The Use of an Intraoral Scanner for the Fabrication of Maxillary Obturator Prosthesis in a Young Adult With Oronasal Fistula: A Case Report.

Cleft lip and palate require complex treatment, often involving early surgery. Postoperative complications, such as palatal fistulas, can impair speech and feeding. While surgical correction is standard, large fistulas may pose challenges due to age, cost, and recurrence risks.

The interplay of health, economy, and politics in MENA region migration patterns: a panel data analysis (2000-2020).

Background: The MENA region experiences a high migration rate. Migration has a profound effect on the demography, health status, labor market and cultural diversity of the region. This study was conducted with the aim of investigating the migration crisis in MENA region.

Wound-Healing Properties of Henna in Pilonidal Sinus Surgery: A Randomized Study.

Background: Wound complications associated with pilonidal sinus (PS) significantly contribute to its high post-operative morbidity. Therefore, speeding up the wound healing process after surgery can help minimize potential complications. This study investigated the effectiveness of extract (LIE) in promoting wound healing following PS surgery, given its known benefits in this area.

Epidemiology and economic burden of end-stage kidney disease by age, gender, and province among Iranian Hajj pilgrims in 2012-22: a retrospective study of 469,581 participants.

Introduction: Annually, over 3.5 million Hajj pilgrims from approximately 180 countries worldwide travel to Mecca for Hajj rituals. End-stage kidney disease (ESKD) is a high-morbidity condition that necessitates high-cost and time-intensive care, the present study aims to investigate the prevalence and economic burden of ESKD among Iranian Hajj pilgrims during the last decade.

Evidence of biological aging through mitochondrial DNA damage and dysregulation of mitophagy-related genes in veterans with delayed sulfur mustard toxicity.

Sulfur mustard (SM) is a potent alkylating agent known to cause long-term health effects, including accelerated aging. This study investigated mitochondrial dysfunction as a key mechanism underlying biological aging in 142 SM-exposed veterans (25 years post-exposure) and 54 matched controls. The SM-exposed veterans were stratified into subgroups (asymptom, mild, and severe) based on clinical criteria and lung function tests.

Emotional and External Eating Behaviors Associated with Fat-Free Mass Loss Following Sleeve Gastrectomy.

Background: Rapid weight loss after metabolic bariatric surgery may lead to excessive fat-free mass (FFM) loss, potentially reducing the procedure's health benefits. This study aimed to investigate the association between eating behaviors and FFM loss as well as total weight loss (TWL) at midterm (about 2-4 years) following sleeve gastrectomy (SG).

Methods: This cross-sectional study included 146 adults assessed approximately 2-4 years post-SG.

Cannabidiol Extracted from L. Plant Shows Neuroprotective Impacts Against 6-HODA-Induced Neurotoxicity via Signal Transduction Pathway.

Background: As a prevalent neurodegenerative illness, Parkinson's disease (PD) is associated with serious disability and reduced quality of patients' lives. Therefore, finding new adjuvant treatment approaches that can improve patients' quality of life is crucial.

Objectives: This study evaluated the impacts of cannabidiol (CBD) on the PC12 cell line and elucidated its mechanism of action, emphasizing the antioxidant pathway.

Automated multiple sclerosis lesion segmentation from 3D-FLAIR MRI using R2AUNet: A deep learning approach with recurrent residual and attention mechanisms.

Background: Multiple sclerosis (MS) is a progressive neurological disorder marked by demyelinating lesions in the central nervous system. While MRI is essential for MS diagnosis, manual lesion segmentation is time-consuming and prone to variability. This study develops an automated deep learning (DL) approach for MS lesion segmentation using 3D-FLAIR MRI.

Evaluating the interrelationship of mindfulness, sexual relational concern, and health related behaviors on women's life satisfaction through path analysis.

