HF and a left ventricular ejection fraction of ≥40%.

Chirality-Induced Spin Selectivity: A Minimal Model.

Chirality-induced spin selectivity (CISS) is an intriguing yet poorly understood phenomenon observed when electrons travel through a chiral medium or molecule. We propose a current-constrained approach to drive a current through a linear Hubbard chain of twisted orbitals, thus simulating the electron motion through a chiral molecular system. In this original approach, CISS can be addressed in systems with correlated electrons coupled to nonadiabatic molecular vibrations.

Ab initio study of electromigration in liquid GeAsSe alloys for selector devices.

Selenide amorphous alloys are of interest for applications in selector devices that exploit a sort of reversible dielectric breakdown called ovonic threshold switching. In the on-state of the device, the system is typically brought into the supercooled liquid phase above the glass transition temperature, where the atomic mobility is sufficiently high to cause demixing driven by the electric field. The electromigration force F responsible for ionic migration is proportional to the electric field E via the effective charge Z* (F = |e|Z*E, where e is the electron charge), which is thus of great relevance for the electrothermal modeling of the devices.

Association of PILS-based and filter-based particle-bound reactive oxygen species with urban nanoparticles, secondary organic aerosols, and in-vitro oxidative responses.

Exposures to fine particulate matter (PM) have been associated with health impacts, but our understanding of PM concentration-response (PM-CR) relationships remains incomplete. This study investigates the association between particulate-bound reactive oxygen species (PB-ROS) and cellular oxidative stress responses induced by urban nanoparticles. PB-ROS were measured using the DCFH assay, both on PTFE filters (24-hour resolution, PB-ROS) and PB-ROS measured using a Particle-Into-Liquid Sampler (2-hour resolution, PB-ROS).

Handling multiple time-varying exposures in survival analysis using real-world pediatric data from the pedianet database.

In survival analysis, models typically assess the impact of a single Time-Varying Exposure (TVE), where the exposure status can change over time. However, situations with multiple TVEs frequently arise, and adequate statistical handling remains an area of active research. To apply multiple time-varying approaches and to compare estimates derived from different models using an application with real-world data in the paediatric field.

The impact of leukodystrophies on parents' lives.

Objective: Leukodystrophies are a group of genetically determined neurological disorders affecting the white matter of the central nervous system and they have a profound impact on the daily lives of patients and their caregivers. However, only a few studies have analyzed the psychological experiences of parents of children with these conditions. The main aims of the present study were to assess parental burden and parenting stress in caregivers and to evaluate the relationships between parents' experiences and the perceived clinical characteristics of their children.

Human bodies in virtual worlds: a systematic review of implicit sense of agency and ownership measured in immersive virtual reality environments.

Introduction: Virtual reality (VR) offers novel tools for investigating the sense of agency (SoA) and sense of body ownership (SoO), key components of bodily self-consciousness, by enabling experimental manipulations beyond traditional paradigms. This review systematically examines how these manipulations affect SoA and SoO, focusing on their implicit indexes (e.g.

Expert consensus on the management of cytomegalovirus infection in pediatric allogeneic hematopoietic stem cell transplantation.

Cytomegalovirus (CMV) infection is the most frequent viral complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the pediatric setting, several issues on its management are still debated due to the limited evidence compared to adults. The aim of this consensus was to promote harmonization of practices to improve prevention, control and treatment of CMV infection in children and adolescents.

Push-Off Efficacy in Parkinson's Disease compared to healthy controls and its relationship with step length.

The reduction of step length is one of the most common gait impairments in patients with Parkinson's Disease (PD). However, the neuromuscular strategies associated to this gait impairment are still unclear. This study aimed to investigate the potential relationship between muscle activation and step length in PD and healthy controls.

Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis.

Background And Aim: Primary sclerosing cholangitis (PSC) is a cholangiopathy associated with high risk of development into end-stage liver disease and hepatobiliary cancer. The pathogenesis is poorly understood, and current clinical care offers limited therapeutic options, primarily relying on liver transplantation. Claudin-1 (CLDN1), a transmembrane protein highly expressed in liver epithelial cells, plays a crucial role in cell-cell communication and signaling.

Spatial sensorimotor mismatch increases the excitability of the primary somatosensory cortex: Insight from an EEG-virtual reality study.

Under typical conditions, the somatosensory system maintains stable functionality. However, the somatosensory cortex can rapidly reorganize in response to sensory input changes, as demonstrated by studies on sensory deprivation and experience-dependent plasticity. Nevertheless, somatosensory plasticity related to unusual sensorimotor activation, such as spatial incongruence between motor commands and somatosensory feedback patterns during body-environment interactions, remains less investigated.

Repair Versus Replacement in Mitral Valve Papillary Muscle Rupture: A Multicenter Study.

Objectives: Papillary muscle rupture (PMR) is a rare but potentially fatal mechanical complication after acute myocardial infarction (AMI). Although surgery is considered the gold-standard treatment for post-AMI PMR, the optimal surgical strategy remains unclear.

Methods: Data from post-AMI PMR patients submitted to mitral valve replacement (MVR) or mitral valve repair (MVr) surgery in the period between 2001 and 2019, from 20 international centres, were collected in the CAUTION study database.

Tunable functional coverage of biocompatible magnesium silicate nanotubes by microwave-assisted silanization.

The controlled synthesis of biocompatible nanomaterials with tailored composition, size, and functionalities has driven the advancement of nanomedicine, enabling the development of innovative diagnostic and therapeutic strategies. A key challenge in this field is the design of nano-objects exhibiting multiple functionalities, each dedicated to a specific diagnostic or therapeutic purpose. Among these, synthetic stoichiometric chrysotile nanotubes stand out as a highly biocompatible class of non-carbon nanotubes, already demonstrating their potential for diverse applications, including fluorescence, magnetism, singlet-oxygen generation, and scintillation.

Digital health technologies for improving the management of people with chronic obstructive pulmonary disease.

Advances made in digital health in recent years have the potential to improve the care of patients living with chronic obstructive pulmonary disease (COPD) for whom substantial disability still exists. In particular, telehealth and telerehabilitation programs, wearable devices, and apps have been studied as novel methods of providing care to COPD patients who may have limited access to clinical centers or who may benefit from an increased level of monitoring. Many of these interventions gained traction during the COVID-19 pandemic when mandated social isolation required the rapid implementation of remote care models.