Nanoengineered Scheelite-Structured SrWO Decorated on MXene Sheets: A Novel Platform for Electrochemical Sensing of the Anti-Cancer Drug Nilutamide with DFT Insights.

The persistent presence of the pharmaceutical pollutant nilutamide (NLT) in environmental and biological systems poses a serious threat to ecosystems and human health, necessitating efficient and sustainable detection strategies. In this study, we present a nanoengineered SrWO@MXene electrocatalyst as a high-performance platform for electrochemical sensing. The hybrid material seamlessly integrates the catalytic activity and electrochemical stability of SrWO with the exceptional conductivity and tunable surface chemistry of MXenes, resulting in a synergistic architecture optimized for rapid and selective NLT detection.

Systematic optimization of histidine-tagged enhanced green fluorescent protein (His-EGFP) purification using packed bed immobilized metal affinity chromatography: A multistage design of experiments approach.

A systematic purification process for His-tagged enhanced green fluorescent protein (His-EGFP) from recombinant E. coli was developed using immobilized metal affinity chromatography (IMAC) in a packed bed format. Large-scale fermentation was conducted in a 5 L bioreactor, followed by cell harvesting and sonication-based disruption at 20 kHz and 4 °C.

Effect of halogen/chalcogen substitution on the dielectric constant of asymmetric acceptor alloy to improve the efficiency and stability of inverted organic photovoltaics.

The dielectric constant ( ) of non-fullerene acceptors is a key parameter in organic solar cells, significantly influencing exciton dissociation efficiency and charge recombination dynamics. Substituting bromine, characterized by moderate electronegativity and high polarizability, at the -benzodipyrrole core of acceptors effectively modulates their optical properties, molecular packing, and dielectric constants. The asymmetric monobrominated CBrB-Cl acceptor exhibits a more red-shifted absorption spectrum, enhanced crystallinity, and a higher of 3.

Machine learning-integrated SERS platform based on AuSe nanowires for indigo carmine detection in real samples.

Surface-enhanced Raman scattering (SERS) substrate composed of gold nanoparticles-decorated selenium nanowires (AuSe NWs) was developed for trace detection of the food dye, indigo carmine (IC). The Se NWs were synthesized via co-precipitation and functionalized with Au nanoparticles through photoreduction. The resulting substrate exhibited strong SERS activity due to synergistic electromagnetic and chemical enhancement within AuSe NWs.

Tweaking the electrocatalytic efficiency of sonochemically synthesized BiS nanorods through decoration with f-MWCNTs: A selective on-site detection of METOL in environmental samples.

In this study, we have established a highly conductive BiS/f-MWCNT nanocomposite through a sonochemical approach using a probe sonicator (100 W, 25 kHz), which functions as an effective electrochemical probe for the detection of 4-(methylamino)phenol sulfate or METOL (MET) in environmental water samples. MET, a widely used chemical in hair dyes and the photographic industries, poses significant environmental concerns when released into water systems, contributing to water pollution and ecological disruption. Comprehensive characterization techniques confirmed the structural integrity and enhanced electrochemical properties of the BiS/f-MWCNT nanocomposite.

Nanozyme-integrated CuS@f-CB composite based electrochemical sensor for ultrasensitive detection of L-tryptophan in biological and food matrices.

Nanozyme-based composites, a promising novel class of materials that mimic natural enzymes while offering greater stability, more catalytic activity, and cost-effectiveness, making them ideal for developing next-generation sensors. This work presents the synthesis and testing of a redox-active CuS@f-CB composite, synthesized by a combined hydrothermal-ultrasonication method, as a nanozyme-based electrocatalyst for label-free detection of L-tryptophan (L-TRP). This nanozyme-based composite combines the oxidase-like catalytic activity of copper sulfide with the high surface area, conductivity, and defect-rich structure of acid-treated carbon black.

From Mandate to Choice: How Voluntary Mask Wearing Shapes Interpersonal Distance Among University Students After COVID-19.

As COVID-19 policies shift from government mandates to individual responsibility, understanding how voluntary protective behaviors shape social interactions remains a public health priority. This study examines the association between voluntary mask wearing and interpersonal distance (IPD) preferences in a post-mandate context, focusing on Taiwan, where mask wearing continues to be culturally prevalent. One hundred university students (50 males, 50 females) in Taiwan completed an online IPD simulation task.

Doctor-Patient Communication Models, Patient Decision-Making Participation, and Patient Emotional Expression: A Cross-Cultural Comparison of Samples from the UK and China.