Background: Life satisfaction, a fundamental dimension of subjective well-being, exerts a positive influence on both physical and mental health outcomes. The present research aims to explicate the intricate interplay among mindfulness, sexual relational concerns, and health-related behaviors concerning women's life satisfaction, employing a path analysis framework.

Methods: The current cross-sectional study, conducted between July and August 2024, involved a cohort of 250 Iranian women aged 18 to 45 years.

Diagnostic Performance of Artificial Intelligence in Detecting and Distinguishing Pancreatic Ductal Adenocarcinoma via Computed Tomography: A Systematic Review and Meta-Analysis.

We conducted a systematic review and meta-analysis in diagnostic performance of studies that tried to use artificial intelligence (AI) algorithms in detecting pancreatic ductal adenocarcinoma (PDAC) and distinguishing them from other types of pancreatic lesions. We systematically searched for studies on pancreatic lesions and AI from January 2014 to May 2024. Data were extracted and a meta-analysis was performed using contingency tables and a random-effects model to calculate pooled sensitivity and specificity.

Marker-trait association analysis for root and shoot traits at the seedling stage of wild barley ( subsp. ) under water stress and normal conditions.

Wild barley ( subsp), the progenitor of cultivated barley, is an invaluable genetic resource for enhancing crop resilience, particularly in drought-prone regions. Its natural adaptation to water-limited environments makes it an ideal candidate for studying mechanisms of drought tolerance. This study aims to investigate the genetic basis of drought tolerance by examining the correlation between molecular markers and root traits across a diverse collection of wild barley genotypes.

Enhancing EEG-based sleep staging efficiency with minimal channels through adversarial domain adaptation and active deep learning.

. Accurate sleep-stage classification is crucial for advancing both sleep research and healthcare applications. Traditional deep learning (DL) and domain adaptation (DA) methods often struggle due to the limited availability of labeled data in the target domain and their inability to capture the subtle distinctions between sleep-stage classes, which hampers classification accuracy.

NO: a key player in microbiome dynamics and cancer pathogenesis.

The human microbiome refers to the genomic content of microorganisms inhabiting the human body, including the lungs, oral cavity, intestinal tract, esophagus, and other areas. The human oral microbiota is a diverse and complex ecosystem that includes bacteria, microeukaryotes, archaea, and viruses. These communities have a highly structured biogeography resulting from the various microenvironments in the oral cavity, shaping local metabolic exchange.

Exploring Genetic Diversity in a Core Collection of Aegilops tauschii Coss. Populations Using iPBS and SCoT Markers.

Evaluation of population structure and genetic diversity is one of the primary steps in any plant breeding program. Wheat (Triticum aestivum L.) is a key staple cereal crop that plays an important role in global food security.

Evaluation of the Determinants of Dental Implant.

Considering the increasing use of dental implants, their failure is a serious challenge encountered by dentists. An accurate prediction of the rate of failure based on the underlying factors allows patients to accept the risk of failure. This study assessed the failure rate and time of implant treatment in patients referred to a specialized clinic.

Effect of Citrus Aurantium L. on pain and blood pressure in patients undergoing hand reconstructive surgery.

Background And Purpose: Postoperative pain and blood pressure are common patient complaints. This study examined the effects of Citrus Aurantium (CA) on pain and blood pressure in patients undergoing hand reconstructive surgery.

Methods: A double-blind, randomized clinical trial was conducted with 76 patients.

Efficacy of dostarlimab in recurrent or advanced mismatch Repair-Deficient endometrial Cancer as a Single-Agent therapy: A systematic review and Meta-Analysis.

Background: The effectiveness of PD-1 inhibitors for treating endometrial cancer (EC) remains a topic of debate. Guidelines lack consistency regarding the preferred treatments for advanced cases, as well as for patients experiencing metastasis or recurrence. Thus, our goal was to assess the efficacy of Dostarlimab, a PD-1 inhibitor, in EC by incorporating data from clinical trials to create a more comprehensive database.

Biomechanical Characterization of Immature Roots Following Regenerative Endodontic Treatment and MTA Apexification: A Clinical Study.

