The Effect of Treatment With Hyaluronic Acid Dermal Fillers on Skin Changes and Quality of Life in Oncology Patients.

Background: Patients treated with cancer therapies often experience changes in physical appearance, body image perception, and self-esteem, which influence their quality of life (QoL).

Aims: To assess the effect of treatment with hyaluronic acid (HA) dermal fillers on QoL, safety, and perceived skin changes of oncology patients.

Methods: A single-center prospective study conducted between 2021 and 2023 among female oncology patients aged 30-70 years receiving active cancer treatment.

Reduction in Dressing Change Burden in Patients With Epidermolysis Bullosa-Impact of Oleogel-S10.

Epidermolysis bullosa (EB) is a severe genetic disorder marked by skin fragility and blistering from minimal trauma. Management relies on frequent and painful dressing changes. The EASE study (NCT03068780), the largest to date in EB, previously demonstrated accelerated wound healing and reduced wound burden for Oleogel-S10 (birch triterpenes) versus control gel.

infection presenting as pseudo-appendicitis in children: identifying predictors for early diagnosis.

Aims: To characterize enteritis presenting as pseudo-appendicitis and identify distinguishing predicting factors.

Methods: This retrospective multicentre study included all children <18 years with confirmed infection, hospitalized from 2014 to 2023 for presumed appendicitis (pseudo-appendicitis group). Each case was matched with 2 controls with confirmed appendicitis.

Real-world evidence of tezepelumab for severe asthma: a retrospective multicentre cohort.

Background: Tezepelumab, a monoclonal antibody targeting thymic stromal lymphopoietin, has demonstrated efficacy for severe asthma in clinical trials, but real-world evidence remains limited. We aimed to evaluate the characteristics and outcomes of patients initiating tezepelumab in a real-world setting.

Methods: We conducted a retrospective, multicentre cohort study across four tertiary care centres to evaluate the real-world effectiveness of tezepelumab in patients with severe asthma.

Posthumous sperm retrieval in the context of armed conflict.

Study Question: What are the clinical and logistical predictors of sperm viability in posthumous sperm retrieval (PHSR), and how do post-mortem interval (PMI), body refrigeration, and mechanism of death affect outcomes?

Summary Answer: Shorter PMI and body refrigeration significantly enhance post-mortem sperm viability, with the mechanism of death modulating viability patterns in a time-dependent manner.

What Is Known Already: PHSR has gained increasing prominence in reproductive medicine, yet technical aspects remain under-researched. Key questions regarding optimal timing, storage conditions, and cause of death effects on sperm quality lack systematic investigation.

Early Reoperations After Gastrectomy: Impact on Morbidity, Mortality, and Long-Term Oncologic Outcomes.

Background: Gastrectomy is central to the curative treatment of gastric cancer but carries substantial postoperative risks. Early reoperations represent severe complications, yet their impact on long-term oncologic outcomes remains unclear. Understanding this relationship is crucial for optimizing cancer care and patient counseling.

Real-Life Management of Elevated Troponin Level in Patients Treated with Immune Checkpoint Inhibitors.

Background: Immune checkpoint inhibitors (ICIs) have revolutionized the clinical outcomes of cancer. Nevertheless, their use may lead to myocardial injury. The 2022 European Society of Cardiology cardio-oncology guidelines recommend routine follow-up of troponin level; however, current guidelines do not provide specific protocols for managing elevated troponin levels during ICI therapy.

Long-term Hyperbaric Oxygen Treatment Enhances Nerve Regeneration and Remyelination in a Rat Sciatic Nerve Graft Model.

Background: Peripheral nerve injuries often lead to inconsistent outcomes due to the complexity of nerve regeneration. Hyperbaric oxygen therapy (HBOT) has been proposed to enhance regeneration by improving oxygenation, promoting angiogenesis, and facilitating cellular repair processes. This study evaluated the effects of long-term HBOT on axonal regeneration, remyelination, and functional recovery in a rat model of sciatic nerve injury repaired with autologous nerve grafts.

MPO-anchored ENO1 mediates neutrophil extracellular trap DNA for enhancing Treg differentiation via IFITM2 during sepsis.

Sepsis is a life-threatening disease caused by a dysfunctional host response to infection. During sepsis, inflammation-related immunosuppression is the critical factor causing secondary infection and multiple organ dysfunction syndrome. The regulatory mechanisms underlying regulatory T-cell (Treg) differentiation and function, which significantly contribute to septic immunosuppression, require further clarification.

Gestational Diabetes Mellitus and Its Association with Newborn Thyroid Screening: A Population-Based Study.

Objective: Gestational diabetes mellitus (GDM) affects maternal-fetal metabolism, but its impact on neonatal thyroid function remains unclear. This study aimed to evaluate the association between maternal GDM and total thyroxine (TT4) levels in newborn screening (NBS) and to identify contributing maternal and neonatal factors.

Methods: This observational cohort study linked national NBS thyroid data with hospital medical records.

Mildly elevated left ventricular outflow tract gradients are associated with increased short-term mortality in inpatients without septal hypertrophy.

Background: Left ventricular outflow tract (LVOT) obstruction is influenced by anatomical and physiological factors. While extensively studied in hypertrophic cardiomyopathy (HCM), the significance of elevated LVOT gradients (LVOTG) in patients without septal hypertrophy remains poorly understood, particularly in the inpatient setting.

