Artificial Intelligence and Network Medicine: Path to Precision Medicine.

Over the past two decades, network medicine (NM) has evolved to help define disease mechanisms, identify drug targets, and guide increasingly precise therapies. In recent years, the integration of NM with artificial intelligence (AI), particularly deep learning techniques, has evolved with increasing applications. AI techniques help elucidate complex disease mechanisms and define precise therapies.

Definition of running-related injury in recreational runners: achieving consensus among runners using the e-Delphi Method.

Background: Definitions of running-related injuries (RRI) in the literature are often determined by experts rather than by runners themselves. Incorporating the perspective of runners can provide valuable insights, particularly in the context of self-reported injury surveillance. This study aimed to develop a consensus definition of RRI by integrating the perspectives of recreational runners, acknowledging them as experts in their own injury experiences.

Staying sharp: Gendered work-family life courses and later-life cognitive functioning across four European welfare states.

Cognitive functioning in later life is influenced by reserves accumulated through employment and family roles over the life course. This study examined men's and women's combined employment, parenthood, and partnership roles between ages 15 and 49, and their associations with later-life memory. We used retrospective and prospective data from nine waves of the Survey of Health, Ageing and Retirement in Europe (SHARE) for 5,638 men (24,199 observations) and 6,371 women (27,114 observations) in Italy, France, the Netherlands, and Sweden.

The integrated control of decision and movement vigor.

Decision-making and motor control are closely interdependent processes. It has been proposed that the vigor of decisions and the vigor of movements are jointly controlled to optimize behavior utility. However, recent studies indicate that decision and movement vigor are co-regulated by default, whether or not this benefits behavior utility, and that they can be decoupled if utility is compromised.

First Laboratory Evaluation of FUS-3000 Plus: A New-Generation Urine Analyzer.

Background: Urine sediment analysis is a cornerstone of diagnostic testing. This study evaluates FUS-3000 Plus, an automated urine sediment analyzer using advanced imaging and artificial intelligence, to assess its technical performance and diagnostic accuracy for routine clinical use.

Methods: The study analyzed 98 urine samples for chemical parameters (pH, protein, blood, leukocyte esterase, and nitrite) and 76 samples for particle analysis (red blood cells [RBCs], white blood cells, epithelial cells, crystals, bacteria) by both FUS-3000 Plus and sediMAX™, the current laboratory analyzer in use.

Word-selective EEG/MEG responses in the English language obtained with fast periodic visual stimulation (FPVS).

Fast periodic visual stimulation (FPVS) allows the objective measurement of brain responses of human word discrimination (i.e., reproducible word-category-selective responses) with a high signal-to-noise ratio.

Deferred revascularization of left main stenosis based on instantaneous wave-free ratio: Long-term clinical outcomes from the PHYNAL registry.

Background: An accurate assessment of intermediate left main (LM) stenoses is crucial for revascularization decision-making. However, data on LM revascularization strategy according to instantaneous wave-free ratio (iFR) are limited. This study aimed to evaluate the safety of deferring LM revascularization according to iFR.

Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice.

Group I metabotropic glutamate receptors (mGluRs), particularly mGluR5, regulate synaptic plasticity via long-term depression (mGluR-LTD), a process implicated in declarative memory. We previously identified TRPC1, a highly expressed hippocampal ion channel, as a key mGluR5 effector. Using a Cre-tamoxifen system, we acutely deleted in a Fragile X syndrome (FXS) mouse model, characterized by mGluR5 hyperactivity, enhanced mGluR-LTD, and social deficits.

Early diagnosis of liver graft steatosis and fibrosis: are non-invasive tests the answer?

Background: Graft steatosis and fibrosis detection is a challenge to avoid graft loss. The role of liver biopsy (LB) after liver transplantation (LT) is changing with the emergence of non-invasive tests. Our aim is to evaluate the accuracy of transient elastography (TE) in predicting steatosis and fibrosis post-LT.

The number sense: likely innate, surely not visual. A commentary on "Is there an innate sense of number in the brain?".

Lorenzi et al. (2025) convincingly support the idea of an innate number sense. However, in their paper, and in most of the commentaries it triggered, authors assume that the number sense is visually grounded.

Intimate partner violence during pregnancy against 601,534 women aged 15 to 49 years in 57 LMICs: prevalence, disparities, trends and associated factors using Demographic and Health Survey data.

Background: Pregnant women are at increased risk of intimate partner violence (IPV), with harmful outcomes for both mother and unborn baby. As this public health issue remained poorly documented in low- and middle-income countries (LMICs), this comprehensive study aimed to investigate prevalence and disparities of intimate partner violence during pregnancy (IPVDP) in 57 LMICs, grouped into WHO Regions and World Bank 2022 Income Classification. We also examined changes in IPVDP in LMICs and associated factors.

Revealing rhythm categorization in human brain activity.

Humans across cultures show an outstanding capacity to perceive, learn, and produce musical rhythms. These skills rely on mapping the infinite space of possible rhythmic sensory inputs onto a finite set of internal rhythm categories. What is the nature of the brain processes underlying rhythm categorization? We used electroencephalography to measure brain activity as human participants listened to a continuum of rhythmic sequences characterized by repeating patterns of two interonset intervals.

