Sports for persons with disabilities: A bibliometric analysis of research landscape and future directions.

Research on sports for persons with disabilities (PWDs) has grown significantly in recent years, particularly in parasports, disability sports, and adapted sports. Numerous studies have consistently highlighted the role of sports as a powerful tool for promoting social integration, enhancing psychological well-being, and improving the physical health of PWDs. However, comprehensive reviews on the development and progression of this field remain limited.

1,2,4-Triazole amides: Design, synthesis, characterisation, in vitro and in silico evaluation against blood stage parasites of Plasmodium falciparum.

Malaria, a protozoan parasitic disease caused by Plasmodium species, poses significant health risks in endemic regions and contributes to substantial morbidity and mortality. The intricate lifecycle of the parasite, coupled with the emergence of drug-resistant strains, has severely impacted the effectiveness of current anti-malarial treatments. In response, the present study attempts to demonstrate the blood-stage anti-plasmodial action of 30 triazole derivatives designed based on molecular hybridisation technique, and physicochemical properties.

A review on recent advancements of ChatGPT and datafication in healthcare applications.

Integrating ChatGPT, a large language model (LLM), with datafication strategies presents the capacity to provide reliable and user-friendly healthcare applications. This paper provides a structured and critical review of how ChatGPT, supported by datafication and big data frameworks, shapes areas such as clinical decision support, telemedicine, and personalized healthcare. It examines the cognitive capabilities of ChatGPT in interpreting complex medical language while addressing key ethical concerns, such as algorithmic bias, data privacy, and explainability, that arise in its deployment.

Lithium-Lithium Titanate Composite Anode for Semi-Solid-State Lithium-Sulfur Batteries.

Lithium-sulfur batteries have attracted significant attention recently as sulfur is one of the most abundant elements in the earth's crust, low-cost, has a non-toxic nature, multi-electron transfer property coupled with its remarkable theoretical specific capacity of 1672 mAh g and energy density of 2600 Wh kg. However, lithium-deficient sulfur cathodes associated with lithium metal anodes together to face challenges, such as significant volume expansion during cycling, dendrite formation, and polysulfide shuttling effect from the sulfur cathodes, leading to corrosion, all of which negatively impact the cycle lifespan of the battery. On the other hand, moving away from liquid to solid-state garnet-based solid electrolytes is highly aided for lithium-sulfur batteries because of their high ionic conductivity of 10 S cm stability with lithium metal, lithium-based alloys and moreover in mitigating the polysulfide issues.

An overview of production, characterization, and bioactive potentials of Aspergillus exopolysaccharides.

Exopolysaccharides (EPS) produced by Aspergillus have attracted considerable scientific interest due to their complex structural, chemical, biological, and functional properties. This article summarizes the literature published between 2011 and 2024, during which scientists extensively explored the production, structural characterization, and biological activities of Aspergillus-derived EPS (Asp-EPS). Various factors influence Asp-EPS biosynthesis, including nutrient composition, pH, temperature, and aeration conditions.

Integrated Microbiome Data Analysis Reveals Potential Pneumonia Microbial Biomarkers in ICU Patients: A Machine Learning Approach.

The human microbiome is pivotal in maintaining health and managing diseases. By examining the core microbiome in intensive care units (ICU) patients with pneumonia, we can gain valuable insights into the microbial communities associated with disease conditions. Pneumonia is the second most common infection in ICU settings, and recent research has highlighted the significance of endotracheal aspirate (ETA) microbiota in influencing pneumonia.

Electrochemical synthesis of phosphorylated oxazolines from -allylamides.

A green and efficient electrochemical method for the synthesis of phosphorylated oxazolines has been developed ferrocene-mediated electrochemical cyclization of -allylamides with diarylphosphine oxides. This protocol operates under mild, oxidant-free conditions in an undivided cell setup with constant current. Notably, a wide range of -allylamides were well tolerated, affording the desired products in moderate to very good yields.

Characteristics, source apportionment, and health risk assessment of heavy metal pollution in soil of jiangmen, China.

Heavy metal accumulated in soil pose substantial threats to soil environmental quality and human health. Accurate identification of pollution sources is critical for implementing targeted prevention and control strategies. In this study, 118 surface soil samples were collected from Jiangmen City to examine the concentration, spatial distribution, sources, and health risks of heavy metals in the soil.

Identification of dual inhibitors of ROCK1 and TGFBR1 for overcoming metastasis: an integrated pharmacophore and docking driven CADD strategy.

