The Efficacy and Safety of Teprotumumab in Geriatrics Patients: A Multicenter Study.

Purpose: To evaluate the efficacy and safety of teprotumumab for the treatment of thyroid eye disease in geriatric patients.

Methods: This was a multicenter cohort study of patients aged 75 and older, treated between February 2020 and September 2023 across 10 tertiary institutions. Patients were included if they had moderate-to-severe thyroid eye disease and at least 1 infusion of teprotumumab.

Pregnancy Outcomes After HIV Diagnosis in Women Living With HIV in Japan, South Korea and Hong Kong Special Administrative Region: A Brief Report.

The study analyzed pregnancy outcomes among 498 women living with HIV in East Asia. We found 15% had pregnancies postdiagnosis, with 57% resulting in live births. Older age at antiretroviral therapy initiation and higher pre-antiretroviral therapy viral loads were negatively associated with pregnancy.

Can We Combine Mouthrinses With Probiotics? An Evaluation of Their Compatibility and Combined Therapy on Oral Biofilms.

Aim: Multiple oral pathologies requiring antiseptic mouthrinses for prevention or treatment. However, nonselective elimination of the microbes may also harm beneficial commensal, healthy bacteria. Promicrobial strategies, such as probiotics, aim to rebalance the oral microbiome rather than eradicate it; however, we hypothesised that their incorporation might be challenged due to the microbiome's inherent resistance to outsiders.

Models of care for children and adolescents with type 1 diabetes in low- and middle-income countries: a scoping review.

Background: In order to improve the outcomes of children and adolescents with type 1 diabetes mellitus (T1DM), access to and quality of comprehensive acute and chronic care services in low- and middle-income countries (LMIC) must be improved.

Objectives: To identify and summarise the characteristics of models of care for T1DM in children and adolescents in LMIC.

Search Methods: We searched MEDLINE, Scopus, the Cochrane Central Register of Controlled Trials (CENTRAL), and the World Health Organization (WHO) Global Index Medicus from inception to 11 December 2023 without restrictions.

Unveiling the Riddoch phenomenon: a regression analysis of stroke-induced homonymous hemianopia.

Introduction: A subset of patients with homonymous hemianopia can consciously perceive motion within their blind visual fields-a phenomenon known as the Riddoch phenomenon. However, the factors predicting this residual motion perception remain poorly understood. This study aims to identify clinical and neuroanatomical predictors of the Riddoch phenomenon in stroke patients.

Psychometric properties of the 12-item short form health survey version 2 among general Thai samples: a Rasch analysis.

Background: Although the 12-item Short Form Health Survey version 2 (SF-12v2) is suitable for measuring health status in the general Thai population, it has been evaluated using classical test theory. Rasch analysis, however, offers a psychometric testing method that converts ordinal scales to interval-level data without breaching parametric assumptions. Thus, this study aimed to assess the measurement properties of Thai SF-12v2 and SF-6D items derived from it among the general Thai population.

Shock epidemiology and outcomes among internal medicine patients.

Background: Shock, characterised by circulatory hypoperfusion and cellular hypoxia, represents a critical medical condition requiring immediate attention. Despite its significance, there are limited data on shock incidence and outcomes, particularly within the context of Thailand.

Objectives: This retrospective observational study aimed to investigate the incidence, management and outcomes of shock patients admitted to the internal medicine department of Siriraj Hospital, a referral university hospital in Bangkok, Thailand.

Corrigendum to: Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021 [Blood Cell Therapy. 2024; 7(4): 129-137. doi:10.31547/bct-2024-020].

[This corrects the article DOI: 10.31547/bct-2024-020.].

Bruxism and other jaw loading behaviours are associated with somatic symptoms and psychological distress in orofacial pain-free adults: a cross-sectional study.

Background: Oral behaviours, both functional and non-functional, are commonly reported and can negatively impact oral health. Among orofacial pain patients, non-functional oral behaviours have been observed in association with elevated psychosocial factors. However, the extent to which these findings apply to individuals without orofacial pain remains inconclusive.