Neurodegenerative plasma biomarkers for prediction of hippocampal atrophy in older adults with suspected Alzheimer's disease in Kinshasa, Democratic Republic of Congo.

BackgroundHippocampal atrophy is a key feature of Alzheimer's disease (AD), but neuroimaging is often inaccessible in low-resource settings. Blood-based biomarkers such as amyloid-β (Aβ), phosphorylated tau-181 (p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) may offer a practical alternative, though their utility in African populations remains understudied.ObjectiveThis study investigated the ability of plasma biomarkers of AD and AD-related dementias-Aβ, p-tau181, NfL, and GFAP-to predict hippocampal atrophy in older adults in Kinshasa, Democratic Republic of Congo.

Child Migration in Eastern and Southern Africa: Tied and Orphaned.

Understanding the circumstances in which children migrate is important to ensure their well-being. Yet, child migration in sub-Saharan Africa is not easy to measure. Health and Demographic Surveillance Systems (HDSS) provide an excellent opportunity to estimate child migration in the region.

Factors associated with a reduction in the preventive effect of intravenous dexamethasone on rebound pain after axillary brachial plexus block.

Background: Rebound pain after regional anaesthesia remains a significant clinical problem. Intravenous dexamethasone is commonly used as an adjuvant to prevent rebound pain although its effectiveness varies among patients. We aimed to identify phenotypic and biological factors influencing glucocorticoid sensitivity contributing to dexamethasone resistance in the prevention of rebound pain.

Best Practice: International Multisociety Consensus Statement for Post-COVID-19 Residual Abnormalities on Chest CT Scans.

Residual lung abnormalities on CT scans after COVID-19 respiratory infection may be associated with persistent or progressive respiratory symptoms and frequently correlate with abnormal pulmonary function testing results. These abnormalities have been described using varying terms in numerous publications. Chest CT lung abnormalities after COVID-19 infection tend to stabilize or regress over time, indicating that they are nonprogressive and postinfectious in nature.

Work-Family Conflict and Enrichment, Family Routines and Rituals Meaning, and Parental Burnout in UK and Vietnamese Families.

Limited research has examined how micro- and mesosystem-level family factors relate to parental burnout across cultural contexts. Using a cross-cultural design, this study explored the relationships and underlying mechanisms linking work-family conflict, work-family enrichment, family routine, and family ritual meaning to parental burnout. The sample consisted of 1373 parents from the United Kingdom and Vietnam (Mage = 37.

Safety and Use of Eptacog Beta 225 µg/kg in Patients With Haemophilia A or B With Inhibitors.

Introduction: Eptacog beta is an activated recombinant human factor VII bypassing agent approved for treating bleeding episodes (BEs) in patients aged ≥12 years with haemophilia A or B with inhibitors. Two initial dose regimens (IDRs) of either 75 or 225 µg/kg, followed by 75 µg/kg, are approved. We examined the safety of eptacog beta 225 µg/kg across completed clinical trials.

Standardization of Terminology, Definitions, and Outcome Criteria for Bleeding in Hereditary Hemorrhagic Telangiectasia: International Consensus Report.

Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu disease) is the second most common inherited bleeding disorder worldwide, affecting approximately 1 in 5000 people. Development of disease-modifying and efficacious hemostatic agents to treat HHT has finally begun after decades without such medical therapies. However, the lack of consensus on standardized severity definitions, outcome criteria, and terminology remains a major obstacle to clinical investigation and therapeutic development in HHT.

Olfactory implants: international opinion paper on emerging technologies and clinical applications.

Olfactory dysfunction affects a large proportion of the general population and causes significant personal and societal burden. At present, there are limited treatment options available. Though as yet experimental and untested in people, olfactory implants are a novel form of neuroprosthesis, modelled on existing implants for other sensory deficits such as hearing loss.

Alcohol embolization versus non-invasive treatment for pain relief in peripheral venous malformations: a comparative study.

Background: Pain is one of the most important symptoms affecting quality of life in patients with venous malformations. Alcohol embolization is a common approach among other treatment modalities. However, the benefits and complications of this therapy require rigorous evaluation in the face of emerging alternative treatments.

Extreme weather event attribution predicts climate policy support across the world.

Extreme weather events are becoming more frequent and intense due to climate change. Yet, little is known about the relationship between exposure to extreme events, subjective attribution of these events to climate change, and climate policy support, especially in the Global South. Combining large-scale natural and social science data from 68 countries ( = 71,922), we develop a measure of exposed population to extreme weather events and investigate whether exposure to extreme weather and subjective attribution of extreme weather to climate change predict climate policy support.

Updated Classification of Vascular Anomalies. A living document from the International Society for the Study of Vascular Anomalies Classification Group.

Introduction: The International Society for the Study of Vascular Anomalies developed in 1996 a Classification of Vascular Anomalies that became internationally accepted. The main feature was the division of vascular anomalies in 2 categories, vascular tumors and malformations. Major revisions occurred in 2014 and 2018, for updates and inclusion of newly described lesions.