Machine learning for myocarditis diagnosis using cardiovascular magnetic resonance: a systematic review, diagnostic test accuracy meta-analysis, and comparison with human physicians.

Myocarditis is an inflammation of heart tissue. Cardiovascular magnetic resonance imaging (CMR) has emerged as an important non-invasive imaging tool for diagnosing myocarditis, however, interpretation remains a challenge for novice physicians. Advancements in machine learning (ML) models have further improved diagnostic accuracy, demonstrating good performance.

Optimizing Robotic Spleen-Preserving Distal Pancreatectomy: Strategies and Innovations to Enhance Safety and Efficacy.

Background: Spleen-preserving distal pancreatectomy by robotic surgery is a safe and feasible surgical technique. Currently, spleen-preserving distal pancreatectomy represents an alternative to the classical distal pancreatectomy with splenectomy, in the case of benign and low-grade malignant diseases of the body or pancreas tail. The reasons for preserving the spleen are based on the reduction of postoperative complications, such as post-splenectomy infections, subphrenic abscess, portal thrombosis, pulmonary hypertension, thrombocytosis, and thromboembolism.

Copeptin in the diagnosis and management of renal tubular disorders.

Copeptin, a stable glycopeptide derived from the precursor of arginine vasopressin (AVP), has emerged as a valuable surrogate biomarker for AVP due to its stability and ease of measurement. This narrative review explores the physiological role of copeptin, its utility as a diagnostic and prognostic biomarker in different kidney diseases, and its clinical relevance in renal tubular disorders. The clinical application of copeptin as a diagnostic biomarker is best established in the differential diagnosis of polyuria-polydipsia syndrome (PPS), distinguishing nephrogenic diabetes insipidus (NDI) from central diabetes insipidus (CDI) and primary polydipsia (PP).

"Characterization of visual function parameters in relation to macular pigment optical density in a pediatric population".

Purpose: To analyze the relationship between various visual function parameters (refractive status, visual acuity and contrast sensitivity) and macular pigment optical density (MPOD) values, as well as dietary intake of lutein and zeaxanthin in a pediatric population.

Methods: Thirty-six healthy White pediatric patients participated in this cross-sectional study conducted at the Optometry Clinic (Faculty of Pharmacy, Seville, Spain). MPOD values were measured using the MPSII (Macular Pigment Screener II).

Cu(II)-Based Pyridyl Bridging Coordination Polymer and Its Fe Composite: Structure, Sensing, Schottky Device, and Hydrogen Evolution Reaction.

[Cu(3-bph)(PABA)(HO)] () (3-bph = ,'-bis(3-pyridylmethylene)hydrazine and PABA = -amino benzoate) is a pyridyl-N bridging Cu coordination polymer, and PABA acts as a carboxylate-O donor forming a square pyramidal CuNO motif following a zigzag one-dimensional (1D) lattice. The shows weak antiferromagnetic coupling ( = -0.196(1) cm), and emission appears at 352 nm (λ = 293 nm), which is selectively quenched by Fe via the FRET mechanism.

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial.

Introduction: Amivantamab plus lazertinib significantly improved progression-free and overall survival versus osimertinib in patients with previously untreated, EGFR-mutant advanced NSCLC. EGFR-targeted therapies are associated with dermatologic adverse events (AEs), which can affect quality of life (QoL). COCOON was conducted to assess prophylactic management and improve treatment experience.

Unmasking Cancer Risk in Heritable PAH: The Hidden Role of BMPR2 in Epithelial Tumorigenesis.

Background: BMPR2 mutations cause heritable pulmonary arterial hypertension (PAH) and may also influence epithelial carcinogenesis.

Case Summary: We report 3 women with BMPR2-related PAH who developed early onset epithelial cancers: 2 breast cancers (34 and 54 years of age) and 1 colorectal cancer (47 years of age). All were on advanced PAH therapy at diagnosis.

