Robotic single-port femoral artery dissection and anastomosis with the da Vinci system: a cadaveric feasibility study.

Vascular surgical site infections (SSI) are common and associated with graft infection, surgical reintervention, and increased lengths of stay. While antibiotic prophylaxis and negative pressure dressings have improved SSI rates, reported incidence remains as high as 30%. Robotic approaches have decreased surgical site infections in multiple surgical specialties, but remain without a vascular surgery indication.

Association Between Postoperative Debridement Patterns After Initial Endoscopic Sinus Surgery and Revision Endoscopic Sinus Surgery.

1 versus 0 PDs within 90 days of initial ESS was associated with 11% decreased risk of revision ESS. 2 versus 1 PD or a first PD 8-30 versus 1-7 days after initial ESS did not affect risk of revision ESS. 3+ versus 1 PD or a first PD 31-90 versus 1-7 days after initial ESS was associated with increased risk of revision ESS.

Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features and CREB3L2::PPARγ Fusion.

A 58-year-old woman presented with an asymptomatic, soft-to-palpation, mobile, right thyroid mass. Subsequent ultrasonography revealed numerous, bilateral, mildly heterogenous, cystic and solid nodules, including a hypoechoic, 1.7 × 1.

Comparative study of open and robot-assisted approaches to ureteropelvic junction obstruction in children ≤ 12 months: A multi-institutional retrospective analysis.

Background: The utilization of robot-assisted laparoscopic pyeloplasty (RALP) for the surgical correction of ureteropelvic junction obstruction (UPJO) continues to increase. The aim of this study was to determine whether robot-assisted laparoscopic pyeloplasty (RALP) is a safe and equally efficacious procedure compared to open pyeloplasty (OP) in infants ≤12 months old.

Methods: All patients ≤12 months old who underwent RALP or OP between January 2012 and January 2021 at five participating centers were included in this study.

Patterns of practice, research, and engagement in the first 10 years of practice: A survey of APSA early career pediatric surgeons.

Background: The APSA Board of Governors Early Career Representative sought to better understand the experiences, engagement, and challenges experienced by early career surgeons (ECS).

Methods: A survey was distributed to ECS, defined as within 10 years of fellowship completion. All survey respondents were current APSA members.

Conduction System Pacing With Stylet Driven Leads: A Step-By-Step Guide to Implant.

Background: In recent years, there has been a surge of interest in strategies to perform conduction system pacing (CSP). Of these, left bundle branch area pacing (LBBAP) has rapidly gained popularity as the preferred approach to perform CSP due to favorable pacing thresholds and greater perceived ease of implant.

Aim: The majority of initial descriptions of LBBAP has focused on use of lumenless pacing leads.

Common and distinct circulating microRNAs in four neurovascular disorders.

Background: Familial cerebral cavernous malformations (FCCM), Sturge-Weber Syndrome (SWS), and hereditary hemorrhagic telangiectasia (HHT) are driven by genetic mutations causing varying vascular dysmorphism and risk of brain bleeding. Cerebral microbleeds (CMBs) are associated with the aging process with less characterized genetic drivers. This study hypothesizes that common and distinct circulating microRNAs (miRNAs) can reflect mechanisms of vascular dysmorphism and bleeding, which can serve as potential biomarkers in clinical contexts.

NAMPT haploinsufficiency is a collateral lethal therapeutic vulnerability in high-risk myeloid malignancies with inactivation.

Monosomy 7 (-7) and deletions of chromosome arm 7q (del(7q)) are prevalent high-risk cytogenetic abnormalities that often co-occur with del(17p) (harboring ). To identify novel targeted therapies based on specific vulnerabilities in high-risk myeloid malignancies, we investigated druggable, chromosome 7-encoded essential genes that are monoallelically deleted in the context of -7/del(7q), that is, collateral lethal genes. By mining genome-wide CRISPR-Cas9 screen data sets, we identified nicotinamide phosphoribosyltransferase () on 7q22.

Representation matters: advocating for increased diversity in the pediatric surgical workforce to address health inequity.

Equitable health is the state in which all have the opportunity to attain full health potential and no disadvantage from achieving this because of social position or another socially defined circumstance [1]. One measure of society is marked by how vulnerable populations, like children, are treated, including the right to achieve and access good health. Focusing on health equity helps to address the social determinants of health which can adversely affect pediatric care and threatens surgical outcomes for the most vulnerable children in society [1-5].

Carboplatin, gemcitabine, and mifepristone for advanced breast and recurrent/persistent epithelial ovarian cancer.

Purpose: Preclinical models of glucocorticoid receptor (GR)-positive breast cancer (BC) and ovarian cancer (OC) suggest GR activity inhibits chemotherapy-induced apoptosis, and GR antagonism using mifepristone (Mif) enhances cytotoxicity. We performed a phase I trial combining mifepristone, carboplatin (C), gemcitabine (G).

