A qualitative analysis of a nationally representative survey of the state of chronic non-cancer pain management in Australia.

Background And Objectives: Although general practitioners (GPs) are the first-line treatment providers for chronic non-cancer pain (CNCP) in Australia, the experience of patients in this context is not well documented. This study explored patients' experiences with GPs managing their CNCP.

Method: Qualitative responses to two open-ended questions about GP care from adult respondents (n=200) to Chronic Pain Australia's 2021 National Pain Survey were thematically analysed.

Metaproteomic Analysis to Assess the Impact of Storage Media on Human Gut Microbiome in Fecal Samples.

The human gut microbiome is a diverse community of microorganisms residing in the gastrointestinal tract. The storage condition of fecal samples may impact the taxonomic and protein compositions of microbiomes in these samples. Here, we performed a mass spectrometry-based metaproteomic study to assess the impact of storage media on human gut microbiome in fecal samples.

Pooled CAR-T screening in nonhuman primates identifies designs with enhanced proliferation, trafficking, and persistence.

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized treatment for B-cell malignancies, yet over 60% of patients relapse within one year, often due to insufficient CAR-T persistence. While mouse and primary cell models have been instrumental in advancing CAR-T therapy, they frequently fail to predict clinical outcomes, underscoring the need for more translationally relevant models. To address this limitation, we conducted the first systematic evaluation of CAR structure-function relationships in an immunocompetent nonhuman primate (NHP) model.

New Comorbidity Index Associated with Survival After Chimeric Antigen Receptor T Cell Therapy for Large B-Cell Lymphoma.

The cumulative impact of baseline comorbidities on outcomes of chimeric antigen receptor T cell (CAR-T) therapy is not well-established. Therefore, we developed and validated a Cellular Therapy Comorbidity Index (CT-CI) to predict outcomes following CD19-directed CAR-T therapy for large B-cell lymphoma (LBCL). Patients aged 18 or older receiving commercial CAR-T therapy for LBCL during 2017-2020 were selected from the CIBMTR registry.

Building a Synthetic Cell Together.

Synthetic cells (SynCells) are artificial constructs designed to mimic cellular functions, offering insights into fundamental biology, as well as promising impact in the fields of medicine, biotechnology, and bioengineering. Achieving a functional SynCell from the bottom up, i.e.

Assessing the Educational Landscape of Culturally Responsive Education in Pediatric Critical Care Fellowships.

Objective: Health disparities persist among marginalized racial, ethnic, and lower socioeconomic status groups, extending to pediatric intensive care units. Complex interactions between structural forces and provider biases influence patients' risk for critical illness, access, timing, and quality of care. An understanding of how these social influencers of health directly impact health outcomes should be necessary components of pediatric critical care medicine (PCCM) fellowship.

The development and feasibility of a psychologist-led screening and modular-based psychological intervention in an Australian intensive care unit: A pilot study.

Background: Psychological distress is common among intensive care unit (ICU) patients and can lead to long-term adverse psychological sequelae. While early psychological interventions may help mitigate these effects, their feasibility within critical care settings remains largely unexplored. Additionally, the role of psychologists in delivering such interventions in Australia remains unclear, particularly given inconsistencies in workforce availability and integration into standard care.

Augmented Reality in Airway Management: A Scoping Review.

Augmented reality, which overlays virtual information onto the physical environment, is an emerging technology in health care with promising applications in education, diagnostics, and procedural support. Its use in airway management-an essential aspect of anesthesiology and critical care-remains underexplored. This scoping review evaluates the current literature on augmented reality in airway management, with the aim of identifying its benefits, limitations, and future potential.

Five Data-Informed Principles for Advancing Inclusive Research in Clinical Trials: A Pharma Perspective.

Advancing inclusive research (AIR) in clinical trials requires frameworks and metrics for assessing real-world data and measuring population science. Because different factors drive health inequities and variables in measuring population science, relying on one metric for measuring progress may have limitations. Five principles (5Ps) are proposed for AIR globally that form the basis for a data-informed framework to measure and systematically define inclusive research to ensure rigor and benchmarking within organizations and across the broader sector.

Trauma-Informed Care in Anesthesia for Women With a History of Sexual Assault: Investigating Provider Perceptions.

According to the Centers for Disease Control and Prevention, one in four women in the United States has experienced attempted or completed rape, and over half have experienced a form of sexual violence in their lifetime. Despite this prevalence, there is currently no formal position statement regarding the role of trauma-informed care (TIC) in anesthesia. This study investigates provider knowledge and attitudes regarding TIC principles and specific applications to perioperative practices during the care of female-identifying patients.

Integrated biotechnological and AI innovations for crop improvement.

Crops provide food, clothing and other important products for the global population. To meet the demands of a growing population, substantial improvements are required in crop yield, quality and production sustainability. However, these goals are constrained by various environmental factors and limited genetic resources.

Policy view: worldwide patterns of tobacco use with recommendations for tobacco control.

The global epidemic of tobacco-related diseases continues to be a major health and economic issue. The WHO Framework Convention on Tobacco Control (WHO FCTC), adopted in 2003, is a legally binding treaty aimed at reducing the demand for and supply of tobacco products, with 183 Parties, comprising countries and the EU, covering more than 90% of the world's population. This Policy View presents an analysis of the global patterns of tobacco use, the effects of the WHO FCTC and measures implemented for tobacco control, barriers to progress, and the principal ways forward.

Hematologic versus non-accidental trauma etiologies for bruising identified using an emergency department bruising pathway.

Background: Bruising is a common presentation of child abuse, and a frequent finding in hematologic disorders.

Objectives: This study's aims were to describe: (1) how often high-risk bruising, identified with an established emergency department (ED) pathway, is related to a new hematologic disorder diagnosis and/or child abuse and (2) characteristics of patients, presentation, or bruising patterns associated with these diagnoses.

Participants And Setting: Patients under 48-months-old presenting to Seattle Children's ED between October 2020 and June 2023 with high-risk bruising for abuse.

Revisiting the Obligation to Share Aggregate Results with Research Participants in the Era of Open Science.

Open science initiatives, intended to democratize access to research products, have made steady progress in shifting the global science culture toward practices like preregistration and data sharing. However, current open science efforts have not yet addressed the special obligation to ensure that research results are made accessible to the portion of the general population who contribute most directly to scientific advances: research participants. In this article, we explore the ethical obligation to communicate aggregate results to research participants and consider elements of open science infrastructure that could be amended for this purpose.