The effect of 0.5 mg dose of colchicine on clinical outcomes in patients with acute myocardial infarction: An updated meta-analysis of randomized controlled trials.

Background: Inflammation plays a critical role in the progression of atherosclerosis, and the anti-inflammatory effects on clinical outcomes of patients with acute myocardial infarction (AMI) are still uncertain.

Objectives: We aimed to study the effects of a 0.5 mg dose of colchicine on clinical outcomes following AMI.

Nanocurcumin mediated photodynamic therapy as a novel approach for root canal disinfection: ex-vivo study.

Background: Antibacterial photodynamic therapy (aPDT) has been recommended to enhance root canal disinfection. Naturally derived photosensitizers have been suggested to enhance the effectiveness of aPDT.

Aim: To evaluate the in vitro characteristics, antibacterial activity and tubular penetration depth of nanocurcumin used as a photosensitizer for endodontic disinfection.

Hyomental distance measured ultrasonography versus weight-based criteria for laryngeal mask size selection in children: a randomized controlled trial.

Background: Typically, when choosing a size for a child’s laryngeal mask airway (LMA), weight is considered; however, this approach has limitations. This study evaluated the efficacy of ultrasonography (US) measured hyomental distance (HMD) compared to weight-based criteria for optimizing the selection of LMA size in pediatrics.

Methods: This randomized controlled trial included 60 children aged 3–14 years scheduled for surgery requiring LMA.

Nursing Students' Global Warming Knowledge and Sustainability Attitudes: The Moderating Role of Eco-Anxiety.

Recently, global warming and climate change knowledge and sustainability attitudes have gained prominence in nursing education; however, studies are scarce about how eco-anxiety moderates between these associations. This study explored the moderating role of nursing students' eco-anxiety between global warming knowledge and sustainability attitudes. Utilising a cross-sectional and correlational design, nursing students (n = 561) were recruited via consecutive sampling between November 2024 and February 2025.

Nationwide study of spondyloarthritis spectrum and disease characteristics in Egypt.

The aim of this study was to describe the array and disease characteristics of spondyloarthritis (SpA) across Egypt. This work included 1401 SpA patients recruited from 15 specialized Egyptian rheumatology centers representing 20 major cities. The demographic and clinical features, as well as the therapeutic data, were recorded.

Cultural Influences: Female Students' Awareness and Perception Regarding Human Papillomavirus Vaccine.

Background: Human papillomavirus infection (HPV) is a highly prevalent sexually transmitted infection worldwide. HPV is responsible for about 70% of all worldwide cervical cancer incidence. Culture plays a critical role in shaping female perceptions and awareness of the HPV vaccine, influencing both individual and community-level health behaviors.

Empowering breast cancer clients through AI chatbots: transforming knowledge and attitudes for enhanced nursing care.

Background: Breast cancer remains a leading cause of morbidity worldwide, necessitating innovative and accessible interventions that address both clinical and psychosocial needs. AI-powered chatbots are increasingly used in health education due to their 24/7 availability, personalization, and interactivity. However, empirical evidence on their effectiveness in enhancing knowledge, empowerment, and attitudes in oncology settings remains limited.

Targeting miR-32-5p suppresses c-MYC-driven proliferation and induces apoptosis in MCF-7 breast cancer cells.

Progress in molecular medicine has resulted in novel cancer therapies, with microRNAs (miRNAs) recognized as promising instruments for cancer detection and treatment. MicroRNAs are tiny non-coding RNA sequences that manipulate gene expression at the post-transcriptional stage and are involved in cellular differentiation and death. miR-32-5p demonstrates oncogenic activity in several cancers, while c-MYC oncogene is a well-known driver of cancer, promoting tumor growth by stimulating cell proliferation, blocking apoptosis, and suppressing immune responses.

The efficacy and safety of coronary sinus reducer in refractory angina: a systematic review and meta-analysis.

