Title: Love, Sex and Artificial Intelligence.

This paper explores the intricate relationship between love, sexuality, and the emerging realm of Artificial Intelligence (AI) through an interdisciplinary lens encompassing psychological, neurological, and endocrinological frameworks. By dissecting love as a multifaceted construct-rooted in attachment, emotion, and interdependence-and analyzing its convergence with sexuality, the study proposes a refined model of romantic bonding. Emphasizing the potential pitfalls of love mimickers such as obsession, possession, and paranoia, the paper also considers how personality traits and sociocultural influences affect couple dynamics.

From triple-mode network to triple-layered model - novel insights in social cognition.

Modern studies have revealed various pathophysiological mechanisms underlying neurodegenerative dementias. Among these, disruption of the "triple mode network" is widely recognized as a pivotal common pathway leading to the development of the neurodegenerative dementias including Alzheimer's dementia. Contemporary studies have shown strong association of impaired social cognition with various dementias.

Ipsilateral diabetic striatopathy: A case of clinicoradiological discordance and evolving movement disorders.

Background: Diabetic striatopathy (DS) typically presents with hemichoreoballism and contralateral striatal lesions on neuroimaging. However, cases of unilateral movement disorders with predominant ipsilateral striatal lesions are rare.

Case Presentation: We present a case of DS in a 62-year-old woman from rural India with poorly controlled diabetes mellitus who developed acute-onset right hemichoreoballism.

Investigating RND efflux pumps in P4: the role of nonpathogenic bacteria in antibiotic resistance gene spread amid environmental contamination.

The widespread and inappropriate application of antibiotics across human and veterinary medicine has generated pressing global health threats, principally the emergence of antimicrobial resistance (AMR) and the contamination of the environment with antibiotics. A fundamental mechanism fueling environmental AMR is the proliferation and horizontal dissemination of antibiotic resistance genes (ARGs), with efflux transporter proteins functioning as central intermediaries. Surprisingly, nonpathogenic bacteria, which are usually regarded as harmless, now pose a substantial risk to society due to the presence of efflux transporters, which make them AMR contributors.

Striatopathy and stroke in diabetes: insights from two cases and literature review.

Introduction: There is varied phenotypic presentations of diabetic striatopathy (DS), traditionally characterized by hyperglycemia, acute-onset choreoballism, and/or specific neuroimaging findings. Emerging evidence indicates that DS may coexist with stroke, complicating diagnosis and treatment, as both conditions can influence each other's progression.

Materials And Methods: Two cases of DS with concurrent stroke at a single center and 15 similar previously published cases have been analyzed.

Prevalence and pattern of cognitive dysfunction in young adults and middle-aged patients with type-2 diabetes.

Background And Aims: With the world's aging population, twin epidemics of type-2 diabetes (T2D) and dementia take a great toll on the healthcare burden. T2D carries a 2-3 times greater risk of developing cognitive impairment than controls. Early identification of cognitive impairment is important as it impairs diabetes self-management, making patients prone to complications.

Microplastic surge in the Ariyankuppam river, Puducherry, India: A study on abundance, characterization, and pollution load index.

The increasing rate of microplastic (MP) pollution in the aquatic environment poses an escalating threat to marine ecosystems and several health concerns to humans. Ocean and Sea MP pollution has been a grave concern in recent decades, and rivers are considered one of the main channels that carry MP to the sea. Here, we investigated the MP abundance in the Ariyankuppam River, which flows through the Puducherry region in South India and merges with the Bay of Bengal.

Biodegradation of phthalates DIBP, DMP, and DEP by Paenarthrobacter sp. strain PH1 - analysis of degradation, pathway, and its bioremediation potentiality in soil microcosm.

Phthalic acid esters (PAEs), a class of anthropogenic hazardous chemicals, have become one of the lead toxic chemicals on the environmental contamination list. Their weak chemical bonding makes them easily assimilated into the environment, leading to serious environmental concerns. This study assessed the degradation of three low-molecular-weight phthalates, di-isobutyl phthalate (DIBP), diethyl phthalate (DEP), and dimethyl phthalate (DMP), in batch culture and artificial soil microcosms by a gram-positive strain Paenarthrobacter sp.

Antigenic homology between mouse spermatozoa and Vibrio cholerae: in-silico, in-vitro, and in-vivo evidence for immune-mediated infertility.

Molecular mimicry, a key concept in the field of autoimmune diseases and diagnosis, is increasingly being explored in the context of human infertility. A significant hypothesis in infertility research is the presence of anti-sperm antibodies (ASAs), which are found in males, females, prepubescent boys, and virgin girls. The mechanisms triggering ASA production in both sexes are varied, but the origin of these antibodies in children and adolescents remains unclear.

Acute hand dystonia and action myoclonus unveiling diabetic striatopathy: The critical role of hyperglycemia.