Plasma small extracellular vesicles: Markers and mediators of atrial scar, in patients with atrial fibrillation.

Background: High % of low-voltage area (LVA), a surrogate of scar, is associated with atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). Noninvasive biomarkers of LVA are a medical need for PVI decision.

Objective: We aimed to identify the proteome profile of plasma extracellular vesicles (EVs) associated with high % LVA, their cellular origin, and their regulation by hyperglycemia.

Patterns of Caffeine Use in Adolescents and Their Association with Sleep Quality: A Latent Class Analysis.

Background: Although there is substantial evidence of the negative impact of caffeine use on sleep quality, few studies focus specifically on adolescents' patterns of use. This study aimed to identify patterns of caffeine use among adolescents and analyze their association with sleep quality.

Method: A cross-sectional study was conducted in southern Sweden including 1,404 adolescents aged 15-17 (56.

Targeting histone acetylation to enhance somatic embryogenesis in Quercus suber L.

Somatic embryogenesis (SE) is an in vitro mass propagation system widely employed in plant breeding programs. However, its efficiency in many forest species remains limited due to their recalcitrance. SE relies on the induction of somatic cell reprogramming into embryogenic pathways, a process influenced by transcriptomic changes regulated, among other factors, by epigenetic modifications such as DNA methylation, histone methylation, and histone acetylation.

Emphysema at Baseline Low-Dose CT Lung Cancer Screening Predicts Death from Chronic Obstructive Pulmonary Disease and Cardiovascular Disease Up to 25 Years Later.

Background The prognostic value of baseline visual emphysema scoring at low-dose CT (LDCT) in lung cancer screening cohorts is unknown. Purpose To determine whether a single visual emphysema score at LDCT is predictive of 25-year mortality from all causes, chronic obstructive pulmonary disease (COPD), and cardiovascular disease (CVD). Materials and Methods In this prospective cohort study, asymptomatic adults aged 40-85 years with a history of smoking underwent baseline LDCT screening for lung cancer between June 2000 and December 2008.

The Role of Human Papillomavirus Genotypes on Anal Squamous Intraepithelial Lesions Among Gay, Bisexual and Other Men Who Have Sex With Men Living With HIV: Beyond HPV-16.

Persistent high-risk human papillomavirus (hHPV) infection, especially HPV-16, plays a central role in the development of high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the performance of co-testing (cytology and hHPV detection) in a real-world cohort of men who have sex with men (MSM) and transgender women (TW) living with HIV. We conducted a prospective study (2017-2023) at a tertiary care center in Spain.

Synergistic Effect of Nitrogen Doping and Textural Design on Metal-Free Carbide-Derived Carbon Electrocatalysts for the ORR.

The oxygen reduction reaction (ORR) is critical to energy conversion technologies and requires efficient catalysts for superior performance. Herein, nitrogen-doped carbide-derived carbon (N-CDC) catalysts are prepared using novel engineered molecular architectures based on polymer-derived ceramic technology. The obtained catalyst materials show a surface N concentration of >5 wt % and a hierarchically porous structure, resulting in a specific surface area of over 2000 m g.

Surface-Driven Electron Localization and Defect Heterogeneity in Ceria.

The exceptional performance of ceria (CeO) in catalysis and energy conversion is fundamentally governed by its defect chemistry, particularly oxygen vacancies. The formation of each oxygen vacancy (V) is assumed to be compensated by two localized electrons on cations (Ce). Here, we show by combining theory with experiment that while this 1 V: 2Ce ratio accounts for the global charge compensation, it does not apply at the local scale, particularly in nanoparticles.

Impact of Serum/Xeno-Free Medium and Cytokine Supplementation on CAR-T Cell Therapy Manufacturing in Stirred Tank Bioreactors.

