Targeted Therapy for Glioblastoma: Synergistic Effects of GO/C-TMZ,@, PmAb and Magnetic Hyperthermia.

This study investigates the therapeutic potential of a nanohybrid structure, GO/C-TMZ@PmAb MNP, for targeted glioblastoma treatment by integrating chemotherapy with magnetic hyperthermia. Characterization of the nanohybrid confirmed successful conjugation of Panitumumab (PmAb) and effective loading of Temozolomide (TMZ), ensuring targeted delivery to glioblastoma cells. In vitro experiments demonstrated enhanced cytotoxicity and a significant increase in late-stage apoptosis in U-87 MG and U-251 MG glioblastoma cell lines, particularly when combined with an alternating magnetic field (AMF), highlighting the synergistic effect of combined therapy.

Fucoidan-functionalized molybdenum carbide nanospheres for combined therapy: Photothermal, photodynamic, and chemotherapeutic effects on triple-negative breast cancer cell lines.

This study evaluates the therapeutic potential of fucoidan-functionalized molybdenum carbide (Mo₂C@C@Fuc) nanospheres and their combination with paclitaxel (PTX) for targeted cancer therapy, with a focus on triple-negative breast cancer (TNBC) cell lines. The nanospheres exhibited 85-90 % drug-loading efficiency and pH-responsive release, ensuring enhanced delivery in acidic tumor microenvironments. Reactive oxygen species (ROS) assays revealed significant ROS generation under near-infrared (NIR) irradiation, particularly in the PTX/Mo₂C@C@Fuc group, selectively inducing oxidative stress in TNBC cells (4T1 and MDA-MB-231) while sparing healthy fibroblasts (L929).

Effectiveness of structured myofascial release in the treatment of primary dysmenorrhea.

Objectives: To determine the effect of structured myofascial release techniques on symptoms in individuals with primary dysmenorrhea.

Material And Methods: Based on an expected effect size (d = 0.25), α = 0.

Evaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO/g-CN@RGH nanocomposite material.

A novel electrochemical sensor based on LaNiO/g-CN@RGH nanocomposite material was developed to simultaneously determine Ribociclib (RIBO) and Alpelisib (ALPE). Ribociclib and Alpelisib are vital anticancer medications used in the treatment of advanced breast cancer. The sensor exhibited excellent electrocatalytic activity towards the oxidation of RIBO and ALPE, enabling their simultaneous detection.

Development of a CrAlC MAX phase/g-CN composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples.

A highly sensitive electrochemical sensor is reported that employs a modified electrode for the precise measurement of cabotegravir, a potent anti-HIV drug. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were utilized for this purpose. Electrode modification involved the immobilization of CrAlC MAX phase/g-CN onto a glassy carbon electrode (GCE) to enhance its electrocatalytic activity and selectivity for cabotegravir detection.

Synthesis of PES membranes modified with polyurethane-paraffin wax nanocapsules and performance of bovine serum albumin and humic acid rejection.

Membrane fouling is a serious handicap of membrane-based separation, as it reduces permeation flux and hence increases operational and maintenance expenses. Polyurethane-paraffin wax (PU/PW) nanocapsules were integrated into the polyethersulfone membrane to manufacture a composite membrane with higher antifouling and permeability performance against humic acid (HA) and bovine serum albumin (BSA) foulants. All manufactured membranes were characterized by scanning electron microscopy (SEM), scanning electron microscopy-energy dispersive spectrometry (SEM-EDS), and contact angle.

Development of antimicrobial nanocomposite scaffolds via loading CZTSe quantum dots for wound dressing applications.

The antimicrobial properties of scaffolds designed for use in wound healing are accepted as an important factor in the healing process to accelerate the wound healing process without causing inflammation. For this purpose, chitosan-polyvinyl alcohol composite membranes loaded with CuZnSnSequantum dots (CZTSe QDs) as an antibacterial and cytocompatible biomaterial to regulate the wound healing process were produced. CZTSe QDs particles were synthesized under hydrothermal conditions.

Investigation of the antifouling properties of polyethersulfone ultrafiltration membranes by blending of boron nitride quantum dots.

This study aims to investigate the modification of polyethersulfone (PES) membrane with boron nitride quantum dots (BNQD) for improving the antifouling performance. The composite membranes were synthesized by blending different amounts of BNQD (0.50, 1.