Intracranial and Extracranial Vascular Involvement in Takayasu Arteritis Unresponsive to Multiple Lines of Immunomodulation on 68Ga-FAPI PET/CT: A Game Changer.

Takayasu arteritis (TAK) is a large-vessel vasculitis characterized by granulomatous inflammation of the aorta and its primary branches. The clinical presentation of TAK is heterogeneous. Intracranial vascular involvement in TAK is uncommon and is understudied.

Lu-177 DOTATATE Therapy in a Treatment Naive Metastatic NET Pineal Gland With Drop Metastasis to Spinal Cord: A Great Leap Forward in Oncology.

Neuroendocrine tumors (NETs) are a heterogeneous group of tumors, which are usually indolent with metastatic disease at the initial presentation in most clinical situations. Intramedullary spinal cord metastasis (ICSM) is usually rare in the case of neuroendocrine tumors. Peptide receptor radionuclide therapy (PRRT) with Lu-177 DOTATATE has been in use for treatment of metastatic NETs for a long time.

Circlet Sign: Urinary Contamination on 177Lu-DOTATATE Posttherapy Imaging.

Peptide receptor radionuclide therapy has revolutionized the management of somatostatin receptor-positive metastatic neuroendocrine tumours. Treating nuclear medicine physicians must be aware of the radiation hazards posed by radioactive contamination and the imaging fallacies attributable to radioactive contamination on posttherapy planar imaging. The image fallacies, if not properly looked upon, upstage the disease.

Educational and Socioeconomic Correlates of Stroke Risk Behaviors: Findings from the SPRINT INDIA Trial.

Background And Objectives: Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India (SPRINT INDIA) trial was a randomized control trial that enrolled 4298 stroke patients and administered educational interventions at 31 centers across India, with the aim to reduce recurrent stroke through increased stroke knowledge. This SPRINT INDIA trial post hoc study aims to investigate the incidence of recurrent stroke, high-risk transient ischemic attack (TIA), acute coronary syndrome (ACS), death, and lifestyle behavioral factors at 1 year. In addition, it examines the relationship between patients' baseline characteristics and education levels, risk factors, and outcomes and performs subgroup analysis within the intervention and control groups.

A Rare Case of Tuberculosis Masquerading as Collapsing Glomerulopathy.

Collapsing glomerulopathy (CG), usually presents with renal dysfunction, hypertension and proteinuria. The etiology is uncertain, yet a number of associations, including many viral infections commonly have been reported. Tuberculosis (TB), one of the most common infections, is not known to cause CG.

Ashwagandha and Shatavari Extracts Dose-Dependently Reduce Menopause Symptoms, Vascular Dysfunction, and Bone Resorption in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Study.

Objectives: In this study, we investigate the effects of dietary supplementation with standardized aqueous extracts of shatavari (, Ar), ashwagandha (, Ws), or their combination on menopausal symptoms, vascular dysfunction, bone turnover, and serum concentrations of inflammatory and oxidative stress markers in postmenopausal women.

Methods: Postmenopausal women aged 40-55 were enrolled in a double-blind randomized study to receive one of six treatments: placebo, Ar 250 mg/500 mg, Ws 250 mg/500 mg, or 500 mg extract combining Ar 250 mg and Ws 250 mg. Primary outcomes were changes in the menopause-specific quality of life (MENQOL) questionnaire, bone mineral density/bone turnover markers (BTMs), and reflection index (RI) after 24 weeks.

SPRINT INDIA: Regional Variations in Primary and Secondary Stroke Outcomes Based on Baseline Characteristics in North and South Indian Sites.

Background And Objectives: Regional differences in stroke prevalence and outcomes in India, driven by demographic and risk factors, are crucial for guiding effective prevention and management strategies. This subanalysis of Secondary prevention with a structured semi-interactive stroke prevention package in INDIA (SPRINT INDIA) randomized controlled trial compared the demographics, risk factors, and clinical outcomes of stroke patients from North and South India to identify regional differences and inform targeted interventions for stroke prevention.

Methods: The study analyzed data of 4298 participants from 31 stroke centers across India, focusing on demographics, stroke types, and risk factors.

Building climate resilience and mitigating the impact of climate change on cancer care: strategies and solutions for low and middle income countries.

Climate change poses an enormous threat to human health. It increases exposure to risk factors related to cancer while simultaneously threatening effective cancer care in the face of overstrained resources and natural hazards. Low and middle income countries (LMICs) are disproportionately affected by the effects of climate change which further limits their ability to respond effectively to this growing threat.

Evolving Gender Dynamics in India's Nephrology Workforce: A Decadal Analysis (2013-2023).

The field of medicine has long been marked by gender disparities, with men predominantly occupying higher academic ranks while women were underrepresented. In recent years, there have been marked changes in the gender ratio among medical professionals in Nephrology. This study analysed gender dynamics within the Indian Nephrology fraternity.

Coexisting Ulnar Nerve Schwannoma and Lateral Humeral Condyle Nonunion Presenting as Tardy Ulnar Nerve Palsy: A Report of a Rare Case.

Tardy ulnar nerve palsy (TUNP) is a progressive neuropathy commonly associated with cubitus valgus deformity following lateral humeral condyle nonunion. However, concurrent ulnar nerve schwannoma as a contributing factor remains undocumented. We present a rare case in which both chronic traction neuropathy and intraneural compression coexisted, with the schwannoma remaining undetected on high-resolution ultrasound (HRUS) preoperatively.

CEP72 Emerges as a Key Centriolar Satellite Protein in Health and Disease.