Diabetic striatopathy is a rare complication of diabetes mellitus characterised by movement disorders secondary to hyperglycemia. While most commonly associated with chorea and ballism, it may also present with other hyperkinetic manifestations, including, albeit rarely, isolated dystonia and myoclonus. We report a case of a patient with poorly controlled diabetes mellitus who developed acute hand dystonia and action myoclonus, highlighting the broader spectrum of hyperglycemia-induced movement disorders.

Insulinoma in Patients with Diabetes- A Systematic Review of Previously Reported Cases.

Introduction: Paradoxical co-existence of insulinoma and diabetes is extremely rare. Although a few case reports addressed this association, a comprehensive study elucidating this relationship has been lacking. We performed a systematic review of published cases of insulinoma in diabetes.

Redefining Cognitive Domains in the Era of ChatGPT: A Comprehensive Analysis of Artificial Intelligence's Influence and Future Implications.

Background And Objectives: Despite its extensive utilization, research on Chat Generative Pre-trained Transformer (ChatGPT)'s potential negative impact on specific cognitive processes is scarce. This article explores the widespread use of ChatGPT in educational, corporate, and various other sectors, focusing on its interaction with distinct cognitive domains such as attention, executive function, language, memory, visuospatial abilities, and social cognition.

Methods: A literature review was conducted using PubMed, identifying 256 articles, with 29 peer-reviewed articles analyzed after screening for relevance.

Diet in Thyroid Disorders: A Survey among Clinicians and a Review of the Current Perspective.

Physicians and endocrinologists commonly face various questions related to dietary interventions during clinical encounters with their patients with thyroid disorders. Indeed, both patients and treating physicians have various misconceptions regarding thyroid-specific diets, possibly because of misinformation circulated in lay media or grey literature and the misinterpretation of contradictory scientific data, respectively. In this review, we attempted to answer some frequently asked questions by the patients in the backdrop of contraindicatory perceptions of physicians observed in our survey.

From freezing to functioning: cellular strategies of cold-adapted bacteria for surviving in extreme environments.

The ability of cold-adapted bacteria to survive in extreme cold and diverse temperatures is due to their unique attributes like cell membrane stability, up-regulation of peptidoglycan biosynthesis, increased production of extracellular polymeric substances, and expansion of membrane pigment. Various cold-adapted proteins, including ice-nucleating proteins (INPs), antifreeze proteins (AFPs), cold shock proteins (Csps), and cold-acclimated proteins (CAPs), help the bacteria to survive in these environments. To sustain cells from extreme cold conditions and maintain stability in temperature fluctuations, survival strategies at the molecular level and their mechanism play significant roles in adaptations in cryospheric conditions.

Biodegradation of DEP, DIBP, and BBP by a psychrotolerant Sphingobium yanoikuyae strain P4: Degradation potentiality and mechanism study.

Phthalic acid esters (PAEs) are human made chemicals widely used as plasticizers to enhance the flexibility of plastic products. Due to the lack of chemical bonding between phthalates and plastics, these materials can easily enter the environment. Deleterious effects caused by this chemo-pollutant have drawn the attention of the scientific community to remediate them from different ecosystem.

Expanding the Spectrum of Diabetic Striatopathy: Insights from a Case of Hyperglycemia-Induced Propriospinal Myoclonus.

This video abstract delves into the expanded definition of diabetic striatopathy, linked initially to hyperglycemia-induced choreoballism and striatal hyperintensity on magnetic resonance imaging, but now recognized to encompass a broader range of acute onset, non-choreoballistic movement disorders in diabetes mellitus, including tremors, hemifacial spasm, parkinsonism, different types of myoclonus, dystonia, restless leg syndrome, ataxia, and dyskinesias. We report the case of a 45-year-old female patient with type-2 diabetes mellitus who developed propriospinal myoclonus, characterized by painless, involuntary jerky movements of the bilateral lower limbs in a supine position after admission for suspected rhino-orbital mucormycosis. The abnormal movements resolved entirely following the control of her blood glucose levels, suggesting a direct correlation between hyperglycemia and the clinical picture.

Role of Novel Glucagon-like Peptide-1 Receptor Analogue Polyethylene Glycol Loxenatide in Type 2 Diabetes: A Systematic Review and Meta-analysis.

Background: Polyethylene glycol loxenatide (peg-loxenatide) is a novel glucagon-like peptide-1 receptor agonist developed and available for clinical use in China. This meta-analysis was performed as no meta-analysis has analysed the efficacy and safety of peg-loxenatide in type 2 diabetes (T2DM).

Methods: Electronic databases were systematically reviewed for RCTs having patients living with T2DM receiving peg-loxenatide in treatment arm and placebo/any other diabetes medicine in control arm.