Background: Refractory angina is a challenging medical disorder associated with continuous anginal symptoms that do not respond to medical treatments or revascularization interventions. Coronary sinus reducer (CSR) has been introduced as a promising treatment option for patients with refractory angina. However, the avaliable evidence regarding the exact role of CSR in managing refractory angina is still inconclusive and limited by several factors, such as small sample size studies, and short follow up periods.

Comparative Study Between Conservative Versus Surgical Management of Iatrogenic Pancreatic Injury During Radical Nephrectomy.

Background Pancreatic injury is a rare but serious complication of radical nephrectomy. The best management strategy for this complication, either conservative or surgical, remains debated, with limited comparative data. Objective To compare conservative management (CM) (drain placement, nutritional support, or somatostatin analogs) with surgical management (SM) (direct pancreatic repair, surgical drainage procedures, or partial pancreatectomy) in terms of outcomes, hospital stay, and mortality.

Unraveling research self-efficacy and concerns as factors associated with psychological distress among nursing scholars in the era of artificial intelligence: a multi-campus survey.

Background: The relentless march of artificial intelligence (AI) has emerged as a formidable catalyst, offering a toolbox of novel tools and methodologies with the potential to revolutionize the very essence of research practices.

Objectives: To explore the association of levels of research self-efficacy and concerns related to artificial intelligence with psychological distress among nursing scholars.

Methods: A descriptive, multi-campus survey, cross-sectional design was adopted in this study.

Exploring Blood Flow Restriction Exercise Protocols for Elderly Populations: A Scoping Review of Cuff Pressure, Frequency, and Duration for Muscle Strength, Hypertrophy, and Functional Abilities Outcomes.

As aging leads to a decline in muscle mass, strength, and functional capacity, identifying effective, low-risk interventions for older adults is essential. Blood flow restriction training (BFRT) has gained recognition as a potential substitute for traditional high-load resistance training, offering comparable benefits with reduced mechanical stress. This scoping review explores current BFRT protocols-specifically cuff pressure, training frequency, and duration-and their impact on muscular strength, hypertrophy, and functional capabilities among healthy elderly individuals.

Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats.

Monosodium glutamate (MSG)-induced excitotoxicity is a major factor contributing to cognitive decline and neurodegeneration. Given the well-established roles of vitamin D (Vit D) and omega-3 polyunsaturated fatty acids (N-3 PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in neuroprotection, the present study aimed at analyzing their possible neuroprotective efficacy against MSG-induced neurotoxicity in rats, concerning the behavioral performance, hippocampal histological integrity, and pathological protein accumulation, along with determination of the inflammatory marker levels and mRNA expression of vitamin D receptors (VDR) and other neurodegeneration-related genes. Fifty male Sprague Dawley rats were randomly allocated to a control, an MSG, and three treatment groups that received MSG and either Vit D or N-3 PUFA supplements in combinations or alone for 4 weeks.

Effect of laparoscopic sleeve gastrectomy (LSG) on the erectile function of Egyptian obese men.

Objective: The primary aim of the study is to identify the effect of laparoscopic sleeve gastrectomy on the erectile function of Egyptian obese men via measurement of subjective feelings measured by the International Index of Erectile Function questionnaire (IIEF-5) and objective sex hormone test. The secondary aim of the study is to evaluate weight loss changes and changes in other blood test results.

Patients And Methods: One hundred Egyptian men with morbid obesity (mean BMI 45.

A cross-sectional study on colorectal cancer screening knowledge and barriers among university students.

Background: Colorectal cancer (CRC) is a significant contributor to cancer-related mortality on a global scale. Timely identification by screening can decrease the morbidity and mortality associated with CRC. This study aimed to evaluate the level of knowledge and perceived barriers related to CRC screening among university students.

Trends and Practices in Bariatric Surgery in Egypt: Insights on Esophagogastroduodenoscopy (EGD) Utilization and Surgical Volumes.