Methods: We conducted a retrospective observational study, analyzing a cohort of 27,478 inpatients without septal hypertrophy.

Motor planning stage of gait initiation: effects of aging, Parkinson's disease, and associations with cognitive function.

The response to a request to walk involves a motor planning phase followed by an execution phase. The initial phase of gait initiation, specifically the time to anticipatory postural adjustment (APA), can be viewed as a form of reaction time. However, it is not clear how to characterize the cognitive processes involved in this stage.

Obstructive Sleep Apnea in Women: Associations with Reproductive Aging and Screening Challenges.

Topic Importance: Obstructive sleep apnea (OSA) is a common, chronic sleep disorder affecting up to 49% of men and 23% of women, yet it remains highly underdiagnosed. Sex-specific prevalence and OSA phenotype suggests that affected women are comparatively more likely to experience certain symptoms, such as insomnia and mood disturbances, and less likely to have loud snoring and observed apneas. Sex differences in symptom presentation may contribute to OSA underdiagnosis in women, as traditional diagnostic criteria and clinical assessments often prioritize symptoms more common in men.

Salvage of Infected Cardiac Implantable Electronic Device and Pregnancy Preservation Using CITA-MIS.

Background: Managing pocket infections in cardiac implantable electronic devices (CIEDs) during early pregnancy presents significant clinical challenges, as current guidelines mandate complete system extraction. However, extraction carries high maternal-fetal risks, including surgical complications, radiation exposure, and teratogenic effects of systemic antibiotics.

Case Summary: A 29-year-old woman, 5-week pregnant, was referred for a CIED pocket infection with an extruding implantable cardioverter-defibrillator implanted 9 years earlier for idiopathic ventricular fibrillation.

Statin Treatment for Reducing Mortality Risk in Individuals over 75 Years of Age: A Large-Scale Retrospective Analysis.

: Despite the worldwide increase in life expectancy, individuals aged 75 years and older with an unknown history of cardiovascular disease often receive suboptimal statin treatment for primary prevention, reflecting uncertainties regarding statin efficacy and safety in this aging group. We aimed to assess the impact of statin treatment on all-cause mortality among individuals aged 75 years and older without prior cardiovascular diagnoses. : This retrospective study utilized real-world data from a large cohort of individuals aged 75 years and older who were treated as outpatients in or were admitted to the Tel Aviv Sourasky Medical Center.

Does a Dual-Mobility Cup Offer Better Stability than Conventional Bearings in Hip Arthroplasty Following Femoral Neck Fracture?

Instability following total hip arthroplasty (THA) remains a challenging complication. Dual-mobility (DM) hip components are aimed at improving joint stability by increasing the head-neck ratio and jump distance. However, data regarding the efficacy of these implants in the trauma setting are scarce.

Comparative Effects of THC and CBD on Chemotherapy-Induced Peripheral Neuropathy: Insights from a Large Real-World Self-Reported Dataset.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting adverse effect of various chemotherapeutic agents. Previous work demonstrated that cannabis alleviates symptoms of oxaliplatin-induced CIPN. To evaluate the effects of cannabis components, cannabidiol (CBD) and tetrahydrocannabinol (THC), on CIPN-related symptoms.

Impact of Large Ventral Hernia Repair on Postoperative Renal Function.

Introduction: Large hernia repairs, particularly those involving abdominal wall reconstruction (AWR), can elevate intra-abdominal pressure (IAP) due to the reintegration of herniated contents into the abdominal cavity, potentially contributing to renal injury. Despite the theoretical risk, the long-term impact of AWR-induced IAP elevation on renal function remains insufficiently studied. This study aims to evaluate the incidence of acute kidney injury (AKI) and chronic kidney disease (CKD) following AWR and to identify key factors associated with postoperative renal impairment.

Next-generation morphology, a novel multilayer morphometric digital analysis, reveals both the basic topology and new trends of myelodysplasia of peripheral blood specimens.

Traditional microscopy compromises between resolution and field of view, limiting its diagnostic sensitivity. We present here next-generation morphology (NGM), a novel five-layer analytical approach leveraging a physical solution that enables high-resolution, large-field digital imaging, data mining and analysis of blood specimens. To test NGM performance, peripheral blood smears (PBS) from 37 myelodysplastic syndrome (MDS) patients and 30 age-matched controls were analysed.

Gastrointestinal side effects of incretin-based obesity management medications: insights from healthcare professionals and patients' experiences.

Background: Gastrointestinal (GI) symptoms are the most frequently reported adverse events of incretin-based Obesity Management Medications (OMMs). There is a lack of comprehensive knowledge and experience regarding the management of GI side effects in patients treated with incretin-based OMMs, highlighting the need to develop practical recommendations. This study aims to gain an in-depth understanding of the perceptions and experiences of patients and healthcare professionals (HCPs) regarding the GI side effects associated with incretin-based OMMs treatment, focusing on the unique perspectives of these two populations.

International, Multispecialty Expert Consensus on Nomenclature for Facial Paralysis.

Variable terminology is used in the literature to describe facial synkinesis and hypertonicity following incomplete recovery from facial paralysis and its associated medical and surgical treatments. Establish a nomenclature consensus for this condition among a group of facial nerve experts. Consensus study.