Methods: A standard "3 + 3" dose escalation scheme was used.

Development of a risk score predicting survival after adult heart transplantation in the United States.

Background: In the US, donor hearts for transplant are currently allocated to the candidates with the highest risk of death on the waiting list, based on a categorical status-based system. The upcoming continuous distribution system provides an opportunity to implement a post-transplant risk score that may help avoid futile transplants.

Methods: In this observational study of the Scientific Registry of Transplant Recipients (SRTR), a novel US transplant risk score (US-TRS) was developed and validated using a mixed-effects Cox proportional hazards model.

Non-pulmonary postoperative complications of cardiothoracic surgery.

Cardiothoracic surgery, including coronary artery bypass grafting, valve replacement, and transplantation, has considerably advanced, improving patient survival and outcomes. However, non-pulmonary postoperative complications remain a major concern, contributing to morbidity and mortality. These complications encompass cardiovascular events, vascular injuries, infections, and device-related issues that can severely impact recovery.

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings.

Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele-the most severe form of spina bifida often associated with a markedly diminished quality of life-accounts for a significant portion of cases. A broad range of genetic and environmental factors, many of which are still unknown, influence spina bifida, making it difficult to provide a comprehensive etiology for the disorder.

Sentiment Analysis of Transsphenoidal Surgery in the Cushing's Subreddit.

 While the definitive treatment of Cushing's disease (CD) is transsphenoidal surgery (TSS), little is known about patients' perceptions of their treatment experience. Reddit, an online forum, allows users to interact on "subreddits" specific to interests. We aimed to assess patient sentiments regarding TSS for CD on the Cushing's subreddit.

"Just Got Diagnosed; What Worked for You?": A Mixed-Methods Analysis of Treatment Experiences in the Prolactinoma Subreddit.

 With improvement in complication and remission rates, recent studies have suggested the viability of transsphenoidal surgery as first-line management for prolactinomas. Reddit, an online forum, allows posters to interact with one another, and discuss symptoms, treatments, and disease courses through specialized forums known as "subreddits." Given the lack of research comparing patient experience on pharmacotherapy versus surgery, we sought to assess the sentiment of treatment within the "r/Prolactinoma subreddit" community.

Innovative left internal carotid stenting via right brachial access in a high-risk patient.

Carotid artery stenosis in patients with complex comorbidities, severe calcification, and prior surgical interventions presents significant procedural challenges. Traditional access routes for stenting, such as transfemoral or transcarotid, may be unfeasible in such cases, requiring innovative alternatives. A 79-year-old man with symptomatic high-grade left internal carotid artery stenosis, severe aortoiliac occlusive disease, and a history of failed transfemoral stenting was treated successfully with left internal carotid artery stenting via right brachial artery access.

The evolution of conduction system pacing and gaps in understanding.

The field of cardiac pacing has changed dramatically since the first pacemakers were implanted in the 1950s. Over the ensuing decades, advancements in pacing technology have yielded longer battery life, smaller devices, sturdier leads, and more sophisticated pacemaker programming. Cardiac resynchronization therapy (CRT) represented a significant revolution in pacing approach, with the goal of correcting interventricular dyssynchrony through biventricular pacing.

Olfaction and diabetes among older adults.

Both poor olfaction and diabetes are common in older adults. It is biologically plausible that they may be related and interact to affect the health of older adults. We examined the association between poor olfaction and diabetes and their joint associations with mortality among 2,416 older adults from the Health, Aging, and Body Composition Study.

Karyotypic clonal fraction predicts adverse outcome in -mutated myeloid neoplasms: an International investigators Network (iTiN) study.

We investigated the prognostic impact of blast counts, allelic state determinants (number of hits, del(17p), variant allele frequency, complex karyotype),and a novel karyotypic clonal cell fraction (≤50% clonal cells vs >50% clonal cells (termed 'CK50')) in 495 individuals with mutated ( ) myeloid neoplasms. Outcome examined was 24-month survival (OS24). The cohort (median age 71) included 29% (144/495) myelodysplastic syndromes (MDS)/MDS-acute myeloid leukaemia (AML) (1%-19% blasts) and 71% (351/495) AML (≥20% blasts), with 18% (81/460) having low CK50.

Correlation between treatments and outcomes of patients with EGFR-mutated non-small-cell lung cancer that transitioned into small-cell lung cancer: an international retrospective study.

Background: Histological transformation to small-cell lung cancer (SCLC) is an under-recognized but clinically relevant mechanism of resistance in epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC). While platinum-based chemotherapy (CT) has emerged as standard treatment after small-cell transformation, optimal treatment strategies are not defined, particularly with regard to the role of immune checkpoint inhibitors (ICIs) or continuation of EGFR-tyrosine kinase inhibitors (TKIs).

Materials And Methods: We conducted an international, retrospective, observational study on patients with EGFR-mutated NSCLC that transformed to SCLC, focusing on treatment and outcomes.