Background: Effective doctor-patient communication is critical to healthcare outcomes, but cultural differences can significantly influence communication dynamics. Understanding how cultural factors shape communication styles is essential, particularly in cross-cultural healthcare settings. Power distance and individualism/collectivism are key cultural dimensions that may impact doctor-patient interactions.

Synergistic effects of nano-heterostructured layered materials for efficient hydrogen generation via water splitting and urea oxidation, and photocatalytic remediation of food coloring agent wastewater.

The electrochemical water-splitting process is a promising approach for green hydrogen (H) production, contributing to net-zero carbon emissions and sustainable energy systems. In this work, we report the design and synergistic integration of graphene oxide (GO), graphitic carbon nitride (g-CN), and MXene (TiCT) to develop multifunctional heterostructured catalysts for both electrochemical and photocatalytic applications. The GO/MXene heterostructure exhibits enhanced electrocatalytic performance for the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and urea oxidation reaction (UOR), attributed to the high conductivity of MXene and the increased active surface area from GO.

Continuous purification of lysozyme from chicken egg white using weak-strong acidic dual functional ion exchange nanofiber membranes.

This study reports the first use of dual-functional weak-strong acidic ion exchange nanofiber membranes for continuous lysozyme purification from chicken egg white (CEW). Lysozyme, a natural antimicrobial protein (E1105), requires selective separation from other CEW proteins. The process was optimized under mild, food-compatible conditions and assessed by hydrodynamic analysis, dynamic binding capacity, recovery yield, and purification factor.

New methodology to quantify source contributions to nitrate, sulfate and ammonium using PMF-AI.

Identifying inorganic aerosol (IA), the major component of PM, which can originate from both primary and secondary sources, is challenging without significant tracers for sources. Furthermore, there is a lack of studies, specifically investigating a novel method (i.e.

Spheroid assembly of mesenchymal stem cells enhances secretome-mediated corneal reinnervation and epithelial repair in a mouse model of experimental dry eye.

Dry eye disease is a complex ocular surface disorder with multifactorial pathophysiology, including corneal epithelial damage, chronic inflammation, and corneal nerve dysfunction. Among these, impaired corneal innervation plays a particularly critical role, as it disrupts neurotrophic support and tear reflexes, perpetuating disease progression, and delaying healing. However, conventional treatments often provide only temporary symptom relief without addressing underlying tissue damage or promoting nerve regeneration.

Jing Guan Fang, an herbal formula, as an immunomodulator: opposing effects on basal and lipopolysaccharide-induced inflammation of macrophage via JAK/STAT3 and MAPK pathways.

Jing Guan Fang, a formula based on , is commonly used for preventing SARS-CoV-2 infection and alleviating cold-like symptoms. However, the precise immunoregulatory mechanisms underlying its effects remain unclear and warrant investigation. This study aims to investigate the immunomodulatory effects of JGF and further elucidate the underlying mechanisms.

Antagonistic effect of arsenic exposure and chronic hepatitis viral infection on hepatocellular carcinoma.

Background: Arsenic from drinking water causes many health hazards including liver diseases, but the long-term effects of arsenic exposure and methylation capability on hepatitis viral infection related liver cancer remain to be elucidated.

Methods: This 19-year community-based follow-up study included 7,837 participants with urinary arsenic metabolites level from an arseniasis area in northeastern Taiwan. They were recruited in 1991-1994 and followed up to December 2021.

Synergistic Carbon Nanostructures for High Energy Density Lithium Metal Capacitors.

Lithium metal capacitors (LMCs) are analogues to lithium metal batteries (LMBs), sharing similar anode (lithium) but differing cathodes (porous carbon and transition metal compounds, respectively) and storage mechanisms. Porous carbon cathode of LMCs can be synthesized from carbon-negative sustainable sources, but the transition metal compounds in LMBs leave significantly high carbon and material footprints. Herein, ultrahigh specific energy LMCs are demonstrated using biomass-derived commercial carbon modified with carbon quantum dots (CDs) and single-walled carbon nanotubes (SWCNTs) that outperformed the theoretical capacity of several LMB cathodes.

IPSC-Derived Conditioned Medium Reduces Oxidative Stress and Vascular Remodeling in Rat Models of Pulmonary Arterial Hypertension.

Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by elevated pulmonary vascular resistance, leading to right ventricular (RV) hypertrophy and eventual heart failure. Although current therapies provide symptomatic relief, they offer limited efficacy in reversing the underlying vascular remodeling. In this preclinical study, we investigated the therapeutic potential of induced pluripotent stem cell-derived conditioned medium (iPSC-CM) in a monocrotaline (MCT)-induced rat model of PAH, employing both prophylactic and therapeutic administration strategies.

