Perspectives of physical activity in combating metabolic syndrome: insights from a multi-ethnic urban population.

The United Arab Emirates is experiencing a rising burden of non-communicable diseases, particularly metabolic syndrome (MetS), driven by rapid urbanization and lifestyle changes. In Dubai's diverse population, where expatriates constitute 85% of residents, understanding perspectives on physical activity (PA) is essential for effective prevention strategies. This qualitative study explored stakeholder experiences and views on PA as a preventive measure for MetS.

Effect of a treatment strategy utilising golimumab, methotrexate and corticosteroids versus methotrexate and corticosteroids in early, untreated psoriatic arthritis (GOLMePsA): a single-centre, double-blind, parallel-group, randomised controlled trial.

Background: The optimal treatment strategy in early psoriatic arthritis remains unknown. We aimed to assess whether the combination of methotrexate and golimumab plus corticosteroids is superior to methotrexate plus corticosteroids in reducing disease activity in early, untreated psoriatic arthritis.

Methods: We did a double-blind, randomised, placebo-controlled, parallel-group, single-centre study in adults with treatment-naïve active psoriatic arthritis.

Reflecting on the social value of movement and dance.

Aims: This short report summarises the findings of a 51-page report on the social value of movement and dance in England, highlighting its contribution to public health, individual wellbeing, and community development.

Methods: The report synthesises data from multiple sources and quantifies the social value of movement and dance.

Results: Findings indicate that movement and dance contribute £3.

Using Recontextualisation Theory to Understand Learning Across Multiple Sites in Simulation-Based Nurse Education.

Aim: The aim of this discussion paper is to explore whether recontextualisation theory deepens our understanding of learning across multiple sites when introducing simulation-based education (SBE) into nurse education.

Background: The requirement for students to learn in clinical placements remains an aspiration as well as a regulatory requirement internationally. Yet, the increasing complexity of healthcare and the numbers of vacancies in the healthcare workforce globally have led to poor learning environments.

Sowing the seeds of sustainability: Digitalization, renewable energy, and carbon emissions in emerging economies' global value chains.

This study explores how digitalization moderates the link between renewable energy consumption and carbon emissions within global value chains across 31 emerging economies from 2001 to 2022. Employing a robust panel data approach, the research utilizes advanced econometric techniques such as fixed and random effects models with Driscoll and Kraay standard errors, and feasible generalized least squares (FGLS) estimators to account for cross-sectional dependence, heteroscedasticity, and autocorrelation. Our findings reveal that renewable energy consumption significantly lowers carbon emissions in global value chains, emphasizing its environmental benefits.

Capacitive Sensors for Label-Free Detection in High-Ionic-Strength Bodily Fluids: A Review.

Capacitive sensors are platforms that enable label-free, real-time detection at low non-perturbing voltages. These sensors do not rely on Faradaic processes, thereby eliminating the need for redox-active species and simplifying system integration for point-of-care diagnostics. However, their sensitivity in high-ionic-strength solutions, such as bodily fluids, is limited due to a reduced Debye length and non-specific interactions.

Mobile phone-based systems for community-led injury response and coordination: a scoping review protocol.

Traumatic injuries remain a leading cause of preventable death globally, and continue to burden global healthcare services, particularly in low-resource settings. Mobile phone-based community injury response and coordination (mCIRC) systems represent a promising solution in facilitating rapid identification of injured persons, and coordinating a community-led response as an alternative or adjunct to a formal emergency service. mCIRC systems may use technologies such as geolocation and push notifications to mobilize trained responders in the vicinity of the incident, ensuring timely intervention before professional medical services arrive.

Mental health issues, risks and barriers to care for Bangladeshi children and adolescents: insights from lived experiences.

Background: Mental health issues among Bangladeshi children and adolescents are increasing due to sociocultural factors. Despite its importance, in-depth research is scarce. This study addresses the gap by exploring mental health issues, risk factors and barriers to accessing care in rural and urban Bangladesh through qualitative methods.

Mental health and the environment - evolutionary perspectives.

This paper provides an overview of key concepts in evolutionary psychiatry, summarising major evolutionary explanations for mental illness and highlighting the potential of these perspectives to enhance assessment, diagnosis, explanation to the patient, treatment and prevention strategies. Expanding beyond conventional evolutionary approaches, we explore environmental influences on mental health and illness, emphasising the significant areas of convergence between evolutionary and environmental viewpoints. We then propose an integrated framework that combines insights from both perspectives, offering general principles for improving mental health outcomes at both individual and population levels.

Recovery for Professional and Elite Amateur Golfers: A Scoping Review of Evidence-Based Methods.

The lifestyle and athletic demands of a professional or elite amateur golfer are both physically and mentally challenging. Players need to withstand large forces during the swing, frequently travel between time zones, and often cycle through a variety of training and competition environments for large portions of the competitive season. Thus, with numerous factors contributing to physical and cognitive stress, optimising recovery for golfers is paramount.

Glucagon-like peptide-1 receptor agonists for treatment of diabetes and obesity: advantage of oral delivery.

GLP-1 receptor agonists ((GLP-1 RAs) are currently receiving a lot of attention because of their impact in diabetes, weight loss and other areas. While GLP-1 RAs in injectable form are highly efficacious, further work is required to develop oral versions which can deliver these peptides efficiently without requiring use of excessively high doses. This paper describes the ability of an oral peptide delivery formulation, Axcess™, to enhance uptake of GLP-1 receptor agonists via the intestine, resulting in changes in insulin and glucose blood levels indicative of biopotencies of 9% for exendin-4 and 14.

Is 2nd JAKi treatment for UC worth the effort? A retrospective, multi-Centre UK study.