Background: Esophagogastroduodenoscopy (EGD) is crucial in bariatric surgery for detecting gastro-esophageal conditions and incidental pathologies, impacting surgical decisions and outcomes. The International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) recommends routine EGD before and after bariatric procedures to identify incidental pathologies. However, global adherence to these guidelines varies, especially in resource-constrained settings where economic limitations often dictate practice patterns.

Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma.

Background: Multiple Myeloma (MM) is a plasma cell malignancy associated with systemic and renal complications. This study evaluates the prognostic and diagnostic significance of poliovirus receptor (PVR) gene expression and protein levels, serum amylase, and urinary biomarkers (IGFBP-7, TIMP-2) in MM patients.

Methods: In a prospective case-control study, 50 MM patients and 50 healthy controls were assessed.

Small interfering RNA effect on lipoprotein(a): a systematic review.

Background: This systematic review investigates the effect of small interfering RNA (siRNA) therapies on lipoprotein(a) [Lp(a)] levels. The purpose is to evaluate the outcomes of recent randomized controlled trials (RCTs) involving siRNA treatments aimed at lowering Lp(a) levels, a known cardiovascular risk factor.

Methods: A comprehensive search across multiple databases was conducted, identifying 20 published and ongoing RCTs that examined the effects of siRNA therapies such as inclisiran, olpasiran, and SLN360 on Lp(a) levels.

Intra-Ligamentous Pigmented Villonodular Synovitis of the Anterior Cruciate Ligament, a Case Report.

Introduction: Pigmented villonodular synovitis arising from cruciate ligaments is a very rare condition. Arthroscopic management of these lesions is the treatment of choice. Probing of the anterior cruciate ligament (ACL) is very crucial due to the possibility of intraligamentous invasion of this lesion.

Nephrogenic adenoma of the urinary bladder. Clinical features, long-term follow-up and recurrence predictors.

Objectives: To review the clinical features of nephrogenic adenoma (NA) of the urinary bladder and assess the long-term recurrence rates.

Material And Methods: A retrospective analysis of all diagnosed NA of the urinary bladder between 2000 and 2023 was done. All patients' demographics, symptoms, history of previous bladder surgeries, macroscopic and microscopic features of NA and coincidental pathology were reviewed.

Estimation of Anti-SARS-CoV-2 IgM/IgG Seroprevalence Among Non-Vaccinated and Vaccinated University Students: A Cross-Sectional Egyptian Study.

It is essential to comprehend the humoral immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its vaccines to maximize the effectiveness of anti-SARSCoV-2 community immunization efforts. The aim of this cross-sectional study was to determine the seroprevalence of anti-SARS-CoV-2 IgM/IgG among newcomer students at Kafr Elsheikh University in Egypt, whether they had been vaccinated or not. Blood samples from 400 healthy newcomer students (200 non-vaccinated and 200 vaccinated) were evaluated for the presence of anti-SARS-CoV-2 IgM/IgG using colloidal gold immunochromatography lateral flow immunoassay cards, and then the results were confirmed by using specific ELISA tests.

Effectiveness of Palliative Care in Advanced Heart Failure: A Comprehensive Meta-Analysis.

Advanced heart failure (HF) significantly diminishes quality of life (QoL) due to severe symptom burden and psychological distress. This meta-analysis investigates the impact of palliative care interventions on QoL, psychological well-being, symptom burden, and mortality in adults with advanced HF. A systematic search of major databases through August 2024 identified 13 randomized controlled trials involving 1541 participants from the USA, China, Iran, and Sweden.

Enhancing water productivity and wheat (Triticum aestivum L.) production through applying different irrigation manners.

The availability and quality of irrigation water in Egypt have become major challenges for the agricultural sector. Thus, increasing water productivity and improving irrigation efficiency are critical goals. A field experiment was conducted under Upper Egypt conditions at the El-Mattana Agricultural Research Station, Luxor governorate, Egypt, to evaluate the effects of different irrigation methods traditional furrow irrigation (Ti), surge furrow irrigation (Si), and alternate furrow irrigation (Ai), on water productivity, growth, and yield of wheat in clay loam soil.