Unlabelled: Rho-associated coiled-coil kinase 1 (ROCK1) and transforming growth factor-beta receptor 1 (TGFBR1) plays crucial roles in epithelial-mesenchymal transition (EMT), cytoskeleton remodeling, cell adhesion, and tumor metastasis. Targeting both ROCK1 and TGFBR1 simultaneously offers a strategic approach to disrupt these pathways, potentially leading to more effective treatments for cancer metastasis. To identify dual inhibitors, a multifaceted computational approach integrating pharmacophore modeling, molecular docking, and molecular dynamics (MD) simulations was employed.

Computational identification of dual COX-1 and NIK inhibitors from marine microalga Chlorella vulgaris.

The search for safe and effective anti-inflammatory agents remains a critical area of research due to the widespread impact of chronic inflammatory diseases. Natural compounds, particularly those derived from marine sources, present a promising avenue for developing novel therapeutics. In this study, we investigated the potential of Chlorella vulgaris, a unicellular green alga with a rich profile of bioactive compounds, as a source of anti-inflammatory agents.

Toxic traces: First insights into metals and metalloids in dugongs (Dugong dugon) from India.

Metals and metalloid pollution poses significant threats to coastal ecosystem and their inhabitants, particularly dugongs, which rely exclusively on seagrass habitats. Dugongs, one of the most vulnerable herbivores, face declining populations due to habitat loss, unsustainable fishing, and rising pollution. Although earlier studies revealed increasing metal and metalloid accumulation in dugong tissues over time, globally there remains a dearth of information across their distribution range including India.

Identification of pyrazole-acrylonitrile derivatives as potential anticancer agents and mechanistic insights.

Developing highly effective anticancer drugs remains a primary focus for drug designers worldwide. In this investigation, we designed and developed novel pyrazole-acrylonitriles incorporating various N-heterocyclic groups and evaluated their anticancer properties. Comprehensive in vitro profiling included evaluation of cell cytotoxicity, colony formation and cell adhesion in 3D cultures, cell cycle analysis, DNA damage induction, and apoptosis.

A Quadruple Relay Approach Toward Highly Functionalized Furans: Merging Carbene Insertion, Semi-Pinacol Rearrangement, Decarbonylation, and Paal-Knorr Cyclization.

A discovery of the quadruple relay process by merging carbene insertive epoxide ring opening, semipinacol rearrangement, decarbonylation, and Paal-Knorr cyclization reactions to produce highly functionalized furans using chalcone epoxides and diazo compounds has been disclosed for the first time. This unprecedented novel process also produced a variety of α-aryl-β-ketomalonates in high yields with very good functional group tolerance. Interestingly, this novel domino process creates three consecutive bonds (two C-C bonds and one C-O bond) during the furan ring construction.

Harnessing plasmonic charge dynamics for next-generation battery chemistries.

Plasmonic nanostructures have gained prominence as versatile materials capable of enhancing light-matter interactions at the nanoscale, providing pathways to accelerate charge transfer, modulate interfacial reactions, and overcome intrinsic kinetic limitations in energy storage systems. This review critically examines the integration of localized surface plasmon resonances (LSPRs) into plasmon-assisted batteries and hybrid supercapacitors. We discuss key material design strategies, emphasizing how nanoscale architecture and compositional tailoring from traditional noble metals to advanced heterostructures, enable fine-tuning of optical and electronic properties to optimize electrochemical responses.

Cationic Lipid Stearylamine Displays Fast-Acting Antimalarial Action Against In Vitro Blood Stages of Chloroquine Susceptible and Resistant Plasmodium falciparum Strains.

The growing resistance of malarial parasites to antiplasmodial drugs has necessitated the development of a new class of potent molecules to reduce the global malaria burden. This study evaluated the antimalarial efficacy of the cationic lipid stearylamine (SA) on blood-stage Plasmodium falciparum using SYBR-Green I assay. We conducted in vitro studies to assess the timing of SA action in drug-sensitive (Pf3D7) and chloroquine-resistant (PfINDO) strains of P.

Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.

Irrational antibiotic use contributes to the development of antibiotic resistance in bacteria, which is a major cause of healthcare-associated infections globally. Molecular research has shown that multiple resistance frequently develops from the uptake of pre-existing resistance genes, which are subsequently intensified under selective pressures. Resistant genes spread and are acquired through mobile genetic elements which are essential for facilitating horizontal gene transfer.

Temporal transcriptome and WGCNA analysis unveils divergent drought response strategies in wild and cultivated varieties.