Dengue Virus Biosafety: An Analysis of Evidence, Global Inconsistencies, and Risk Gaps.

Introduction: Dengue virus (DENV) poses a significant global health threat, particularly in tropical and subtropical regions, where it is primarily transmitted by spp. mosquitoes. Its biosafety and biosecurity management present unique challenges due to both its vector-borne nature and rare instances of nonvector transmission.

Improvement in Unhealthy Behaviors Among Patients with Chronic Kidney Disease Receiving Integrated Care at Community Hospitals in Thailand.

Purpose: Unhealthy behaviors can accelerate the progression of chronic kidney disease (CKD). This study aimed to evaluate the effectiveness of a community-based integrated care program in modifying key unhealthy behaviors among CKD patients in rural Thailand and to assess the impact of these behaviors on the rate of kidney function decline.

Patients And Methods: This is a post-hoc analysis of the ESCORT-2 trial, which is a 3-year prospective cohort study that enrolled 914 patients with CKD stages 3-4 in rural Thailand.

Are Sex-Specific Cutoffs Needed With a Next-Generation Urine Tenofovir Lateral Flow Assay for Antiretroviral Adherence Monitoring?

Accurate point-of-care tools are needed to detect early nonadherence to daily HIV regimens and support timely transitions to long-acting options. Emerging evidence suggests that females may require higher adherence than males to achieve equivalent protection. Our next-generation urine tenofovir assay showed high accuracy across sexes but lower urine drug levels among female participants.

Synergistic effects of QST 713 and L-arginine supplementation during late gestation on reproductive performance in Landrace × Yorkshire sows: A randomized controlled trial.

Background And Aim: Low birth weight and within-litter variations are major challenges in swine production, often exacerbated by highly prolific sow lines. Nutritional interventions such as amino acid and probiotic supplementation have shown promise, but their combined effects remain unexplored. This study aimed to evaluate the individual and interactive effects of QST 713 and L-arginine supplementation during late gestation on reproductive performance in sows.

Echocardiographic assessment of left ventricular function in mules under general anesthesia induced with a high-dose xylazine-based protocol.

Background And Aim: Echocardiographic assessment in equines is typically performed on standing animals; however, no studies have evaluated left ventricular function in anesthetized mules using high-dose xylazine. Given the unique pharmacokinetics in mules and their higher anesthetic requirements, this study aimed to assess the effects of acepromazine-xylazine-diazepam-ketamine anesthesia, using the upper limit xylazine dose (1.6 mg/kg), on the left ventricular size and function in mules.

Hydrolyzable tannins in local Thai plants: Potential applications as poultry feed supplements: A systematic review.

Background And Aim: The global shift toward antibiotic-free poultry production necessitates sustainable alternatives to conventional growth promoters. Hydrolyzable tannins (HTs) from plants have shown antimicrobial, antioxidant, and gut-modulatory effects, making them promising feed additives. However, reliance on imported tannins from temperate species limits access for tropical producers, especially in Thailand.

Determinants of prolonged weaning-to-service interval in primiparous Landrace × Yorkshire sows under tropical conditions: Impact of age at first farrowing, lactation length, and litter size at weaning.

Background And Aim: Primiparous sows are particularly vulnerable to prolonged weaning-to-service interval (WSI), which negatively impacts reproductive efficiency and farm profitability. This study aimed to identify critical risk factors associated with prolonged WSI (>6 days) in first-parity Landrace × Yorkshire sows raised under tropical conditions.

Materials And Methods: A retrospective cohort analysis was performed using production records from 3,222 sows on a commercial farm in Central Vietnam.

Quinolone resistance in from Thai ducks: Mutation analysis of , and genes.

Background And Aim: is a Gram-negative bacterium causing systemic infections in ducks, often treated with quinolones. However, increasing resistance to quinolones poses a threat to effective treatment, and the molecular mechanisms underlying this resistance remain inadequately understood in Thailand. This study aimed to determine the minimum inhibitory concentrations (MICs) of nalidixic acid, ciprofloxacin, and enrofloxacin; identify mutations in the quinolone resistance-determining regions of and ; and detect () genes in isolates from Thai ducks.

