Dengue Epidemiology in 7 Southeast Asian Countries: 24-Year, Retrospective, Multicountry Ecological Study.

Background: Dengue fever remains the most significant vector-borne disease in Southeast Asia, imposing a substantial burden on public health systems. Global warming and increased international mobility may exacerbate the disease's prevalence. Furthermore, the unprecedented COVID-19 pandemic may have influenced the epidemiological patterns of dengue.

Enhancing Team Strategies and Tools to Enhance Performance and Patient Safety Performance Through Medical Movies, Massive Open Online Courses, and 3D Virtual Simulation-Based Interprofessional Education: Mixed Methods Double-Blind Quasi-Experimental Study.

Background: The interprofessional educational curriculum for patient and personnel safety is of critical importance, especially in the context of the COVID-19 pandemic, to prepare junior multiprofessional teams for emergency settings.

Objective: This study aimed to evaluate the effectiveness of an innovative interprofessional educational curriculum that integrated medical movies, massive open online courses (MOOCs), and 3D computer-based or virtual reality (VR) simulation-based interprofessional education (SimBIE) with team co-debriefing to enhance interprofessional collaboration and team performance using Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS). This study addressed 3 key questions.

Natural Inhibitors Against Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease From Three Vietnamese Bryophytes.

Erythrodontium julaceum, Marchantia polymorpha, and Plagiochila bantamensis are widely distributed bryophytes in Vietnam. However, comprehensive chemical and biological data on their composition remain limited. Bio-guided isolation based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) M inhibition was applied to these species, resulting in the identification of 23 metabolites.

Clinicopathologic Features, Pathogenesis, and Treatment of Monoclonal Gammopathy-Associated Myopathies.

Monoclonal gammopathy-associated myopathies (MGAMs) are rare yet treatable myopathies that occur in association with monoclonal gammopathies. These myopathies include light chain (AL) amyloidosis myopathy, sporadic late-onset nemaline myopathy (SLONM), scleromyxedema with associated myopathy, and newly reported monoclonal gammopathy-associated glycogen storage myopathy (MGGSM), including the vacuolar myopathy with monoclonal gammopathy and stiffness. All these 4 distinct subtypes of MGAMs typically present in patients aged 40 or older, frequently with a subacute onset of rapidly progressive proximal and axial muscle weakness.

Comparative biocompatibility of hydrophilic vs. hydrophobic intraocular lenses following phacoemulsification in patients with uveitis.

Purpose: To evaluate and compare the biocompatibility of hydrophilic and hydrophobic intraocular lenses (IOLs) in patients with uveitis undergoing phacoemulsification, with particular focus on posterior capsule opacification (PCO), postoperative inflammation, and visual outcomes.

Methods: Patients with uveitis who underwent phacoemulsification with IOL implantation between 2015 and 2023 were retrospectively reviewed. Propensity score matching (1:1) was performed to account for clinical and demographic variables, yielding 132 eyes (66 per group) for analysis.

Global antimicrobial resistance-The ostrich's head is in the sand.

Antimicrobial resistance (AMR) is a growing problem that should be ignored at our peril. The development of new diagnostics, drugs, and vaccines to tackle AMR faces technical difficulties and challenges that need to be addressed urgently.

Quantitative Analysis of Sexual Dimorphism in Three-Dimensional Facial Anthropometry in Contemporary Thai Population: Implications for Facial Feminization Surgery.

Facial feminization surgery (FFS) reshapes masculine facial attributes to align with feminine norms, yet normative anthropometric data for Asian populations remain sparse. We therefore quantified sex-related 3-dimensional (3D) facial metrics in healthy Asian adults to delineate dimorphic benchmarks for surgical planning. We prospectively recruited 40 healthy Asian adults (20 males, 20 females; age 18 to 45 years, mean 28.

Treatment outcomes and risk factors for severity and mortality in Clostridioides difficile infection: a single-center study in Thailand.

Introduction: Clostridioides difficile often causes hospital-acquired diarrhea, leading to unfavorable treatment outcomes. This study investigates CDI treatment outcomes and factors affecting severity and mortality at a university hospital in Thailand.

Methodology: A retrospective study was conducted from June 2019 to December 2021.

Prevalence of common bacterial STI pathogens and the microscopic diagnostic approach to abnormal vaginal discharge in a tertiary care hospital in Bangkok, Thailand.

In Thailand, sexually transmitted infections (STIs) persist as a significant public health issue, notwithstanding the affordability of treatments. The primary challenge lies in diagnostic methodologies. According to the Thai National Treatment Guidelines for abnormal vaginal discharge, wet preparation using proportion of white blood cell (WBC) counts and epithelial cell (EC) guides presumptive STI treatment.

3D-Printed Flexible Conductive Hydrogel as a Wearable Platform for Dual Functions of Strain and Colorimetric Lactate Sensors.

Strain sensors have received considerable attention in personal healthcare due to their ability to monitor real-time human movement. However, the lack of chemical sensing capabilities in existing strain sensors limits their utility for continuous biometric monitoring. Although the development of dual wearable sensors capable of simultaneously monitoring human motion and biometric data presents significant challenges, the ability to fabricate these sensors with geometries tailored to individual users is highly desirable.

Thiopurine S-methyltransferase (TPMT) Activity Cutoffs in the Thai population.

Background: Thiopurine S-methyltransferase (TPMT) is crucial for metabolising thiopurine drugs. This study aimed to establish the cutoff values for TPMT activity in a cohort of healthy individuals. We defined normal TPMT activity ranges and identified clinically applicable thresholds to distinguish individuals with normal TPMT function from those with reduced or deficient activity.

Vietnamese version of the Health Literacy Questionnaire: translation, linguistic validation, and assessment of cross-cultural adaptation.

