Introducing Normalized Surface-adjusted Precipitation Index (NSPI) for regional drought assessment.

Drought is a natural event, but its frequency and severity are increasingly influenced by human activity and climate change. In the current Anthropocene era, human-induced changes to the hydrological cycle combined with natural climate variability are reshaping how droughts develop and persist. Droughts often result from complex interactions between atmospheric conditions and land surface processes, which affect how water and energy move through the environment.

Cu-MOF@TMB Integrated Test Strips for Naked Eye Colorimetric Detection of a Critical Biomarker for Metabolic and Renal Disorders.

Uric acid (UA) serves as a vital biomarker for diagnosing metabolic and renal disorders, prompting the need for rapid and selective detection methods. Herein, a new copper-based metal-organic framework (Cu-MOF), formulated as [Cu(TCi)] [Cu(TCi)(HO)(μ-OH)], was synthesized using Cu(II) ions and tris(2-carboxyethyl) isocyanurate (HTCi) as a flexible linker. Comprehensive characterization through PXRD, FTIR, SEM, EDAX, TGA, XPS, BET and elemental mapping confirmed the framework's structural integrity.

DWT-OEFS: discrete wavelet transform based optimized ensemble feature selection for Parkinson's disease severity classification.

Parkinson's disease (PD) is a cognitive degenerative condition of central nervous system which highly impacts the motor function, resulting in gait dysfunction. Determining the severity of PD is essential for timely and efficient medical management. Doctors often utilize clinical manifestations to grade the severity of PD using Hoehn & Yahr scale where their evaluation is heavily reliant on skill and experience.

Control of and dual species interkingdom biofilm development via SAP5 inhibition.

Aim: Microbial biofilms, particularly polymicrobial ones formed by and , exhibit increased resistance to conventional treatment. This study investigates the inhibitory effect of 4-hydroxyphenylacetic acid on Secreted Aspartyl Protease 5, a key virulence factor involved in hyphal development and biofilm formation in , to investigate its therapeutic potential in inhibiting polymicrobial biofilms developed with .

Materials & Methods: Biofilm formation was studied using a Biofilm Infection Simulator System and polymethylmethacrylate coupons.

Mathematical Model of Cancer Treatment with Virotherapy and Immune System.

The global burden of cancer is rising, causing significant strain on individuals, families, and healthcare systems. Traditional treatments, such as chemotherapy and radiation, are effective but harm healthy cells and lead to side effects. In contrast, virotherapy specifically targets cancer cells, leaving healthy cells unharmed.

Numerical Simulation Analysis of Two-Terminal Monolithic Perovskite-CIGS Tandem Solar Cell for Enhanced Photovoltaic Performance Using SCAPS-1d.

This research designs and simulates a high-efficiency tandem solar cell (TSC) using SCAPS-1D (3.3.12), exploiting tandem perovskite technology for enhanced performance.

Overcoming antimicrobial resistance in Helicobacter pylori: the roles of collateral sensitivity and biofilm dynamics.

Objectives: The increasing prevalence of antimicrobial resistance (AMR) in Helicobacter pylori (H. pylori) poses a significant challenge to eradication strategies. This study investigates the role of biofilm formation in AMR and explores the potential of collateral sensitivity (CS) as a therapeutic approach to optimize treatment regimens.

Role of predator and time delay on an eco-epidemic spatial model: an appearance of chaos and complexity.

Traditionally, disease spread is attributed to direct individual contact. However, various mechanisms influence transmission. This paper formulates a delay-induced reaction-diffusion system where predators significantly contribute to disease spread in prey populations.

A hybrid AI method for lung cancer classification using explainable AI techniques.

Purpose: The use of Artificial Intelligence (AI) methods for the analysis of CT (computed tomography) images has greatly contributed to the development of an effective computer-assisted diagnosis (CAD) system for lung cancer (LC). However, complex structures, multiple radiographic interrelations, and the dynamic locations of abnormalities within lung CT images make extracting relevant information to process and implement LC CAD systems difficult. These prominent problems are addressed in this paper by presenting a hybrid method of LC malignancy classification, which may help researchers and experts properly engineer the model's performance by observing how the model makes decisions.

White Light Emission from Luminescent Lanthanide Molecular Complex/Terbium Doped Graphene Quantum Dots/PMMA Composites.

Construction of multicolor emissive PMMA composite films are reported using luminescent lanthanide Schiff-Base complexes and Terbium doped Graphene Quantum dots (GQD@Tb) for white light generation. Terbium-doped green emissive Graphene Quantum Dots are synthesized hydrothermally using ortho-phenyldiammine (OPDA), Triethylamine and Tb(NO).6HO and is thoroughly characterized by microscopic and spectroscopic techniques.

A comprehensive review of emerging 3D-printing materials against bacterial biofilm growth on the surface of healthcare settings.

A significant burden on the healthcare system, microbial contamination of biomedical surfaces can result in hospital-acquired illnesses. Bacteria, viruses, and fungi may live on surfaces for days or months and spread to patients and medical personnel. This article describes the 3D printing technologies, such as fused deposition modeling, bioprinting, binder jetting/inkjet, poly-jet, electron beam manufacturing, stereolithography, selective laser sintering, and laminated object manufacturing used for manufacturing the healthcare setting's surface to reduce bacterial contamination with exploring anti-biofilm activity against different bacterial species responsible for infections, based on the critical evaluation of published reports.

Bactericidal action of ginger (Zingiber officinale Roscoe) extract against Escherichia coli through synergistic modulation of the AcrAB-TolC efflux pump and inhibition of peptidoglycan synthesis: In vitro and in silico approaches.