Chimeric antigen receptor T-cell (CAR-T) therapies have demonstrated clinical efficacy in treating haematological malignancies, resulting in multiple regulatory approvals. However, there is a need for robust manufacturing platforms and the use of GMP-aligned reagents to meet the clinical and commercial demands. This study investigates the impact of serum/xeno-free medium (SXFM) and cytokine supplementation on CAR-T cell production in static and agitated culture systems, using 24-well plate G-Rex vessels and 500 mL stirred tank bioreactors (STRs), respectively.

Overall Survival with Amivantamab-Lazertinib in -Mutated Advanced NSCLC.

Background: Previous results from this phase 3 trial showed that progression-free survival among participants with previously untreated (epidermal growth factor receptor)-mutated advanced non-small-cell lung cancer (NSCLC) was significantly improved with amivantamab-lazertinib as compared with osimertinib. Results of the protocol-specified final overall survival analysis in this trial have not been reported.

Methods: We randomly assigned, in a 2:2:1 ratio, participants with previously untreated -mutated (exon 19 deletion or L858R substitution), locally advanced or metastatic NSCLC to receive amivantamab-lazertinib, osimertinib, or lazertinib.

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?

Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported. While resistance typically arises through mutations in Fks hotspots, emerging evidence suggests a contributing role of changes in membrane sterol composition due to mutations. Here, we present a clinical case of () in which combined mutations in and , but not alone, appear to confer echinocandin resistance.

Measuring the Science of Caring: A Patient-Centred Predictive Model for the Caring Interaction.

Background: The nurse-patient relationship is central to quality nursing care, yet its impact remains difficult to quantify. While existing models assess caring competencies from the perspective of nursing students and professionals, there is a lack of validated instruments incorporating direct patient feedback.

Objective: This study aimed to develop and validate the Nursing Interaction in Caring_Competence Assessment-Patient (NIC_CA-Patient) tool, a patient-centred instrument designed to measure caring interaction in nursing practice and establish a predictive model of its development from the patient's perspective.

EXPRESS: Influence of word Age-of-Acquisition (AoA), vocabulary size, formal-lexical similarity, and semantic richness of words on lexical recognition and production: A study on foreign-word training.

A distinctive feature of the lexicon is its susceptibility to the order in which words are acquired; those learned earlier are accessed and retrieved more quickly than those acquired later-a phenomenon known as the age of acquisition (AoA) effect. This study investigates how vocabulary size (i.e.

Implementation of a Feeding Protocol in Patients With Humidified HIGH Flow Nasal Cannula in a Pediatric Intensive Care Unit Improves Enteral Nutrition: The HIGHPE Study.

Purpose: There is limited evidence to guide the use of enteral nutrition (EN) for children with bronchiolitis who received Humidified high flow nasal cannula (HHFNC) and often kept nil per mouth for aspiration and progression to mechanical ventilation risk.

Methods: This quality improvement project included children with bronchiolitis who were supported by HHFNC in the paediatric intensive care unit (PICU). An algorithm to increase EN use in those participants was created by stakeholders.

Influence of Manufacturing Tolerance and Formula Thickness Type in the Prediction Error of Multifocal Intraocular Lens Power Calculation.

Purpose: To assess differences in intraocular lens (IOL) power calculation prediction error (PE) considering the manufacturing tolerance or exact power (EP) versus labeled power (LP), and to compare accuracy using the Barrett formula with optimized constant versus a thick-lens formula.

Methods: The PE and absolute PE were calculated for a random eye of patients implanted with the multifocal Liberty Q-Flex 640PM IOL (Medicontur Ltd) considering the LP and the EP provided by the manufacturer. The outcomes for the Barrett with optimized constant formula and a thick-lens formula personalized for the surgeon, biometer, and IOL were compared.

Evaluation of Perception of Photic Phenomena Through Diffractive Multifocal Intraocular Lens Designs by Its Virtual Implantation.

Purpose: To analyze the difference in objective and subjective photic phenomena following virtual implantation of three different presbyopia-correcting diffractive intraocular lens (IOL) designs.

Methods: The study was conducted at JENVIS Research Germany. A prospective cross-over and double-masked trial design was used.