Centriolar satellites are membrane-less granules that are now accepted as core structural and functional components of the centrosomes and the cilia. While initially associated with centrosome assembly and primary cilia formation, these complexes and their dynamic structures seem to be involved in various other cellular processes, including protein homeostasis, autophagy, and responses to cellular stress. Since the identification of the first centriolar satellite protein, PCM1, substantial progress has been made in understanding the molecular composition and biological functions of centriolar satellites.

Comparison of fentanyl and dexmedetomidine versus fentanyl and midazolam in procedural sedation for tube thoracostomy in emergency department - A randomized control study.

Objectives: Effective sedation and analgesia during procedures not only provide relief of suffering but also frequently facilitate the successful and timely completion of the procedure. The aim of the study was to evaluate the efficacy of fentanyl and dexmedetomidine compared to fentanyl and midazolam in procedural sedation for tube thoracostomy in the emergency department (ED) in terms of analgesia and patient satisfaction with sedation during the procedure using Pain Numerical Rating Scale and a 7-point Likert-like verbal rating scale for comfort rating of sedation.

Methods: A randomized control study was conducted in 64 subjects admitted to the ED.

Comparing Stroke Profiles and Outcomes between Urban and Rural India: A Secondary Analysis of the SPRINT INDIA Trial.

Introduction: Stroke causes significant death and disability, with urban-rural disparities in healthcare and limited studies in India, despite its rural majority of 70%. The post hoc study aimed to explore differences in stroke profiles, risk factors, and outcomes between urban and rural participants using data from the Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India (SPRINT INDIA) trial.

Methods: The SPRINT INDIA trial was a multi-center randomized clinical trial across 31 Indian sites.

Impact of the COVID-19 pandemic on care delivery, follow-up and outcomes in chronic myeloid leukemia patients: An observational cohort study.

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that comprises a chronic phase. Therefore, it is of interest to evaluate the impact of care delivery and loss of follow-up or defaulted treatment due to the COVID-19 pandemic affecting the outcome in known chronic myeloid leukemia patients. Data was retrospectively retrieved and prospectively evaluated from the known and treated CML patients.

Empowering Patients' Knowledge, Attitude, and Practices in Low Resource Settings: A Study of Pictorial Tools for Pretest Counseling of Invasive Prenatal Diagnostic Procedures.

Objective: This study aimed to evaluate the effectiveness of a bilingual (English-Telugu) poster in enhancing pregnant individuals' knowledge, attitudes, and practices regarding invasive prenatal diagnosis procedures.

Methods: A cross-sectional survey involving 100 pregnant individuals attending prenatal diagnostic counseling was conducted. Participants reviewed the bilingual poster and completed a questionnaire assessing their understanding, satisfaction, and anxiety levels.

Implementation Strategies to Improve Survival Outcomes after Out-of-Hospital Cardiac Arrest: Global Challenges and Disparities.

Out-of-hospital cardiac arrest (OHCA) is a major global public health problem, contributing to high mortality and morbidity. There is significant variability in OHCA incidence and survival rates across different countries and communities and in various geographical locations, even within the same country. Cardiopulmonary resuscitation (CPR) knowledge and skills are critical to achieving better survival outcomes during OHCA.

Decade-Long Study on Phenotype and Prognosis of Lupus Myelitis (LM) in Systemic Lupus Erythematosus (SLE): Insights from a Single-Centre in India.

Background: Systemic lupus erythematosus (SLE)-associated myelitis or lupus myelitis (LM), one of the twelve neuropsychiatric lupus (NPSLE) syndromes, is a rare but severe complication of lupus. In this study, we observed the clinical and imaging profiles of LM patients to assess long-term outcomes. Methods: This was a retrospective study; data of LM with follow-up were extracted from the lupus registry in the last 15 years (2007-2022).

"Snake in the Scrotum Sign": Reappraising the Potential of 18 F-FDG PET/CT in Post-Renal Transplant Patient with Pyrexia of Unknown Origin.

18 F-FDG PET/CT, the workhorse of oncological imaging has changed the diagnostic and management paradigm in cases of fever and inflammation of unknown origin, with diagnostic superiority over the conventional imaging modalities. Various complications like acute and chronic graft pyelonephritis, acute rejection, infections, and surgery-related complications can occur post-renal transplantation. The authors in the present study demonstrate coexisting graft pyelonephritis, prostatitis, epididymo-orchitis, and funiculitis on 18 F-FDG PET/CT in a patient, post renal transplant with clinical presentation as pyrexia of unknown origin.

Cardiac evaluation in patients awaiting kidney transplant-position statement of the Cardiological Society of India and Indian Society of Nephrology.

Cardiovascular diseases are a major cause of death after kidney transplantation. This statement addresses preoperative cardiac decision-making and management with the aim of assessing and reducing the risk of the kidney transplant surgery. Important issues from a clinician's perspective include the basic cardiovascular workup of these patients, coronary evaluation and management of coronary artery disease, valvular heart disease and left ventricular systolic dysfunction.

Survey on the impact of WHO 2021 classification of brain tumors on adult glioma management in Africo-Asian region.

The 2021 WHO classification of central nervous system (CNS) tumors introduced significant changes based on molecular and biological tumor characteristics, aiming to improve prognostication and enable more precise treatment approaches. This study investigated the awareness, adoption, and impact of the new classification on adult glioma management among healthcare professionals in Africo-Asian region. Through a structured survey questionnaire distributed across these regions, assessment of the level of awareness, diagnostic changes, challenges faced, and future perspectives among respondents was done.