eHealth Self-Management Interventions for Patients With Liver Cirrhosis: Scoping Review.

Background: Liver cirrhosis (LC) is a morbid condition associated with frequent hospitalization and high mortality. Effective self-management is essential for patients with LC to monitor fluctuating symptoms and follow complex treatment regimens. However, strategies are often unsustainable and insufficiently tailored to individuals with cognitive impairments.

Biological Age Estimation From the Age Gap Using Deep Learning Integrating Morbidity and Mortality: Model Development and Validation Study.

Background: Biological age (BA) is increasingly recognized as a valuable alternative to chronological age (CA) for assessing an individual's health and aging status. However, existing models are based on limited clinical parameters and have not thoroughly integrated morbidity and mortality data.

Objective: This study aimed to develop and validate a novel transformer-based model, referred to as the BA - CA gap model, for BA estimation that incorporates morbidity and mortality information to improve predictive accuracy and enhance clinical use in the early identification of the risk of age-related diseases.

Photodynamic inactivation of pathogenic bacteria using chlorogenic acid and UV-A (365 nm) irradiation.

This study explored the antimicrobial efficacy and mechanism of a combined treatment using chlorogenic acid (CGA) and UV-A (365 nm) irradiation against four major foodborne pathogens-Escherichia coli O157:H7, Salmonella Typhimurium, Listeria monocytogenes, and Staphylococcus aureus-in both buffer and acidic beverage matrices. The CGA + UVA treatment showed strong bactericidal effects, particularly in green plum juice, where complete inactivation of L. monocytogenes was achieved (> 8-log reduction).

Threshold-based analysis of eutrophication dynamics in a semi-enclosed bay: The dominant role of dissolved inorganic nitrogen in Masan Bay, South Korea (2010-2015).

Eutrophication in semi-enclosed coastal systems remains a persistent concern due to restricted water circulation and continuous nutrient inputs. To better characterize nutrient-driven water quality degradation, we applied a threshold-based analysis to seasonal monitoring data collected from Masan Bay, South Korea, between 2010 and 2015. Eutrophication status was assessed using a composite Eutrophication Index (EI) integrating chemical oxygen demand (COD), dissolved inorganic nitrogen (DIN), and dissolved inorganic phosphorus (DIP).

Chia seed mucilage biosorbent synergism with hydrophobic iron (III)-natural phenolic nanoparticles for dispersive solid-phase extraction of tetracycline residues in milk and honey samples before HPLC analysis.

This study utilized the synergistic effectiveness of chia seed mucilage and iron (III)-natural phenolic nanoparticles as biosorbents for the first time in the dispersive solid-phase extraction (DSPE) of oxytetracycline, tetracycline, chlortetracycline, and doxycycline followed by HPLC-UV quantification. An in-situ iron (III)-natural phenolic solid adsorbent was created using natural phenolics found in the copper pod tree bark. An ultrasonic-assisted extraction was performed to enhance the extraction efficiency of DSPE-based biosorbents.

Silica-coating-mediated depassivation of nanosized zero-valent iron by Fe(II) at circumneutral pH.

Surface passivation of materials based on nanosized zero-valent iron (nZVI) limits the reductive reactivities of such materials at near-neutral pH. To overcome this, a reactivation strategy was developed involving adding aqueous Fe(II) to a silica-coated nZVI (nZVI@SiO) system, which markedly increased the nitrobenzene reduction efficiency. The Fe(0) core in nZVI@SiO acted as the main reductant, and Fe(II) sorbed to the SiO coating acted as a reactivating agent that facilitated electron conduction mainly through the 'chemi-conductor' mechanism.

Construction of Co/CoN nanoparticles embedded S and N-doped carbon from a cobalt-complex as a bifunctional Electrocatalyst for ORR and OER.

Advancing impactful, economical, and durable Co-based bifunctional electrocatalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) has been crucial in developing sustainable energy technologies. In this work, Co and CoN nanoparticles (NPs)-incorporated S, N-doped carbon catalysts (Co/CoN/SNC) were prepared via direct pyrolysis of the CoDATT complex, exhibiting high bifunctional electrocatalytic performance for ORR and OER. The complex precursor, CoDATT, was synthesized for the first time using diaminoterthiophene (DATT) and CoCl.

A pilot study of evaluation of a deep-learning-based homologous recombination deficiency assay in korean patients with ovarian high-grade serous carcinoma: Diagnostic performance and clinical implications.