Introduction: This clinical investigation aims to determine and compare the volume, hardness, and elastic modulus of immature roots following regenerative endodontic treatment (RET) and mineral trioxide aggregate (MTA) apexification.

Methods: A total of six volunteers aged between 9 and 14 years participated in the study, each providing a pair of mandibular or maxillary premolars with normal pulp and periapex planned for extraction due to orthodontic reasons. After full pulpectomy, each pair received either an MTA obturation or RET using blood clot as scaffold, followed by permanent restoration.

Optimized ultrasound-assisted extraction of glycyrrhizic acid from followed by one-pot hydrolysis to and nanoemulsified separation of glycyrrhetinic acid for food applications.

Unlabelled: The superior bioavailability and bioactivity of glycyrrhetinic acid (GT) as a food supplement, has always been a research focus in the food industry. This study aims to extract glycyrrhizic acid (GA) from using ultrasound radiation and then simultaneously hydrolyze to and separate GT using a novel approach involving a nanoemulsion medium. The extraction of GA was optimized using response surface methodology (RSM) to determine the optimal time, liquid-to-solid ratio, and ammonia percentage, resulting in a 9% extraction yield.

Resilience in aid workers in disaster and emergencies: a systematic review and thematic analysis.

Introduction: Resilience is a critical attribute for aid workers operating in disasters and emergencies, as it directly influences their ability to cope with high-stress environments' psychological and physical challenges. Understanding the components of resilience can inform targeted interventions and training programs, ultimately fostering a more robust and adaptable workforce capable of meeting disaster response demands.

Objectives: This study aimed to identify components of resilience in disaster and emergency aid workers by systematic review and thematic analysis.

Cognitive Effect of Levetiracetam in Patients with Alzheimer's Disease or Mild Cognitive Impairment: A Systematic Review.

Background: Various therapeutic interventions have been investigated for cognitive impairment, a common problem in Alzheimer's disease (AD). Levetiracetam (LEV), an antiepileptic drug, has been shown to alleviate cognitive impairment.

Objective: The present systematic review aimed to evaluate the cognitive effects of LEV in patients with AD or mild cognitive impairment (MCI).

Isolated from Ready-To-at Food Products in Tehran: Prevalence and Antimicrobial Resistance.

L. monocytogenes is a significant foodborne pathogen that is associated with a range of clinical illnesses, from self-limited gastroenteritis to invasive infection, which can lead to hospitalization of immunocompromised individuals. In the present study, the incidence of L.

Glycine betaine treatment extends the shelf life and retards cap browning of button mushrooms.

This research examined the impact of exogenous Glycine Betaine (GB) at various concentrations (0, 5, 10, and 15 mM) on cap browning and the overall quality of button mushrooms during a 15-day storage period at 4 °C. The study found that a concentration of 10 mM GB resulted in the least amount of cap browning. Additionally, mushrooms treated with 10 mM GABA showed lower levels of weight loss, electrolyte leakage, and malondialdehyde (MDA) content, while maintaining higher firmness.

Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies.

COVID-19 has globally impacted millions. This study investigates DHEAS (dehydroepiandrosterone sulfate) as a factor for COVID-19 progression, analyzing its relationship with disease status, temporal patterns, age, gender, and comorbidities to improve outcomes. DHEAS was quantified with a competitive chemiluminescent immunoassay.

The association of PTEN/PI3K/Akt pathway gene expression with insulin indices in adipose tissues of non-diabetic female adults: a cross-sectional study.

Insulin resistance (IR) is a complex metabolic condition that serves as a common thread connecting type 2 diabetes (T2DM), metabolic syndrome (MetS), cardiovascular disease (CVD), and even certain cancer outcomes. Understanding and addressing IR is crucial for the prevention and management of these interrelated health challenges. Adipose tissue (AT) is one of the main targets for insulin action, and insulin suppresses lipolysis in this tissue.