Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study.

Background: Thrombosis and coronary artery disease (CAD) are complex disorders influenced by genetic factors. Specific gene variations, such as Factor V (FV) G1691A (Leiden), FV H1299R, and Prothrombin (FII) G20210A, have been implicated in thrombotic events and CAD. However, their precise role in CAD development remains controversial.

How early is early for JIA? Insights from the infantile-onset juvenile idiopathic arthritis patients of the PERA research group cohort.

Objective: Juvenile idiopathic arthritis (JIA) is the most common chronic childhood arthritis, with distinct categories based on pathophysiology and clinical manifestations. The age of onset varies by category but is reported to be approximately six years. This study aimed to evaluate the clinical, laboratory, and outcome characteristics of patients with the infantile-onset JIA.

Anti-Metastatic Effects of Aprepitant on Glioblastoma Cells: Targeting the Substance P/Neurokinin-1 Pathway.

Background: Glioblastoma (GB) is an aggressive brain tumor characterized by rapid proliferation, invasion, and resistance to therapy. The substance P (SP)/neurokinin-1 receptor (NK-1R) pathway contributes to GB progression by promoting angiogenesis, inflammation, and extracellular matrix remodeling. Aprepitant, an FDA-approved NK-1R antagonist, has shown potential as a therapeutic agent in glioma treatment.

Evaluating Secukinumab as Treatment for Axial Spondyloarthritis and Psoriatic Arthritis in Patients with Comorbidities: Multicenter Real-Life Experience.

: Secukinumab is a fully human monoclonal antibody that targets interleukin (IL)-17A and is used to treat axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). Treating axSpA and PsA can be challenging in patients with comorbidities. In this multicenter retrospective study, we aimed to evaluate the efficacy and safety of secukinumab treatment in patients with axSpA and PsA who had a history of tuberculosis, multiple sclerosis (MS), or congestive heart failure (CHF).

Investigation of the efficacy and safety of endoscopic wide band resection in the treatment of colorectal polyps.

Background And Studys Purpose: Endoscopic band ligation is commonly used in gastroenterology but limited in colorectal polyps (CRPs) treatment due to narrow cap diameters. Endoscopic mucosal resection and endoscopic submucosal dissection (ESD) are effective but carry higher bleeding risks in patients with concomitant comorbidities. Considering the narrowest part of the colon, the rectosigmoid junction measures approximately 2.

Bleeding inequality: How menstrual poverty undermines academic success via social anxiety in female university students-A structural equation modeling study.

In this cross-sectional study, we investigated the relationships between income, menstrual poverty, social anxiety, and academic success among 640 female undergraduates at Pamukkale University, Türkiye, using structural equation modeling. We collected data between April 1 and 15, 2025. We found moderate menstrual poverty (mean score 35.

Clinical characteristics, mid-term outcomes and management of asymptomatic primary hyperparathyroidism: A multicentre retrospective cohort study.

Purpose: The primary objective of this study was to retrospectively evaluate the demographic, biochemical, and clinical characteristics of patients with asymptomatic primary hyperparathyroidism (aPHPT), analyze their long-term outcomes, and discuss the effectiveness of current therapeutic strategies in light of the existing literature. We anticipate that our study will provide clinicians with guidance regarding surgical decision-making beyond the standard criteria for aPHPT.

Methods: This was a nationwide, multicenter, observational, retrospective cohort study.

Fucoidan-functionalized molybdenum carbide nanospheres for combined therapy: Photothermal, photodynamic, and chemotherapeutic effects on triple-negative breast cancer cell lines.

This study evaluates the therapeutic potential of fucoidan-functionalized molybdenum carbide (Mo₂C@C@Fuc) nanospheres and their combination with paclitaxel (PTX) for targeted cancer therapy, with a focus on triple-negative breast cancer (TNBC) cell lines. The nanospheres exhibited 85-90 % drug-loading efficiency and pH-responsive release, ensuring enhanced delivery in acidic tumor microenvironments. Reactive oxygen species (ROS) assays revealed significant ROS generation under near-infrared (NIR) irradiation, particularly in the PTX/Mo₂C@C@Fuc group, selectively inducing oxidative stress in TNBC cells (4T1 and MDA-MB-231) while sparing healthy fibroblasts (L929).

The clinical effects of miR-26a, miR-16, let-7, miR-128a and miR-223 in acromegaly.

Background: MicroRNAs (miRNAs) have been shown to function either as oncogenes or tumor suppressors, depending on the cellular context. This study aimed to explore the potential involvement of specific miRNAs in pituitary tumorigenesis and to assess their association with clinical features in patients diagnosed with acromegaly.

Methods: The study comprised 39 acromegaly patients and 39 healthy controls who were matched for age and gender.

The Effect of Abaloparatide on New Bone Formation in Critical Calvarial Defectsin a Postmenopausal Model.

Objective: We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.

Method: Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O. Each rat received an 8-mm calvarial defect with a trephine drill.

The Use of Prophylactic Steroid and Heparin to Prevent Fat Embolism Syndrome After Liposuction.

Background: Liposuction is one of the most commonly performed aesthetic procedures. It carries a risk of complications, including the rare but potentially fatal fat embolism syndrome (FES). Prophylactic measures such as steroids and heparin have been suggested for preventing FES, but their effectiveness remains unclear.

The Effect of Iron Deficiency Anemia and Serum Ferritin Deficiency on Cognitive Functions in Children 1 to 5 Years Old.

Objective: We aimed to investigate the effects of iron deficiency anemia and serum ferritin deficiency on mental and motor functions in children 1 to 5 years of age and whether these effects could be improved by treatment.