The emergence of multidrug-resistant Escherichia coli is considered a severe threat to global health, largely attributed to the bacterium's ability to expel antibiotics via efflux pump systems. This study explores the antibacterial efficacy of a methanol extract derived from Zingiber officinale R. (ginger), a traditional medicinal spice, against an E.

Multi-computational screening identifies homovanillic acid as a potential SAP5 inhibitor against Candida albicans biofilms.

This work aims to find inhibitors of SAP5, a virulence factor in Candida albicans polymicrobial biofilms. The methodology included docking simulations, MMGBSA calculations, and molecular dynamics simulations. Of the 107 phenolic acids retrieved from PubChem, 20 passed ADMET screening.

Recent progress in metal-organic frameworks based nanocomposites for antibiotic removal from water: An in-depth review.

Antibiotic pollution has emerged as a critical concern due to the widespread use of antibiotics, their persistence in the environment, and their detrimental effects on aquatic ecosystems and human health. Therefore, developing and implementing effective strategies to eliminate these contaminants is essential. Metal-organic frameworks (MOFs) have garnered substantial interest in water purification due to their remarkable potential.

Chitosan-Hydroxyapatite Composite Membranes Reinforced with Functionalized Multiwalled Carbon Nanotubes for Advancing Guided Bone Regeneration.

Dental implant failure, often due to bone resorption and poor osteointegration, can be mitigated using barrier membranes to prevent non-osteogenic tissue interference during bone healing. In addition to the existing barrier membranes, guided bone regeneration has opened new avenues for membrane design, allowing them to actively participate in bone regeneration rather than merely serving as barriers. In this context, the aim of this study was to fabricate a composite membrane that can mimic the native extracellular matrix of the native tissue.

Supercapacitor Materials Database Generated using Web Scrapping and Natural Language Processing.

Electrochemical energy storage plays a vital role in achieving environmental sustainability. Supercapacitors emerge as promising alternatives to batteries due to their high-power density and extended lifespan. Extensive scholarly research has been conducted on supercapacitor energy storage, providing valuable insights into materials and performance parameters.

Co(II)-Based 2D Coordination Polymer Featuring Energy Storage and Detection of Aqueous Inorganic Anions.

Herein, we have synthesized a Co(II)-based 2D coordination polymer [Co(5-AIA)(Imidazole)] () (AIA = 5-aminoisophthalic acid) via a solvothermal approach. SCXRD (single-crystal X-ray diffraction) was utilized to analyze the crystal structure of fabricated . Moreover, PXRD, TGA, FTIR, and SEM analyses were done to identify the structural features of fabricated .

Quartz-Enhanced Photoacoustic Spectroscopy-Based Acetone and Ammonia Measurements from Human Breath Near 8 μm Wavelength Band.

Human breath gas analysis is a noninvasive disease diagnostic approach used to identify different pathological conditions in the human body. Monitoring breath acetone (CHO) and ammonia (NH) as biomarkers is vital in diagnosing diabetes mellitus and liver disorders, respectively. In this article, the quartz-enhanced photoacoustic spectroscopy (QEPAS) technique is proposed and demonstrated for measuring CHO and NH in human exhaled breath samples.

Antibacterial and antibiofilm activities of extract and bioactive compounds from Bergenia ciliata (Haw.) Sternb. flowers against Streptococcus mutans through cell membrane damage.

Ethnopharmacological Relevance: Bergenia ciliata (Haw.) Sternb. (Family Saxifragaceae) remains mentioned as Pashanbheda in Ayurveda and Zakhmehayat in Unani.

Carvacrol, a monoterpenoid, binds quorum sensing proteins (LasI and LasR) and swarming motility protein BswR of resulting in loss of pathogenicity: an in silico approach.

The pathogenic utilizes a quorum-sensing pathway for biofilm formation. The quorum-sensing proteins LasI and LasR of the Las system, alongside the swarming motility protein BswR, play a crucial role in the biofilm-mediated antibiotic resistance phenomenon. In this in silico study, LasI, LasR, and BswR were the prime targets for binding studies by promising drug candidates like linalool, ferutinin, citronellal, and carvacrol.

Vocal tasks-based EEG and speech signal analysis in children with neurodevelopmental disorders: a multimodal investigation.

Neurodevelopmental disorders (NDs) often hamper multiple functional prints of a child brain. Despite several studies on their neural and speech responses, multimodal researches on NDs are extremely rare. The present work examined the electroencephalography (EEG) and speech signals of the ND and control children, who performed "Hindi language" vocal tasks (V) of seven different categories, viz.

Anti-fungal peptides: an emerging category with enthralling therapeutic prospects in the treatment of candidiasis.

infections, particularly invasive candidiasis, pose a serious global health threat. is the most prevalent species causing candidiasis, and resistance to key antifungal drugs, such as azoles, echinocandins, polyenes, and fluoropyrimidines, has emerged. This growing multidrug resistance (MDR) complicates treatment options, highlighting the need for novel therapeutic approaches.

CropGCNN: color space-based crop disease classification using group convolutional neural network.

Classifying images is one of the most important tasks in computer vision. Recently, the best performance for image classification tasks has been shown by networks that are both deep and well-connected. These days, most datasets are made up of a fixed number of color images.

Bioflavonoid Baicalein Modulates Tetracycline Resistance by Inhibiting Efflux Pump in .

The rise in antibiotic resistance among bacterial pathogens, particularly , has become a critical global health issue, necessitating the search for novel antimicrobial agents. uses various mechanisms to resist antibiotics, including the activation of efflux pumps, biofilm formation, and enzymatic modification of drugs. This study explores the potential of baicalein, a bioflavonoid from , in modulating tetracycline resistance in by inhibiting efflux pumps.