Health literacy (HL) is a fundamental factor in raising health awareness and self-management, especially in contexts with increasingly complicated health systems. Its accurate and culturally appropriate measurement is necessary to support effective medical interventions. Accordingly, we translated the Health Literacy Questionnaire (HLQ) into Vietnamese and analysed its psychometric properties on the basis of data derived from respondents who completed the translated instrument.

Binder-Free Nickel Borate/Nickel Hydroxide Bifunctional Catalyst for Coupled Nitrate Reduction and Glycerol Oxidation Toward Sustainable Ammonia Production.

The accumulation of nitrate (NO) from agricultural runoff poses a growing threat to ecosystems and public health. Converting nitrate into ammonia (NH) through the electrochemical nitrate reduction reaction (NORR) offers a promising strategy to mitigate environmental contamination while creating a sustainable circular route to fertilizer production. However, achieving high NH production and energy efficiency remains challenging.

Student Engagement in Program Evaluation: Redesigning the Premedical Curriculum Through Instructor-Learner Co-Creation.

Background: Engaging students in curriculum development provides valuable insights and promotes alignment with their learning needs. Premedical curricula often overemphasize basic sciences, highlighting the need to incorporate social sciences and earlier patient exposure. This study involved students as key stakeholders in redesigning and evaluating the curriculum's clinical relevance.

Fit accuracy of complete crowns fabricated by generative artificial intelligence design: a comparative clinical study.

Purpose: Designing restorations remains challenging because the process is time-consuming and requires operator skill and experience. This clinical study evaluated the fit accuracy of polymerized complete crowns fabricated using a web-based 3D generative artificial intelligence design (GAID) method compared to crowns fabricated using a conventional computer-aided design (CCAD) method.

Materials And Methods: Sixty-two patients requiring complete crowns in maxillary and mandibular premolars and molars were enrolled.

Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence.

Introduction: Depression and anxiety are prevalent comorbidities in individuals with chronic diseases, significantly impairing their quality of life and complicating disease management. Curcumin, derived from turmeric (Curcuma longa), has garnered attention for its potential therapeutic benefits in alleviating symptoms of depression and anxiety. However, its specific effects on depressive or anxiety symptoms associated with chronic diseases (DACD) remain unclear.

Correction: α-Mangostin alleviated inflammation in rats with adjuvant-induced arthritis by disrupting adipocytes-mediated metabolism-immune feedback.

[This corrects the article DOI: 10.3389/fphar.2021.

Anchovy drying using step-down microwave technique.

Conventional drying methods, such as hot air-reciprocal tray (HART) and microwave-hot air with a reciprocal tray (MHART), often suffer from low energy efficiency and product degradation at high temperatures or microwave power. This study introduced a step-down microwave-hot air with a reciprocal tray system (SMHART) to enhance drying performance using a programmable MHART setup. SMHART significantly reduced drying time and energy consumption (as low as 332.

Emerging HER2 Targeting Immunotherapy for Cholangiocarcinoma.

Cholangiocarcinoma (CCA) is a fatal bile duct malignancy. CCA is intrinsically resistant to standard chemotherapy, responds poorly to it, and has a poor prognosis. Effective treatments for cholangiocarcinoma remain elusive, and a breakthrough in CCA treatment is still awaited.

Enzyme-Enhanced Selective Physicochemical Transformation of Lignocellulosic Fibers for Green Textiles: A Case Study with Dual-Purpose Pineapple Plant toward Sustainable Agro-Industries.

Using leaf fibers from pineapple (PALFs) as a model dual-purpose plant, we deliberately explore the effect of bio- and semibiobased treatment using xylanase, cellulase, and a mixture of pectinase and amylase. We assess these treatments for their potential to selectively and precisely remove lignocellulosic components. Additionally, we examine how they modify the relative content of cellulose, hemicellulose, and lignin, as these are key factors affecting the physical appearance, dimensional structures, and mechanical integrity.

Ceric Ammonium Nitrate Immobilized on Linoleic Acid-Functionalized FeO Nanoparticles as a Magnetically Recyclable Catalyst for C3-Selective Formylation of N-H Indoles.

In this study, a novel magnetically recyclable catalyst was developed by immobilizing ceric ammonium nitrate (CAN) onto linoleic acid-functionalized magnetite nanoparticles (FeO-LA@CAN). The catalyst was thoroughly characterized using FT-IR, XRD, TEM, SEM-EDX, VSM, TGA, and N adsorption-desorption analyses. The catalytic efficiency of FeO-LA@CAN was evaluated in the C3-selective formylation of free (N-H) indole derivatives, exhibiting excellent activity and broad substrate scope.

Magnetically Recoverable WO/FeO Catalyst for the Selective Oxidation of Styrene to Benzaldehyde.

A magnetically recoverable catalyst, WO/FeO, was successfully synthesized via a coprecipitation and calcination method and applied for the selective oxidation of styrene to benzaldehyde. Structural and surface characterizations (XRD, XRF, SEM, TEM, BET, VSM, and XPS) confirmed the successful integration of both components, mesoporosity, strong magnetic properties, and the presence of W and Fe/Fe species. Catalytic studies identified optimal conditions: 33 wt % WO loading, 40 mg catalyst, 10 equiv HO, 70 °C, and 24 h, resulting in a styrene conversion of 74.

Multimodal Deep Learning for Generating Potential Anti-Dengue Peptides.

Dengue virus remains a significant global health threat, imposing a substantial disease burden on nearly half of the world's population. The urgent need for effective antiviral therapeutics, including therapeutic peptides targeting the Dengue virus, is critical in the current healthcare landscape. However, the availability of anti-Dengue peptides (ADPs) data remains limited in existing data sets, posing a challenge for computational modeling and discovery.