A hybrid 1DCNN-GRU deep learning framework for classifying caprine granulosa cell fertility potential using single-cell transcriptomics.

Background And Aim: Granulosa cells (GCs) are crucial mediators of follicular development and oocyte competence in goats, with their gene expression profiles serving as potential biomarkers of fertility. However, the lack of a standardized, quantifiable method to assess GC quality using transcriptomic data has limited the translation of such findings into reproductive applications. This study aimed to develop a hybrid deep learning model integrating one-dimensional convolutional neural networks (1DCNNs) and gated recurrent units (GRUs) to classify GCs as fertility-supporting (FS) or non-fertility-supporting (NFS) using single-cell RNA sequencing (scRNA-seq) data.

Selective bactericidal efficacy of 465-nm blue light phototherapy against standard and canine wound pathogens: An evaluation.

Background And Aim: Antibiotic resistance poses a growing threat to wound management in veterinary medicine. Blue light phototherapy has emerged as a non-antibiotic bactericidal alternative with additional benefits for wound healing. However, its effectiveness in clinical veterinary contexts remains inadequately explored.

Oxidative stress index of porcine follicular fluid influences meiotic maturation and embryo development during culture.

Background And Aim: Porcine follicular fluid (pFF) is frequently used to mimic the follicular microenvironment during maturation (IVM) of oocytes. However, the influence of oxidative stress levels within pFF on oocyte quality and embryo development remains unclear. This study aimed to investigate how varying oxidative stress index (OSI) of pFF affect porcine oocyte meiotic progression, fertilization, and embryonic development during IVM.

Eco-friendly microencapsulation of using seed extract: A novel plant-based delivery system enhancing probiotic stability and gastrointestinal tolerance.

Background And Aim: Probiotic viability remains a critical challenge during gastrointestinal (GI) transit, storage, and feed processing. Conventional encapsulation materials often fail under acidic and thermal stress. This study aimed to develop and characterize a novel, eco-friendly microencapsulation system using (FP) seed extract as a natural encapsulating matrix for (LP) WU2502, enhancing its functional resilience and storage stability.

Understanding the financial hardships faced by TB and HIV patients during the COVID-19 pandemic: A mixed-method study in Bandung and Yogyakarta, Indonesia.

The COVID-19 pandemic had significant widespread financial impacts, resulting in decreased household income, increased unemployment, and disrupted health services. Despite the higher prevalence of infections of tuberculosis (TB) and human immunodeficiency virus (HIV) in poorer populations, research on the financial challenges faced by these populations during the pandemic is still limited. Indonesia recorded the highest COVID-19 cases in Southeast Asia (6,815,156) while contending with the dual burden of HIV and TB.

Kin-Directed Altruism and Male Androphilia in Thailand: Investigating the Roles of Femininity and Neuroticism.

The kin selection hypothesis (KSH) proposes that same-sex attracted individuals offset their lowered direct reproduction via kin-directed altruism that increases close genetic relatives' reproduction, thereby enhancing inclusive fitness. Retrospective research found that childhood concerns for kin's well-being are elevated among birth-assigned males who are androphilic (i.e.

Ultrasound-assisted extraction of biosurfactants from water hyacinth for enhanced soil washing of diesel-contaminated soils: performance evaluation and phytotoxicity assessment.

Soil washing with surfactants is a promising technique for remediating petroleum hydrocarbon-contaminated soils. This study evaluates a biosurfactant extracted from Eichhornia crassipes (water hyacinth), an abundant aquatic weed in Thailand, using ultrasound-assisted extraction for diesel-contaminated soil remediation. The biosurfactant extract (Extract WH) was characterized for its surface tension reduction, critical micelle concentration (CMC), emulsification capacity with diesel, and phytotoxicity.