Background: Homologous recombination deficiency (HRD)-related genetic mutations in ovarian high-grade serous carcinoma (HGSC) are known to be ethnic specific. Here, we assessed the diagnostic performance of HRD and its clinical implication in Korean HGSC patients using the SOPHiA DDM HRD Solution.

Methods: Sixty-three ovarian cancer (OC) patients were enrolled, including 53 with HGSC and 10 with other subtypes.

Amphiphilic Poly(SBMA--EGDEA) Coatings for Marine Antifouling: Insights into Design Criteria for Hydrophobic Monomers.

Marine biofouling poses significant economic and environmental challenges, highlighting the need for effective antifouling coatings. We report amphiphilic poly(SBMA--EGDEA) copolymer coatings that resist both marine diatom adhesion and sediment adsorption. The coatings were synthesized via surface-initiated ATRP and RAFT polymerization using hydrophilic sulfobetaine methacrylate (SBMA) and hydrophobic ethylene glycol dicyclopentenyl ether acrylate (EGDEA).

Distribution and Risk Factors of Scrub Typhus in South Korea, From 2013 to 2019: Bayesian Spatiotemporal Analysis.

Background: Scrub typhus (ST), also known as tsutsugamushi disease, is a common febrile vector-borne illness in South Korea, transmitted by trombiculid mites infected with Orientia tsutsugamushi, with rodents serving as the main hosts. Although vector-borne diseases like ST require both a One Health approach and a spatiotemporal perspective to fully understand their complex dynamics, previous studies have often lacked integrated analyses that simultaneously address disease dynamics, vectors, and environmental shifts.

Objective: We aimed to explore spatiotemporal trends, high-risk areas, and risk factors of ST by simultaneously incorporating host and environmental information.

Anatomical Risk Factors for Portal Vein Complications Following Right Hepatectomy in Living Donors.

Objective: To determine the incidence, clinical outcomes, and anatomical risk factors of portal vein (PV)-related complications after right lobe donor hepatectomy (RLDH).

Summary Background Data: With the increase in living donor liver transplantation, large-scale studies on donor morbidity have been conducted to ensure donor safety. However, reports evaluating PV-related complications following right hepatectomy in living donors are lacking.

Bacterial infections and antimicrobial resistance patterns: a comprehensive analysis of health dynamics across regions in Pakistan (2013-2023).

Antimicrobial resistance (AMR) is a significant public health concern globally, and Pakistan is no exception. The misuse and overuse of antibiotics, inadequate regulation of their sale, and a lack of awareness contribute to the rising levels of AMR in the country. study presents a detailed analysis of blood and urine samples collected in Pakistan over various periods, focusing on pathogen prevalence, gender distribution, and age-wise patterns.

Neural Quantum Embedding via Deterministic Quantum Computation with One Qubit.

Quantum computing is expected to provide an exponential speedup in machine learning. However, optimizing the data loading process, commonly referred to as "quantum data embedding," to maximize classification performance remains a critical challenge. In this Letter, we propose a neural quantum embedding (NQE) technique based on deterministic quantum computation with one qubit (DQC1).

Strong Magnon-Phonon Coupling in the Kagome Antiferromagnets.

Magnon-phonon hybridization in ordered materials is a crucial phenomenon with significant implications for spintronics, magnonics, and quantum materials research. We present direct experimental evidence and theoretical insights into magnon-phonon coupling in Mn_{3}Ge, a kagome antiferromagnet with noncollinear spin order. Using inelastic x-ray scattering and ab initio modeling, we uncover strong hybridization between planar spin fluctuations and transverse optical phonons, resulting in a large hybridization gap of ∼2  meV.

Positive Neutrino Masses with DESI DR2 via Matter Conversion to Dark Energy.

The Dark Energy Spectroscopic Instrument (DESI) is a massively parallel spectroscopic survey on the Mayall telescope at Kitt Peak, which has released measurements of baryon acoustic oscillations determined from over 14 million extragalactic targets. We combine DESI Data Release 2 with CMB datasets to search for evidence of matter conversion to dark energy (DE), focusing on a scenario mediated by stellar collapse to cosmologically coupled black holes (CCBHs). In this physical model, which has the same number of free parameters as ΛCDM, DE production is determined by the cosmic star formation rate density (SFRD), allowing for distinct early- and late-time cosmologies.

Potential role of miR-29b from mesenchymal stromal cell-derived extracellular vesicles in leukemic cell progression.

Crosstalk between leukemic cells and their surrounding mesenchymal stromal cells (MSCs) in the bone marrow microenvironment is crucial for the pathogenesis of myelodysplastic syndromes (MDS) and is mediated by extracellular vesicles (EVs). The EV-specific miRNAs derived from MDS-MSCs remain poorly explored. EVs isolated from HS-5, an immortalized stromal cell line, promoted the proliferation and 5-azacytidine (AZA) resistance of SKM-1 cells.