Drought, exacerbated by climate change, threatens global food security, particularly impacting crop products, including tomatoes, which are economically essential but drought sensitive. This study explores drought responses in the wild-type (WT), known for drought tolerance, and cultivated (CT), through RNA-Seq analysis at three drought intervals (2 Weeks +5D, +8D, and +11D). Across these points, WT and CT showed 716 and 1459 differentially expressed genes (DEGs), respectively.

Effect of Plant-Based Proteins on Recovery from Resistance Exercise-Induced Muscle Damage in Healthy Young Adults-A Systematic Review.

Background: Plant-based protein supplementation in supporting muscle recovery following resistance exercise remains an area of growing interest, particularly among vegan athletes, as a potential alternative to animal-based proteins. This systematic review aimed to evaluate the effectiveness of plant-based proteins on recovery from resistance exercise-induced muscle damage in healthy young adults.

Methods: A systematic and comprehensive search was administered in eight databases up to 1 May 2025, identifying 1407 articles.

Therapeutic Potential of ECP-SA1: A Novel Lytic Phage against Multidrug-Resistant Escherichia coli.

Bacteriophages are increasingly explored as potential alternatives to antibiotics due to their specificity and ability to combat antibiotic-resistant bacteria. In this work, we describe the isolation and characterisation of a new bacteriophage, designated Phage-ECP-SA1, targeting Escherichia coli, a pathogen responsible for various infections in humans and animals. Phage-ECP-SA1 was isolated from sewage samples using a host-specific enrichment method.

Multifaceted Evaluation of Nano Encapsulated Polymeric Scopoletin Against HT-29 Colon Cancer Cells.

In the sphere of medical research, nanoencapsulated polymeric drugs in biological circumstances are an intriguing issue for therapeutical diagnosis. The nanoprecipitation approach was employed in this study to synthesis the nanoencapsulated polymeric scopoletin (NEP-Sc) and tested its effect against the HT-29 cell line (human colorectal adenocarcinoma cells). Further, the synthesized NEP-Sc was then characterized by ultra-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) with energy dispersive X-ray analysis (EDAX), and dynamic light scattering (DLS) analysis.

Evaluating Cardiovascular Disease Risk in Young Healthcare Professionals: Insights from Q-Risk 3 Calculations.

Background: There is a global rise in cardiovascular diseases (CVD), particularly among the current generation of young adults, including the health professionals. Factors such as poor lifestyle choices, inadequate nutrition, sedentary work, and prolonged working hours contribute to occupational stress.

Aim: This study aimed to investigate the prevalence of CVD risk factors in young healthcare workers aged 25-40 and assess their 10-year CVD risk using the QRISK 3 prediction algorithm.

Interfacial Engineering of a NaGdF@NaYF:Nd-Reinforced PVA/Chitosan Janus Hydrogel for Osteosarcoma and Osseointegration via the Entrapment of Strontium in Bisphosphonates.

Postoperative impacts after osteosarcoma excision such as tumor recurrence and critical-sized bone defects continue to pose significant therapeutic challenges. Conventional implants employed to treat these defects often pose negligence in eliminating the residual tumor cells. The current study aims to address these constraints through the development of a multifunctional Janus hydrogel.

Investigating RND efflux pumps in P4: the role of nonpathogenic bacteria in antibiotic resistance gene spread amid environmental contamination.

The widespread and inappropriate application of antibiotics across human and veterinary medicine has generated pressing global health threats, principally the emergence of antimicrobial resistance (AMR) and the contamination of the environment with antibiotics. A fundamental mechanism fueling environmental AMR is the proliferation and horizontal dissemination of antibiotic resistance genes (ARGs), with efflux transporter proteins functioning as central intermediaries. Surprisingly, nonpathogenic bacteria, which are usually regarded as harmless, now pose a substantial risk to society due to the presence of efflux transporters, which make them AMR contributors.

Enhanced antibacterial potential of exopolysaccharide-stabilized spice oil emulsions against foodborne pathogens.

Exopolysaccharides (EPSs) from lactic acid bacteria (LAB) are known to have diverse applications in food and pharmaceuticals due to their functional properties. Emulsification is one of the important potentials of microbial polysaccharides, revealing its role as a natural emulsifier. In this study, glucan has been explored for emulsification with spice oils from (Xae), (Mm), and (Fl) Cameroon underutilized spices.

Metagenomic Analyses of Gut Bacteria of Two Sandfly Species from Western Ghats, India, Differing in Their Vector Competence for Leishmaniasis.

Phlebotomine sandflies are the primary vectors of parasites, the causative agents of leishmaniasis. In India, is the confirmed vector of . The sandfly gut microbiota plays a crucial role in development and transmission, yet it remains largely understudied.