Background And Aims: Janus Kinase inhibitors (JAKi) provide effective treatment for ulcerative colitis (UC), but inadequate response (IR) or intolerance occurs frequently. This study aimed to assess effectiveness of a second JAKi in a real-world UC cohort.

Methods: A retrospective multicentre cohort study encompassing 19 UK hospitals was undertaken.

Management of Ureteric Small Bowel Fistula: A Case Report and Review of the Current Literature.

Ureteric small bowel fistulas are rare entities, with limited reports in the literature. These pathological connections between the ureter and small bowel can lead to recurrent upper urinary tract infections and pose significant diagnostic and therapeutic challenges. The primary cause of ureteric small bowel fistula formation is iatrogenic intervention, such as percutaneous nephrolithotomy (PCNL) or abdominal surgery involving tissue resection.

Effect of Tourniquet Release Timing on Blood Loss, Surgical Time, and Wound Outcomes in Total Knee Arthroplasty: A Prospective Comparative Study.

Background The timing of tourniquet release in total knee arthroplasty (TKA) remains a topic of debate, with studies suggesting varying impacts on blood loss, operative time, and wound healing. Despite widespread global research, data from our region are limited, and objective assessment tools remain underutilised. Methods We conducted a prospective comparative study involving 113 patients undergoing primary TKA.

Understanding Marital Rape Perception in MENA and South Asia: The Role of Resistance, Sexual Deprivation, and Jealousy.

Exploring perceptions of marital rape (MR) across diverse regions, including the Middle East and North Africa (MENA) and South Asia, this study recruited participants ( = 576, = 24.88,  = 9.36) via convenience and snowball sampling for online surveys.

Maternal experience in the intensive care unit and Post-discharge care: the third report from the MaCriCare study.

Background: Obstetric critical care patients face unique challenges during intensive care unit (ICU) admission, including separation from their newborns and psychological trauma. The ICU environment, primarily designed to support physiological recovery, may not be optimised for maternal experience. Healthcare staff caring for these patients may also experience psychological distress.

PAVFCOS: The development of a core outcome set for pouch anal and vaginal fistula.

Aims: The primary aim was to develop a patient-centred core outcome set (COS) for interventional studies in patients with pouch anal and vaginal fistula (PAVF).

Method: PAVFCOS was developed using the methodology outlined by the Core Outcome Measures in Effectiveness Trials (COMET). Systematic review and qualitative patient interviews produced a long list of candidate outcomes.

Design and Simulation-Based Testing of a Mobile Application for Self-Care Management in Type 2 Diabetes Mellitus and Prediabetes.

Mobile health applications are increasingly recognized as valuable tools for supporting self-care management among individuals with type 2 diabetes mellitus (T2DM) and prediabetes. This study explores the development and testing of NusaCare, a mobile app designed to assist patients through lifestyle tracking, education, and personalized interventions. Using a co-design approach, the process began with desk reviews and focus group discussions to gather initial insights.

Early Detection of Lung Cancer Using a Convolutional Neural Network Integrating Multidimensional Clinical Information.

Lung cancer remains one of the leading causes of cancer-related deaths worldwide, primarily due to late-stage detection. Early diagnosis significantly improves survival rates, yet current screening methods face limitations in cost, accessibility, and predictive accuracy. This study leverages the comprehensive data from Taiwan's National Health Insurance Research Database (NHIRD) to develop a predictive model for early lung cancer detection.

Beyond the type 1 pattern: comprehensive risk stratification in Brugada syndrome.

Brugada Syndrome (BrS) is an inherited cardiac ion channelopathy associated with an elevated risk of sudden cardiac death, particularly due to ventricular arrhythmias in structurally normal hearts. Affecting approximately 1 in 2,000 individuals, BrS is most prevalent among middle-aged males of Asian descent. Although diagnosis is based on the presence of a Type 1 electrocardiographic (ECG) pattern, either spontaneous or induced, accurately stratifying risk in asymptomatic and borderline patients remains a major clinical challenge.

The application of EPSiT in pilonidal sinus disease: an international Delphi consensus study endorsed by the Association of Laparoscopic Surgeons of Great Britain and Ireland (ALSGBI).

Background: Endoscopic pilonidal sinus treatment (EPSiT) is a novel, minimally invasive surgical technique that has shown promise in the treatment of pilonidal sinus disease. Despite the apparent benefits and call for increased use, widespread uptake has been slow. This study aims to gather and understand expert international opinions on EPSiT and develop recommendations for its application in the surgical community.

Graviola Induces Apoptosis in Two Osteosarcoma Cell Lines and Downregulates the Cytokines IL-6 and TGFβ1 Which Are Implicated in Tumour Growth and Metastasis.

BackgroundOsteosarcoma (OS) is an aggressive bone tumour which affects mostly young children. Despite advances in chemotherapy regimens there is still high fatality and cure rates remain low. Graviola (GR) is a tropical fruit bearing tree whose leaves, stems and fruits have indigenous medicinal properties.

The Effects of Probiotics Consumption on Blood Pressure, Lipid Profile, Glycemic Indices, and Inflammatory Parameters in Overweight and Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Recent evidence suggests that probiotic supplementation might have beneficial impacts on improving obesity-related metabolic and inflammatory impairments in animal models and humans. This systematic review and meta-analysis aimed to review the existing literature about the effects of probiotics on blood pressure, glycemic control, lipid profile, inflammatory factors, and C-reactive protein levels in people with overweight or obesity. Comprehensive research was conducted across various online databases, including PubMed/MEDLINE, Cochrane, EMBASE, SCOPUS, Web of Science, and ProQuest, as well as ClinicalTrials.