Bioadaptive liquid-infused multifunctional fibers for long-term neural recording via BDNF stabilization and enhanced neural interaction.

Brain-computer interfaces (BCIs) enable direct communication between the brain and computers. However, their long-term functionality remains limited due to signal degradation caused by acute insertion trauma, chronic foreign body reaction (FBR), and biofouling at the device-tissue interface. To address these challenges, we introduce a multifunctional surface modification strategy called targeting-specific interaction and blocking nonspecific adhesion (TAB) coating for flexible fiber, achieving a synergistic integration of mechanical compliance and biochemical stability.

Reconciling a Kinetic Model for Dimerization of the EGFR Using Single-Molecule Tracking in Living Cells.

Epidermal growth factor receptor (EGFR) dimerization plays a pivotal role in cellular signaling, influencing proliferation and disease progression, particularly in cancer. Despite extensive studies, the quantitative relationship between EGFR expression levels and dimerization efficiency remains incompletely understood. In this study, we investigated EGFR dimerization kinetics using ensemble-level biochemical assays and single-molecule tracking (SMT) in living cells.

Evidence for Similar Collectivity of High Transverse-Momentum Particles in p-Pb and Pb-Pb Collisions.

Charged hadron elliptic anisotropies (v_{2}) are presented over a wide transverse momentum (p_{T}) range for proton-lead (pPb) and lead-lead (PbPb) collisions at nucleon-nucleon center-of-mass energies of 8.16 and 5.02 TeV, respectively.

Observation of Three Resonant Structures in the Cross Section of e^{+}e^{-}→π^{+}π^{-}h_{c}.

Using e^{+}e^{-} collision data collected with the BESIII detector operating at the Beijing electron positron collider, the cross section of e^{+}e^{-}→π^{+}π^{-}h_{c} is measured at 59 points with center-of-mass energy sqrt[s] ranging from 4.009 to 4.950 GeV with a total integrated luminosity of 22.

Onset of Constituent Quark Number Scaling in Heavy-Ion Collisions at RHIC.

Partonic collectivity is one of the necessary signatures for the formation of quark-gluon plasma in high-energy nuclear collisions. Number of constituent quarks (NCQ) scaling has been observed for hadron elliptic flow v_{2} in top energy nuclear collisions at the Relativistic Heavy Ion Collider and the LHC, and this has been theoretically suggested as strong evidence for partonic collectivity. In this Letter, a systematic analysis of v_{2} of π^{±}, K^{±}, K_{S}^{0}, p, and Λ in Au+Au collisions at sqrt[s_{NN}]=3.

Impact of depression, anxiety, and COVID-19 diagnosis on social isolation trajectories during the pandemic: A 3-year prospective cohort study.

Background: The coronavirus disease 2019 (COVID-19) pandemic has profoundly affected physical and mental health. Since the onset of the pandemic, the prevalence of depression and anxiety has significantly increased. Quarantine and social distancing, implemented to control the spread of COVID-19, have exacerbated social isolation.

Cardiovascular Evaluations of a Mixed Extract of and Pall. (USCP-GVH-014): A 12 Weeks Clinical Perspective.

and Pall. are traditionally used to manage cardiovascular health. However, clinical evidence evaluating standardized extracts for specific cardiovascular benefits is still evolving.

First Report of in Bats and Ticks Collected from Bat Habitats.

The zoonotic infectious disease, severe fever with thrombocytopenia syndrome (SFTS), caused by the SFTS virus (SFTSV), , was first identified in China in 2009 and reported in the Republic of Korea in 2013. The primary vector is the tick (.) , which is endemic to the Asia-Pacific region and has a wide range of hosts.

Cardiac Biomarkers and Risk Stratification in Liver Transplantation for Acute-on-Chronic Liver Failure: Refining Current Risk Models for Improved Prediction of Post-transplant Mortality.

Background: Cardiovascular complications are the leading cause of mortality following liver transplantation (LT) in patients with acute-on-chronic liver failure (ACLF). However, the extent of cardiac impairment in these patients remains unclear. Current risk models, including the CLIF-C-organ failure (CLIF-C-OF), NACSELD-ACLF, and the novel Sundaram ACLF-LT-mortality (SALT-M) scores primarily focus on blood pressure and the use of cardiovascular drugs, without directly assessing biomarkers of cardiac injury.