Dual-Mode Photonic Synapse Based on a Lead-Free 2D Ruddlesden-Popper Perovskite for Neuromorphic Vision.

Inspired by the human visual system, photonic synapses with photonic sensing and data memorization offer a promising alternative to traditional von Neumann architectures for neuromorphic computing. This study introduces a multifunctional artificial photonic synapse based on solution-processed PEASnI 2D Ruddlesden-Popper perovskite. By modulation of the applied bias voltage, the PEASnI device can switch between two distinct optoelectronic modes.

Structural Evolution, Mechanical Properties, and Thermal Stability of Multi-Principal TiZrHf(Ta, Y, Cr) Alloy Films.

Mixing enthalpy (Δ), mixing entropy (Δ), atomic-size difference (δ), and valence electron concentration (VEC) are the indicators determining the phase structures of multi-principal element alloys. Exploring the relationships between the structures and properties of multi-principal element films is a fundamental study. TiZrHf films with a Δ of 0.

Development and Validation of a Custom-Built System for Real-Time Monitoring of In Vitro Rumen Gas Fermentation.

While the Ankom RF system facilitates efficient high-throughput in vitro fermentation studies, its high cost and limited flexibility constrain its broader applicability. To address these limitations, we developed and validated a low-cost, modular gas monitoring system (FerME), assembled from commercially available components. To evaluate its performance and reproducibility relative to the Ankom RF system (Ankom Technology, Macedon, NY, USA), in vitro rumen fermentation experiments were conducted under strictly controlled and identical conditions.

Fused Dithienoheterocycle-Based Hole-Transporting Materials for Efficient Perovskite Solar Cells.

The development of efficient and stable hole-transporting materials (HTMs) is critical for advancing perovskite solar cell (PSC) technology. This study presents two novel HTMs, LK-1 and LK-2, based on fused dithienoheterocycle derivatives, namely, dithieno[3,2-f:2',3'-h]quinoxaline (DTQu) and dithieno[3,2-a:2',3'-c]phenazine (DTPh), designed for PSCs. These donor-acceptor-donor (D-A-D) structured HTMs exhibit planar, rigid cores that enhance π-π stacking, improving hole mobility and stability.

Monolayer graphene/platinum-modified 3D origami microfluidic paper-based biosensor for smartphone-assisted biomarkers detection.

Background And Purpose: Imbalances in biomarkers such as dopamine and NADH are linked to neurological and metabolic disorders, including Parkinson's disease, depression, and stroke, underscoring the need for rapid and accessible diagnostics. This study presents a smartphone-assisted, 3D origami microfluidic paper-based analytical device (μPAD) modified with photochemically synthesized graphene/platinum (G/Pt) nanocatalysts for multiplex colorimetric detection of dopamine and NADH.

Experimental Approach: G/Pt catalysts were prepared using 2.

Enhanced electrochemical detection of propyl gallate in foods using molybdenum diselenide decorated on graphitic carbon nitride modified electrode.

The growing reliance on antioxidants such as propyl gallate (PG) for food preservation, while beneficial for extending shelf life, raises important concerns regarding consumer safety and product integrity. To address this issue, we present a high-performance electrochemical sensor based on a MoSe/g-CN heterostructure for the ultrasensitive detection of PG. The sensor was fabricated by modifying a glassy carbon electrode with hydrothermally synthesized MoSe integrated with g-CN nanosheets, exploiting their improved conductivity and catalytic properties due to the composite structure.

New Oxyhalide Solid Electrolytes with Enhanced Conductivity for All-Solid-State Batteries.

Departing from conventional Li--X frameworks, we develop a Li--X oxyhalide chemistry (LiTaOCl, 0.8/3 ≤ ≤ 1.4/3) to overcome the conductivity limitation of halide-based solid electrolytes (SEs).

How Humor Use by Nurse Supervisors, Reduced Time Pressure, and Years in the Profession Jointly Reduce Nurse Turnover Intention.

Aim: To investigate how humor use by nurse supervisors, reduced time pressure, and years in the profession jointly reduce nurse turnover intention.

Background: Nurses encounter various workplace stressors that cause negative outcomes. Humor use among nurse supervisors is known to help form cohesive relationships and reduce job burnout.

Feature-based molecular networking of two Arenga species extracts, appraisal of their anti-inflammatory, analgesic, and antidiarrheal activity.

Objective: Genus Arenga was used in traditional medicine for their analgesia and anti-inflammatory activities. This study is aimed to report the chemical profile and therapeutic potential in management of diarrhea and pain control for the aqueous methanolic extract (AME) of A. engleri and A.