Materials And Methods: The study was conducted between February 2021 and July 2021 and included a total of 79 children between 1 and 5 years old. Participants were divided into 3 groups according to their blood results: iron deficiency anemia (n = 19), nonanemic iron deficiency (n = 21), and control group (n = 39).

The quality and reliability of YouTube and TikTok videos on epidural blood patch: A cross-sectional analysis.

Epidural blood patch (EBP) is widely recognized as the definitive treatment for postdural puncture headache, a rare but debilitating complication of spinal anesthesia or unintentional dural puncture. However, the lack of sufficient research on available online content about EBP, especially on social media platforms such as YouTube and TikTok, raises concerns about its reliability. In this context, this study was conducted to evaluate the quality and reliability of YouTube and TikTok videos about EBP and to identify sources that provide high-quality and reliable information.

A Newborn Case of Esophagus and Vocal Cord Burn After CS (O-Chlorobenzylindene Malononitrile) Gas Inhalation.

Among the agents used for self-defense, O-chlorobenzylidene malononitrile (CS) is the most commonly used substance. It has been suggested that CS use is characterized by rapid onset of action, short duration of action, and minimal side effects. When the clinical situations and case series resulting from exposure to CS were examined, we saw that no cases of exposure during the neonatal period were identified.

The role of complement C3 deposition in ANCA-associated glomerulonephritis: a registry-based study of clinical, histopathological, and prognostic insights.

Background: ANCA-associated glomerulonephritis (ANCA-GN) is a leading cause of pauci-immune crescentic GN. Recent evidence indicates that complement activation, marked by C3 deposition in glomeruli, may contribute to more severe renal injury and influence renal outcomes. We aim to evaluate the clinical, histopathological, and prognostic implications of C3 deposition in ANCA-GN.

Biological therapies in pediatric Behçet's disease: results of an international collaborative study by the PRES Vasculitis Working Party.

Objective: This study aims to examine the indications for pediatric rheumatologists to use biologic therapies in childhood Behçet's disease (BD), as well as the efficacy, safety, and remission rates of such treatments. We also compare demographic and clinical characteristics of Turkish and European cohorts.

Methods: In this multicentric retrospective study, the data of 109 pediatric BD (pedBD) patients diagnosed before 18 years of age, obtained from Pediatric Rheumatology European Society (PRES) vasculitis study group, which involves 19 centers across six countries were analyzed.

Do Autistic Traits Predict Obsessive-Compulsive Symptoms? A Community-Based Study.

Obsessive Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD) have similar characteristics. People with one of these disorders are more likely to meet the diagnosis of the other disorder than the general population. This study mainly investigated whether autistic traits predicted obsessive-compulsive symptom subtypes after controlling for some demographic features and clinical variables.

Key players in the breast cancer microenvironment: From fibroblasts to immune cells.

Breast cancer is one of the most common malignancies worldwide and is a major cause of cancer-related mortality among women. Beyond tumor cells, the tumor microenvironment (TME) also plays an important role in cancer progression, therapy resistance, and metastasis. The TME is a complex ecosystem consisting of stromal and immune cells, extracellular matrix (ECM), and various signaling molecules that dynamically interact with tumor cells.

Impact of Treatment Duration in First-Line Atezolizumab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Multicenter Real-World Retrospective Study.

Small-cell lung cancer (SCLC) is an exceedingly aggressive neoplasm distinguished by an unfavorable prognosis. Recent studies have confirmed chemo-immunotherapy as the conventional first treatment for extensive-stage small-cell lung cancer (ES-SCLC), but the impact of treatment duration remains unclear. The goal of this study was to find out how the length of treatment affected progression-free survival (PFS) and overall survival (OS) in patients with ES-SCLC who were receiving first-line atezolizumab plus chemotherapy.

Prognostic Role of Inflammatory and Nutritional Indices in NSCLC Patients Treated with Immune Checkpoint Inhibitors: Retrospective, Multicenter, Turkish Oncology Group Study of Overall and Elderly Populations.

Despite advances in immunotherapy, predicting survival outcomes in patients with non-small-cell lung cancer (NSCLC) remains challenging. Inflammatory and nutritional indices such as the Prognostic Nutritional Index (PNI), Geriatric Nutritional Risk Index (GNRI), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Inflammatory Burden Index (IBI) have emerged as promising prognostic markers associated with overall survival (OS) in NSCLC patients. We retrospectively analyzed a total of 196 NSCLC patients treated with second-line nivolumab across multiple centers in Turkey.

Trends and methods in intensive care unit (ICU) research using machine learning: latent dirichlet allocation (LDA)-based thematic literature review.

Introduction: The use of machine learning (ML) in intensive care units (ICUs) has led to a large yet fragmented body of literature. It is imperative to conduct a systematic analysis and synthesis of this research to identify methodological trends, clinical applications, and knowledge deficits.

Methods: A systematic literature review was conducted in accordance with the PRISMA guidelines, encompassing 2,507 ICU-focused ML publications from 2019 to 2024.

Palate Postoperative Problems Score in the early post-operative period of modified barbed reposition pharyngoplasty and tonsillectomy.

Objectives: To evaluate early postoperative complaints using the Palate postoperative Problems Score in patients undergoing modified barbed reposition pharyngoplasty with tonsillectomy and tonsillectomy alone.

Methods: The study included 40 patients who underwent modified barbed reposition pharyngoplasty with tonsillectomy and 18 patients who had tonsillectomy alone. Patients completed the Palate Postoperative Problems Score questionnaire at the first, third and sixth months post-operatively, and changes in their complaints were observed.